6JWU
Crystal structure of Plasmodium falciparum HPPK-DHPS wild type with STZ-DHP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003848 | molecular_function | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity |
| A | 0004156 | molecular_function | dihydropteroate synthase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005740 | cellular_component | mitochondrial envelope |
| A | 0005829 | cellular_component | cytosol |
| A | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0042558 | biological_process | pteridine-containing compound metabolic process |
| A | 0044237 | biological_process | cellular metabolic process |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046656 | biological_process | folic acid biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0003848 | molecular_function | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity |
| B | 0004156 | molecular_function | dihydropteroate synthase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005740 | cellular_component | mitochondrial envelope |
| B | 0005829 | cellular_component | cytosol |
| B | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0042558 | biological_process | pteridine-containing compound metabolic process |
| B | 0044237 | biological_process | cellular metabolic process |
| B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| B | 0046656 | biological_process | folic acid biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | binding site for residue XTZ A 801 |
| Chain | Residue |
| A | SER436 |
| A | PHE580 |
| A | LYS582 |
| A | PHE603 |
| A | GLY605 |
| A | LYS609 |
| A | ARG610 |
| A | ARG686 |
| A | PO4803 |
| A | HOH902 |
| A | HOH941 |
| A | PRO438 |
| A | ASP482 |
| A | ASN502 |
| A | ILE504 |
| A | MET529 |
| A | ASP539 |
| A | ASP575 |
| A | GLY579 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue PH2 A 802 |
| Chain | Residue |
| A | THR57 |
| A | VAL58 |
| A | GLU60 |
| A | TYR61 |
| A | PHE163 |
| A | ASN165 |
| A | ASP208 |
| A | ARG326 |
| A | SER328 |
| A | HOH917 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 A 803 |
| Chain | Residue |
| A | ASN396 |
| A | ARG686 |
| A | HIS688 |
| A | XTZ801 |
| A | HOH931 |
| A | HOH1017 |
| A | HOH1050 |
| site_id | AC4 |
| Number of Residues | 15 |
| Details | binding site for residue AMP A 804 |
| Chain | Residue |
| A | LEU181 |
| A | ASP208 |
| A | ASP210 |
| A | ILE211 |
| A | ASN312 |
| A | ILE313 |
| A | GLU314 |
| A | PHE315 |
| A | LEU316 |
| A | SER317 |
| A | ILE318 |
| A | HIS320 |
| A | MG805 |
| A | HOH952 |
| A | HOH974 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 805 |
| Chain | Residue |
| A | ASP208 |
| A | ASP210 |
| A | AMP804 |
| A | HOH940 |
| A | HOH987 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 806 |
| Chain | Residue |
| A | GLU42 |
| A | GLY46 |
| A | GLU99 |
| A | HOH1027 |
| A | HOH1055 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue ACT A 807 |
| Chain | Residue |
| A | HIS530 |
| A | ARG532 |
| A | ASP550 |
| A | HOH949 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue ACT A 808 |
| Chain | Residue |
| A | ARG374 |
| A | LEU385 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 A 809 |
| Chain | Residue |
| A | ASP335 |
| A | ARG350 |
| A | ARG374 |
| A | GLU599 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 A 810 |
| Chain | Residue |
| A | ILE49 |
| A | ASN50 |
| A | TYR110 |
| A | ASN560 |
| A | VAL563 |
| A | LEU564 |
| A | HOH911 |
| site_id | AD2 |
| Number of Residues | 19 |
| Details | binding site for residue XTZ B 801 |
| Chain | Residue |
| B | ASP482 |
| B | ASN502 |
| B | ILE504 |
| B | MET529 |
| B | MET538 |
| B | ASP539 |
| B | ASP575 |
| B | GLY579 |
| B | PHE580 |
| B | PHE603 |
| B | GLY605 |
| B | LYS609 |
| B | ARG610 |
| B | ARG686 |
| B | ACT802 |
| B | HOH912 |
| B | HOH921 |
| B | HOH922 |
| B | HOH937 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue ACT B 802 |
| Chain | Residue |
| B | HIS688 |
| B | XTZ801 |
| B | ASN396 |
| B | ARG686 |
| site_id | AD4 |
| Number of Residues | 12 |
| Details | binding site for residue AMP B 803 |
| Chain | Residue |
| B | ASP208 |
| B | ASP210 |
| B | ILE211 |
| B | ASN312 |
| B | ILE313 |
| B | GLU314 |
| B | PHE315 |
| B | SER317 |
| B | HIS320 |
| B | MG804 |
| B | HOH911 |
| B | HOH941 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue MG B 804 |
| Chain | Residue |
| B | ASP208 |
| B | ASP210 |
| B | AMP803 |
| B | HOH913 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue CA B 805 |
| Chain | Residue |
| B | GLU42 |
| B | GLY46 |
| B | LYS47 |
| B | GLU99 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue ACT B 806 |
| Chain | Residue |
| A | ASN510 |
| A | HOH985 |
| B | HIS530 |
| B | ARG532 |
| B | TYR554 |
| B | HOH954 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue ACT B 807 |
| Chain | Residue |
| A | TYR97 |
| A | GLU98 |
| A | GLU99 |
| B | TYR486 |
| B | ASN510 |
Functional Information from PROSITE/UniProt
| site_id | PS00793 |
| Number of Residues | 14 |
| Details | DHPS_2 Dihydropteroate synthase signature 2. GAsVIDIGGesSaP |
| Chain | Residue | Details |
| A | GLY425-PRO438 |
