6KA0

Silver-bound E.coli Malate dehydrogenase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006096	biological_process	glycolytic process
A	0006099	biological_process	tricarboxylic acid cycle
A	0006108	biological_process	malate metabolic process
A	0006113	biological_process	fermentation
A	0009061	biological_process	anaerobic respiration
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0016615	molecular_function	malate dehydrogenase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0019752	biological_process	carboxylic acid metabolic process
A	0019898	cellular_component	extrinsic component of membrane
A	0030060	molecular_function	L-malate dehydrogenase activity
A	0042803	molecular_function	protein homodimerization activity
B	0003824	molecular_function	catalytic activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006096	biological_process	glycolytic process
B	0006099	biological_process	tricarboxylic acid cycle
B	0006108	biological_process	malate metabolic process
B	0006113	biological_process	fermentation
B	0009061	biological_process	anaerobic respiration
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0016615	molecular_function	malate dehydrogenase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0019752	biological_process	carboxylic acid metabolic process
B	0019898	cellular_component	extrinsic component of membrane
B	0030060	molecular_function	L-malate dehydrogenase activity
B	0042803	molecular_function	protein homodimerization activity
C	0003824	molecular_function	catalytic activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006096	biological_process	glycolytic process
C	0006099	biological_process	tricarboxylic acid cycle
C	0006108	biological_process	malate metabolic process
C	0006113	biological_process	fermentation
C	0009061	biological_process	anaerobic respiration
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0016615	molecular_function	malate dehydrogenase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0019752	biological_process	carboxylic acid metabolic process
C	0019898	cellular_component	extrinsic component of membrane
C	0030060	molecular_function	L-malate dehydrogenase activity
C	0042803	molecular_function	protein homodimerization activity
D	0003824	molecular_function	catalytic activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006096	biological_process	glycolytic process
D	0006099	biological_process	tricarboxylic acid cycle
D	0006108	biological_process	malate metabolic process
D	0006113	biological_process	fermentation
D	0009061	biological_process	anaerobic respiration
D	0016020	cellular_component	membrane
D	0016491	molecular_function	oxidoreductase activity
D	0016615	molecular_function	malate dehydrogenase activity
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0019752	biological_process	carboxylic acid metabolic process
D	0019898	cellular_component	extrinsic component of membrane
D	0030060	molecular_function	L-malate dehydrogenase activity
D	0042803	molecular_function	protein homodimerization activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue AG A 401

Chain	Residue
A	CYS113
A	LEU242
A	TRS403

---

site_id	AC2
Number of Residues	2
Details	binding site for residue AG A 402

Chain	Residue
A	CYS251
A	HOH501

---

site_id	AC3
Number of Residues	6
Details	binding site for residue TRS A 403

Chain	Residue
A	LYS272
A	AG401
A	ASP71
A	LYS111
A	CYS113
A	LYS142

---

site_id	AC4
Number of Residues	4
Details	binding site for residue AG B 401

Chain	Residue
B	ASP71
B	CYS113
B	LYS142
B	TRS402

---

site_id	AC5
Number of Residues	5
Details	binding site for residue TRS B 402

Chain	Residue
B	ASP71
B	LYS111
B	LYS142
B	LYS272
B	AG401

---

site_id	AC6
Number of Residues	3
Details	binding site for residue AG C 401

Chain	Residue
C	CYS113
C	LEU242
C	TRS402

---

site_id	AC7
Number of Residues	8
Details	binding site for residue TRS C 402

Chain	Residue
C	ASP71
C	LYS111
C	ALA112
C	CYS113
C	LYS142
C	LEU242
C	LYS272
C	AG401

---

site_id	AC8
Number of Residues	4
Details	binding site for residue AG D 401

Chain	Residue
D	ASP71
D	CYS113
D	LEU242
D	TRS402

---

site_id	AC9
Number of Residues	7
Details	binding site for residue TRS D 402

Chain	Residue
D	ASP71
D	LYS111
D	ALA112
D	CYS113
D	LYS142
D	LYS272
D	AG401

---

Functional Information from PROSITE/UniProt

site_id	PS00068
Number of Residues	13
Details	MDH Malate dehydrogenase active site signature. VTTLDiiRSntfV

Chain	Residue	Details
A	VAL146-VAL158

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_01516, ECO:0000305|PubMed:11389141

Chain	Residue	Details
A	HIS177
B	HIS177
C	HIS177
D	HIS177

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01516, ECO:0000269|PubMed:11389141, ECO:0000269|PubMed:8331658

Chain	Residue	Details
A	GLY7
B	MET227
C	GLY7
C	ASP34
C	ASN94
C	ILE117
C	MET227
D	GLY7
D	ASP34
D	ASN94
D	ILE117
A	ASP34
D	MET227
A	ASN94
A	ILE117
A	MET227
B	GLY7
B	ASP34
B	ASN94
B	ILE117

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01516, ECO:0000305|PubMed:1507230, ECO:0000305|PubMed:8331658

Chain	Residue	Details
A	ARG81
C	ARG87
C	ASN119
C	ARG153
D	ARG81
D	ARG87
D	ASN119
D	ARG153
A	ARG87
A	ASN119
A	ARG153
B	ARG81
B	ARG87
B	ASN119
B	ARG153
C	ARG81

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	2
Details	M-CSA 527

Chain	Residue	Details
A	ASP150	modifies pKa
A	HIS177	proton acceptor, proton donor

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site_id	MCSA2
Number of Residues	2
Details	M-CSA 527

Chain	Residue	Details
B	ASP150	modifies pKa
B	HIS177	proton acceptor, proton donor

---

site_id	MCSA3
Number of Residues	2
Details	M-CSA 527

Chain	Residue	Details
C	ASP150	modifies pKa
C	HIS177	proton acceptor, proton donor

---

site_id	MCSA4
Number of Residues	2
Details	M-CSA 527

Chain	Residue	Details
D	ASP150	modifies pKa
D	HIS177	proton acceptor, proton donor

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