6KE2

ABloop reengineered Ferritin Nanocage

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004322	molecular_function	ferroxidase activity
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0005776	cellular_component	autophagosome
A	0005829	cellular_component	cytosol
A	0006826	biological_process	iron ion transport
A	0006879	biological_process	intracellular iron ion homeostasis
A	0006955	biological_process	immune response
A	0008198	molecular_function	ferrous iron binding
A	0008199	molecular_function	ferric iron binding
A	0008285	biological_process	negative regulation of cell population proliferation
A	0016491	molecular_function	oxidoreductase activity
A	0031410	cellular_component	cytoplasmic vesicle
A	0042802	molecular_function	identical protein binding
A	0044754	cellular_component	autolysosome
A	0046872	molecular_function	metal ion binding
A	0048147	biological_process	negative regulation of fibroblast proliferation
A	0070062	cellular_component	extracellular exosome
A	0070288	cellular_component	ferritin complex
A	0110076	biological_process	negative regulation of ferroptosis
A	0140315	molecular_function	iron ion sequestering activity
A	1904724	cellular_component	tertiary granule lumen
A	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue MG A 201

Chain	Residue
A	HOH317
A	HOH317
A	HOH352
A	HOH352
A	HOH497
A	HOH497
A	HOH556
A	HOH556

---

site_id	AC2
Number of Residues	6
Details	binding site for residue MG A 202

Chain	Residue
A	HOH329
A	HOH329
A	HOH495
A	HOH495
A	HOH495
A	HOH329

---

site_id	AC3
Number of Residues	5
Details	binding site for residue MG A 203

Chain	Residue
A	HOH343
A	HOH377
A	HOH396
A	HOH443
A	HOH508

---

site_id	AC4
Number of Residues	5
Details	binding site for residue MG A 204

Chain	Residue
A	ARG78
A	HOH308
A	HOH337
A	HOH394
A	HOH452

---

site_id	AC5
Number of Residues	3
Details	binding site for residue MG A 205

Chain	Residue
A	HOH344
A	HOH459
A	HOH484

---

site_id	AC6
Number of Residues	6
Details	binding site for residue FE A 206

Chain	Residue
A	GLU28
A	GLU61
A	HIS64
A	HOH326
A	HOH330
A	HOH351

---

site_id	AC7
Number of Residues	6
Details	binding site for residue FE A 207

Chain	Residue
A	GLN57
A	GLU60
A	HOH327
A	HOH360
A	HOH433
A	HOH437

---

site_id	AC8
Number of Residues	4
Details	binding site for residue CL A 208

Chain	Residue
A	ARG10
A	ASN12
A	TYR13
A	HOH462

---

site_id	AC9
Number of Residues	7
Details	binding site for residue CL A 209

Chain	Residue
A	GLU133
A	THR134
A	HIS135
A	TYR136
A	LEU137
A	ASN138
A	GLU139

---

site_id	AD1
Number of Residues	4
Details	binding site for residue CA A 210

Chain	Residue
A	ASP130
A	GLU133
A	HOH315
A	HOH315

---

Functional Information from PROSITE/UniProt

site_id	PS00204
Number of Residues	21
Details	FERRITIN_2 Ferritin iron-binding regions signature 2. DphLCDFIEthYLneqvkaIK

Chain	Residue	Details
A	ASP125-LYS145

---

site_id	PS00540
Number of Residues	19
Details	FERRITIN_1 Ferritin iron-binding regions signature 1. EeREhaEKLMklQNqRgGR

Chain	Residue	Details
A	GLU60-ARG78

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"1992356","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FHA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00085","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Site: {"description":"Essential for association with cargo receptor NCOA4","evidences":[{"source":"PubMed","id":"26436293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---