6JZC

Structural basis of tubulin detyrosination

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000768	biological_process	syncytium formation by plasma membrane fusion
A	0001938	biological_process	positive regulation of endothelial cell proliferation
A	0003779	molecular_function	actin binding
A	0004180	molecular_function	carboxypeptidase activity
A	0004181	molecular_function	metallocarboxypeptidase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0006508	biological_process	proteolysis
A	0008017	molecular_function	microtubule binding
A	0008233	molecular_function	peptidase activity
A	0016787	molecular_function	hydrolase activity
A	0045765	biological_process	regulation of angiogenesis
A	0045766	biological_process	positive regulation of angiogenesis
A	0060674	biological_process	placenta blood vessel development
A	0060711	biological_process	labyrinthine layer development
A	0060716	biological_process	labyrinthine layer blood vessel development
A	0061564	biological_process	axon development
A	0106423	molecular_function	tubulin-tyrosine carboxypeptidase
A	0140253	biological_process	cell-cell fusion
B	0000768	biological_process	syncytium formation by plasma membrane fusion
B	0001938	biological_process	positive regulation of endothelial cell proliferation
B	0003779	molecular_function	actin binding
B	0004180	molecular_function	carboxypeptidase activity
B	0004181	molecular_function	metallocarboxypeptidase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0006508	biological_process	proteolysis
B	0008017	molecular_function	microtubule binding
B	0008233	molecular_function	peptidase activity
B	0016787	molecular_function	hydrolase activity
B	0045765	biological_process	regulation of angiogenesis
B	0045766	biological_process	positive regulation of angiogenesis
B	0060674	biological_process	placenta blood vessel development
B	0060711	biological_process	labyrinthine layer development
B	0060716	biological_process	labyrinthine layer blood vessel development
B	0061564	biological_process	axon development
B	0106423	molecular_function	tubulin-tyrosine carboxypeptidase
B	0140253	biological_process	cell-cell fusion
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005737	cellular_component	cytoplasm
C	0005856	cellular_component	cytoskeleton
C	0006508	biological_process	proteolysis
C	0008017	molecular_function	microtubule binding
C	0009306	biological_process	protein secretion
C	0010596	biological_process	negative regulation of endothelial cell migration
C	0016504	molecular_function	peptidase activator activity
C	0031397	biological_process	negative regulation of protein ubiquitination
C	0045177	cellular_component	apical part of cell
C	0061564	biological_process	axon development
C	1905048	biological_process	regulation of metallopeptidase activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005737	cellular_component	cytoplasm
D	0005856	cellular_component	cytoskeleton
D	0006508	biological_process	proteolysis
D	0008017	molecular_function	microtubule binding
D	0009306	biological_process	protein secretion
D	0010596	biological_process	negative regulation of endothelial cell migration
D	0016504	molecular_function	peptidase activator activity
D	0031397	biological_process	negative regulation of protein ubiquitination
D	0045177	cellular_component	apical part of cell
D	0061564	biological_process	axon development
D	1905048	biological_process	regulation of metallopeptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue GOL A 401

Chain	Residue
A	LEU111
A	GLN112
A	SER206
A	ASP217
A	LYS218
A	PRO219

---

site_id	AC2
Number of Residues	8
Details	binding site for residue GOL A 402

Chain	Residue
A	ALA213
A	MET216
A	HOH511
A	HOH525
A	HOH542
A	LYS119
A	SER210
A	ARG211

---

site_id	AC3
Number of Residues	10
Details	binding site for residue GOL A 403

Chain	Residue
A	ASN52
A	LYS53
A	SER54
A	GLY55
A	PHE130
A	PHE131
A	GLU132
A	GLU148
A	HOH513
A	HOH558

---

site_id	AC4
Number of Residues	5
Details	binding site for residue GOL A 404

Chain	Residue
A	TRP63
A	ARG85
A	ASN86
A	HOH569
D	GLU38

---

site_id	AC5
Number of Residues	8
Details	binding site for residue GOL B 401

Chain	Residue
B	GLN112
B	SER206
B	LEU207
B	ASP217
B	LYS218
B	PRO219
B	HOH559
B	HOH575

---

site_id	AC6
Number of Residues	7
Details	binding site for residue GOL B 402

Chain	Residue
B	SER210
B	ARG211
B	ALA213
B	MET216
B	HOH516
B	HOH531
B	HOH542

---

site_id	AC7
Number of Residues	10
Details	binding site for residue GOL B 403

Chain	Residue
B	ASN52
B	LYS53
B	SER54
B	GLY55
B	PHE56
B	PHE130
B	PHE131
B	GLU132
B	GLU148
B	HOH543

---

site_id	AC8
Number of Residues	5
Details	binding site for residue GOL B 404

Chain	Residue
B	TRP63
B	ARG85
B	HOH532
C	LEU31
C	GLU38

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PubMed","id":"29146868","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26794318","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"evidences":[{"source":"PubMed","id":"26794318","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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