Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004799 | molecular_function | thymidylate synthase activity |
| A | 0006231 | biological_process | dTMP biosynthetic process |
| A | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| B | 0004799 | molecular_function | thymidylate synthase activity |
| B | 0006231 | biological_process | dTMP biosynthetic process |
| B | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue UMP A 301 |
| Chain | Residue |
| A | ARG25 |
| A | HIS232 |
| A | TYR234 |
| A | D16302 |
| A | HOH430 |
| A | HOH461 |
| B | ARG151 |
| B | ARG152 |
| A | CYS171 |
| A | HIS172 |
| A | GLN190 |
| A | ARG191 |
| A | SER192 |
| A | ALA193 |
| A | ASP194 |
| A | ASN202 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | binding site for residue D16 A 302 |
| Chain | Residue |
| A | PHE56 |
| A | ILE84 |
| A | ASP194 |
| A | LEU197 |
| A | GLY198 |
| A | PHE201 |
| A | TYR234 |
| A | MET287 |
| A | ALA288 |
| A | UMP301 |
| A | HOH556 |
| A | HOH562 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | binding site for residue UMP B 301 |
| Chain | Residue |
| A | ARG151 |
| A | ARG152 |
| B | CYS171 |
| B | HIS172 |
| B | GLN190 |
| B | ARG191 |
| B | SER192 |
| B | ASP194 |
| B | ASN202 |
| B | HIS232 |
| B | TYR234 |
| B | D16302 |
| B | HOH416 |
| B | HOH422 |
| B | HOH423 |
| B | HOH569 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue D16 B 302 |
| Chain | Residue |
| B | PHE56 |
| B | ASP194 |
| B | LEU197 |
| B | GLY198 |
| B | PHE201 |
| B | TYR234 |
| B | MET287 |
| B | UMP301 |
| B | HOH528 |
Functional Information from PROSITE/UniProt
| site_id | PS00091 |
| Number of Residues | 29 |
| Details | THYMIDYLATE_SYNTHASE Thymidylate synthase active site. RriImcaWNpvdvpkma.....LpPCHclcQFyV |
| Chain | Residue | Details |
| A | ARG151-VAL179 | |
