6JWU
Crystal structure of Plasmodium falciparum HPPK-DHPS wild type with STZ-DHP
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003848 | molecular_function | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity |
A | 0004156 | molecular_function | dihydropteroate synthase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
A | 0016301 | molecular_function | kinase activity |
A | 0042558 | biological_process | pteridine-containing compound metabolic process |
A | 0044237 | biological_process | cellular metabolic process |
A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
A | 0046656 | biological_process | folic acid biosynthetic process |
A | 0046872 | molecular_function | metal ion binding |
B | 0003848 | molecular_function | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity |
B | 0004156 | molecular_function | dihydropteroate synthase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
B | 0016301 | molecular_function | kinase activity |
B | 0042558 | biological_process | pteridine-containing compound metabolic process |
B | 0044237 | biological_process | cellular metabolic process |
B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
B | 0046656 | biological_process | folic acid biosynthetic process |
B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 19 |
Details | binding site for residue XTZ A 801 |
Chain | Residue |
A | SER436 |
A | PHE580 |
A | LYS582 |
A | PHE603 |
A | GLY605 |
A | LYS609 |
A | ARG610 |
A | ARG686 |
A | PO4803 |
A | HOH902 |
A | HOH941 |
A | PRO438 |
A | ASP482 |
A | ASN502 |
A | ILE504 |
A | MET529 |
A | ASP539 |
A | ASP575 |
A | GLY579 |
site_id | AC2 |
Number of Residues | 10 |
Details | binding site for residue PH2 A 802 |
Chain | Residue |
A | THR57 |
A | VAL58 |
A | GLU60 |
A | TYR61 |
A | PHE163 |
A | ASN165 |
A | ASP208 |
A | ARG326 |
A | SER328 |
A | HOH917 |
site_id | AC3 |
Number of Residues | 7 |
Details | binding site for residue PO4 A 803 |
Chain | Residue |
A | ASN396 |
A | ARG686 |
A | HIS688 |
A | XTZ801 |
A | HOH931 |
A | HOH1017 |
A | HOH1050 |
site_id | AC4 |
Number of Residues | 15 |
Details | binding site for residue AMP A 804 |
Chain | Residue |
A | LEU181 |
A | ASP208 |
A | ASP210 |
A | ILE211 |
A | ASN312 |
A | ILE313 |
A | GLU314 |
A | PHE315 |
A | LEU316 |
A | SER317 |
A | ILE318 |
A | HIS320 |
A | MG805 |
A | HOH952 |
A | HOH974 |
site_id | AC5 |
Number of Residues | 5 |
Details | binding site for residue MG A 805 |
Chain | Residue |
A | ASP208 |
A | ASP210 |
A | AMP804 |
A | HOH940 |
A | HOH987 |
site_id | AC6 |
Number of Residues | 5 |
Details | binding site for residue CA A 806 |
Chain | Residue |
A | GLU42 |
A | GLY46 |
A | GLU99 |
A | HOH1027 |
A | HOH1055 |
site_id | AC7 |
Number of Residues | 4 |
Details | binding site for residue ACT A 807 |
Chain | Residue |
A | HIS530 |
A | ARG532 |
A | ASP550 |
A | HOH949 |
site_id | AC8 |
Number of Residues | 2 |
Details | binding site for residue ACT A 808 |
Chain | Residue |
A | ARG374 |
A | LEU385 |
site_id | AC9 |
Number of Residues | 4 |
Details | binding site for residue PO4 A 809 |
Chain | Residue |
A | ASP335 |
A | ARG350 |
A | ARG374 |
A | GLU599 |
site_id | AD1 |
Number of Residues | 7 |
Details | binding site for residue PO4 A 810 |
Chain | Residue |
A | ILE49 |
A | ASN50 |
A | TYR110 |
A | ASN560 |
A | VAL563 |
A | LEU564 |
A | HOH911 |
site_id | AD2 |
Number of Residues | 19 |
Details | binding site for residue XTZ B 801 |
Chain | Residue |
B | ASP482 |
B | ASN502 |
B | ILE504 |
B | MET529 |
B | MET538 |
B | ASP539 |
B | ASP575 |
B | GLY579 |
B | PHE580 |
B | PHE603 |
B | GLY605 |
B | LYS609 |
B | ARG610 |
B | ARG686 |
B | ACT802 |
B | HOH912 |
B | HOH921 |
B | HOH922 |
B | HOH937 |
site_id | AD3 |
Number of Residues | 4 |
Details | binding site for residue ACT B 802 |
Chain | Residue |
B | HIS688 |
B | XTZ801 |
B | ASN396 |
B | ARG686 |
site_id | AD4 |
Number of Residues | 12 |
Details | binding site for residue AMP B 803 |
Chain | Residue |
B | ASP208 |
B | ASP210 |
B | ILE211 |
B | ASN312 |
B | ILE313 |
B | GLU314 |
B | PHE315 |
B | SER317 |
B | HIS320 |
B | MG804 |
B | HOH911 |
B | HOH941 |
site_id | AD5 |
Number of Residues | 4 |
Details | binding site for residue MG B 804 |
Chain | Residue |
B | ASP208 |
B | ASP210 |
B | AMP803 |
B | HOH913 |
site_id | AD6 |
Number of Residues | 4 |
Details | binding site for residue CA B 805 |
Chain | Residue |
B | GLU42 |
B | GLY46 |
B | LYS47 |
B | GLU99 |
site_id | AD7 |
Number of Residues | 6 |
Details | binding site for residue ACT B 806 |
Chain | Residue |
A | ASN510 |
A | HOH985 |
B | HIS530 |
B | ARG532 |
B | TYR554 |
B | HOH954 |
site_id | AD8 |
Number of Residues | 5 |
Details | binding site for residue ACT B 807 |
Chain | Residue |
A | TYR97 |
A | GLU98 |
A | GLU99 |
B | TYR486 |
B | ASN510 |
Functional Information from PROSITE/UniProt
site_id | PS00793 |
Number of Residues | 14 |
Details | DHPS_2 Dihydropteroate synthase signature 2. GAsVIDIGGesSaP |
Chain | Residue | Details |
A | GLY425-PRO438 |