Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6JUW

BOVINE HEART CYTOCHROME C OXIDASE IN CATALITIC INTERMEDIATES AT 1.80 ANGSTROM RESOLUTION

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004129	molecular_function	cytochrome-c oxidase activity
A	0005743	cellular_component	mitochondrial inner membrane
A	0006119	biological_process	oxidative phosphorylation
A	0009060	biological_process	aerobic respiration
A	0016020	cellular_component	membrane
A	0020037	molecular_function	heme binding
A	0022904	biological_process	respiratory electron transport chain
A	0045277	cellular_component	respiratory chain complex IV
A	0046872	molecular_function	metal ion binding
A	1902600	biological_process	proton transmembrane transport
B	0004129	molecular_function	cytochrome-c oxidase activity
B	0005507	molecular_function	copper ion binding
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0017004	biological_process	cytochrome complex assembly
B	0022900	biological_process	electron transport chain
B	0022904	biological_process	respiratory electron transport chain
B	0031966	cellular_component	mitochondrial membrane
B	0042773	biological_process	ATP synthesis coupled electron transport
B	0045277	cellular_component	respiratory chain complex IV
B	0046872	molecular_function	metal ion binding
B	1902600	biological_process	proton transmembrane transport
C	0004129	molecular_function	cytochrome-c oxidase activity
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
C	0008535	biological_process	respiratory chain complex IV assembly
C	0009055	molecular_function	electron transfer activity
C	0016020	cellular_component	membrane
C	0019646	biological_process	aerobic electron transport chain
C	0022904	biological_process	respiratory electron transport chain
C	0045277	cellular_component	respiratory chain complex IV
C	1902600	biological_process	proton transmembrane transport
D	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
D	0045277	cellular_component	respiratory chain complex IV
E	0005743	cellular_component	mitochondrial inner membrane
E	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
E	0045277	cellular_component	respiratory chain complex IV
F	0005740	cellular_component	mitochondrial envelope
F	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
F	0045277	cellular_component	respiratory chain complex IV
G	0005743	cellular_component	mitochondrial inner membrane
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0006119	biological_process	oxidative phosphorylation
H	0016020	cellular_component	membrane
H	0045277	cellular_component	respiratory chain complex IV
I	0005743	cellular_component	mitochondrial inner membrane
I	0006119	biological_process	oxidative phosphorylation
I	0016020	cellular_component	membrane
I	0045277	cellular_component	respiratory chain complex IV
J	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
J	0045277	cellular_component	respiratory chain complex IV
K	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
L	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
L	0045277	cellular_component	respiratory chain complex IV
M	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
M	0045277	cellular_component	respiratory chain complex IV
N	0004129	molecular_function	cytochrome-c oxidase activity
N	0005743	cellular_component	mitochondrial inner membrane
N	0006119	biological_process	oxidative phosphorylation
N	0009060	biological_process	aerobic respiration
N	0016020	cellular_component	membrane
N	0020037	molecular_function	heme binding
N	0022904	biological_process	respiratory electron transport chain
N	0045277	cellular_component	respiratory chain complex IV
N	0046872	molecular_function	metal ion binding
N	1902600	biological_process	proton transmembrane transport
O	0004129	molecular_function	cytochrome-c oxidase activity
O	0005507	molecular_function	copper ion binding
O	0005739	cellular_component	mitochondrion
O	0005743	cellular_component	mitochondrial inner membrane
O	0016020	cellular_component	membrane
O	0016491	molecular_function	oxidoreductase activity
O	0017004	biological_process	cytochrome complex assembly
O	0022900	biological_process	electron transport chain
O	0022904	biological_process	respiratory electron transport chain
O	0031966	cellular_component	mitochondrial membrane
O	0042773	biological_process	ATP synthesis coupled electron transport
O	0045277	cellular_component	respiratory chain complex IV
O	0046872	molecular_function	metal ion binding
O	1902600	biological_process	proton transmembrane transport
P	0004129	molecular_function	cytochrome-c oxidase activity
P	0005739	cellular_component	mitochondrion
P	0005743	cellular_component	mitochondrial inner membrane
P	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
P	0008535	biological_process	respiratory chain complex IV assembly
P	0009055	molecular_function	electron transfer activity
P	0016020	cellular_component	membrane
P	0019646	biological_process	aerobic electron transport chain
P	0022904	biological_process	respiratory electron transport chain
P	0045277	cellular_component	respiratory chain complex IV
P	1902600	biological_process	proton transmembrane transport
Q	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
Q	0045277	cellular_component	respiratory chain complex IV
R	0005743	cellular_component	mitochondrial inner membrane
R	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
R	0045277	cellular_component	respiratory chain complex IV
S	0005740	cellular_component	mitochondrial envelope
S	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
S	0045277	cellular_component	respiratory chain complex IV
T	0005743	cellular_component	mitochondrial inner membrane
U	0005739	cellular_component	mitochondrion
U	0005743	cellular_component	mitochondrial inner membrane
U	0006119	biological_process	oxidative phosphorylation
U	0016020	cellular_component	membrane
U	0045277	cellular_component	respiratory chain complex IV
V	0005743	cellular_component	mitochondrial inner membrane
V	0006119	biological_process	oxidative phosphorylation
V	0016020	cellular_component	membrane
V	0045277	cellular_component	respiratory chain complex IV
W	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
W	0045277	cellular_component	respiratory chain complex IV
X	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
Y	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
Y	0045277	cellular_component	respiratory chain complex IV
Z	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
Z	0045277	cellular_component	respiratory chain complex IV

Functional Information from PDB Data

site_id	AC1
Number of Residues	32
Details	binding site for residue HEA A 601

Chain	Residue
A	GLY27
A	ALA62
A	MET65
A	ILE66
A	VAL70
A	ILE73
A	GLY125
A	TRP126
A	TYR371
A	PHE377
A	HIS378
A	MET28
A	LEU381
A	SER382
A	VAL386
A	MET417
A	PHE425
A	GLN428
A	ARG438
A	ARG439
A	VAL465
A	HOH734
A	THR31
A	HOH743
A	HOH800
A	HOH819
A	SER34
A	ILE37
A	ARG38
A	TYR54
A	VAL58
A	HIS61

site_id	AC2
Number of Residues	31
Details	binding site for residue HEA A 602

Chain	Residue
A	TRP126
A	TRP236
A	VAL243
A	TYR244
A	HIS290
A	HIS291
A	THR309
A	ILE312
A	ALA313
A	THR316
A	GLY317
A	GLY352
A	GLY355
A	ILE356
A	LEU358
A	ALA359
A	ASP364
A	HIS368
A	VAL373
A	HIS376
A	PHE377
A	VAL380
A	LEU381
A	ARG438
A	HOH711
A	HOH724
A	HOH774
A	HOH826
A	HOH873
B	ILE34
B	PRO69

site_id	AC3
Number of Residues	5
Details	binding site for residue CU A 603

Chain	Residue
A	HIS240
A	HIS290
A	HIS291
A	HOH711
A	HOH803

site_id	AC4
Number of Residues	6
Details	binding site for residue MG A 604

Chain	Residue
A	HIS368
A	ASP369
A	HOH891
B	GLU198
B	HOH422
B	HOH471

site_id	AC5
Number of Residues	4
Details	binding site for residue NA A 605

Chain	Residue
A	GLU40
A	GLY45
A	SER441
A	HOH869

site_id	AC6
Number of Residues	4
Details	binding site for residue DMU A 606

Chain	Residue
A	MET423
K	VAL26
K	TRP29
K	VAL30

site_id	AC7
Number of Residues	14
Details	binding site for residue PGV A 607

Chain	Residue
A	ASN406
A	THR408
A	TRP409
A	ARG480
A	HOH719
A	HOH740
K	PHE9
K	HIS10
K	DMU103
M	LYS4
M	GLN15
M	ALA16
M	LEU19
M	SER20

site_id	AC8
Number of Residues	17
Details	binding site for residue PGV A 608

Chain	Residue
A	MET97
A	HIS151
A	HOH785
A	HOH798
C	HIS9
C	GLY20
C	ALA24
C	ASN50
C	TRP57
C	TRP58
C	GLU64
C	HIS71
C	GLY82
C	PEK309
A	PHE94
A	PRO95
A	ARG96

site_id	AC9
Number of Residues	15
Details	binding site for residue PSC A 609

Chain	Residue
A	PHE321
A	HOH703
A	HOH704
B	VAL38
B	HIS52
B	MET56
B	ASP57
E	ASP8
E	PHE11
E	LEU41
E	HOH336
I	ARG10
I	ALA14
I	LEU17
I	HOH128

site_id	AD1
Number of Residues	14
Details	binding site for residue TGL A 610

Chain	Residue
A	TYR379
A	ASN422
A	PHE426
A	PHE430
A	LEU433
A	HOH883
B	LEU7
B	LEU28
B	PHE32
B	SER35
B	SER36
D	HOH461
I	ARG43
I	HOH151

site_id	AD2
Number of Residues	8
Details	binding site for residue EDO A 611

Chain	Residue
A	ARG5
A	ASN11
A	LYS13
A	ASP14
A	TRP81
A	PRO500
A	TYR502
L	ASN10

site_id	AD3
Number of Residues	6
Details	binding site for residue EDO A 612

Chain	Residue
A	TYR260
A	TYR261
A	HIS395
A	HOH733
A	HOH736
M	ILE1

site_id	AD4
Number of Residues	8
Details	binding site for residue EDO A 613

Chain	Residue
A	HIS256
A	LYS265
A	THR490
A	ASN491
A	HOH772
A	HOH775
A	HOH783
A	HOH791

site_id	AD5
Number of Residues	6
Details	binding site for residue EDO A 614

Chain	Residue
A	GLY269
A	MET271
A	GLY272
B	ALA58
B	GLU62
T	HOH219

site_id	AD6
Number of Residues	9
Details	binding site for residue EDO A 615

Chain	Residue
A	PRO444
A	ASP445
A	ALA446
A	HOH867
B	FME1
B	ALA2
B	LEU133
B	HOH417
B	HOH483

site_id	AD7
Number of Residues	4
Details	binding site for residue EDO A 616

Chain	Residue
A	LYS265
A	THR489
A	HOH717
D	HOH407

site_id	AD8
Number of Residues	5
Details	binding site for residue EDO A 617

Chain	Residue
A	PHE393
A	ALA410
A	HIS413
A	MET468
A	HOH782

site_id	AD9
Number of Residues	3
Details	binding site for residue EDO A 618

Chain	Residue
A	ASP486
A	LEU487
A	HOH771

site_id	AE1
Number of Residues	6
Details	binding site for residue CUA B 301

Chain	Residue
B	HIS161
B	CYS196
B	GLU198
B	CYS200
B	HIS204
B	MET207

site_id	AE2
Number of Residues	2
Details	binding site for residue DMU B 302

Chain	Residue
B	HIS26
B	ILE34

site_id	AE3
Number of Residues	9
Details	binding site for residue EDO B 303

Chain	Residue
A	TYR447
B	FME1
B	ALA2
B	GLN10
B	LEU136
B	PRO166
B	TYR193
B	HOH432
B	HOH483

site_id	AE4
Number of Residues	3
Details	binding site for residue EDO B 304

Chain	Residue
B	SER94
B	TYR113
H	GLN12

site_id	AE5
Number of Residues	8
Details	binding site for residue EDO B 305

Chain	Residue
B	TRP104
B	TYR121
B	ASN203
B	PHE206
B	HOH406
B	HOH467
B	HOH481
B	HOH527

site_id	AE6
Number of Residues	4
Details	binding site for residue EDO B 306

Chain	Residue
B	HIS102
B	GLU157
B	ASP158
B	HOH489

site_id	AE7
Number of Residues	5
Details	binding site for residue EDO B 307

Chain	Residue
B	THR125
B	ARG134
B	LEU135
B	HOH426
B	HOH460

site_id	AE8
Number of Residues	4
Details	binding site for residue NA C 301

Chain	Residue
C	HIS148
C	HIS232
C	GLU236
C	HOH412

site_id	AE9
Number of Residues	9
Details	binding site for residue DMU C 302

Chain	Residue
C	ASN38
C	SER39
C	THR41
C	HOH402
C	HOH406
J	GLY41
J	GLY42
J	TYR45
J	DMU101

site_id	AF1
Number of Residues	3
Details	binding site for residue DMU C 303

Chain	Residue
C	MET40
C	HOH401
C	HOH507

site_id	AF2
Number of Residues	3
Details	binding site for residue DMU C 304

Chain	Residue
C	TYR102
C	VAL254
G	CDL102

site_id	AF3
Number of Residues	12
Details	binding site for residue CHD C 305

Chain	Residue
A	HIS233
A	ASP300
A	THR301
A	TYR304
A	HOH712
A	HOH812
C	TRP99
C	HIS103
C	HOH480
P	LEU127
T	CDL102
T	PGV104

site_id	AF4
Number of Residues	4
Details	binding site for residue CHD C 306

Chain	Residue
C	ARG156
C	PHE164
C	LEU223
J	PHE1

site_id	AF5
Number of Residues	20
Details	binding site for residue CDL C 307

Chain	Residue
C	THR48
C	MET51
C	LEU52
C	TYR55
C	TRP58
C	ARG59
C	ILE62
C	ARG63
C	PHE67
C	VAL171
C	THR213
C	PHE220
C	LYS224
C	HIS226
C	PGV310
C	HOH407
C	HOH426
J	LYS8
J	PHE12
J	HOH203

site_id	AF6
Number of Residues	7
Details	binding site for residue PEK C 308

Chain	Residue
C	PHE98
C	TRP240
C	VAL247
C	HOH518
T	ALA4
T	LYS5
T	CDL102

site_id	AF7
Number of Residues	19
Details	binding site for residue PEK C 309

Chain	Residue
A	HIS151
A	PGV608
C	GLN177
C	TYR181
C	TYR182
C	ALA184
C	PHE186
C	THR187
C	ILE188
C	PHE198
C	GLY202
C	PHE203
G	TRP62
G	THR68
G	PHE69
G	PHE70
G	HIS71
G	ASN76
G	HOH216

site_id	AF8
Number of Residues	21
Details	binding site for residue PGV C 310

Chain	Residue
C	MET51
C	TRP58
C	VAL61
C	SER65
C	THR66
C	LEU206
C	HIS207
C	ILE210
C	PHE214
C	ARG221
C	HIS226
C	PHE227
C	HIS231
C	HIS232
C	PHE233
C	GLY234
C	CDL307
C	HOH428
C	HOH432
C	HOH450
C	HOH470

site_id	AF9
Number of Residues	6
Details	binding site for residue EDO C 311

Chain	Residue
C	ASN12
C	GLN68
C	HIS70
C	HOH410
J	LEU18
J	VAL20

site_id	AG1
Number of Residues	4
Details	binding site for residue EDO C 312

Chain	Residue
C	GLU111
C	EDO314
C	HOH437
C	HOH464

site_id	AG2
Number of Residues	8
Details	binding site for residue EDO C 313

Chain	Residue
C	TRP146
C	SER150
C	HIS158
C	HOH433
F	ALA1
G	ALA13
G	ARG14
G	ARG17

site_id	AG3
Number of Residues	4
Details	binding site for residue EDO C 314

Chain	Residue
B	GLY177
C	GLU111
C	EDO312
C	HOH415

site_id	AG4
Number of Residues	4
Details	binding site for residue EDO C 315

Chain	Residue
C	GLN68
C	EDO316
C	HOH410
J	GLN13

site_id	AG5
Number of Residues	3
Details	binding site for residue EDO C 316

Chain	Residue
C	HIS70
C	EDO315
C	HOH449

site_id	AG6
Number of Residues	3
Details	binding site for residue EDO C 317

Chain	Residue
C	THR145
C	HIS148
C	HIS243

site_id	AG7
Number of Residues	2
Details	binding site for residue DMU D 201

Chain	Residue
D	HIS101
K	ILE36

site_id	AG8
Number of Residues	16
Details	binding site for residue TGL D 202

Chain	Residue
A	TRP334
A	LEU342
A	GLY343
A	HOH713
B	LEU39
B	ILE42
B	THR47
B	LYS49
B	HOH552
D	ARG73
D	THR75
D	TRP78
D	HOH336
I	ARG16
I	HOH152
K	DMU104

site_id	AG9
Number of Residues	6
Details	binding site for residue EDO D 203

Chain	Residue
D	TYR11
D	ALA12
D	LEU13
D	SER15
D	HOH301
D	HOH310

site_id	AH1
Number of Residues	4
Details	binding site for residue EDO D 204

Chain	Residue
D	LYS56
D	HOH316
E	ASN94
E	GLY97

site_id	AH2
Number of Residues	4
Details	binding site for residue EDO D 205

Chain	Residue
D	LYS121
D	ASP125
D	TRP138
D	HOH324

site_id	AH3
Number of Residues	4
Details	binding site for residue EDO D 206

Chain	Residue
D	GLU114
D	TRP115
D	LYS118
D	HOH322

site_id	AH4
Number of Residues	5
Details	binding site for residue EDO D 207

Chain	Residue
D	VAL17
D	ASP18
D	HOH314
D	HOH368
M	THR2

site_id	AH5
Number of Residues	4
Details	binding site for residue EDO E 201

Chain	Residue
E	TYR18
E	LYS21
E	GLU28
E	HOH323

site_id	AH6
Number of Residues	2
Details	binding site for residue EDO E 202

Chain	Residue
E	ARG53
E	ARG57

site_id	AH7
Number of Residues	4
Details	binding site for residue EDO E 203

Chain	Residue
B	SER54
B	HOH470
E	TYR39
E	HOH319

site_id	AH8
Number of Residues	4
Details	binding site for residue ZN F 101

Chain	Residue
F	CYS60
F	CYS62
F	CYS82
F	CYS85

site_id	AH9
Number of Residues	8
Details	binding site for residue EDO F 103

Chain	Residue
A	THR490
A	HOH792
F	SER67
F	THR68
F	VAL69
F	TRP71
F	HOH209
F	HOH248

site_id	AI1
Number of Residues	6
Details	binding site for residue EDO F 104

Chain	Residue
A	GLU266
F	ASN66
F	SER67
F	THR68
F	HOH270
F	HOH274

site_id	AI2
Number of Residues	6
Details	binding site for residue EDO F 105

Chain	Residue
C	HIS231
C	HOH471
F	ASP9
F	GLU17
F	HOH220
F	HOH237

site_id	AI3
Number of Residues	6
Details	binding site for residue EDO F 106

Chain	Residue
A	TYR510
F	LYS37
F	THR39
F	LEU48
F	HOH218
F	HOH238

site_id	AI4
Number of Residues	7
Details	binding site for residue EDO F 107

Chain	Residue
D	HOH310
F	PHE72
F	GLN80
F	ARG81
F	EDO110
F	HOH225
F	HOH247

site_id	AI5
Number of Residues	7
Details	binding site for residue EDO F 108

Chain	Residue
F	ALA24
F	GLN28
F	ASP29
F	ILE33
F	LEU34
F	HOH206
F	HOH235

site_id	AI6
Number of Residues	8
Details	binding site for residue EDO F 109

Chain	Residue
A	GLU507
C	THR5
F	PRO30
F	ASN32
F	PRO50
F	ARG56
F	HIS94
F	HOH279

site_id	AI7
Number of Residues	5
Details	binding site for residue EDO F 110

Chain	Residue
E	TRP27
F	ALA79
F	GLN80
F	ARG81
F	EDO107

site_id	AI8
Number of Residues	13
Details	binding site for residue CHD G 101

Chain	Residue
F	PEK102
G	ARG14
G	ARG17
G	PHE21
G	GLY22
G	HOH203
G	HOH209
G	HOH217
G	HOH220
N	MET271
O	GLU62
O	THR63
O	THR66

site_id	AI9
Number of Residues	7
Details	binding site for residue EDO G 103

Chain	Residue
C	GLY120
G	ALA46
G	PHE47
G	ILE48
G	LEU53
G	ARG54
G	HOH202

site_id	AJ1
Number of Residues	4
Details	binding site for residue PO4 H 101

Chain	Residue
H	ARG27
H	GLN31
H	ARG38
H	HOH252

site_id	AJ2
Number of Residues	9
Details	binding site for residue EDO H 102

Chain	Residue
A	ASP227
A	HOH779
B	GLY177
C	HOH477
H	ASN24
H	THR26
H	HOH213
H	HOH240
H	HOH262

site_id	AJ3
Number of Residues	9
Details	binding site for residue DMU J 101

Chain	Residue
A	LEU110
C	MET33
C	PHE37
C	DMU302
J	SER46
J	TYR48
J	CYS49
J	LEU50
J	TRP52

site_id	AJ4
Number of Residues	5
Details	binding site for residue CHD J 102

Chain	Residue
J	TYR32
J	ARG33
J	MET36
J	THR37
J	LEU40

site_id	AJ5
Number of Residues	7
Details	binding site for residue EDO J 103

Chain	Residue
A	VAL118
A	GLU119
J	ALA53
J	SER54
J	PHE55
J	PRO56
L	LYS46

site_id	AJ6
Number of Residues	3
Details	binding site for residue DMU K 102

Chain	Residue
K	ALA33
K	TRP40
K	HOH202

site_id	AJ7
Number of Residues	3
Details	binding site for residue DMU K 103

Chain	Residue
A	PGV607
K	SER20
K	THR23

site_id	AJ8
Number of Residues	1
Details	binding site for residue DMU K 104

Chain	Residue
D	TGL202

site_id	AJ9
Number of Residues	5
Details	binding site for residue CHD L 102

Chain	Residue
L	TRP19
L	ALA23
M	GLU14
M	ILE17
M	HOH228

site_id	AK1
Number of Residues	20
Details	binding site for residue TGL L 103

Chain	Residue
A	THR17
A	LEU21
A	PHE22
A	TRP25
A	LEU113
A	PHE393
A	PHE400
A	ILE472
L	ILE11
L	PRO12
L	PHE13
L	SER14
L	ARG20
L	MET24
L	PHE29
L	SER31
L	DMU101
L	HOH225
L	HOH227
L	HOH228

site_id	AK2
Number of Residues	6
Details	binding site for residue EDO L 104

Chain	Residue
A	HOH823
L	GLY8
L	ILE11
L	PHE13
L	SER14
L	HOH221

site_id	AK3
Number of Residues	8
Details	binding site for residue DMU M 101

Chain	Residue
D	TRP98
D	TYR102
M	LEU27
M	LEU28
M	GLY31
M	TRP32
M	TYR35
M	HIS36

site_id	AK4
Number of Residues	5
Details	binding site for residue EDO M 102

Chain	Residue
A	LEU47
D	VAL103
M	ASP38
M	LYS41
M	HOH203

site_id	AK5
Number of Residues	29
Details	binding site for residue HEA N 601

Chain	Residue
N	MET28
N	THR31
N	SER34
N	ILE37
N	ARG38
N	TYR54
N	VAL58
N	HIS61
N	ALA62
N	MET65
N	ILE66
N	VAL70
N	GLY125
N	TRP126
N	TYR371
N	PHE377
N	HIS378
N	SER382
N	VAL386
N	MET417
N	PHE425
N	GLN428
N	ARG438
N	ARG439
N	VAL465
N	HOH737
N	HOH757
N	HOH783
N	HOH854

site_id	AK6
Number of Residues	31
Details	binding site for residue HEA N 602

Chain	Residue
N	TRP126
N	TRP236
N	VAL243
N	TYR244
N	HIS290
N	HIS291
N	THR309
N	ILE312
N	ALA313
N	THR316
N	GLY317
N	GLY352
N	GLY355
N	ILE356
N	LEU358
N	ALA359
N	ASP364
N	HIS368
N	VAL373
N	HIS376
N	PHE377
N	VAL380
N	LEU381
N	ARG438
N	HOH717
N	HOH719
N	HOH721
N	HOH805
N	HOH872
O	ILE34
O	PRO69

site_id	AK7
Number of Residues	5
Details	binding site for residue CU N 603

Chain	Residue
N	HIS240
N	HIS290
N	HIS291
N	HOH717
N	HOH843

site_id	AK8
Number of Residues	6
Details	binding site for residue MG N 604

Chain	Residue
N	HIS368
N	ASP369
O	GLU198
O	HOH426
O	HOH462
O	HOH518

site_id	AK9
Number of Residues	4
Details	binding site for residue NA N 605

Chain	Residue
N	GLU40
N	GLY45
N	SER441
N	HOH844

site_id	AL1
Number of Residues	13
Details	binding site for residue PGV N 606

Chain	Residue
N	ASN406
N	THR408
N	TRP409
N	HOH879
Q	ALA84
Q	PHE87
X	PHE9
X	HIS10
Z	PRO12
Z	GLN15
Z	LEU19
Z	SER20
Z	HOH203

site_id	AL2
Number of Residues	17
Details	binding site for residue PGV N 607

Chain	Residue
N	PHE94
N	PRO95
N	ARG96
N	MET97
N	HOH759
P	HIS9
P	GLY20
P	ALA24
P	ASN50
P	MET54
P	TRP57
P	TRP58
P	GLU64
P	HIS71
P	GLY82
P	PEK308
P	HOH442

site_id	AL3
Number of Residues	13
Details	binding site for residue TGL N 608

Chain	Residue
N	TYR379
N	ASN422
N	PHE426
N	HIS429
N	PHE430
N	LEU433
O	LEU7
O	GLY8
O	LEU28
O	PHE32
O	SER35
O	LEU39
V	ARG43

site_id	AL4
Number of Residues	6
Details	binding site for residue EDO N 609

Chain	Residue
N	TYR260
N	TYR261
N	HIS395
N	TRP494
N	HOH745
N	HOH779

site_id	AL5
Number of Residues	5
Details	binding site for residue EDO N 610

Chain	Residue
G	HOH209
N	GLY269
N	MET271
N	GLY272
O	GLU62

site_id	AL6
Number of Residues	8
Details	binding site for residue EDO N 611

Chain	Residue
N	LYS265
N	THR490
N	ASN491
N	HOH705
N	HOH766
N	HOH830
N	HOH847
N	HOH849

site_id	AL7
Number of Residues	9
Details	binding site for residue EDO N 612

Chain	Residue
N	ASN496
N	THR504
N	PHE505
N	GLU507
N	HOH703
N	HOH735
N	HOH884
N	HOH910
S	TRP73

site_id	AL8
Number of Residues	4
Details	binding site for residue EDO N 613

Chain	Residue
N	THR489
N	HOH858
N	HOH867
S	ILE70

site_id	AL9
Number of Residues	6
Details	binding site for residue EDO N 614

Chain	Residue
N	PRO131
N	ASP221
N	HOH716
N	HOH756
N	HOH775
N	HOH792

site_id	AM1
Number of Residues	9
Details	binding site for residue EDO N 615

Chain	Residue
N	ARG5
N	ASN11
N	LYS13
N	ASP14
N	TRP81
N	PRO500
N	TYR502
N	HOH846
Y	ASN10

site_id	AM2
Number of Residues	8
Details	binding site for residue EDO N 616

Chain	Residue
N	LEU483
N	VAL485
N	TRP494
N	GLY497
N	CYS498
N	HOH780
N	HOH902
Q	TYR11

site_id	AM3
Number of Residues	9
Details	binding site for residue EDO N 617

Chain	Residue
N	THR509
N	TYR510
N	VAL511
N	HOH810
N	HOH817
S	ASN32
S	LEU34
S	PRO36
S	ARG56

site_id	AM4
Number of Residues	8
Details	binding site for residue EDO N 618

Chain	Residue
N	PRO174
N	PRO508
N	HOH747
N	HOH760
N	HOH810
P	TYR8
P	HOH431
S	ASN32

site_id	AM5
Number of Residues	6
Details	binding site for residue EDO N 619

Chain	Residue
N	THR10
N	ASN11
N	HIS503
N	HOH732
N	HOH870
Y	EDO104

site_id	AM6
Number of Residues	5
Details	binding site for residue EDO N 620

Chain	Residue
N	FME1
N	ARG5
Y	TYR3
Y	GLU4
Y	HOH206

site_id	AM7
Number of Residues	5
Details	binding site for residue EDO N 621

Chain	Residue
N	GLU507
N	HOH704
P	THR5
S	PRO30
S	ASN32

site_id	AM8
Number of Residues	7
Details	binding site for residue EDO N 622

Chain	Residue
N	TYR19
N	ASN80
N	ASN98
N	GLY160
N	PHE164
N	HOH738
N	HOH769

site_id	AM9
Number of Residues	4
Details	binding site for residue EDO N 623

Chain	Residue
N	GLN52
N	ALA137
N	HOH736
N	HOH876

site_id	AN1
Number of Residues	6
Details	binding site for residue CUA O 301

Chain	Residue
O	HIS161
O	CYS196
O	GLU198
O	CYS200
O	HIS204
O	MET207

site_id	AN2
Number of Residues	2
Details	binding site for residue DMU O 302

Chain	Residue
O	HIS26
O	ILE30

site_id	AN3
Number of Residues	7
Details	binding site for residue EDO O 303

Chain	Residue
N	TYR447
O	ALA2
O	GLN10
O	PRO166
O	TYR193
O	HOH420
O	HOH480

site_id	AN4
Number of Residues	4
Details	binding site for residue EDO O 304

Chain	Residue
O	PHE206
O	HOH428
O	HOH443
O	HOH476

site_id	AN5
Number of Residues	4
Details	binding site for residue NA P 301

Chain	Residue
P	HIS148
P	HIS232
P	GLU236
P	HOH403

site_id	AN6
Number of Residues	1
Details	binding site for residue DMU P 302

Chain	Residue
P	TRP34

site_id	AN7
Number of Residues	6
Details	binding site for residue DMU P 303

Chain	Residue
P	MET33
P	ASN38
P	SER39
P	THR41
P	HOH475
W	TYR45

site_id	AN8
Number of Residues	11
Details	binding site for residue CHD P 304

Chain	Residue
N	HIS233
N	ASP300
N	THR301
N	TYR304
N	HOH702
N	HOH761
P	TRP99
P	HIS103
P	PGV310
P	HOH409
P	HOH486

site_id	AN9
Number of Residues	5
Details	binding site for residue CHD P 305

Chain	Residue
P	ARG156
P	PHE164
P	PHE219
P	LEU223
W	PHE1

site_id	AO1
Number of Residues	19
Details	binding site for residue CDL P 306

Chain	Residue
P	LEU52
P	TYR55
P	ARG59
P	ILE62
P	ARG63
P	PHE67
P	THR213
P	VAL217
P	PHE220
P	ARG221
P	LYS224
P	HIS226
P	PGV309
P	HOH402
P	HOH449
P	HOH519
P	HOH529
W	LYS8
W	HOH215

site_id	AO2
Number of Residues	8
Details	binding site for residue PEK P 307

Chain	Residue
G	HIS8
P	ARG80
P	TYR81
P	ILE84
P	THR95
P	VAL247
P	PHE251
P	PGV310

site_id	AO3
Number of Residues	21
Details	binding site for residue PEK P 308

Chain	Residue
N	HIS151
N	VAL155
N	LEU215
N	PGV607
P	GLN177
P	TYR181
P	TYR182
P	ALA184
P	PHE186
P	THR187
P	ILE188
P	PHE198
P	GLY202
P	PHE203
T	TRP62
T	THR68
T	PHE69
T	PHE70
T	HIS71
T	ASN76
T	HOH234

site_id	AO4
Number of Residues	21
Details	binding site for residue PGV P 309

Chain	Residue
P	MET54
P	TRP58
P	VAL61
P	SER65
P	THR66
P	HIS207
P	ILE210
P	PHE214
P	ARG221
P	HIS226
P	PHE227
P	THR228
P	HIS231
P	HIS232
P	PHE233
P	GLY234
P	CDL306
P	HOH418
P	HOH422
P	HOH436
P	HOH472

site_id	AO5
Number of Residues	12
Details	binding site for residue PGV P 310

Chain	Residue
G	ALA1
G	SER2
P	THR95
P	TRP99
P	LEU106
P	ALA107
P	CHD304
P	PEK307
P	HOH409
P	HOH412
P	HOH491
U	ASN24

site_id	AO6
Number of Residues	4
Details	binding site for residue EDO P 311

Chain	Residue
P	GLU111
P	EDO314
P	HOH447
P	HOH465

site_id	AO7
Number of Residues	7
Details	binding site for residue EDO P 312

Chain	Residue
P	TRP146
P	SER150
P	HIS158
P	HOH439
S	ALA1
T	ARG14
T	ARG17

site_id	AO8
Number of Residues	4
Details	binding site for residue EDO P 313

Chain	Residue
P	GLN68
P	HIS70
S	EDO105
W	GLN13

site_id	AO9
Number of Residues	4
Details	binding site for residue EDO P 314

Chain	Residue
O	GLY177
P	GLU111
P	EDO311
P	HOH410

site_id	AP1
Number of Residues	4
Details	binding site for residue EDO P 315

Chain	Residue
P	HOH448
P	HOH451
Y	HOH215
Y	HOH216

site_id	AP2
Number of Residues	7
Details	binding site for residue EDO P 316

Chain	Residue
P	GLN76
P	ARG80
P	ASN230
P	HIS231
P	HIS232
P	PHE233
P	GLU236

site_id	AP3
Number of Residues	2
Details	binding site for residue EDO P 317

Chain	Residue
P	HIS148
P	HIS149

site_id	AP4
Number of Residues	6
Details	binding site for residue DMU Q 201

Chain	Residue
Q	LEU94
Q	ILE97
Q	HIS101
X	TYR31
X	GLN35
X	ILE36

site_id	AP5
Number of Residues	13
Details	binding site for residue TGL Q 202

Chain	Residue
N	TRP334
N	PHE414
N	ALA415
N	HOH708
O	LEU39
O	ILE42
O	THR47
O	HOH482
Q	ARG73
Q	THR75
Q	TRP78
V	ARG16
V	HIS20

site_id	AP6
Number of Residues	5
Details	binding site for residue EDO Q 203

Chain	Residue
Q	LYS56
Q	HOH369
R	ARG90
R	GLY97
R	SER99

site_id	AP7
Number of Residues	10
Details	binding site for residue EDO Q 204

Chain	Residue
N	LEU495
N	HOH780
Q	TYR11
Q	ALA12
Q	LEU13
Q	PRO14
Q	HOH327
S	PHE72
S	TRP73
S	HOH231

site_id	AP8
Number of Residues	2
Details	binding site for residue EDO Q 205

Chain	Residue
Q	ASP26
R	HOH242

site_id	AP9
Number of Residues	4
Details	binding site for residue ZN S 101

Chain	Residue
S	CYS60
S	CYS62
S	CYS82
S	CYS85

site_id	AQ1
Number of Residues	8
Details	binding site for residue EDO S 102

Chain	Residue
N	THR490
S	SER67
S	THR68
S	VAL69
S	TRP71
S	HOH224
S	HOH236
S	HOH239

site_id	AQ2
Number of Residues	4
Details	binding site for residue EDO S 103

Chain	Residue
S	GLN28
S	ASP29
S	LEU34
S	HOH206

site_id	AQ3
Number of Residues	6
Details	binding site for residue EDO S 104

Chain	Residue
P	HIS231
P	HOH414
S	ASP9
S	GLU17
S	HOH234
S	HOH242

site_id	AQ4
Number of Residues	6
Details	binding site for residue EDO S 105

Chain	Residue
P	EDO313
S	GLY15
S	GLU19
S	HOH211
S	HOH232
W	HOH203

site_id	AQ5
Number of Residues	6
Details	binding site for residue EDO S 106

Chain	Residue
N	TYR510
S	LYS37
S	THR39
S	LEU48
S	HOH209
S	HOH230

site_id	AQ6
Number of Residues	12
Details	binding site for residue CHD T 101

Chain	Residue
A	MET271
B	GLU62
B	THR63
B	THR66
B	HOH462
T	ARG14
T	ARG17
T	PHE21
T	GLY22
T	PEK103
T	HOH219
T	HOH224

site_id	AQ7
Number of Residues	15
Details	binding site for residue PEK T 103

Chain	Residue
A	SER279
B	GLN59
B	THR66
P	LYS157
P	HIS158
P	GLN161
P	THR168
P	TYR172
S	ALA1
T	ARG17
T	PHE21
T	TRP36
T	CHD101
T	CDL102
T	HOH215

site_id	AQ8
Number of Residues	7
Details	binding site for residue EDO T 105

Chain	Residue
P	TRP34
P	PHE35
T	LYS58
T	PRO59
T	SER61
T	HOH209
T	HOH216

site_id	AQ9
Number of Residues	7
Details	binding site for residue EDO T 106

Chain	Residue
P	GLY120
T	ALA46
T	PHE47
T	ILE48
T	LEU53
T	ARG54
T	HOH212

site_id	AR1
Number of Residues	4
Details	binding site for residue PO4 U 101

Chain	Residue
U	ARG27
U	GLN31
U	LEU34
U	ARG38

site_id	AR2
Number of Residues	9
Details	binding site for residue EDO U 102

Chain	Residue
N	ASP227
N	HOH801
N	HOH811
O	GLY177
O	ARG178
U	ASN24
U	THR26
U	HOH227
U	HOH246

site_id	AR3
Number of Residues	7
Details	binding site for residue DMU W 101

Chain	Residue
P	MET33
P	PHE37
W	TYR45
W	SER46
W	TYR48
W	CYS49
W	TRP52

site_id	AR4
Number of Residues	7
Details	binding site for residue EDO W 102

Chain	Residue
N	VAL118
N	GLU119
W	ALA53
W	SER54
W	PHE55
W	PRO56
Y	LYS46

site_id	AR5
Number of Residues	2
Details	binding site for residue DMU X 101

Chain	Residue
N	MET423
X	DMU103

site_id	AR6
Number of Residues	4
Details	binding site for residue DMU X 102

Chain	Residue
X	ALA33
X	TRP40
X	DMU105
X	HOH214

site_id	AR7
Number of Residues	3
Details	binding site for residue DMU X 103

Chain	Residue
X	VAL30
X	THR34
X	DMU101

site_id	AR8
Number of Residues	2
Details	binding site for residue DMU X 104

Chain	Residue
X	TYR31
X	HOH203

site_id	AR9
Number of Residues	1
Details	binding site for residue DMU X 105

Chain	Residue
X	DMU102

site_id	AS1
Number of Residues	7
Details	binding site for residue DMU Y 101

Chain	Residue
W	PHE55
Y	ALA35
Y	ARG41
Y	HIS42
Y	LEU45
Y	HOH209
Y	HOH229

site_id	AS2
Number of Residues	4
Details	binding site for residue CHD Y 102

Chain	Residue
Y	TRP19
Y	HOH201
Z	GLU14
Z	ILE17

site_id	AS3
Number of Residues	14
Details	binding site for residue TGL Y 103

Chain	Residue
N	THR17
N	LEU18
N	LEU20
N	LEU113
N	PHE400
Y	ILE11
Y	PRO12
Y	PHE13
Y	SER14
Y	ARG20
Y	MET24
Y	PHE29
Y	SER31
Y	HOH227

site_id	AS4
Number of Residues	5
Details	binding site for residue EDO Y 104

Chain	Residue
N	EDO619
Y	HIS2
Y	TYR3
Y	HOH215
Y	HOH218

site_id	AS5
Number of Residues	8
Details	binding site for residue DMU Z 101

Chain	Residue
Q	TRP98
Q	HOH313
Z	LEU27
Z	LEU28
Z	GLY31
Z	TRP32
Z	TYR35
Z	HIS36

site_id	AS6
Number of Residues	8
Details	binding site for Poly-Saccharide residues DMU L 101 through EDO L 105

Chain	Residue
J	PHE55
L	ALA35
L	PHE38
L	ARG41
L	HIS42
L	TGL103
L	HOH202
L	HOH209

site_id	AS7
Number of Residues	37
Details	binding site for residues PEK F 102 and CDL G 102

Chain	Residue
C	ASN125
C	LEU127
C	LEU131
C	VAL142
C	LYS157
C	HIS158
C	GLN161
C	TYR172
C	DMU304
C	HOH479
F	ALA1
F	HOH201
F	HOH230
G	ARG17
G	PHE21
G	GLY22
G	LEU23
G	SER27
G	CYS31
G	ASN34
G	LEU37
G	HIS38
G	CHD101
G	HOH223
G	HOH269
N	SER279
N	ILE286
N	ASP300
N	SER307
N	ILE311
N	HOH761
O	GLN59
O	THR66
O	LEU78
O	LEU81
O	ARG82
O	TYR85

site_id	AS8
Number of Residues	30
Details	binding site for Di-peptide CDL T 102 and CYS T 31

Chain	Residue
A	ASP300
A	ALA303
A	SER307
A	ILE311
B	ALA70
B	ILE74
B	ALA77
B	LEU78
B	LEU81
B	TYR85
C	CHD305
C	PEK308
P	ASN125
P	LEU127
P	GLU128
P	LEU131
P	SER135
P	VAL142
P	LEU250
T	SER27
T	VAL28
T	ALA29
T	LEU30
T	THR32
T	LEU33
T	ASN34
T	SER35
T	LEU37
T	HIS38
T	PEK103

site_id	AS9
Number of Residues	13
Details	binding site for Di-peptide PGV T 104 and SER T 2

Chain	Residue
A	PHE285
A	ASP298
C	TRP99
C	LEU106
C	ALA107
C	CHD305
H	ASN24
T	ALA1
T	ALA3
T	HOH206
T	HOH247
T	HOH250
T	HOH272

site_id	AT1
Number of Residues	18
Details	binding site for Di-peptide PSC V 101 and ARG V 10

Chain	Residue
N	PHE321
N	HIS328
O	ILE41
O	HIS52
O	THR55
O	ASP57
O	VAL61
O	TRP65
R	ASP8
R	PHE11
R	ASP12
R	LEU41
R	HOH221
V	GLN8
V	MET9
V	GLY11
V	LEU12
V	HOH220

Functional Information from PROSITE/UniProt

site_id	PS00077
Number of Residues	56
Details	COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyililpgfgmishivtyysgkkepfgymgmvwammsigflgfivwa.HH

Chain	Residue	Details
A	TRP236-HIS291

site_id	PS00078
Number of Residues	49
Details	COX2 CO II and nitrous oxide reductase dinuclear copper centers signature. VlHswavpslglktdaipgrlnqttlmssrpglyygq......CseiCgsnHsfM

Chain	Residue	Details
B	VAL159-MET207

site_id	PS00848
Number of Residues	23
Details	COX5B_1 Cytochrome c oxidase subunit Vb, zinc binding region signature. VIWfwlhkgeaqrCpsCGthYKL

Chain	Residue	Details
F	VAL69-LEU91

site_id	PS01329
Number of Residues	18
Details	COX6A Cytochrome c oxidase subunit VIa signature. IRtKpFsWGDGnHTfFhN

Chain	Residue	Details
G	ILE55-ASN72

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	152
Details	Transmembrane: {"description":"Helical; Name=I","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	18
Details	Topological domain: {"description":"Mitochondrial intermembrane","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8638158","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	174
Details	Transmembrane: {"description":"Helical; Name=II","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	60
Details	Topological domain: {"description":"Mitochondrial matrix","evidences":[{"source":"PubMed","id":"2165784","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	108
Details	Transmembrane: {"description":"Helical; Name=III","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	94
Details	Topological domain: {"description":"Mitochondrial intermembrane","evidences":[{"source":"PubMed","id":"2165784","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	104
Details	Transmembrane: {"description":"Helical; Name=IV","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	112
Details	Transmembrane: {"description":"Helical; Name=V","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	130
Details	Transmembrane: {"description":"Helical; Name=VI","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	78
Details	Transmembrane: {"description":"Helical; Name=VII","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	56
Details	Transmembrane: {"description":"Helical; Name=VIII","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	138
Details	Topological domain: {"description":"Mitochondrial matrix","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=IX","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	214
Details	Topological domain: {"description":"Mitochondrial intermembrane","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	58
Details	Transmembrane: {"description":"Helical; Name=X","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	52
Details	Transmembrane: {"description":"Helical; Name=XI","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	62
Details	Transmembrane: {"description":"Helical; Name=XII","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23537388","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	6
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"20385840","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8638158","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	22
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20385840","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8638158","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	2
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	4
Details	Cross-link: {"description":"1'-histidyl-3'-tyrosine (His-Tyr)","evidences":[{"source":"PubMed","id":"10338009","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P00406","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	384
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P19783","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P13073","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P10888","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI28
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P19783","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI29
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P12787","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI30
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P20674","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI31
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20385840","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8638158","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI32
Number of Residues	6
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P19536","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI33
Number of Residues	92
Details	Domain: {"description":"CHCH","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI34
Number of Residues	20
Details	Motif: {"description":"Cx9C motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI35
Number of Residues	22
Details	Motif: {"description":"Cx10C motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI36
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P56391","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI37
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P17665","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	14
Details	M-CSA 124

Chain	Residue	Details
A	MET65	metal ligand
A	THR294	metal ligand
A	VAL295	metal ligand, proton acceptor, proton donor
A	VAL320	proton acceptor, proton donor, proton relay
A	TRP323	proton acceptor, proton donor, proton relay
A	ASP442	proton acceptor, proton donor, proton relay
A	PRO95	proton acceptor, proton donor, proton relay
A	PRO130	proton acceptor, proton donor, proton relay
A	GLY160	proton acceptor, proton donor, proton relay
A	ALA161	proton acceptor, proton donor, proton relay
A	TYR244	covalently attached, electrostatic stabiliser, metal ligand, radical stabiliser
A	LEU246	proton acceptor, proton donor, proton relay
A	LEU248	covalently attached, hydrogen radical donor, proton acceptor, proton donor, proton relay, single electron acceptor
A	THR259	proton acceptor, proton donor, proton relay

site_id	MCSA2
Number of Residues	14
Details	M-CSA 124

Chain	Residue	Details
N	MET65	metal ligand
N	THR294	metal ligand
N	VAL295	metal ligand, proton acceptor, proton donor
N	VAL320	proton acceptor, proton donor, proton relay
N	TRP323	proton acceptor, proton donor, proton relay
N	ASP442	proton acceptor, proton donor, proton relay
N	PRO95	proton acceptor, proton donor, proton relay
N	PRO130	proton acceptor, proton donor, proton relay
N	GLY160	proton acceptor, proton donor, proton relay
N	ALA161	proton acceptor, proton donor, proton relay
N	TYR244	covalently attached, electrostatic stabiliser, metal ligand, radical stabiliser
N	LEU246	proton acceptor, proton donor, proton relay
N	LEU248	covalently attached, hydrogen radical donor, proton acceptor, proton donor, proton relay, single electron acceptor
N	THR259	proton acceptor, proton donor, proton relay

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)