Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6JWP

crystal structure of EGOC

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000329	cellular_component	fungal-type vacuole membrane
A	0000781	cellular_component	chromosome, telomeric region
A	0003924	molecular_function	GTPase activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005770	cellular_component	late endosome
A	0005774	cellular_component	vacuolar membrane
A	0006360	biological_process	transcription by RNA polymerase I
A	0006383	biological_process	transcription by RNA polymerase III
A	0006817	biological_process	phosphate ion transport
A	0006995	biological_process	cellular response to nitrogen starvation
A	0009267	biological_process	cellular response to starvation
A	0010507	biological_process	negative regulation of autophagy
A	0016237	biological_process	microautophagy
A	0016787	molecular_function	hydrolase activity
A	0031509	biological_process	subtelomeric heterochromatin formation
A	0031902	cellular_component	late endosome membrane
A	0032008	biological_process	positive regulation of TOR signaling
A	0032456	biological_process	endocytic recycling
A	0034599	biological_process	cellular response to oxidative stress
A	0042802	molecular_function	identical protein binding
A	0071230	biological_process	cellular response to amino acid stimulus
A	0071986	cellular_component	Ragulator complex
A	1903778	biological_process	protein localization to vacuolar membrane
A	1904263	biological_process	positive regulation of TORC1 signaling
A	1990131	cellular_component	Gtr1-Gtr2 GTPase complex
B	0000166	molecular_function	nucleotide binding
B	0000329	cellular_component	fungal-type vacuole membrane
B	0000785	cellular_component	chromatin
B	0003924	molecular_function	GTPase activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005770	cellular_component	late endosome
B	0005774	cellular_component	vacuolar membrane
B	0006995	biological_process	cellular response to nitrogen starvation
B	0009267	biological_process	cellular response to starvation
B	0010507	biological_process	negative regulation of autophagy
B	0016237	biological_process	microautophagy
B	0016787	molecular_function	hydrolase activity
B	0031902	cellular_component	late endosome membrane
B	0032008	biological_process	positive regulation of TOR signaling
B	0032456	biological_process	endocytic recycling
B	0034599	biological_process	cellular response to oxidative stress
B	0045121	cellular_component	membrane raft
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0071230	biological_process	cellular response to amino acid stimulus
B	0071986	cellular_component	Ragulator complex
B	1903778	biological_process	protein localization to vacuolar membrane
B	1904263	biological_process	positive regulation of TORC1 signaling
B	1990131	cellular_component	Gtr1-Gtr2 GTPase complex
C	0001919	biological_process	regulation of receptor recycling
C	0007040	biological_process	lysosome organization
C	0016197	biological_process	endosomal transport
C	0031902	cellular_component	late endosome membrane
C	0032008	biological_process	positive regulation of TOR signaling
C	0042632	biological_process	cholesterol homeostasis
C	0043410	biological_process	positive regulation of MAPK cascade
C	0045121	cellular_component	membrane raft
C	0071230	biological_process	cellular response to amino acid stimulus
C	0071986	cellular_component	Ragulator complex
D	0000329	cellular_component	fungal-type vacuole membrane
D	0003674	molecular_function	molecular_function
D	0016237	biological_process	microautophagy
D	0032008	biological_process	positive regulation of TOR signaling
D	0038202	biological_process	TORC1 signaling
D	0071986	cellular_component	Ragulator complex
D	0072665	biological_process	protein localization to vacuole
E	0000329	cellular_component	fungal-type vacuole membrane
E	0003674	molecular_function	molecular_function
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005770	cellular_component	late endosome
E	0005774	cellular_component	vacuolar membrane
E	0006914	biological_process	autophagy
E	0007165	biological_process	signal transduction
E	0015031	biological_process	protein transport
E	0016237	biological_process	microautophagy
E	0031902	cellular_component	late endosome membrane
E	0032008	biological_process	positive regulation of TOR signaling
E	0032456	biological_process	endocytic recycling
E	0042802	molecular_function	identical protein binding
E	0071986	cellular_component	Ragulator complex
F	0000166	molecular_function	nucleotide binding
F	0000329	cellular_component	fungal-type vacuole membrane
F	0000781	cellular_component	chromosome, telomeric region
F	0003924	molecular_function	GTPase activity
F	0005515	molecular_function	protein binding
F	0005525	molecular_function	GTP binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005770	cellular_component	late endosome
F	0005774	cellular_component	vacuolar membrane
F	0006360	biological_process	transcription by RNA polymerase I
F	0006383	biological_process	transcription by RNA polymerase III
F	0006817	biological_process	phosphate ion transport
F	0006995	biological_process	cellular response to nitrogen starvation
F	0009267	biological_process	cellular response to starvation
F	0010507	biological_process	negative regulation of autophagy
F	0016237	biological_process	microautophagy
F	0016787	molecular_function	hydrolase activity
F	0031509	biological_process	subtelomeric heterochromatin formation
F	0031902	cellular_component	late endosome membrane
F	0032008	biological_process	positive regulation of TOR signaling
F	0032456	biological_process	endocytic recycling
F	0034599	biological_process	cellular response to oxidative stress
F	0042802	molecular_function	identical protein binding
F	0071230	biological_process	cellular response to amino acid stimulus
F	0071986	cellular_component	Ragulator complex
F	1903778	biological_process	protein localization to vacuolar membrane
F	1904263	biological_process	positive regulation of TORC1 signaling
F	1990131	cellular_component	Gtr1-Gtr2 GTPase complex
G	0000166	molecular_function	nucleotide binding
G	0000329	cellular_component	fungal-type vacuole membrane
G	0000785	cellular_component	chromatin
G	0003924	molecular_function	GTPase activity
G	0005515	molecular_function	protein binding
G	0005525	molecular_function	GTP binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005770	cellular_component	late endosome
G	0005774	cellular_component	vacuolar membrane
G	0006995	biological_process	cellular response to nitrogen starvation
G	0009267	biological_process	cellular response to starvation
G	0010507	biological_process	negative regulation of autophagy
G	0016237	biological_process	microautophagy
G	0016787	molecular_function	hydrolase activity
G	0031902	cellular_component	late endosome membrane
G	0032008	biological_process	positive regulation of TOR signaling
G	0032456	biological_process	endocytic recycling
G	0034599	biological_process	cellular response to oxidative stress
G	0045121	cellular_component	membrane raft
G	0045944	biological_process	positive regulation of transcription by RNA polymerase II
G	0071230	biological_process	cellular response to amino acid stimulus
G	0071986	cellular_component	Ragulator complex
G	1903778	biological_process	protein localization to vacuolar membrane
G	1904263	biological_process	positive regulation of TORC1 signaling
G	1990131	cellular_component	Gtr1-Gtr2 GTPase complex
H	0001919	biological_process	regulation of receptor recycling
H	0007040	biological_process	lysosome organization
H	0016197	biological_process	endosomal transport
H	0031902	cellular_component	late endosome membrane
H	0032008	biological_process	positive regulation of TOR signaling
H	0042632	biological_process	cholesterol homeostasis
H	0043410	biological_process	positive regulation of MAPK cascade
H	0045121	cellular_component	membrane raft
H	0071230	biological_process	cellular response to amino acid stimulus
H	0071986	cellular_component	Ragulator complex
I	0000329	cellular_component	fungal-type vacuole membrane
I	0003674	molecular_function	molecular_function
I	0016237	biological_process	microautophagy
I	0032008	biological_process	positive regulation of TOR signaling
I	0038202	biological_process	TORC1 signaling
I	0071986	cellular_component	Ragulator complex
I	0072665	biological_process	protein localization to vacuole
J	0000329	cellular_component	fungal-type vacuole membrane
J	0003674	molecular_function	molecular_function
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0005770	cellular_component	late endosome
J	0005774	cellular_component	vacuolar membrane
J	0006914	biological_process	autophagy
J	0007165	biological_process	signal transduction
J	0015031	biological_process	protein transport
J	0016237	biological_process	microautophagy
J	0031902	cellular_component	late endosome membrane
J	0032008	biological_process	positive regulation of TOR signaling
J	0032456	biological_process	endocytic recycling
J	0042802	molecular_function	identical protein binding
J	0071986	cellular_component	Ragulator complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	binding site for residue GNP A 401

Chain	Residue
A	SER15
A	THR41
A	GLY63
A	GLY64
A	GLN65
A	HIS126
A	LYS127
A	ASP129
A	LEU130
A	SER165
A	ILE166
A	GLY16
A	TRP167
A	MG402
A	SER17
A	GLY18
A	LYS19
A	SER20
A	SER21
A	ARG36
A	ALA40

site_id	AC2
Number of Residues	5
Details	binding site for residue MG A 402

Chain	Residue
A	SER20
A	GLY39
A	ALA40
A	THR41
A	GNP401

site_id	AC3
Number of Residues	18
Details	binding site for residue GNP B 401

Chain	Residue
B	ARG18
B	ARG19
B	CYS20
B	GLY21
B	LYS22
B	SER23
B	SER24
B	THR38
B	LEU39
B	SER43
B	THR44
B	GLU62
B	PRO64
B	HIS124
B	LYS125
B	ASP127
B	ILE166
B	MG402

site_id	AC4
Number of Residues	5
Details	binding site for residue MG B 402

Chain	Residue
B	ARG19
B	SER23
B	THR44
B	GLU62
B	GNP401

site_id	AC5
Number of Residues	20
Details	binding site for residue GNP F 401

Chain	Residue
F	SER15
F	GLY16
F	SER17
F	GLY18
F	LYS19
F	SER20
F	SER21
F	THR35
F	ARG36
F	ALA40
F	THR41
F	GLY63
F	GLY64
F	HIS126
F	LYS127
F	ASP129
F	LEU130
F	SER165
F	ILE166
F	MG402

site_id	AC6
Number of Residues	3
Details	binding site for residue MG F 402

Chain	Residue
F	SER20
F	THR41
F	GNP401

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	29
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21816923","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3R7W","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	34
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)