6JW9

Crystal structure of E-64 inhibited falcipain 2 from Plasmodium falciparum, strain 3D7

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008234	molecular_function	cysteine-type peptidase activity
B	0006508	biological_process	proteolysis
B	0008234	molecular_function	cysteine-type peptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue E64 A 301

Chain	Residue
A	GLN36
A	ASN173
A	HIS174
A	GLY40
A	SER41
A	CYS42
A	TYR78
A	ASN81
A	GLY82
A	GLY83
A	LEU84

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Functional Information from PROSITE/UniProt

site_id	PS00139
Number of Residues	12
Details	THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QKnCGSCWAfSS

Chain	Residue	Details
A	GLN36-SER47

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site_id	PS00639
Number of Residues	11
Details	THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. LNHAVMLVGFG

Chain	Residue	Details
A	LEU172-GLY182

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10088

Chain	Residue	Details
A	CYS42
B	CYS42

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site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10089

Chain	Residue	Details
A	HIS174
B	HIS174

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site_id	SWS_FT_FI3
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10090

Chain	Residue	Details
A	ASN204
B	ASN204

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