6K1Z
Crystal structure of farnesylated hGBP1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000139 | cellular_component | Golgi membrane |
| A | 0001530 | molecular_function | lipopolysaccharide binding |
| A | 0003779 | molecular_function | actin binding |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0003925 | molecular_function | G protein activity |
| A | 0004382 | molecular_function | GDP phosphatase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0012506 | cellular_component | vesicle membrane |
| A | 0015629 | cellular_component | actin cytoskeleton |
| A | 0019003 | molecular_function | GDP binding |
| A | 0019899 | molecular_function | enzyme binding |
| A | 0019955 | molecular_function | cytokine binding |
| A | 0030507 | molecular_function | spectrin binding |
| A | 0030659 | cellular_component | cytoplasmic vesicle membrane |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0032703 | biological_process | negative regulation of interleukin-2 production |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0042832 | biological_process | defense response to protozoan |
| A | 0045087 | biological_process | innate immune response |
| A | 0050848 | biological_process | regulation of calcium-mediated signaling |
| A | 0050860 | biological_process | negative regulation of T cell receptor signaling pathway |
| A | 0051715 | biological_process | cytolysis in another organism |
| A | 0051879 | molecular_function | Hsp90 protein binding |
| A | 0070373 | biological_process | negative regulation of ERK1 and ERK2 cascade |
| A | 0071346 | biological_process | cellular response to type II interferon |
| A | 0071347 | biological_process | cellular response to interleukin-1 |
| A | 0071356 | biological_process | cellular response to tumor necrosis factor |
| A | 0072665 | biological_process | protein localization to vacuole |
| A | 0106139 | cellular_component | symbiont cell surface |
| A | 0140546 | biological_process | defense response to symbiont |
| A | 0140639 | biological_process | positive regulation of pyroptotic inflammatory response |
| A | 0160075 | biological_process | non-canonical inflammasome complex assembly |
| A | 1900025 | biological_process | negative regulation of substrate adhesion-dependent cell spreading |
| A | 1903076 | biological_process | regulation of protein localization to plasma membrane |
| A | 1903077 | biological_process | negative regulation of protein localization to plasma membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue FAR A 600 |
| Chain | Residue |
| A | ALA385 |
| A | TYR524 |
| A | HIS527 |
| A | LEU528 |
| A | CYS589 |
| A | ILE591 |
| A | HOH770 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Propeptide: {"description":"Removed in mature form","featureId":"PRO_0000396777","evidences":[{"source":"PubMed","id":"8830800","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 11 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16511497","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39394410","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2B92","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8CQB","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by PIM1","evidences":[{"source":"PubMed","id":"37797010","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Cysteine methyl ester","evidences":[{"source":"PubMed","id":"8830800","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by PIM1","evidences":[{"source":"PubMed","id":"37797010","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Lipidation: {"description":"S-farnesyl cysteine","evidences":[{"source":"PubMed","id":"29144452","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31268602","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32510692","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8830800","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 9 |
| Details | Cross-link: {"description":"(Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"29144452","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
