6K1Z

Crystal structure of farnesylated hGBP1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0000166	molecular_function	nucleotide binding
A	0001530	molecular_function	lipopolysaccharide binding
A	0002376	biological_process	immune system process
A	0003779	molecular_function	actin binding
A	0003924	molecular_function	GTPase activity
A	0003925	molecular_function	G protein activity
A	0004382	molecular_function	GDP phosphatase activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0012506	cellular_component	vesicle membrane
A	0015629	cellular_component	actin cytoskeleton
A	0016787	molecular_function	hydrolase activity
A	0019003	molecular_function	GDP binding
A	0019899	molecular_function	enzyme binding
A	0019955	molecular_function	cytokine binding
A	0030507	molecular_function	spectrin binding
A	0030659	cellular_component	cytoplasmic vesicle membrane
A	0031410	cellular_component	cytoplasmic vesicle
A	0032703	biological_process	negative regulation of interleukin-2 production
A	0042742	biological_process	defense response to bacterium
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0042832	biological_process	defense response to protozoan
A	0045087	biological_process	innate immune response
A	0050848	biological_process	regulation of calcium-mediated signaling
A	0050860	biological_process	negative regulation of T cell receptor signaling pathway
A	0051607	biological_process	defense response to virus
A	0051715	biological_process	cytolysis in another organism
A	0051879	molecular_function	Hsp90 protein binding
A	0070373	biological_process	negative regulation of ERK1 and ERK2 cascade
A	0071346	biological_process	cellular response to type II interferon
A	0071347	biological_process	cellular response to interleukin-1
A	0071356	biological_process	cellular response to tumor necrosis factor
A	0072665	biological_process	protein localization to vacuole
A	0106139	cellular_component	symbiont cell surface
A	0140639	biological_process	positive regulation of pyroptotic inflammatory response
A	0160075	biological_process	non-canonical inflammasome complex assembly
A	1900025	biological_process	negative regulation of substrate adhesion-dependent cell spreading
A	1903076	biological_process	regulation of protein localization to plasma membrane
A	1903077	biological_process	negative regulation of protein localization to plasma membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue FAR A 600

Chain	Residue
A	ALA385
A	TYR524
A	HIS527
A	LEU528
A	CYS589
A	ILE591
A	HOH770

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Propeptide: {"description":"Removed in mature form","featureId":"PRO_0000396777","evidences":[{"source":"PubMed","id":"8830800","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	11
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16511497","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39394410","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2B92","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8CQB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by PIM1","evidences":[{"source":"PubMed","id":"37797010","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Cysteine methyl ester","evidences":[{"source":"PubMed","id":"8830800","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by PIM1","evidences":[{"source":"PubMed","id":"37797010","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	1
Details	Lipidation: {"description":"S-farnesyl cysteine","evidences":[{"source":"PubMed","id":"29144452","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31268602","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32510692","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8830800","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	9
Details	Cross-link: {"description":"(Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"29144452","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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