6K1P

The complex of ISWI-nucleosome in the ADP.BeF-bound state

Replaces:  6IRN

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000786	cellular_component	nucleosome
A	0003677	molecular_function	DNA binding
A	0005634	cellular_component	nucleus
A	0030527	molecular_function	structural constituent of chromatin
A	0046982	molecular_function	protein heterodimerization activity
B	0000786	cellular_component	nucleosome
B	0003677	molecular_function	DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005694	cellular_component	chromosome
B	0006334	biological_process	nucleosome assembly
B	0030527	molecular_function	structural constituent of chromatin
B	0046982	molecular_function	protein heterodimerization activity
C	0000786	cellular_component	nucleosome
C	0003677	molecular_function	DNA binding
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0030527	molecular_function	structural constituent of chromatin
C	0046982	molecular_function	protein heterodimerization activity
D	0000786	cellular_component	nucleosome
D	0003677	molecular_function	DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005694	cellular_component	chromosome
D	0030527	molecular_function	structural constituent of chromatin
D	0046982	molecular_function	protein heterodimerization activity
E	0000786	cellular_component	nucleosome
E	0003677	molecular_function	DNA binding
E	0005634	cellular_component	nucleus
E	0030527	molecular_function	structural constituent of chromatin
E	0046982	molecular_function	protein heterodimerization activity
F	0000786	cellular_component	nucleosome
F	0003677	molecular_function	DNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005694	cellular_component	chromosome
F	0006334	biological_process	nucleosome assembly
F	0030527	molecular_function	structural constituent of chromatin
F	0046982	molecular_function	protein heterodimerization activity
G	0000786	cellular_component	nucleosome
G	0003677	molecular_function	DNA binding
G	0005634	cellular_component	nucleus
G	0005694	cellular_component	chromosome
G	0030527	molecular_function	structural constituent of chromatin
G	0046982	molecular_function	protein heterodimerization activity
H	0000786	cellular_component	nucleosome
H	0003677	molecular_function	DNA binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005694	cellular_component	chromosome
H	0030527	molecular_function	structural constituent of chromatin
H	0046982	molecular_function	protein heterodimerization activity
K	0000182	molecular_function	rDNA binding
K	0000976	molecular_function	transcription cis-regulatory region binding
K	0001178	biological_process	regulation of transcriptional start site selection at RNA polymerase II promoter
K	0003677	molecular_function	DNA binding
K	0003730	molecular_function	mRNA 3'-UTR binding
K	0004386	molecular_function	helicase activity
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005634	cellular_component	nucleus
K	0006325	biological_process	chromatin organization
K	0006338	biological_process	chromatin remodeling
K	0006354	biological_process	DNA-templated transcription elongation
K	0006355	biological_process	regulation of DNA-templated transcription
K	0006363	biological_process	termination of RNA polymerase I transcription
K	0006369	biological_process	termination of RNA polymerase II transcription
K	0007062	biological_process	sister chromatid cohesion
K	0008094	molecular_function	ATP-dependent activity, acting on DNA
K	0009408	biological_process	response to heat
K	0016587	cellular_component	Isw1 complex
K	0016787	molecular_function	hydrolase activity
K	0016887	molecular_function	ATP hydrolysis activity
K	0030874	cellular_component	nucleolar chromatin
K	0031491	molecular_function	nucleosome binding
K	0036436	cellular_component	Isw1a complex
K	0036437	cellular_component	Isw1b complex
K	0045944	biological_process	positive regulation of transcription by RNA polymerase II
K	0046832	biological_process	negative regulation of RNA export from nucleus
K	0140658	molecular_function	ATP-dependent chromatin remodeler activity
K	1902275	biological_process	regulation of chromatin organization
K	1903895	biological_process	negative regulation of IRE1-mediated unfolded protein response

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue BEF K 1201

Chain	Residue
K	GLU325
K	LEU583
K	GLY584
K	ARG611
K	MG1202
K	ADP1203

---

site_id	AC2
Number of Residues	3
Details	binding site for residue MG K 1202

Chain	Residue
K	THR228
K	BEF1201
K	ADP1203

---

site_id	AC3
Number of Residues	12
Details	binding site for residue ADP K 1203

Chain	Residue
K	GLN200
K	MET223
K	GLY224
K	LEU225
K	GLY226
K	LYS227
K	THR228
K	LEU229
K	ASN586
K	ARG614
K	BEF1201
K	MG1202

---

Functional Information from PROSITE/UniProt

site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLqFPV

Chain	Residue	Details
C	ALA21-VAL27

---

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
B	GLY14-HIS18

---

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
A	LYS14-LEU20

---

site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG

Chain	Residue	Details
D	ARG89-GLY111

---

site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
A	PRO66-ILE74

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00541

Chain	Residue	Details
K	ASP221
D	LYS9
D	LYS12
D	LYS17
H	LYS2
H	LYS9
H	LYS12
H	LYS17

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198

Chain	Residue	Details
K	THR694
H	SER11

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956

Chain	Residue	Details
K	SER846
H	SER109

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0C1H4

Chain	Residue	Details
D	LYS117
F	LYS5
H	LYS117

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	MOD_RES: N6-propionyllysine; alternate => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
B	LYS8
B	LYS16
B	LYS44
B	LYS79
F	LYS8
F	LYS16
F	LYS44
F	LYS79

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
B	LYS12
B	LYS20
F	LYS12
F	LYS20

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
B	LYS31
B	LYS91
F	LYS31
F	LYS91

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PAK2 => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
B	SER47
F	SER47

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
B	TYR51
B	TYR88
F	TYR51
F	TYR88

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: N6-glutaryllysine; alternate => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
B	LYS59
F	LYS59

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
B	LYS77
F	LYS77

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
B	LYS31
F	LYS31

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
B	LYS91
F	LYS91

---