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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6JZH

Structure of human A2A adenosine receptor in complex with ZM241385 obtained from SFX experiments under atmospheric pressure

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001609	molecular_function	G protein-coupled adenosine receptor activity
A	0001973	biological_process	G protein-coupled adenosine receptor signaling pathway
A	0004930	molecular_function	G protein-coupled receptor activity
A	0005506	molecular_function	iron ion binding
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0009055	molecular_function	electron transfer activity
A	0016020	cellular_component	membrane
A	0020037	molecular_function	heme binding
A	0022900	biological_process	electron transport chain
A	0042597	cellular_component	periplasmic space
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue NA A 2001

Chain	Residue
A	ASP52
A	SER91
A	HOH2118
A	HOH2138
A	HOH2150

site_id	AC2
Number of Residues	12
Details	binding site for residue ZMA A 2002

Chain	Residue
A	TRP246
A	LEU249
A	HIS250
A	ASN253
A	MET270
A	HOH2133
A	HOH2143
A	HOH2147
A	LEU85
A	PHE168
A	GLU169
A	MET177

site_id	AC3
Number of Residues	2
Details	binding site for residue OLA A 2003

Chain	Residue
A	THR65
A	PHE70

site_id	AC4
Number of Residues	2
Details	binding site for residue OLA A 2005

Chain	Residue
A	SER7
A	THR11

site_id	AC5
Number of Residues	1
Details	binding site for residue OLA A 2006

Chain	Residue
A	PRO266

site_id	AC6
Number of Residues	2
Details	binding site for residue OLA A 2007

Chain	Residue
A	OLA2020
A	CLR2023

site_id	AC7
Number of Residues	1
Details	binding site for residue OLA A 2008

Chain	Residue
A	CLR2022

site_id	AC8
Number of Residues	1
Details	binding site for residue OLA A 2009

Chain	Residue
A	TYR179

site_id	AC9
Number of Residues	3
Details	binding site for residue OLA A 2010

Chain	Residue
A	ALA50
A	LYS122
A	TRP129

site_id	AD1
Number of Residues	2
Details	binding site for residue OLA A 2011

Chain	Residue
A	CYS28
A	LEU58

site_id	AD2
Number of Residues	1
Details	binding site for residue OLA A 2012

Chain	Residue
A	TYR179

site_id	AD3
Number of Residues	3
Details	binding site for residue OLA A 2013

Chain	Residue
A	TYR290
A	OLA2014
A	HOH2149

site_id	AD4
Number of Residues	5
Details	binding site for residue OLA A 2014

Chain	Residue
A	GLY5
A	SER6
A	LEU267
A	TYR271
A	OLA2013

site_id	AD5
Number of Residues	1
Details	binding site for residue OLA A 2015

Chain	Residue
A	TRP268

site_id	AD6
Number of Residues	2
Details	binding site for residue OLA A 2016

Chain	Residue
A	SER7
A	PHE286

site_id	AD7
Number of Residues	4
Details	binding site for residue OLA A 2017

Chain	Residue
A	TRP32
A	PHE201
A	LYS233
A	OLA2018

site_id	AD8
Number of Residues	3
Details	binding site for residue OLA A 2018

Chain	Residue
A	TRP29
A	TRP32
A	OLA2017

site_id	AD9
Number of Residues	2
Details	binding site for residue OLA A 2019

Chain	Residue
A	SER6
A	THR68

site_id	AE1
Number of Residues	5
Details	binding site for residue OLA A 2020

Chain	Residue
A	THR65
A	CYS71
A	OLA2007
A	CLR2022
A	CLR2024

site_id	AE2
Number of Residues	2
Details	binding site for residue OLA A 2021

Chain	Residue
A	ALA73
A	GLY76

site_id	AE3
Number of Residues	6
Details	binding site for residue CLR A 2022

Chain	Residue
A	ALA72
A	ALA73
A	ILE80
A	OLA2008
A	OLA2020
A	CLR2024

site_id	AE4
Number of Residues	3
Details	binding site for residue CLR A 2023

Chain	Residue
A	CYS262
A	SER263
A	OLA2007

site_id	AE5
Number of Residues	7
Details	binding site for residue CLR A 2024

Chain	Residue
A	LEU187
A	PHE255
A	PHE258
A	CYS259
A	OLA2020
A	CLR2022
A	HOH2106

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SSIfSLLAIAIDRYIaI

Chain	Residue	Details
A	SER90-ILE106

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	TRANSMEM: Helical; Name=1

Chain	Residue	Details
A	VAL8-TRP32

site_id	SWS_FT_FI2
Number of Residues	28
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:18832607

Chain	Residue	Details
A	LEU33-ASN42
A	ASP101-ARG120

site_id	SWS_FT_FI3
Number of Residues	23
Details	TRANSMEM: Helical; Name=2

Chain	Residue	Details
A	TYR43-ILE66

site_id	SWS_FT_FI4
Number of Residues	46
Details	TOPO_DOM: Extracellular => ECO:0000269\|PubMed:18832607

Chain	Residue	Details
A	SER67-CYS77
A	ASN144-PRO173
A	CYS259-PRO266

site_id	SWS_FT_FI5
Number of Residues	22
Details	TRANSMEM: Helical; Name=3

Chain	Residue	Details
A	LEU78-ILE100

site_id	SWS_FT_FI6
Number of Residues	22
Details	TRANSMEM: Helical; Name=4

Chain	Residue	Details
A	ALA121-TRP143

site_id	SWS_FT_FI7
Number of Residues	24
Details	TRANSMEM: Helical; Name=5

Chain	Residue	Details
A	MET174-LEU198

site_id	SWS_FT_FI8
Number of Residues	23
Details	TRANSMEM: Helical; Name=6

Chain	Residue	Details
A	LEU235-PHE258

site_id	SWS_FT_FI9
Number of Residues	23
Details	TRANSMEM: Helical; Name=7

Chain	Residue	Details
A	LEU267-TYR290

site_id	SWS_FT_FI10
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:21593763, ECO:0007744\|PDB:2YDO

Chain	Residue	Details
A	GLU169
A	ASN253
A	SER277
A	HIS278

site_id	SWS_FT_FI11
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	GLN154

site_id	SWS_FT_FI12
Number of Residues	2
Details	BINDING: axial binding residue

Chain	Residue	Details
A	TRP1007
A	ILE1102

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PDB entries from 2024-07-24

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