6K7Q

Crystal structure of thymidylate synthase from shrimp

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004799	molecular_function	thymidylate synthase activity
A	0006231	biological_process	dTMP biosynthetic process
A	0016741	molecular_function	transferase activity, transferring one-carbon groups
B	0004799	molecular_function	thymidylate synthase activity
B	0006231	biological_process	dTMP biosynthetic process
B	0016741	molecular_function	transferase activity, transferring one-carbon groups
C	0004799	molecular_function	thymidylate synthase activity
C	0006231	biological_process	dTMP biosynthetic process
C	0016741	molecular_function	transferase activity, transferring one-carbon groups
D	0004799	molecular_function	thymidylate synthase activity
D	0006231	biological_process	dTMP biosynthetic process
D	0016741	molecular_function	transferase activity, transferring one-carbon groups
E	0004799	molecular_function	thymidylate synthase activity
E	0006231	biological_process	dTMP biosynthetic process
E	0016741	molecular_function	transferase activity, transferring one-carbon groups
F	0004799	molecular_function	thymidylate synthase activity
F	0006231	biological_process	dTMP biosynthetic process
F	0016741	molecular_function	transferase activity, transferring one-carbon groups
G	0004799	molecular_function	thymidylate synthase activity
G	0006231	biological_process	dTMP biosynthetic process
G	0016741	molecular_function	transferase activity, transferring one-carbon groups
H	0004799	molecular_function	thymidylate synthase activity
H	0006231	biological_process	dTMP biosynthetic process
H	0016741	molecular_function	transferase activity, transferring one-carbon groups
I	0004799	molecular_function	thymidylate synthase activity
I	0006231	biological_process	dTMP biosynthetic process
I	0016741	molecular_function	transferase activity, transferring one-carbon groups
J	0004799	molecular_function	thymidylate synthase activity
J	0006231	biological_process	dTMP biosynthetic process
J	0016741	molecular_function	transferase activity, transferring one-carbon groups
K	0004799	molecular_function	thymidylate synthase activity
K	0006231	biological_process	dTMP biosynthetic process
K	0016741	molecular_function	transferase activity, transferring one-carbon groups
L	0004799	molecular_function	thymidylate synthase activity
L	0006231	biological_process	dTMP biosynthetic process
L	0016741	molecular_function	transferase activity, transferring one-carbon groups
M	0004799	molecular_function	thymidylate synthase activity
M	0006231	biological_process	dTMP biosynthetic process
M	0016741	molecular_function	transferase activity, transferring one-carbon groups
N	0004799	molecular_function	thymidylate synthase activity
N	0006231	biological_process	dTMP biosynthetic process
N	0016741	molecular_function	transferase activity, transferring one-carbon groups
O	0004799	molecular_function	thymidylate synthase activity
O	0006231	biological_process	dTMP biosynthetic process
O	0016741	molecular_function	transferase activity, transferring one-carbon groups
P	0004799	molecular_function	thymidylate synthase activity
P	0006231	biological_process	dTMP biosynthetic process
P	0016741	molecular_function	transferase activity, transferring one-carbon groups

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue SO4 A 301

Chain	Residue
A	ARG151
A	ARG152
B	ARG191
B	SER192

---

site_id	AC2
Number of Residues	4
Details	binding site for residue SO4 A 302

Chain	Residue
A	ARG191
A	SER192
B	ARG151
B	ARG152

---

site_id	AC3
Number of Residues	8
Details	binding site for residue SO4 C 301

Chain	Residue
C	HIS280
C	HOH401
C	HOH409
C	HOH417
C	HOH445
F	ARG250
F	HIS280
C	ARG250

---

site_id	AC4
Number of Residues	4
Details	binding site for residue SO4 C 302

Chain	Residue
C	ARG151
C	ARG152
D	ARG191
D	SER192

---

site_id	AC5
Number of Residues	5
Details	binding site for residue SO4 D 301

Chain	Residue
C	ARG191
C	SER192
D	ARG151
D	ARG152
D	HOH430

---

site_id	AC6
Number of Residues	4
Details	binding site for residue SO4 E 301

Chain	Residue
E	ARG151
E	ARG152
F	ARG191
F	SER192

---

site_id	AC7
Number of Residues	4
Details	binding site for residue SO4 F 301

Chain	Residue
E	ARG191
E	SER192
F	ARG151
F	ARG152

---

site_id	AC8
Number of Residues	5
Details	binding site for residue SO4 G 301

Chain	Residue
G	ARG191
G	SER192
G	HOH403
H	ARG151
H	ARG152

---

site_id	AC9
Number of Residues	5
Details	binding site for residue SO4 G 302

Chain	Residue
G	ARG151
G	ARG152
H	ARG191
H	SER192
H	HOH306

---

site_id	AD1
Number of Residues	5
Details	binding site for residue SO4 I 301

Chain	Residue
I	ARG151
I	ARG152
I	HOH409
J	ARG191
J	SER192

---

site_id	AD2
Number of Residues	6
Details	binding site for residue SO4 J 301

Chain	Residue
I	ARG191
I	SER192
J	ARG151
J	ARG152
J	HOH509
J	HOH528

---

site_id	AD3
Number of Residues	6
Details	binding site for residue SO4 J 302

Chain	Residue
J	ARG250
J	HIS280
J	HOH505
J	HOH527
P	ARG250
P	HIS280

---

site_id	AD4
Number of Residues	6
Details	binding site for residue SO4 K 301

Chain	Residue
K	ARG151
K	ARG152
K	HOH415
K	HOH421
L	ARG191
L	SER192

---

site_id	AD5
Number of Residues	5
Details	binding site for residue SO4 L 301

Chain	Residue
K	ARG191
K	SER192
L	ARG151
L	ARG152
L	HOH413

---

site_id	AD6
Number of Residues	4
Details	binding site for residue SO4 M 301

Chain	Residue
M	ARG151
M	ARG152
N	ARG191
N	SER192

---

site_id	AD7
Number of Residues	5
Details	binding site for residue SO4 N 301

Chain	Residue
M	ARG191
M	SER192
M	HOH430
N	ARG151
N	ARG152

---

site_id	AD8
Number of Residues	4
Details	binding site for residue SO4 O 301

Chain	Residue
O	ARG151
O	ARG152
P	ARG191
P	SER192

---

site_id	AD9
Number of Residues	5
Details	binding site for residue SO4 P 301

Chain	Residue
O	ARG191
O	SER192
P	ARG151
P	ARG152
P	HOH422

---

Functional Information from PROSITE/UniProt

site_id	PS00091
Number of Residues	29
Details	THYMIDYLATE_SYNTHASE Thymidylate synthase active site. RriImcaWNpvdvpkma.....LpPCHclcQFyV

Chain	Residue	Details
A	ARG151-VAL179

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