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6K80

Crystal Structure of Drosophila melanogaster Dopamine N-Acetyltransferase in Complex with CoA and Tryptophol

Functional Information from GO Data
ChainGOidnamespacecontents
A0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
Functional Information from PDB Data
site_idAC1
Number of Residues9
Detailsbinding site for residue ZCW A 301
ChainResidue
AHIS184
AARG200
AMET201
AGLN202
AVAL221
AGLY222
AILE223
AGLN224
AHOH491

site_idAC2
Number of Residues8
Detailsbinding site for residue ZCW A 302
ChainResidue
AGLU47
AASN50
ALEU61
APHE114
AMET121
AILE145
ALEU180
AHOH444

site_idAC3
Number of Residues7
Detailsbinding site for residue ZCW A 303
ChainResidue
ATYR185
AHIS196
AGLU229
AACO304
AHOH435
AHOH468
AHOH557

site_idAC4
Number of Residues37
Detailsbinding site for residue ACO A 304
ChainResidue
APHE43
AASP46
APRO48
AASP132
AVAL133
APRO135
AGLY143
ALYS144
AILE145
ALEU146
ASER147
AVAL148
AARG153
AGLY154
ALEU155
AGLY156
AILE157
AALA158
ALEU180
ASER182
AVAL189
ALYS192
AZCW303
AHOH420
AHOH425
AHOH433
AHOH440
AHOH458
AHOH459
AHOH479
AHOH480
AHOH487
AHOH490
AHOH497
AHOH502
AHOH559
AHOH582

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:22716280, ECO:0007744|PDB:3TE4
ChainResidueDetails
ALEU146
AGLY154

site_idSWS_FT_FI2
Number of Residues3
DetailsSITE: Has a role in the catalytic activity => ECO:0000269|PubMed:25406072
ChainResidueDetails
AGLU47
ASER182
ASER186

site_idSWS_FT_FI3
Number of Residues1
DetailsSITE: Might be involved in substrate binding => ECO:0000269|PubMed:25406072
ChainResidueDetails
ATYR64

site_idSWS_FT_FI4
Number of Residues1
DetailsSITE: Regulates binding affinity for coenzyme A (CoASH) => ECO:0000269|PubMed:25406072
ChainResidueDetails
AARG153

site_idSWS_FT_FI5
Number of Residues1
DetailsSITE: Acetyl-CoA => ECO:0000269|PubMed:22716280, ECO:0007744|PDB:3TE4
ChainResidueDetails
ALYS192

227561

PDB entries from 2024-11-20

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