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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6JXK

Rb+-bound E2-MgF state of the gastric proton pump (Wild-type)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000287molecular_functionmagnesium ion binding
A0005215molecular_functiontransporter activity
A0005391molecular_functionP-type sodium:potassium-exchanging transporter activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006813biological_processpotassium ion transport
A0006883biological_processintracellular sodium ion homeostasis
A0008556molecular_functionP-type potassium transmembrane transporter activity
A0008900molecular_functionP-type potassium:proton transporter activity
A0010248biological_processestablishment or maintenance of transmembrane electrochemical gradient
A0016020cellular_componentmembrane
A0016324cellular_componentapical plasma membrane
A0016887molecular_functionATP hydrolysis activity
A0030007biological_processintracellular potassium ion homeostasis
A0030955molecular_functionpotassium ion binding
A0036376biological_processsodium ion export across plasma membrane
A0046872molecular_functionmetal ion binding
A0071805biological_processpotassium ion transmembrane transport
A0090533cellular_componentcation-transporting ATPase complex
A0098797cellular_componentplasma membrane protein complex
A1902600biological_processproton transmembrane transport
A1990573biological_processpotassium ion import across plasma membrane
B0001671molecular_functionATPase activator activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0005890cellular_componentsodium:potassium-exchanging ATPase complex
B0006811biological_processmonoatomic ion transport
B0006813biological_processpotassium ion transport
B0006814biological_processsodium ion transport
B0006883biological_processintracellular sodium ion homeostasis
B0007155biological_processcell adhesion
B0016324cellular_componentapical plasma membrane
B0030007biological_processintracellular potassium ion homeostasis
B0036376biological_processsodium ion export across plasma membrane
B0071805biological_processpotassium ion transmembrane transport
B1902600biological_processproton transmembrane transport
B1990573biological_processpotassium ion import across plasma membrane
E0000166molecular_functionnucleotide binding
E0000287molecular_functionmagnesium ion binding
E0005215molecular_functiontransporter activity
E0005391molecular_functionP-type sodium:potassium-exchanging transporter activity
E0005515molecular_functionprotein binding
E0005524molecular_functionATP binding
E0005886cellular_componentplasma membrane
E0006811biological_processmonoatomic ion transport
E0006813biological_processpotassium ion transport
E0006883biological_processintracellular sodium ion homeostasis
E0008556molecular_functionP-type potassium transmembrane transporter activity
E0008900molecular_functionP-type potassium:proton transporter activity
E0010248biological_processestablishment or maintenance of transmembrane electrochemical gradient
E0016020cellular_componentmembrane
E0016324cellular_componentapical plasma membrane
E0016887molecular_functionATP hydrolysis activity
E0030007biological_processintracellular potassium ion homeostasis
E0030955molecular_functionpotassium ion binding
E0036376biological_processsodium ion export across plasma membrane
E0046872molecular_functionmetal ion binding
E0071805biological_processpotassium ion transmembrane transport
E0090533cellular_componentcation-transporting ATPase complex
E0098797cellular_componentplasma membrane protein complex
E1902600biological_processproton transmembrane transport
E1990573biological_processpotassium ion import across plasma membrane
F0001671molecular_functionATPase activator activity
F0005515molecular_functionprotein binding
F0005886cellular_componentplasma membrane
F0005890cellular_componentsodium:potassium-exchanging ATPase complex
F0006811biological_processmonoatomic ion transport
F0006813biological_processpotassium ion transport
F0006814biological_processsodium ion transport
F0006883biological_processintracellular sodium ion homeostasis
F0007155biological_processcell adhesion
F0016324cellular_componentapical plasma membrane
F0030007biological_processintracellular potassium ion homeostasis
F0036376biological_processsodium ion export across plasma membrane
F0071805biological_processpotassium ion transmembrane transport
F1902600biological_processproton transmembrane transport
F1990573biological_processpotassium ion import across plasma membrane
Functional Information from PROSITE/UniProt
site_idPS00154
Number of Residues7
DetailsATPASE_E1_E2 E1-E2 ATPases phosphorylation site. DKTGTLT
ChainResidueDetails
AASP385-THR391
site_idPS00390
Number of Residues21
DetailsATPASE_NA_K_BETA_1 Sodium and potassium ATPases beta subunits signature 1. FqrYcWNpdtgqmLGRTlsrW
ChainResidueDetails
BPHE17-TRP37
site_idPS00391
Number of Residues16
DetailsATPASE_NA_K_BETA_2 Sodium and potassium ATPases beta subunits signature 2. KfsCKftadmLqnCSG
ChainResidueDetails
BLYS149-GLY164
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues388
DetailsTransmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues214
DetailsTopological domain: {"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues1232
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues44
DetailsRegion: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues28
DetailsCompositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsActive site: {"description":"4-aspartylphosphate intermediate","evidences":[{"source":"PubMed","id":"1720615","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31436534","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6JXH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"29618813","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31436534","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5YLU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JXH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q6PIE5","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P50993","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P09626","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by PKA","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Signal-anchor for type II membrane protein","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues464
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues192
DetailsRegion: {"description":"immunoglobulin-like","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues12
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"UniProtKB","id":"P18597","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

249697

PDB entries from 2026-02-25

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