Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6JXK

Rb+-bound E2-MgF state of the gastric proton pump (Wild-type)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0005215	molecular_function	transporter activity
A	0005391	molecular_function	P-type sodium:potassium-exchanging transporter activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005886	cellular_component	plasma membrane
A	0005889	cellular_component	potassium:proton exchanging ATPase complex
A	0006813	biological_process	potassium ion transport
A	0006883	biological_process	intracellular sodium ion homeostasis
A	0008556	molecular_function	P-type potassium transmembrane transporter activity
A	0008900	molecular_function	P-type potassium:proton transporter activity
A	0010248	biological_process	establishment or maintenance of transmembrane electrochemical gradient
A	0016020	cellular_component	membrane
A	0016324	cellular_component	apical plasma membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0030007	biological_process	intracellular potassium ion homeostasis
A	0030955	molecular_function	potassium ion binding
A	0036376	biological_process	sodium ion export across plasma membrane
A	0046872	molecular_function	metal ion binding
A	0071805	biological_process	potassium ion transmembrane transport
A	1902600	biological_process	proton transmembrane transport
A	1990573	biological_process	potassium ion import across plasma membrane
B	0001671	molecular_function	ATPase activator activity
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0005889	cellular_component	potassium:proton exchanging ATPase complex
B	0005890	cellular_component	sodium:potassium-exchanging ATPase complex
B	0006813	biological_process	potassium ion transport
B	0006814	biological_process	sodium ion transport
B	0006883	biological_process	intracellular sodium ion homeostasis
B	0007155	biological_process	cell adhesion
B	0016324	cellular_component	apical plasma membrane
B	0030007	biological_process	intracellular potassium ion homeostasis
B	0036376	biological_process	sodium ion export across plasma membrane
B	0071805	biological_process	potassium ion transmembrane transport
B	1902600	biological_process	proton transmembrane transport
B	1990573	biological_process	potassium ion import across plasma membrane
E	0000166	molecular_function	nucleotide binding
E	0000287	molecular_function	magnesium ion binding
E	0005215	molecular_function	transporter activity
E	0005391	molecular_function	P-type sodium:potassium-exchanging transporter activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005886	cellular_component	plasma membrane
E	0005889	cellular_component	potassium:proton exchanging ATPase complex
E	0006813	biological_process	potassium ion transport
E	0006883	biological_process	intracellular sodium ion homeostasis
E	0008556	molecular_function	P-type potassium transmembrane transporter activity
E	0008900	molecular_function	P-type potassium:proton transporter activity
E	0010248	biological_process	establishment or maintenance of transmembrane electrochemical gradient
E	0016020	cellular_component	membrane
E	0016324	cellular_component	apical plasma membrane
E	0016887	molecular_function	ATP hydrolysis activity
E	0030007	biological_process	intracellular potassium ion homeostasis
E	0030955	molecular_function	potassium ion binding
E	0036376	biological_process	sodium ion export across plasma membrane
E	0046872	molecular_function	metal ion binding
E	0071805	biological_process	potassium ion transmembrane transport
E	1902600	biological_process	proton transmembrane transport
E	1990573	biological_process	potassium ion import across plasma membrane
F	0001671	molecular_function	ATPase activator activity
F	0005515	molecular_function	protein binding
F	0005886	cellular_component	plasma membrane
F	0005889	cellular_component	potassium:proton exchanging ATPase complex
F	0005890	cellular_component	sodium:potassium-exchanging ATPase complex
F	0006813	biological_process	potassium ion transport
F	0006814	biological_process	sodium ion transport
F	0006883	biological_process	intracellular sodium ion homeostasis
F	0007155	biological_process	cell adhesion
F	0016324	cellular_component	apical plasma membrane
F	0030007	biological_process	intracellular potassium ion homeostasis
F	0036376	biological_process	sodium ion export across plasma membrane
F	0071805	biological_process	potassium ion transmembrane transport
F	1902600	biological_process	proton transmembrane transport
F	1990573	biological_process	potassium ion import across plasma membrane

Functional Information from PROSITE/UniProt

site_id	PS00154
Number of Residues	7
Details	ATPASE_E1_E2 E1-E2 ATPases phosphorylation site. DKTGTLT

Chain	Residue	Details
A	ASP385-THR391

site_id	PS00390
Number of Residues	21
Details	ATPASE_NA_K_BETA_1 Sodium and potassium ATPases beta subunits signature 1. FqrYcWNpdtgqmLGRTlsrW

Chain	Residue	Details
B	PHE17-TRP37

site_id	PS00391
Number of Residues	16
Details	ATPASE_NA_K_BETA_2 Sodium and potassium ATPases beta subunits signature 2. KfsCKftadmLqnCSG

Chain	Residue	Details
B	LYS149-GLY164

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	TRANSMEM: Helical; Signal-anchor for type II membrane protein => ECO:0000255

Chain	Residue	Details
B	TRP37-LEU57
A	GLN996-LYS1016
E	GLU97-ALA117
E	LEU141-PHE161
E	GLU298-ILE317
E	MET330-ALA347
E	LYS782-ILE801
E	GLY812-ALA832
E	LEU853-PHE875
E	TYR928-LYS947
E	ARG962-TYR980
F	TRP37-LEU57
E	GLN996-LYS1016
A	GLU298-ILE317
A	MET330-ALA347
A	LYS782-ILE801
A	GLY812-ALA832
A	LEU853-PHE875
A	TYR928-LYS947
A	ARG962-TYR980

site_id	SWS_FT_FI2
Number of Residues	464
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
B	CYS58-LYS290
E	CYS981-PHE995
F	CYS58-LYS290
A	TYR802-LEU811
A	THR876-CYS927
A	CYS981-PHE995
E	ALA118-TYR140
E	VAL318-ALA329
E	TYR802-LEU811
E	THR876-CYS927

site_id	SWS_FT_FI3
Number of Residues	12
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000250\|UniProtKB:P18597

Chain	Residue	Details
B	ASN99
F	ASN161
F	ASN193
F	ASN221
B	ASN130
B	ASN146
B	ASN161
B	ASN193
B	ASN221
F	ASN99
F	ASN130
F	ASN146

site_id	SWS_FT_FI4
Number of Residues	2
Details	ACT_SITE: 4-aspartylphosphate intermediate => ECO:0000269\|PubMed:1720615

Chain	Residue	Details
A	ASP385
E	ASP385

site_id	SWS_FT_FI5
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269\|PubMed:31436534, ECO:0007744\|PDB:6JXH

Chain	Residue	Details
A	VAL338
E	GLU343
E	GLU795
E	GLU820
A	ALA339
A	VAL341
A	GLU343
A	GLU795
A	GLU820
E	VAL338
E	ALA339
E	VAL341

site_id	SWS_FT_FI6
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:29618813, ECO:0000269\|PubMed:31436534, ECO:0007744\|PDB:5YLU, ECO:0007744\|PDB:6JXH

Chain	Residue	Details
A	ASP385
A	THR387
A	ASP726
E	ASP385
E	THR387
E	ASP726

site_id	SWS_FT_FI7
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	ASP730
E	ASP730

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:Q6PIE5

Chain	Residue	Details
A	SER461
E	SER461

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P50993

Chain	Residue	Details
A	SER599
E	SER599

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P09626

Chain	Residue	Details
A	SER838
E	SER838

site_id	SWS_FT_FI11
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PKA => ECO:0000250

Chain	Residue	Details
A	SER952
E	SER952

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)