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6K9K

Monomeric human ATM (Ataxia telangiectasia mutated) kinase

Functional Information from GO Data
ChainGOidnamespacecontents
A0000077biological_processDNA damage checkpoint signaling
A0000166molecular_functionnucleotide binding
A0000425biological_processpexophagy
A0000723biological_processtelomere maintenance
A0000724biological_processdouble-strand break repair via homologous recombination
A0000729biological_processDNA double-strand break processing
A0000781cellular_componentchromosome, telomeric region
A0002331biological_processpre-B cell allelic exclusion
A0003677molecular_functionDNA binding
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004677molecular_functionDNA-dependent protein kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005694cellular_componentchromosome
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005782cellular_componentperoxisomal matrix
A0005813cellular_componentcentrosome
A0005819cellular_componentspindle
A0005829cellular_componentcytosol
A0006281biological_processDNA repair
A0006302biological_processdouble-strand break repair
A0006303biological_processdouble-strand break repair via nonhomologous end joining
A0006338biological_processchromatin remodeling
A0006974biological_processDNA damage response
A0007094biological_processmitotic spindle assembly checkpoint signaling
A0007095biological_processmitotic G2 DNA damage checkpoint signaling
A0007127biological_processmeiosis I
A0007131biological_processreciprocal meiotic recombination
A0007165biological_processsignal transduction
A0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
A0010212biological_processresponse to ionizing radiation
A0010468biological_processregulation of gene expression
A0010506biological_processregulation of autophagy
A0010557biological_processpositive regulation of macromolecule biosynthetic process
A0010628biological_processpositive regulation of gene expression
A0016301molecular_functionkinase activity
A0016303molecular_function1-phosphatidylinositol-3-kinase activity
A0016740molecular_functiontransferase activity
A0030330biological_processDNA damage response, signal transduction by p53 class mediator
A0030335biological_processpositive regulation of cell migration
A0030889biological_processnegative regulation of B cell proliferation
A0031410cellular_componentcytoplasmic vesicle
A0032210biological_processregulation of telomere maintenance via telomerase
A0032212biological_processpositive regulation of telomere maintenance via telomerase
A0033554biological_processcellular response to stress
A0034614biological_processcellular response to reactive oxygen species
A0035861cellular_componentsite of double-strand break
A0035979molecular_functionhistone H2AXS139 kinase activity
A0036092biological_processphosphatidylinositol-3-phosphate biosynthetic process
A0036289biological_processpeptidyl-serine autophosphorylation
A0042770biological_processsignal transduction in response to DNA damage
A0042802molecular_functionidentical protein binding
A0042981biological_processregulation of apoptotic process
A0043065biological_processpositive regulation of apoptotic process
A0043517biological_processpositive regulation of DNA damage response, signal transduction by p53 class mediator
A0044877molecular_functionprotein-containing complex binding
A0045785biological_processpositive regulation of cell adhesion
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046777biological_processprotein autophosphorylation
A0050821biological_processprotein stabilization
A0051726biological_processregulation of cell cycle
A0071044biological_processhistone mRNA catabolic process
A0071300biological_processcellular response to retinoic acid
A0071480biological_processcellular response to gamma radiation
A0071481biological_processcellular response to X-ray
A0071500biological_processcellular response to nitrosative stress
A0080135biological_processregulation of cellular response to stress
A0090398biological_processcellular senescence
A0090399biological_processreplicative senescence
A0097694biological_processestablishment of RNA localization to telomere
A0097695biological_processestablishment of protein-containing complex localization to telomere
A0098850cellular_componentextrinsic component of synaptic vesicle membrane
A0106310molecular_functionprotein serine kinase activity
A1900034biological_processregulation of cellular response to heat
A1901701biological_processcellular response to oxygen-containing compound
A1901796biological_processregulation of signal transduction by p53 class mediator
A1904262biological_processnegative regulation of TORC1 signaling
A1904354biological_processnegative regulation of telomere capping
A1904358biological_processpositive regulation of telomere maintenance via telomere lengthening
A1904884biological_processpositive regulation of telomerase catalytic core complex assembly
A1990391cellular_componentDNA repair complex
A2000781biological_processpositive regulation of double-strand break repair
A2000785biological_processregulation of autophagosome assembly
Functional Information from PROSITE/UniProt
site_idPS00915
Number of Residues15
DetailsPI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. VKgr.DDLRQDavmqQ
ChainResidueDetails
AVAL2716-GLN2730

site_idPS00916
Number of Residues21
DetailsPI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. SvAtssIvgYILgLgDRHvqN
ChainResidueDetails
ASER2855-ASN2875

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues32
DetailsDomain: {"description":"FATC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00534","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU00535","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues6
DetailsRegion: {"description":"G-loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues8
DetailsRegion: {"description":"Catalytic loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues24
DetailsRegion: {"description":"Activation loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues2
DetailsMotif: {"description":"Microbody targeting signal; atypical","evidences":[{"source":"PubMed","id":"26344566","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by autocatalysis","evidences":[{"source":"PubMed","id":"16858402","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"17923702","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30944854","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

246905

PDB entries from 2025-12-31

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