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6KAZ

X-ray structure of human PPARalpha ligand binding domain-pemafibrate co-crystals obtained by soaking

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0004879molecular_functionnuclear receptor activity
A0005634cellular_componentnucleus
A0006355biological_processregulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues7
Detailsbinding site for residue GOL A 501
ChainResidue
ALYS222
AARG226
ALEU229
ASER323
AMET325
AASN326
AASN366

site_idAC2
Number of Residues14
Detailsbinding site for residue P7F A 502
ChainResidue
ACYS276
ATHR279
ASER280
ATYR314
AILE317
APHE318
ALEU321
AVAL324
AMET355
AHIS440
ATYR464
AHOH626
APHE273
ACYS275

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsBINDING: BINDING => ECO:0000269|PubMed:19116277, ECO:0007744|PDB:3ET1
ChainResidueDetails
ASER280
ATYR314
ATYR464

site_idSWS_FT_FI2
Number of Residues1
DetailsSITE: Essential for heterodimerization with RXRA
ChainResidueDetails
ALEU433

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PDB entries from 2024-11-06

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