6JX2

Crystal structure of Ketol-acid reductoisomerase from Corynebacterium glutamicum

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004455	molecular_function	ketol-acid reductoisomerase activity
A	0005829	cellular_component	cytosol
A	0008652	biological_process	amino acid biosynthetic process
A	0008677	molecular_function	2-dehydropantoate 2-reductase activity
A	0009082	biological_process	branched-chain amino acid biosynthetic process
A	0009097	biological_process	isoleucine biosynthetic process
A	0009099	biological_process	L-valine biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0046872	molecular_function	metal ion binding
A	0050661	molecular_function	NADP binding
B	0000287	molecular_function	magnesium ion binding
B	0004455	molecular_function	ketol-acid reductoisomerase activity
B	0005829	cellular_component	cytosol
B	0008652	biological_process	amino acid biosynthetic process
B	0008677	molecular_function	2-dehydropantoate 2-reductase activity
B	0009082	biological_process	branched-chain amino acid biosynthetic process
B	0009097	biological_process	isoleucine biosynthetic process
B	0009099	biological_process	L-valine biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0046872	molecular_function	metal ion binding
B	0050661	molecular_function	NADP binding
C	0000287	molecular_function	magnesium ion binding
C	0004455	molecular_function	ketol-acid reductoisomerase activity
C	0005829	cellular_component	cytosol
C	0008652	biological_process	amino acid biosynthetic process
C	0008677	molecular_function	2-dehydropantoate 2-reductase activity
C	0009082	biological_process	branched-chain amino acid biosynthetic process
C	0009097	biological_process	isoleucine biosynthetic process
C	0009099	biological_process	L-valine biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0046872	molecular_function	metal ion binding
C	0050661	molecular_function	NADP binding
D	0000287	molecular_function	magnesium ion binding
D	0004455	molecular_function	ketol-acid reductoisomerase activity
D	0005829	cellular_component	cytosol
D	0008652	biological_process	amino acid biosynthetic process
D	0008677	molecular_function	2-dehydropantoate 2-reductase activity
D	0009082	biological_process	branched-chain amino acid biosynthetic process
D	0009097	biological_process	isoleucine biosynthetic process
D	0009099	biological_process	L-valine biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
D	0046872	molecular_function	metal ion binding
D	0050661	molecular_function	NADP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue MG A 401

Chain	Residue
A	ASP192
A	GLU196

---

site_id	AC2
Number of Residues	4
Details	binding site for residue MG A 402

Chain	Residue
A	GLU228
A	GLU232
B	ASP192
B	GLU196

---

site_id	AC3
Number of Residues	5
Details	binding site for residue MG A 403

Chain	Residue
A	ASN100
A	ASP103
A	ALA73
A	ALA75
A	ASN98

---

site_id	AC4
Number of Residues	2
Details	binding site for residue MG A 404

Chain	Residue
A	TYR250
A	ASP254

---

site_id	AC5
Number of Residues	15
Details	binding site for residue NAP A 405

Chain	Residue
A	GLY25
A	TYR26
A	GLY27
A	SER28
A	ARG49
A	SER52
A	LYS53
A	SER54
A	THR68
A	LEU81
A	ALA82
A	PRO83
A	ILE90
A	HOH509
A	HOH533

---

site_id	AC6
Number of Residues	2
Details	binding site for residue EDO A 406

Chain	Residue
A	GLU297
A	HOH514

---

site_id	AC7
Number of Residues	4
Details	binding site for residue EDO A 407

Chain	Residue
A	ASP116
A	ASP155
A	GLN156
A	HOH518

---

site_id	AC8
Number of Residues	3
Details	binding site for residue MG B 401

Chain	Residue
A	ASP192
B	GLU228
B	GLU232

---

site_id	AC9
Number of Residues	2
Details	binding site for residue MG B 402

Chain	Residue
B	ASP192
B	GLU196

---

site_id	AD1
Number of Residues	1
Details	binding site for residue MG B 403

Chain	Residue
B	ASP116

---

site_id	AD2
Number of Residues	1
Details	binding site for residue MG B 404

Chain	Residue
B	ASP254

---

site_id	AD3
Number of Residues	4
Details	binding site for residue MG B 405

Chain	Residue
B	ALA73
B	ALA75
B	ASN100
B	ASP103

---

site_id	AD4
Number of Residues	2
Details	binding site for residue EDO B 406

Chain	Residue
B	ASP123
B	GLU213

---

site_id	AD5
Number of Residues	4
Details	binding site for residue EDO B 407

Chain	Residue
B	GLU4
B	LEU5
D	ASP10
D	ASN298

---

site_id	AD6
Number of Residues	3
Details	binding site for residue EDO B 408

Chain	Residue
B	HIS114
B	THR184
B	GLU186

---

site_id	AD7
Number of Residues	2
Details	binding site for residue MG C 401

Chain	Residue
C	ASP192
C	GLU196

---

site_id	AD8
Number of Residues	3
Details	binding site for residue MG C 402

Chain	Residue
C	GLU228
C	GLU232
D	ASP192

---

site_id	AD9
Number of Residues	19
Details	binding site for residue NAP C 403

Chain	Residue
C	GLY25
C	TYR26
C	GLY27
C	SER28
C	GLN29
C	SER52
C	SER54
C	THR68
C	LEU81
C	ALA82
C	PRO83
C	ASP84
C	GLN87
C	ILE90
C	GLY108
C	HIS109
C	GLY133
C	PRO134
C	HOH501

---

site_id	AE1
Number of Residues	4
Details	binding site for residue MG D 401

Chain	Residue
C	ASP192
C	GLU196
D	GLU228
D	GLU232

---

site_id	AE2
Number of Residues	2
Details	binding site for residue MG D 402

Chain	Residue
D	ASP192
D	GLU196

---

site_id	AE3
Number of Residues	12
Details	binding site for residue NAP D 403

Chain	Residue
D	GLY25
D	TYR26
D	GLY27
D	SER28
D	ARG49
D	SER52
D	LYS53
D	SER54
D	THR68
D	LEU81
D	PRO83
D	ILE90

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	720
Details	Domain: {"description":"KARI N-terminal Rossmann","evidences":[{"source":"PROSITE-ProRule","id":"PRU01197","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00435","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	60
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00435","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	145
Details	Domain: {"description":"KARI C-terminal knotted","evidences":[{"source":"PROSITE-ProRule","id":"PRU01198","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---