6K9Y

Crystal structure of human VAT-1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003960	molecular_function	quinone reductase (NADPH) activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0005741	cellular_component	mitochondrial outer membrane
A	0005829	cellular_component	cytosol
A	0006869	biological_process	lipid transport
A	0008270	molecular_function	zinc ion binding
A	0008753	molecular_function	NADPH dehydrogenase (quinone) activity
A	0010637	biological_process	negative regulation of mitochondrial fusion
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0035578	cellular_component	azurophil granule lumen
A	0070062	cellular_component	extracellular exosome
A	0120010	biological_process	intermembrane phospholipid transfer
A	0120014	molecular_function	phospholipid transfer activity
B	0003960	molecular_function	quinone reductase (NADPH) activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005737	cellular_component	cytoplasm
B	0005741	cellular_component	mitochondrial outer membrane
B	0005829	cellular_component	cytosol
B	0006869	biological_process	lipid transport
B	0008270	molecular_function	zinc ion binding
B	0008753	molecular_function	NADPH dehydrogenase (quinone) activity
B	0010637	biological_process	negative regulation of mitochondrial fusion
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0035578	cellular_component	azurophil granule lumen
B	0070062	cellular_component	extracellular exosome
B	0120010	biological_process	intermembrane phospholipid transfer
B	0120014	molecular_function	phospholipid transfer activity
C	0003960	molecular_function	quinone reductase (NADPH) activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005737	cellular_component	cytoplasm
C	0005741	cellular_component	mitochondrial outer membrane
C	0005829	cellular_component	cytosol
C	0006869	biological_process	lipid transport
C	0008270	molecular_function	zinc ion binding
C	0008753	molecular_function	NADPH dehydrogenase (quinone) activity
C	0010637	biological_process	negative regulation of mitochondrial fusion
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0035578	cellular_component	azurophil granule lumen
C	0070062	cellular_component	extracellular exosome
C	0120010	biological_process	intermembrane phospholipid transfer
C	0120014	molecular_function	phospholipid transfer activity
D	0003960	molecular_function	quinone reductase (NADPH) activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005737	cellular_component	cytoplasm
D	0005741	cellular_component	mitochondrial outer membrane
D	0005829	cellular_component	cytosol
D	0006869	biological_process	lipid transport
D	0008270	molecular_function	zinc ion binding
D	0008753	molecular_function	NADPH dehydrogenase (quinone) activity
D	0010637	biological_process	negative regulation of mitochondrial fusion
D	0016020	cellular_component	membrane
D	0016491	molecular_function	oxidoreductase activity
D	0035578	cellular_component	azurophil granule lumen
D	0070062	cellular_component	extracellular exosome
D	0120010	biological_process	intermembrane phospholipid transfer
D	0120014	molecular_function	phospholipid transfer activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue NO3 A 401

Chain	Residue
A	ALA221
A	SER222
A	LYS225
A	TYR240
A	LYS377
A	HOH525

---

site_id	AC2
Number of Residues	7
Details	binding site for residue NO3 A 402

Chain	Residue
A	GLY200
A	VAL201
A	LYS382
A	HOH510
A	LEU88
A	ASN89
A	ASN172

---

site_id	AC3
Number of Residues	4
Details	binding site for residue NO3 B 401

Chain	Residue
B	ALA221
B	SER222
B	LYS225
B	LYS377

---

site_id	AC4
Number of Residues	8
Details	binding site for residue NO3 B 402

Chain	Residue
B	LEU88
B	ASN89
B	ASN172
B	GLY200
B	VAL201
B	ASN379
B	LYS382
B	HOH508

---

site_id	AC5
Number of Residues	8
Details	binding site for residue NO3 C 401

Chain	Residue
C	LEU88
C	ASN89
C	ASN172
C	GLY200
C	VAL201
C	MET374
C	LYS382
C	HOH513

---

site_id	AC6
Number of Residues	3
Details	binding site for residue NO3 C 402

Chain	Residue
C	SER222
C	LYS225
C	HIS241

---

site_id	AC7
Number of Residues	7
Details	binding site for residue NO3 D 401

Chain	Residue
D	LEU88
D	ASN89
D	ASN172
D	GLY200
D	VAL201
D	LYS382
D	HOH508

---

site_id	AC8
Number of Residues	5
Details	binding site for residue NO3 D 402

Chain	Residue
D	PHE90
D	ALA91
D	MET94
D	GLY286
D	MET287

---

Functional Information from PROSITE/UniProt

site_id	PS01162
Number of Residues	22
Details	QOR_ZETA_CRYSTAL Quinone oxidoreductase / zeta-crystallin signature. GHsvLvhmAAGGvGmaavQlcR

Chain	Residue	Details
A	GLY189-ARG210

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Region: {"description":"Extruded flexible loop; potentially involved in lipid transfer and membrane binding","evidences":[{"source":"PubMed","id":"32005660","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Motif: {"description":"Required for negative regulation of mitochondrial fusion","evidences":[{"source":"UniProtKB","id":"Q3MIE4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	52
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33483563","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6LHR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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