Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005737 | cellular_component | cytoplasm |
A | 0045765 | biological_process | regulation of angiogenesis |
B | 0005515 | molecular_function | protein binding |
B | 0005576 | cellular_component | extracellular region |
B | 0005737 | cellular_component | cytoplasm |
B | 0005856 | cellular_component | cytoskeleton |
B | 0006508 | biological_process | proteolysis |
B | 0008017 | molecular_function | microtubule binding |
B | 0009306 | biological_process | protein secretion |
B | 0010596 | biological_process | negative regulation of endothelial cell migration |
B | 0016504 | molecular_function | peptidase activator activity |
B | 0031397 | biological_process | negative regulation of protein ubiquitination |
B | 0045177 | cellular_component | apical part of cell |
B | 0061564 | biological_process | axon development |
B | 1905048 | biological_process | regulation of metallopeptidase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 8 |
Details | binding site for residue I3C A 401 |
Chain | Residue |
A | LYS135 |
A | SER181 |
A | PHE182 |
A | HIS192 |
A | HIS193 |
A | LYS247 |
A | LYS265 |
A | HOH540 |
site_id | AC2 |
Number of Residues | 7 |
Details | binding site for residue I3C B 101 |
Chain | Residue |
A | SER60 |
A | TRP63 |
B | LEU31 |
B | GLN35 |
B | GLU38 |
B | HOH201 |
A | ILE58 |
site_id | AC3 |
Number of Residues | 12 |
Details | binding site for residues I3C A 402 and I3C A 403 |
Chain | Residue |
A | ALA91 |
A | ALA91 |
A | LYS92 |
A | PRO93 |
A | GLN122 |
A | GLN122 |
A | ARG134 |
A | HOH531 |
B | TYR40 |
B | TYR40 |
B | ARG44 |
B | ARG44 |
site_id | AC4 |
Number of Residues | 12 |
Details | binding site for residues I3C A 402 and I3C A 403 |
Chain | Residue |
A | ALA91 |
A | ALA91 |
A | LYS92 |
A | PRO93 |
A | GLN122 |
A | GLN122 |
A | ARG134 |
A | HOH531 |
B | TYR40 |
B | TYR40 |
B | ARG44 |
B | ARG44 |
site_id | AC5 |
Number of Residues | 12 |
Details | binding site for residues I3C A 402 and I3C A 403 |
Chain | Residue |
A | ALA91 |
A | ALA91 |
A | LYS92 |
A | PRO93 |
A | GLN122 |
A | GLN122 |
A | ARG134 |
A | HOH531 |
B | TYR40 |
B | TYR40 |
B | ARG44 |
B | ARG44 |
site_id | AC6 |
Number of Residues | 12 |
Details | binding site for residues I3C A 402 and I3C A 403 |
Chain | Residue |
A | ALA91 |
A | ALA91 |
A | LYS92 |
A | PRO93 |
A | GLN122 |
A | GLN122 |
A | ARG134 |
A | HOH531 |
B | TYR40 |
B | TYR40 |
B | ARG44 |
B | ARG44 |
site_id | AC7 |
Number of Residues | 12 |
Details | binding site for residues I3C A 402 and I3C A 403 |
Chain | Residue |
A | ALA91 |
A | ALA91 |
A | LYS92 |
A | PRO93 |
A | GLN122 |
A | GLN122 |
A | ARG134 |
A | HOH531 |
B | TYR40 |
B | TYR40 |
B | ARG44 |
B | ARG44 |
site_id | AC8 |
Number of Residues | 12 |
Details | binding site for residues I3C A 402 and I3C A 403 |
Chain | Residue |
A | ALA91 |
A | ALA91 |
A | LYS92 |
A | PRO93 |
A | GLN122 |
A | GLN122 |
A | ARG134 |
A | HOH531 |
B | TYR40 |
B | TYR40 |
B | ARG44 |
B | ARG44 |
site_id | AC9 |
Number of Residues | 12 |
Details | binding site for residues I3C A 402 and I3C A 403 |
Chain | Residue |
A | ALA91 |
A | ALA91 |
A | LYS92 |
A | PRO93 |
A | GLN122 |
A | GLN122 |
A | ARG134 |
A | HOH531 |
B | TYR40 |
B | TYR40 |
B | ARG44 |
B | ARG44 |
site_id | AD1 |
Number of Residues | 12 |
Details | binding site for residues I3C A 402 and I3C A 403 |
Chain | Residue |
A | ALA91 |
A | ALA91 |
A | LYS92 |
A | PRO93 |
A | GLN122 |
A | GLN122 |
A | ARG134 |
A | HOH531 |
B | TYR40 |
B | TYR40 |
B | ARG44 |
B | ARG44 |
site_id | AD2 |
Number of Residues | 12 |
Details | binding site for residues I3C A 402 and I3C A 403 |
Chain | Residue |
A | ALA91 |
A | ALA91 |
A | LYS92 |
A | PRO93 |
A | GLN122 |
A | GLN122 |
A | ARG134 |
A | HOH531 |
B | TYR40 |
B | TYR40 |
B | ARG44 |
B | ARG44 |
site_id | AD3 |
Number of Residues | 12 |
Details | binding site for residues I3C A 402 and I3C A 403 |
Chain | Residue |
A | ALA91 |
A | ALA91 |
A | LYS92 |
A | PRO93 |
A | GLN122 |
A | GLN122 |
A | ARG134 |
A | HOH531 |
B | TYR40 |
B | TYR40 |
B | ARG44 |
B | ARG44 |
site_id | AD4 |
Number of Residues | 12 |
Details | binding site for residues I3C A 402 and I3C A 403 |
Chain | Residue |
A | ALA91 |
A | ALA91 |
A | LYS92 |
A | PRO93 |
A | GLN122 |
A | GLN122 |
A | ARG134 |
A | HOH531 |
B | TYR40 |
B | TYR40 |
B | ARG44 |
B | ARG44 |
site_id | AD5 |
Number of Residues | 12 |
Details | binding site for residues I3C A 402 and I3C A 403 |
Chain | Residue |
A | ALA91 |
A | ALA91 |
A | LYS92 |
A | PRO93 |
A | GLN122 |
A | GLN122 |
A | ARG134 |
A | HOH531 |
B | TYR40 |
B | TYR40 |
B | ARG44 |
B | ARG44 |
site_id | AD6 |
Number of Residues | 12 |
Details | binding site for residues I3C A 402 and I3C A 403 |
Chain | Residue |
A | ALA91 |
A | ALA91 |
A | LYS92 |
A | PRO93 |
A | GLN122 |
A | GLN122 |
A | ARG134 |
A | HOH531 |
B | TYR40 |
B | TYR40 |
B | ARG44 |
B | ARG44 |
site_id | AD7 |
Number of Residues | 12 |
Details | binding site for residues I3C A 402 and I3C A 403 |
Chain | Residue |
A | ALA91 |
A | ALA91 |
A | LYS92 |
A | PRO93 |
A | GLN122 |
A | GLN122 |
A | ARG134 |
A | HOH531 |
B | TYR40 |
B | TYR40 |
B | ARG44 |
B | ARG44 |
site_id | AD8 |
Number of Residues | 12 |
Details | binding site for residues I3C A 402 and I3C A 403 |
Chain | Residue |
A | ALA91 |
A | ALA91 |
A | LYS92 |
A | PRO93 |
A | GLN122 |
A | GLN122 |
A | ARG134 |
A | HOH531 |
B | TYR40 |
B | TYR40 |
B | ARG44 |
B | ARG44 |
site_id | AD9 |
Number of Residues | 12 |
Details | binding site for residues I3C A 402 and I3C A 403 |
Chain | Residue |
A | ALA91 |
A | ALA91 |
A | LYS92 |
A | PRO93 |
A | GLN122 |
A | GLN122 |
A | ARG134 |
A | HOH531 |
B | TYR40 |
B | TYR40 |
B | ARG44 |
B | ARG44 |
site_id | AE1 |
Number of Residues | 12 |
Details | binding site for residues I3C A 402 and I3C A 403 |
Chain | Residue |
A | ALA91 |
A | ALA91 |
A | LYS92 |
A | PRO93 |
A | GLN122 |
A | GLN122 |
A | ARG134 |
A | HOH531 |
B | TYR40 |
B | TYR40 |
B | ARG44 |
B | ARG44 |
site_id | AE2 |
Number of Residues | 12 |
Details | binding site for residues I3C A 402 and I3C A 403 |
Chain | Residue |
A | ALA91 |
A | ALA91 |
A | LYS92 |
A | PRO93 |
A | GLN122 |
A | GLN122 |
A | ARG134 |
A | HOH531 |
B | TYR40 |
B | TYR40 |
B | ARG44 |
B | ARG44 |
site_id | AE3 |
Number of Residues | 12 |
Details | binding site for residues I3C A 402 and I3C A 403 |
Chain | Residue |
A | ALA91 |
A | ALA91 |
A | LYS92 |
A | PRO93 |
A | GLN122 |
A | GLN122 |
A | ARG134 |
A | HOH531 |
B | TYR40 |
B | TYR40 |
B | ARG44 |
B | ARG44 |
site_id | AE4 |
Number of Residues | 12 |
Details | binding site for residues I3C A 402 and I3C A 403 |
Chain | Residue |
A | ALA91 |
A | ALA91 |
A | LYS92 |
A | PRO93 |
A | GLN122 |
A | GLN122 |
A | ARG134 |
A | HOH531 |
B | TYR40 |
B | TYR40 |
B | ARG44 |
B | ARG44 |
site_id | AE5 |
Number of Residues | 12 |
Details | binding site for residues I3C A 402 and I3C A 403 |
Chain | Residue |
A | ALA91 |
A | ALA91 |
A | LYS92 |
A | PRO93 |
A | GLN122 |
A | GLN122 |
A | ARG134 |
A | HOH531 |
B | TYR40 |
B | TYR40 |
B | ARG44 |
B | ARG44 |
site_id | AE6 |
Number of Residues | 12 |
Details | binding site for residues I3C A 402 and I3C A 403 |
Chain | Residue |
A | ALA91 |
A | ALA91 |
A | LYS92 |
A | PRO93 |
A | GLN122 |
A | GLN122 |
A | ARG134 |
A | HOH531 |
B | TYR40 |
B | TYR40 |
B | ARG44 |
B | ARG44 |
site_id | AE7 |
Number of Residues | 12 |
Details | binding site for residues I3C A 402 and I3C A 403 |
Chain | Residue |
A | ALA91 |
A | ALA91 |
A | LYS92 |
A | PRO93 |
A | GLN122 |
A | GLN122 |
A | ARG134 |
A | HOH531 |
B | TYR40 |
B | TYR40 |
B | ARG44 |
B | ARG44 |
site_id | AE8 |
Number of Residues | 12 |
Details | binding site for residues I3C A 402 and I3C A 403 |
Chain | Residue |
A | ALA91 |
A | ALA91 |
A | LYS92 |
A | PRO93 |
A | GLN122 |
A | GLN122 |
A | ARG134 |
A | HOH531 |
B | TYR40 |
B | TYR40 |
B | ARG44 |
B | ARG44 |
site_id | AE9 |
Number of Residues | 12 |
Details | binding site for residues I3C A 402 and I3C A 403 |
Chain | Residue |
A | ALA91 |
A | ALA91 |
A | LYS92 |
A | PRO93 |
A | GLN122 |
A | GLN122 |
A | ARG134 |
A | HOH531 |
B | TYR40 |
B | TYR40 |
B | ARG44 |
B | ARG44 |
site_id | AF1 |
Number of Residues | 12 |
Details | binding site for residues I3C A 402 and I3C A 403 |
Chain | Residue |
A | ALA91 |
A | ALA91 |
A | LYS92 |
A | PRO93 |
A | GLN122 |
A | GLN122 |
A | ARG134 |
A | HOH531 |
B | TYR40 |
B | TYR40 |
B | ARG44 |
B | ARG44 |
site_id | AF2 |
Number of Residues | 12 |
Details | binding site for residues I3C A 402 and I3C A 403 |
Chain | Residue |
A | ALA91 |
A | ALA91 |
A | LYS92 |
A | PRO93 |
A | GLN122 |
A | GLN122 |
A | ARG134 |
A | HOH531 |
B | TYR40 |
B | TYR40 |
B | ARG44 |
B | ARG44 |
site_id | AF3 |
Number of Residues | 12 |
Details | binding site for residues I3C A 402 and I3C A 403 |
Chain | Residue |
A | ALA91 |
A | ALA91 |
A | LYS92 |
A | PRO93 |
A | GLN122 |
A | GLN122 |
A | ARG134 |
A | HOH531 |
B | TYR40 |
B | TYR40 |
B | ARG44 |
B | ARG44 |
site_id | AF4 |
Number of Residues | 12 |
Details | binding site for residues I3C A 402 and I3C A 403 |
Chain | Residue |
A | ALA91 |
A | ALA91 |
A | LYS92 |
A | PRO93 |
A | GLN122 |
A | GLN122 |
A | ARG134 |
A | HOH531 |
B | TYR40 |
B | TYR40 |
B | ARG44 |
B | ARG44 |
site_id | AF5 |
Number of Residues | 12 |
Details | binding site for residues I3C A 402 and I3C A 403 |
Chain | Residue |
A | ALA91 |
A | ALA91 |
A | LYS92 |
A | PRO93 |
A | GLN122 |
A | GLN122 |
A | ARG134 |
A | HOH531 |
B | TYR40 |
B | TYR40 |
B | ARG44 |
B | ARG44 |
site_id | AF6 |
Number of Residues | 12 |
Details | binding site for residues I3C A 402 and I3C A 403 |
Chain | Residue |
A | ALA91 |
A | ALA91 |
A | LYS92 |
A | PRO93 |
A | GLN122 |
A | GLN122 |
A | ARG134 |
A | HOH531 |
B | TYR40 |
B | TYR40 |
B | ARG44 |
B | ARG44 |
site_id | AF7 |
Number of Residues | 12 |
Details | binding site for residues I3C A 402 and I3C A 403 |
Chain | Residue |
A | ALA91 |
A | ALA91 |
A | LYS92 |
A | PRO93 |
A | GLN122 |
A | GLN122 |
A | ARG134 |
A | HOH531 |
B | TYR40 |
B | TYR40 |
B | ARG44 |
B | ARG44 |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | CYS158 | |
Chain | Residue | Details |
A | HIS193 | |
A | SER210 | |
Chain | Residue | Details |
A | SER302 | |