6K7X

Human MCU-EMRE complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0051560	biological_process	mitochondrial calcium ion homeostasis
B	0051560	biological_process	mitochondrial calcium ion homeostasis
C	0051560	biological_process	mitochondrial calcium ion homeostasis
D	0051560	biological_process	mitochondrial calcium ion homeostasis
E	0036444	biological_process	calcium import into the mitochondrion
E	0051560	biological_process	mitochondrial calcium ion homeostasis
E	1990246	cellular_component	uniplex complex
F	0036444	biological_process	calcium import into the mitochondrion
F	0051560	biological_process	mitochondrial calcium ion homeostasis
F	1990246	cellular_component	uniplex complex
G	0036444	biological_process	calcium import into the mitochondrion
G	0051560	biological_process	mitochondrial calcium ion homeostasis
G	1990246	cellular_component	uniplex complex
H	0036444	biological_process	calcium import into the mitochondrion
H	0051560	biological_process	mitochondrial calcium ion homeostasis
H	1990246	cellular_component	uniplex complex
K	0051560	biological_process	mitochondrial calcium ion homeostasis
L	0051560	biological_process	mitochondrial calcium ion homeostasis
M	0051560	biological_process	mitochondrial calcium ion homeostasis
N	0051560	biological_process	mitochondrial calcium ion homeostasis
O	0036444	biological_process	calcium import into the mitochondrion
O	0051560	biological_process	mitochondrial calcium ion homeostasis
O	1990246	cellular_component	uniplex complex
P	0036444	biological_process	calcium import into the mitochondrion
P	0051560	biological_process	mitochondrial calcium ion homeostasis
P	1990246	cellular_component	uniplex complex
Q	0036444	biological_process	calcium import into the mitochondrion
Q	0051560	biological_process	mitochondrial calcium ion homeostasis
Q	1990246	cellular_component	uniplex complex
R	0036444	biological_process	calcium import into the mitochondrion
R	0051560	biological_process	mitochondrial calcium ion homeostasis
R	1990246	cellular_component	uniplex complex

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	488
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"31080062","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32494073","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32762847","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32862359","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6K7X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6K7Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O5B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WDN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WDO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XJV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XJX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	48
Details	Topological domain: {"description":"Mitochondrial intermembrane","evidences":[{"source":"PubMed","id":"27099988","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31080062","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"32494073","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"32762847","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	720
Details	Region: {"description":"N-terminal MCU domain","evidences":[{"source":"PubMed","id":"26341627","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	40
Details	Region: {"description":"Juxtamembrane helix","evidences":[{"source":"PubMed","id":"31080062","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33296646","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	472
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	64
Details	Motif: {"description":"Selectivity filter","evidences":[{"source":"PubMed","id":"31080062","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32494073","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31080062","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32494073","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32862359","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6K7X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6K7Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O5B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WDO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI8
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine; by CaMK2","evidences":[{"source":"PubMed","id":"23051746","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI9
Number of Residues	8
Details	Modified residue: {"description":"S-glutathionyl cysteine","evidences":[{"source":"PubMed","id":"28262504","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI10
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q3UMR5","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI11
Number of Residues	88
Details	Topological domain: {"description":"Mitochondrial matrix","evidences":[{"source":"PubMed","id":"27099988","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27642048","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31080062","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"32762847","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	32
Details	Motif: {"description":"GXXXX[G/A/S]","evidences":[{"source":"PubMed","id":"27099988","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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