Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0045765 | biological_process | regulation of angiogenesis |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005856 | cellular_component | cytoskeleton |
| B | 0006508 | biological_process | proteolysis |
| B | 0008017 | molecular_function | microtubule binding |
| B | 0009306 | biological_process | protein secretion |
| B | 0010596 | biological_process | negative regulation of endothelial cell migration |
| B | 0016504 | molecular_function | peptidase activator activity |
| B | 0031397 | biological_process | negative regulation of protein ubiquitination |
| B | 0045177 | cellular_component | apical part of cell |
| B | 0061564 | biological_process | axon development |
| B | 1905048 | biological_process | regulation of metallopeptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue I3C A 401 |
| Chain | Residue |
| A | LYS135 |
| A | SER181 |
| A | PHE182 |
| A | HIS192 |
| A | HIS193 |
| A | LYS247 |
| A | LYS265 |
| A | HOH540 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue I3C B 101 |
| Chain | Residue |
| A | SER60 |
| A | TRP63 |
| B | LEU31 |
| B | GLN35 |
| B | GLU38 |
| B | HOH201 |
| A | ILE58 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | binding site for residues I3C A 402 and I3C A 403 |
| Chain | Residue |
| A | ALA91 |
| A | ALA91 |
| A | LYS92 |
| A | PRO93 |
| A | GLN122 |
| A | GLN122 |
| A | ARG134 |
| A | HOH531 |
| B | TYR40 |
| B | TYR40 |
| B | ARG44 |
| B | ARG44 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | binding site for residues I3C A 402 and I3C A 403 |
| Chain | Residue |
| A | ALA91 |
| A | ALA91 |
| A | LYS92 |
| A | PRO93 |
| A | GLN122 |
| A | GLN122 |
| A | ARG134 |
| A | HOH531 |
| B | TYR40 |
| B | TYR40 |
| B | ARG44 |
| B | ARG44 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | binding site for residues I3C A 402 and I3C A 403 |
| Chain | Residue |
| A | ALA91 |
| A | ALA91 |
| A | LYS92 |
| A | PRO93 |
| A | GLN122 |
| A | GLN122 |
| A | ARG134 |
| A | HOH531 |
| B | TYR40 |
| B | TYR40 |
| B | ARG44 |
| B | ARG44 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | binding site for residues I3C A 402 and I3C A 403 |
| Chain | Residue |
| A | ALA91 |
| A | ALA91 |
| A | LYS92 |
| A | PRO93 |
| A | GLN122 |
| A | GLN122 |
| A | ARG134 |
| A | HOH531 |
| B | TYR40 |
| B | TYR40 |
| B | ARG44 |
| B | ARG44 |
| site_id | AC7 |
| Number of Residues | 12 |
| Details | binding site for residues I3C A 402 and I3C A 403 |
| Chain | Residue |
| A | ALA91 |
| A | ALA91 |
| A | LYS92 |
| A | PRO93 |
| A | GLN122 |
| A | GLN122 |
| A | ARG134 |
| A | HOH531 |
| B | TYR40 |
| B | TYR40 |
| B | ARG44 |
| B | ARG44 |
| site_id | AC8 |
| Number of Residues | 12 |
| Details | binding site for residues I3C A 402 and I3C A 403 |
| Chain | Residue |
| A | ALA91 |
| A | ALA91 |
| A | LYS92 |
| A | PRO93 |
| A | GLN122 |
| A | GLN122 |
| A | ARG134 |
| A | HOH531 |
| B | TYR40 |
| B | TYR40 |
| B | ARG44 |
| B | ARG44 |
| site_id | AC9 |
| Number of Residues | 12 |
| Details | binding site for residues I3C A 402 and I3C A 403 |
| Chain | Residue |
| A | ALA91 |
| A | ALA91 |
| A | LYS92 |
| A | PRO93 |
| A | GLN122 |
| A | GLN122 |
| A | ARG134 |
| A | HOH531 |
| B | TYR40 |
| B | TYR40 |
| B | ARG44 |
| B | ARG44 |
| site_id | AD1 |
| Number of Residues | 12 |
| Details | binding site for residues I3C A 402 and I3C A 403 |
| Chain | Residue |
| A | ALA91 |
| A | ALA91 |
| A | LYS92 |
| A | PRO93 |
| A | GLN122 |
| A | GLN122 |
| A | ARG134 |
| A | HOH531 |
| B | TYR40 |
| B | TYR40 |
| B | ARG44 |
| B | ARG44 |
| site_id | AD2 |
| Number of Residues | 12 |
| Details | binding site for residues I3C A 402 and I3C A 403 |
| Chain | Residue |
| A | ALA91 |
| A | ALA91 |
| A | LYS92 |
| A | PRO93 |
| A | GLN122 |
| A | GLN122 |
| A | ARG134 |
| A | HOH531 |
| B | TYR40 |
| B | TYR40 |
| B | ARG44 |
| B | ARG44 |
| site_id | AD3 |
| Number of Residues | 12 |
| Details | binding site for residues I3C A 402 and I3C A 403 |
| Chain | Residue |
| A | ALA91 |
| A | ALA91 |
| A | LYS92 |
| A | PRO93 |
| A | GLN122 |
| A | GLN122 |
| A | ARG134 |
| A | HOH531 |
| B | TYR40 |
| B | TYR40 |
| B | ARG44 |
| B | ARG44 |
| site_id | AD4 |
| Number of Residues | 12 |
| Details | binding site for residues I3C A 402 and I3C A 403 |
| Chain | Residue |
| A | ALA91 |
| A | ALA91 |
| A | LYS92 |
| A | PRO93 |
| A | GLN122 |
| A | GLN122 |
| A | ARG134 |
| A | HOH531 |
| B | TYR40 |
| B | TYR40 |
| B | ARG44 |
| B | ARG44 |
| site_id | AD5 |
| Number of Residues | 12 |
| Details | binding site for residues I3C A 402 and I3C A 403 |
| Chain | Residue |
| A | ALA91 |
| A | ALA91 |
| A | LYS92 |
| A | PRO93 |
| A | GLN122 |
| A | GLN122 |
| A | ARG134 |
| A | HOH531 |
| B | TYR40 |
| B | TYR40 |
| B | ARG44 |
| B | ARG44 |
| site_id | AD6 |
| Number of Residues | 12 |
| Details | binding site for residues I3C A 402 and I3C A 403 |
| Chain | Residue |
| A | ALA91 |
| A | ALA91 |
| A | LYS92 |
| A | PRO93 |
| A | GLN122 |
| A | GLN122 |
| A | ARG134 |
| A | HOH531 |
| B | TYR40 |
| B | TYR40 |
| B | ARG44 |
| B | ARG44 |
| site_id | AD7 |
| Number of Residues | 12 |
| Details | binding site for residues I3C A 402 and I3C A 403 |
| Chain | Residue |
| A | ALA91 |
| A | ALA91 |
| A | LYS92 |
| A | PRO93 |
| A | GLN122 |
| A | GLN122 |
| A | ARG134 |
| A | HOH531 |
| B | TYR40 |
| B | TYR40 |
| B | ARG44 |
| B | ARG44 |
| site_id | AD8 |
| Number of Residues | 12 |
| Details | binding site for residues I3C A 402 and I3C A 403 |
| Chain | Residue |
| A | ALA91 |
| A | ALA91 |
| A | LYS92 |
| A | PRO93 |
| A | GLN122 |
| A | GLN122 |
| A | ARG134 |
| A | HOH531 |
| B | TYR40 |
| B | TYR40 |
| B | ARG44 |
| B | ARG44 |
| site_id | AD9 |
| Number of Residues | 12 |
| Details | binding site for residues I3C A 402 and I3C A 403 |
| Chain | Residue |
| A | ALA91 |
| A | ALA91 |
| A | LYS92 |
| A | PRO93 |
| A | GLN122 |
| A | GLN122 |
| A | ARG134 |
| A | HOH531 |
| B | TYR40 |
| B | TYR40 |
| B | ARG44 |
| B | ARG44 |
| site_id | AE1 |
| Number of Residues | 12 |
| Details | binding site for residues I3C A 402 and I3C A 403 |
| Chain | Residue |
| A | ALA91 |
| A | ALA91 |
| A | LYS92 |
| A | PRO93 |
| A | GLN122 |
| A | GLN122 |
| A | ARG134 |
| A | HOH531 |
| B | TYR40 |
| B | TYR40 |
| B | ARG44 |
| B | ARG44 |
| site_id | AE2 |
| Number of Residues | 12 |
| Details | binding site for residues I3C A 402 and I3C A 403 |
| Chain | Residue |
| A | ALA91 |
| A | ALA91 |
| A | LYS92 |
| A | PRO93 |
| A | GLN122 |
| A | GLN122 |
| A | ARG134 |
| A | HOH531 |
| B | TYR40 |
| B | TYR40 |
| B | ARG44 |
| B | ARG44 |
| site_id | AE3 |
| Number of Residues | 12 |
| Details | binding site for residues I3C A 402 and I3C A 403 |
| Chain | Residue |
| A | ALA91 |
| A | ALA91 |
| A | LYS92 |
| A | PRO93 |
| A | GLN122 |
| A | GLN122 |
| A | ARG134 |
| A | HOH531 |
| B | TYR40 |
| B | TYR40 |
| B | ARG44 |
| B | ARG44 |
| site_id | AE4 |
| Number of Residues | 12 |
| Details | binding site for residues I3C A 402 and I3C A 403 |
| Chain | Residue |
| A | ALA91 |
| A | ALA91 |
| A | LYS92 |
| A | PRO93 |
| A | GLN122 |
| A | GLN122 |
| A | ARG134 |
| A | HOH531 |
| B | TYR40 |
| B | TYR40 |
| B | ARG44 |
| B | ARG44 |
| site_id | AE5 |
| Number of Residues | 12 |
| Details | binding site for residues I3C A 402 and I3C A 403 |
| Chain | Residue |
| A | ALA91 |
| A | ALA91 |
| A | LYS92 |
| A | PRO93 |
| A | GLN122 |
| A | GLN122 |
| A | ARG134 |
| A | HOH531 |
| B | TYR40 |
| B | TYR40 |
| B | ARG44 |
| B | ARG44 |
| site_id | AE6 |
| Number of Residues | 12 |
| Details | binding site for residues I3C A 402 and I3C A 403 |
| Chain | Residue |
| A | ALA91 |
| A | ALA91 |
| A | LYS92 |
| A | PRO93 |
| A | GLN122 |
| A | GLN122 |
| A | ARG134 |
| A | HOH531 |
| B | TYR40 |
| B | TYR40 |
| B | ARG44 |
| B | ARG44 |
| site_id | AE7 |
| Number of Residues | 12 |
| Details | binding site for residues I3C A 402 and I3C A 403 |
| Chain | Residue |
| A | ALA91 |
| A | ALA91 |
| A | LYS92 |
| A | PRO93 |
| A | GLN122 |
| A | GLN122 |
| A | ARG134 |
| A | HOH531 |
| B | TYR40 |
| B | TYR40 |
| B | ARG44 |
| B | ARG44 |
| site_id | AE8 |
| Number of Residues | 12 |
| Details | binding site for residues I3C A 402 and I3C A 403 |
| Chain | Residue |
| A | ALA91 |
| A | ALA91 |
| A | LYS92 |
| A | PRO93 |
| A | GLN122 |
| A | GLN122 |
| A | ARG134 |
| A | HOH531 |
| B | TYR40 |
| B | TYR40 |
| B | ARG44 |
| B | ARG44 |
| site_id | AE9 |
| Number of Residues | 12 |
| Details | binding site for residues I3C A 402 and I3C A 403 |
| Chain | Residue |
| A | ALA91 |
| A | ALA91 |
| A | LYS92 |
| A | PRO93 |
| A | GLN122 |
| A | GLN122 |
| A | ARG134 |
| A | HOH531 |
| B | TYR40 |
| B | TYR40 |
| B | ARG44 |
| B | ARG44 |
| site_id | AF1 |
| Number of Residues | 12 |
| Details | binding site for residues I3C A 402 and I3C A 403 |
| Chain | Residue |
| A | ALA91 |
| A | ALA91 |
| A | LYS92 |
| A | PRO93 |
| A | GLN122 |
| A | GLN122 |
| A | ARG134 |
| A | HOH531 |
| B | TYR40 |
| B | TYR40 |
| B | ARG44 |
| B | ARG44 |
| site_id | AF2 |
| Number of Residues | 12 |
| Details | binding site for residues I3C A 402 and I3C A 403 |
| Chain | Residue |
| A | ALA91 |
| A | ALA91 |
| A | LYS92 |
| A | PRO93 |
| A | GLN122 |
| A | GLN122 |
| A | ARG134 |
| A | HOH531 |
| B | TYR40 |
| B | TYR40 |
| B | ARG44 |
| B | ARG44 |
| site_id | AF3 |
| Number of Residues | 12 |
| Details | binding site for residues I3C A 402 and I3C A 403 |
| Chain | Residue |
| A | ALA91 |
| A | ALA91 |
| A | LYS92 |
| A | PRO93 |
| A | GLN122 |
| A | GLN122 |
| A | ARG134 |
| A | HOH531 |
| B | TYR40 |
| B | TYR40 |
| B | ARG44 |
| B | ARG44 |
| site_id | AF4 |
| Number of Residues | 12 |
| Details | binding site for residues I3C A 402 and I3C A 403 |
| Chain | Residue |
| A | ALA91 |
| A | ALA91 |
| A | LYS92 |
| A | PRO93 |
| A | GLN122 |
| A | GLN122 |
| A | ARG134 |
| A | HOH531 |
| B | TYR40 |
| B | TYR40 |
| B | ARG44 |
| B | ARG44 |
| site_id | AF5 |
| Number of Residues | 12 |
| Details | binding site for residues I3C A 402 and I3C A 403 |
| Chain | Residue |
| A | ALA91 |
| A | ALA91 |
| A | LYS92 |
| A | PRO93 |
| A | GLN122 |
| A | GLN122 |
| A | ARG134 |
| A | HOH531 |
| B | TYR40 |
| B | TYR40 |
| B | ARG44 |
| B | ARG44 |
| site_id | AF6 |
| Number of Residues | 12 |
| Details | binding site for residues I3C A 402 and I3C A 403 |
| Chain | Residue |
| A | ALA91 |
| A | ALA91 |
| A | LYS92 |
| A | PRO93 |
| A | GLN122 |
| A | GLN122 |
| A | ARG134 |
| A | HOH531 |
| B | TYR40 |
| B | TYR40 |
| B | ARG44 |
| B | ARG44 |
| site_id | AF7 |
| Number of Residues | 12 |
| Details | binding site for residues I3C A 402 and I3C A 403 |
| Chain | Residue |
| A | ALA91 |
| A | ALA91 |
| A | LYS92 |
| A | PRO93 |
| A | GLN122 |
| A | GLN122 |
| A | ARG134 |
| A | HOH531 |
| B | TYR40 |
| B | TYR40 |
| B | ARG44 |
| B | ARG44 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"29146868","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26794318","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"26794318","evidenceCode":"ECO:0000305"}]} |
