6KDM
HIV-1 reverse transcriptase with Q151M/Y115F/F116Y:DNA:entecavir 5'-triphosphate ternary complex
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003676 | molecular_function | nucleic acid binding |
A | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
A | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
A | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
B | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
B | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
C | 0003676 | molecular_function | nucleic acid binding |
C | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
C | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
C | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
D | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
D | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | binding site for residue GOL A 601 |
Chain | Residue |
A | LYS366 |
A | GLN407 |
A | ALA408 |
A | THR409 |
B | GLN394 |
B | THR397 |
site_id | AC2 |
Number of Residues | 4 |
Details | binding site for residue MG A 602 |
Chain | Residue |
A | ET9603 |
A | ASP110 |
A | VAL111 |
A | ASP185 |
site_id | AC3 |
Number of Residues | 19 |
Details | binding site for residue ET9 A 603 |
Chain | Residue |
A | LYS65 |
A | ARG72 |
A | ASP110 |
A | VAL111 |
A | GLY112 |
A | ASP113 |
A | ALA114 |
A | PHE115 |
A | MET151 |
A | GLY152 |
A | MET184 |
A | ASP185 |
A | LYS220 |
A | MG602 |
A | HOH771 |
E | DC0 |
E | DG1 |
E | DC33 |
E | HOH202 |
site_id | AC4 |
Number of Residues | 9 |
Details | binding site for residue GOL B 501 |
Chain | Residue |
A | LEU92 |
A | VAL381 |
B | GLN23 |
B | TRP24 |
B | PRO25 |
B | ASN137 |
B | HOH602 |
B | HOH615 |
B | HOH625 |
site_id | AC5 |
Number of Residues | 8 |
Details | binding site for residue GOL E 101 |
Chain | Residue |
A | ASN265 |
A | TRP266 |
A | GLN269 |
A | HOH765 |
E | DG30 |
E | HOH206 |
E | HOH223 |
E | HOH224 |
site_id | AC6 |
Number of Residues | 4 |
Details | binding site for residue MG C 601 |
Chain | Residue |
C | ASP110 |
C | VAL111 |
C | ASP185 |
C | ET9602 |
site_id | AC7 |
Number of Residues | 19 |
Details | binding site for residue ET9 C 602 |
Chain | Residue |
C | LYS65 |
C | ARG72 |
C | LEU74 |
C | ASP110 |
C | VAL111 |
C | GLY112 |
C | ASP113 |
C | ALA114 |
C | PHE115 |
C | MET151 |
C | GLY152 |
C | ASP185 |
C | LYS220 |
C | MG601 |
C | HOH770 |
C | HOH784 |
F | DC0 |
F | DG1 |
F | DC33 |
site_id | AC8 |
Number of Residues | 11 |
Details | binding site for residue GOL D 501 |
Chain | Residue |
C | LEU92 |
C | VAL381 |
D | GLN23 |
D | TRP24 |
D | PRO25 |
D | PRO133 |
D | ASN137 |
D | HOH604 |
D | HOH617 |
D | HOH639 |
D | HOH654 |
site_id | AC9 |
Number of Residues | 8 |
Details | binding site for residue GOL D 502 |
Chain | Residue |
C | GLN407 |
C | ALA408 |
C | THR409 |
C | HOH739 |
C | HOH741 |
D | ILE393 |
D | GLN394 |
D | THR397 |
site_id | AD1 |
Number of Residues | 6 |
Details | binding site for residue GOL D 503 |
Chain | Residue |
D | GLU328 |
D | TYR342 |
D | PHE346 |
D | ASN348 |
D | TRP426 |
D | HOH608 |
site_id | AD2 |
Number of Residues | 14 |
Details | binding site for Di-nucleotide DG F 1 and OMC F 2 |
Chain | Residue |
C | GLN161 |
C | MET184 |
C | ET9602 |
F | DC0 |
F | DC3 |
F | DG32 |
F | DC33 |
F | HOH103 |
F | HOH130 |
C | ASN81 |
C | GLU89 |
C | GLY152 |
C | LYS154 |
C | PRO157 |
site_id | AD3 |
Number of Residues | 13 |
Details | binding site for Di-nucleotide OMC F 2 and DC F 3 |
Chain | Residue |
C | GLU89 |
C | GLN91 |
C | ILE94 |
C | PRO157 |
C | GLN161 |
C | TYR183 |
C | MET184 |
F | DG1 |
F | OMC4 |
F | DG31 |
F | DG32 |
F | HOH103 |
F | HOH123 |
site_id | AD4 |
Number of Residues | 17 |
Details | binding site for Di-nucleotide DC F 3 and OMC F 4 |
Chain | Residue |
C | GLU89 |
C | GLN91 |
C | LEU92 |
C | ILE94 |
C | TYR183 |
C | HOH798 |
D | LYS22 |
F | OMC2 |
F | DC5 |
F | DG30 |
F | DG31 |
F | DG32 |
F | HOH104 |
F | HOH118 |
F | HOH123 |
F | HOH124 |
F | HOH125 |
site_id | AD5 |
Number of Residues | 14 |
Details | binding site for Di-nucleotide OMC F 4 and DC F 5 |
Chain | Residue |
C | LEU92 |
C | ILE94 |
C | HOH798 |
D | LYS22 |
F | DC3 |
F | DC6 |
F | DG29 |
F | DG30 |
F | DG31 |
F | HOH104 |
F | HOH118 |
F | HOH120 |
F | HOH124 |
F | HOH125 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 14 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | ASP549 | |
C | ASP110 | |
C | ASP185 | |
C | ASP186 | |
C | ASP443 | |
C | GLU478 | |
C | ASP498 | |
C | ASP549 | |
A | ASP110 | |
A | ASP185 | |
A | ASP186 | |
A | ASP443 | |
A | GLU478 | |
A | ASP498 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | SITE: Essential for RT p66/p51 heterodimerization => ECO:0000250 |
Chain | Residue | Details |
A | TRP401 | |
A | TRP414 | |
C | TRP401 | |
C | TRP414 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | SITE: Cleavage; by viral protease; partial => ECO:0000250 |
Chain | Residue | Details |
A | PHE440 | |
C | PHE440 |