6K5L
The crystal structure of isocitrate dehydrogenase kinase/phosphatase wtih two Mn2+ from E. coli
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0004721 | molecular_function | phosphoprotein phosphatase activity |
| A | 0004722 | molecular_function | protein serine/threonine phosphatase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006006 | biological_process | glucose metabolic process |
| A | 0006097 | biological_process | glyoxylate cycle |
| A | 0006099 | biological_process | tricarboxylic acid cycle |
| A | 0008772 | molecular_function | [isocitrate dehydrogenase (NADP+)] kinase activity |
| A | 0016208 | molecular_function | AMP binding |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016788 | molecular_function | hydrolase activity, acting on ester bonds |
| A | 0016791 | molecular_function | phosphatase activity |
| A | 0030145 | molecular_function | manganese ion binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004674 | molecular_function | protein serine/threonine kinase activity |
| B | 0004721 | molecular_function | phosphoprotein phosphatase activity |
| B | 0004722 | molecular_function | protein serine/threonine phosphatase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006006 | biological_process | glucose metabolic process |
| B | 0006097 | biological_process | glyoxylate cycle |
| B | 0006099 | biological_process | tricarboxylic acid cycle |
| B | 0008772 | molecular_function | [isocitrate dehydrogenase (NADP+)] kinase activity |
| B | 0016208 | molecular_function | AMP binding |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016788 | molecular_function | hydrolase activity, acting on ester bonds |
| B | 0016791 | molecular_function | phosphatase activity |
| B | 0030145 | molecular_function | manganese ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue AMP A 1001 |
| Chain | Residue |
| A | ASN104 |
| A | GLU376 |
| A | ASN377 |
| A | HOH1111 |
| A | HOH1114 |
| A | HOH1124 |
| A | HOH1130 |
| A | HOH1160 |
| A | SER105 |
| A | HIS113 |
| A | LEU116 |
| A | LEU121 |
| A | LYS291 |
| A | LYS294 |
| A | THR295 |
| A | TYR298 |
| site_id | AC2 |
| Number of Residues | 21 |
| Details | binding site for residue ADP A 1002 |
| Chain | Residue |
| A | PRO316 |
| A | GLY317 |
| A | ILE318 |
| A | GLY320 |
| A | MET321 |
| A | VAL322 |
| A | MET323 |
| A | VAL325 |
| A | LYS336 |
| A | GLU416 |
| A | ARG417 |
| A | ARG418 |
| A | MET419 |
| A | ASN462 |
| A | TYR474 |
| A | ASP475 |
| A | ASP477 |
| A | MN1003 |
| A | MN1004 |
| A | HOH1120 |
| A | HOH1156 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue MN A 1003 |
| Chain | Residue |
| A | ASN462 |
| A | ASP475 |
| A | ADP1002 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue MN A 1004 |
| Chain | Residue |
| A | ASP475 |
| A | ASP477 |
| A | ADP1002 |
| A | HOH1135 |
| site_id | AC5 |
| Number of Residues | 13 |
| Details | binding site for residue AMP B 1001 |
| Chain | Residue |
| B | ASN104 |
| B | SER105 |
| B | HIS113 |
| B | LEU116 |
| B | LEU121 |
| B | LYS291 |
| B | LYS294 |
| B | THR295 |
| B | TYR298 |
| B | GLU376 |
| B | ASN377 |
| B | HOH1110 |
| B | HOH1134 |
| site_id | AC6 |
| Number of Residues | 18 |
| Details | binding site for residue ADP B 1002 |
| Chain | Residue |
| B | PRO316 |
| B | GLY317 |
| B | ILE318 |
| B | GLY320 |
| B | MET321 |
| B | VAL322 |
| B | MET323 |
| B | VAL325 |
| B | LYS336 |
| B | GLU416 |
| B | ARG417 |
| B | MET419 |
| B | ASN462 |
| B | TYR474 |
| B | ASP475 |
| B | ASP477 |
| B | MN1003 |
| B | MN1004 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue MN B 1003 |
| Chain | Residue |
| B | ASN462 |
| B | ASP475 |
| B | ADP1002 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue MN B 1004 |
| Chain | Residue |
| B | LYS346 |
| B | ASP475 |
| B | ASP477 |
| B | ADP1002 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00747","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
