Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6JT8

Crystal structure of 450-451_deletion mutant of FGAM Synthetase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004642	molecular_function	phosphoribosylformylglycinamidine synthase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0006189	biological_process	'de novo' IMP biosynthetic process
A	0016874	molecular_function	ligase activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue EDO A 1301

Chain	Residue
A	VAL432
A	THR581
A	GLU582
A	GLU583
A	HOH2263

site_id	AC2
Number of Residues	10
Details	binding site for residue EDO A 1302

Chain	Residue
A	ASN1051
A	HOH1635
A	HOH1788
A	HOH1872
A	HOH1940
A	HOH2164
A	LYS327
A	GLY381
A	ARG479
A	VAL660

site_id	AC3
Number of Residues	4
Details	binding site for residue EDO A 1303

Chain	Residue
A	THR783
A	ARG784
A	HOH1994
A	HOH2402

site_id	AC4
Number of Residues	3
Details	binding site for residue EDO A 1304

Chain	Residue
A	ARG936
A	HOH1504
A	HOH2219

site_id	AC5
Number of Residues	6
Details	binding site for residue EDO A 1305

Chain	Residue
A	ARG1039
A	PRO1040
A	ARG1291
A	SO41317
A	HOH1418
A	HOH1526

site_id	AC6
Number of Residues	3
Details	binding site for residue EDO A 1306

Chain	Residue
A	ASN595
A	HOH1699
A	HOH2570

site_id	AC7
Number of Residues	2
Details	binding site for residue EDO A 1307

Chain	Residue
A	HIS813
A	ARG877

site_id	AC8
Number of Residues	6
Details	binding site for residue EDO A 1308

Chain	Residue
A	GLN818
A	LEU819
A	GLY901
A	HOH1449
A	HOH1479
A	HOH2542

site_id	AC9
Number of Residues	2
Details	binding site for residue EDO A 1309

Chain	Residue
A	HIS835
A	LYS853

site_id	AD1
Number of Residues	3
Details	binding site for residue EDO A 1310

Chain	Residue
A	GLU215
A	LYS220
A	HOH2257

site_id	AD2
Number of Residues	3
Details	binding site for residue EDO A 1311

Chain	Residue
A	PRO1274
A	GLU1275
A	HOH2204

site_id	AD3
Number of Residues	33
Details	binding site for residue ADP A 1312

Chain	Residue
A	VAL333
A	THR386
A	GLY387
A	TYR388
A	PHE389
A	LYS649
A	LEU652
A	VAL653
A	GLN668
A	PRO676
A	ALA678
A	ASP679
A	GLU718
A	ASN722
A	SER886
A	MG1348
A	MG1349
A	MG1350
A	HOH1499
A	HOH1524
A	HOH1535
A	HOH1556
A	HOH1633
A	HOH1634
A	HOH1728
A	HOH1753
A	HOH1820
A	HOH1899
A	HOH1918
A	HOH1989
A	HOH2078
A	HOH2082
A	HOH2326

site_id	AD4
Number of Residues	9
Details	binding site for residue SO4 A 1313

Chain	Residue
A	HIS216
A	THR295
A	HIS296
A	ASN297
A	HIS298
A	SER778
A	HOH1408
A	HOH1758
A	HOH2427

site_id	AD5
Number of Residues	9
Details	binding site for residue SO4 A 1314

Chain	Residue
A	HIS1086
A	ARG1126
A	PRO1127
A	GLN1128
A	THR1129
A	HOH1536
A	HOH1548
A	HOH1892
A	HOH2381

site_id	AD6
Number of Residues	6
Details	binding site for residue SO4 A 1315

Chain	Residue
A	LYS1228
A	VAL1229
A	HOH1626
A	HOH1776
A	HOH1856
A	ARG812

site_id	AD7
Number of Residues	8
Details	binding site for residue SO4 A 1316

Chain	Residue
A	TRP305
A	ARG1159
A	ARG1164
A	HOH1453
A	HOH1792
A	HOH1864
A	HOH2010
A	HOH2031

site_id	AD8
Number of Residues	8
Details	binding site for residue SO4 A 1317

Chain	Residue
A	PRO1040
A	LYS1041
A	HIS1086
A	EDO1305
A	HOH1521
A	HOH1621
A	HOH2019
A	HOH2419

site_id	AD9
Number of Residues	6
Details	binding site for residue SO4 A 1318

Chain	Residue
A	SER12
A	ALA13
A	PHE14
A	ASN998
A	HIS1161
A	HOH1968

site_id	AE1
Number of Residues	3
Details	binding site for residue SO4 A 1319

Chain	Residue
A	ASN1113
A	ARG1115
A	HOH2221

site_id	AE2
Number of Residues	8
Details	binding site for residue SO4 A 1320

Chain	Residue
A	GLN1176
A	GLN1183
A	GLY1184
A	MET1185
A	VAL1186
A	HOH1470
A	HOH1576
A	HOH1662

site_id	AE3
Number of Residues	5
Details	binding site for residue SO4 A 1321

Chain	Residue
A	THR632
A	ILE633
A	HOH1485
A	HOH1869
A	HOH2319

site_id	AE4
Number of Residues	5
Details	binding site for residue SO4 A 1322

Chain	Residue
A	LYS833
A	HIS835
A	ARG858
A	HOH1714
A	HOH1821

site_id	AE5
Number of Residues	5
Details	binding site for residue SO4 A 1323

Chain	Residue
A	ALA911
A	HIS953
A	HOH1641
A	HOH1707
A	HOH1815

site_id	AE6
Number of Residues	2
Details	binding site for residue SO4 A 1324

Chain	Residue
A	HIS153
A	GLN154

site_id	AE7
Number of Residues	5
Details	binding site for residue SO4 A 1325

Chain	Residue
A	ASN1251
A	ARG1253
A	HOH1519
A	HOH1537
A	HOH2423

site_id	AE8
Number of Residues	6
Details	binding site for residue SO4 A 1326

Chain	Residue
A	GLY-2
A	SER-1
A	ARG-3
A	HIS152
A	HOH1447
A	HOH2225

site_id	AE9
Number of Residues	6
Details	binding site for residue SO4 A 1327

Chain	Residue
A	PRO356
A	GLU357
A	ARG358
A	HOH1437
A	HOH1452
A	HOH1654

site_id	AF1
Number of Residues	6
Details	binding site for residue SO4 A 1328

Chain	Residue
A	GLN54
A	PHE1112
A	HIS1114
A	HOH1402
A	HOH1577
A	HOH1945

site_id	AF2
Number of Residues	5
Details	binding site for residue SO4 A 1329

Chain	Residue
A	HIS216
A	GLY504
A	ALA505
A	LYS776
A	HOH1574

site_id	AF3
Number of Residues	7
Details	binding site for residue GOL A 1330

Chain	Residue
A	HIS902
A	CYS903
A	GLY961
A	ARG978
A	ASP1012
A	HOH1794
A	HOH1953

site_id	AF4
Number of Residues	7
Details	binding site for residue GOL A 1331

Chain	Residue
A	ARG15
A	GLU368
A	ARG996
A	ASP1163
A	ARG1164
A	HOH1792
A	HOH2251

site_id	AF5
Number of Residues	5
Details	binding site for residue GOL A 1332

Chain	Residue
A	PRO79
A	SER85
A	GLU107
A	ARG108
A	HOH2547

site_id	AF6
Number of Residues	8
Details	binding site for residue GOL A 1333

Chain	Residue
A	PRO1149
A	GLY1150
A	SER1151
A	GLU1152
A	GOL1345
A	HOH1406
A	HOH1439
A	HOH2317

site_id	AF7
Number of Residues	8
Details	binding site for residue GOL A 1334

Chain	Residue
A	ALA709
A	ARG713
A	ASP755
A	LYS758
A	GLU763
A	HOH1804
A	HOH2066
A	HOH2079

site_id	AF8
Number of Residues	8
Details	binding site for residue GOL A 1335

Chain	Residue
A	ASP250
A	TYR251
A	GLU264
A	GLU1007
A	HOH1494
A	HOH1739
A	HOH1775
A	HOH1901

site_id	AF9
Number of Residues	8
Details	binding site for residue GOL A 1336

Chain	Residue
A	ASN836
A	GLY913
A	ASP914
A	ASP915
A	HOH1477
A	HOH1694
A	HOH1732
A	HOH2227

site_id	AG1
Number of Residues	9
Details	binding site for residue GOL A 1337

Chain	Residue
A	VAL616
A	GLN617
A	PRO747
A	GLY748
A	ASP750
A	HOH1561
A	HOH1859
A	HOH2113
A	HOH2600

site_id	AG2
Number of Residues	9
Details	binding site for residue GOL A 1338

Chain	Residue
A	GLY278
A	ARG569
A	ILE1068
A	ASP1069
A	ASP1074
A	ARG1079
A	ILE1080
A	HOH1448
A	HOH1990

site_id	AG3
Number of Residues	5
Details	binding site for residue GOL A 1339

Chain	Residue
A	LYS638
A	GLU976
A	TRP984
A	HOH1443
A	HOH2389

site_id	AG4
Number of Residues	9
Details	binding site for residue GOL A 1340

Chain	Residue
A	GLU648
A	THR650
A	TRP673
A	GLN674
A	GLU1005
A	LYS1009
A	HOH1538
A	HOH1570
A	HOH1911

site_id	AG5
Number of Residues	8
Details	binding site for residue GOL A 1341

Chain	Residue
A	GLU264
A	ALA267
A	HIS288
A	GLN1004
A	HOH1423
A	HOH1426
A	HOH1863
A	HOH2237

site_id	AG6
Number of Residues	6
Details	binding site for residue GOL A 1342

Chain	Residue
A	GLN767
A	ASP859
A	VAL860
A	ALA861
A	HOH1709
A	HOH1887

site_id	AG7
Number of Residues	7
Details	binding site for residue GOL A 1343

Chain	Residue
A	ALA910
A	GLY913
A	ASP914
A	HIS916
A	ALA968
A	ASN969
A	GLN971

site_id	AG8
Number of Residues	8
Details	binding site for residue GOL A 1344

Chain	Residue
A	SER689
A	TYR690
A	TYR691
A	VAL1229
A	GLU1231
A	HOH1534
A	HOH1626
A	HOH2493

site_id	AG9
Number of Residues	6
Details	binding site for residue GOL A 1345

Chain	Residue
A	HIS1125
A	PRO1149
A	GOL1333
A	HOH1406
A	HOH1424
A	HOH1583

site_id	AH1
Number of Residues	5
Details	binding site for residue GOL A 1346

Chain	Residue
A	GLN29
A	HIS31
A	ALA116
A	SER117
A	THR118

site_id	AH2
Number of Residues	5
Details	binding site for residue GOL A 1347

Chain	Residue
A	HIS746
A	PRO747
A	LYS782
A	ARG784
A	GLU793

site_id	AH3
Number of Residues	6
Details	binding site for residue MG A 1348

Chain	Residue
A	ASP679
A	ASN722
A	ASP884
A	ADP1312
A	HOH1634
A	HOH2078

site_id	AH4
Number of Residues	5
Details	binding site for residue MG A 1349

Chain	Residue
A	ADP1312
A	HOH1499
A	HOH1535
A	HOH1820
A	HOH1989

site_id	AH5
Number of Residues	6
Details	binding site for residue MG A 1350

Chain	Residue
A	GLU718
A	ADP1312
A	HOH1556
A	HOH1740
A	HOH1753
A	HOH1899

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI5
Number of Residues	22
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	1
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_00419","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	2
Details	Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00419","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	11
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00419","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	4
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00419","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15301531","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22683785","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24223728","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)