6JT7
Crystal structure of 452-453_deletion mutant of FGAM Synthetase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004642 | molecular_function | phosphoribosylformylglycinamidine synthase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006164 | biological_process | purine nucleotide biosynthetic process |
| A | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| A | 0016874 | molecular_function | ligase activity |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 1501 |
| Chain | Residue |
| A | ASP914 |
| A | ASP915 |
| A | HIS916 |
| A | LEU917 |
| A | EDO1513 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 1502 |
| Chain | Residue |
| A | HIS813 |
| A | ARG877 |
| A | EDO1593 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 1503 |
| Chain | Residue |
| A | ALA273 |
| A | ASP274 |
| A | ARG279 |
| A | HIS283 |
| A | HOH1601 |
| A | HOH1634 |
| A | HOH2559 |
| A | PHE272 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 1504 |
| Chain | Residue |
| A | ARG936 |
| A | TYR954 |
| A | HOH1944 |
| A | HOH2209 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 1505 |
| Chain | Residue |
| A | PRO348 |
| A | ARG639 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 1506 |
| Chain | Residue |
| A | ASP624 |
| A | ALA625 |
| A | GLN849 |
| A | LEU850 |
| A | GLY851 |
| A | HOH1875 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | binding site for residue EDO A 1507 |
| Chain | Residue |
| A | ASP730 |
| A | LYS732 |
| A | LYS864 |
| A | ASP962 |
| A | SER977 |
| A | THR980 |
| A | GOL1564 |
| A | HOH1607 |
| A | HOH1866 |
| A | HOH2438 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 1508 |
| Chain | Residue |
| A | THR632 |
| A | HOH1627 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 1509 |
| Chain | Residue |
| A | PRO1032 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 1510 |
| Chain | Residue |
| A | PRO1274 |
| A | GLU1275 |
| A | HOH2056 |
| A | HOH2314 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 1511 |
| Chain | Residue |
| A | LYS435 |
| A | ASP529 |
| A | VAL576 |
| A | ILE577 |
| A | GLY578 |
| A | ASP579 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 1512 |
| Chain | Residue |
| A | ARG1039 |
| A | PRO1040 |
| A | ARG1291 |
| A | SO41534 |
| A | HOH1631 |
| A | HOH2238 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 1513 |
| Chain | Residue |
| A | ARG628 |
| A | ILE631 |
| A | ILE633 |
| A | EDO1501 |
| A | SO41541 |
| A | HOH1632 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 1514 |
| Chain | Residue |
| A | GLU215 |
| A | SER778 |
| A | MET779 |
| A | SER780 |
| A | HOH1637 |
| site_id | AD6 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 1515 |
| Chain | Residue |
| A | ARG358 |
| A | THR783 |
| A | ARG784 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 1516 |
| Chain | Residue |
| A | ARG1285 |
| A | HOH2029 |
| A | HOH2427 |
| site_id | AD8 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 1517 |
| Chain | Residue |
| A | GLU787 |
| site_id | AD9 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 1518 |
| Chain | Residue |
| A | GLN862 |
| A | GLY947 |
| A | LEU948 |
| A | ALA949 |
| A | ASP950 |
| A | CYS951 |
| A | HOH1622 |
| A | HOH2403 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 1519 |
| Chain | Residue |
| A | HIS1125 |
| A | HOH1609 |
| A | HOH1638 |
| A | HOH1881 |
| A | HOH1990 |
| site_id | AE2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 1520 |
| Chain | Residue |
| A | ASP493 |
| A | ASN495 |
| A | HOH1642 |
| A | HOH1761 |
| A | HOH2285 |
| site_id | AE3 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 1521 |
| Chain | Residue |
| A | ARG994 |
| A | HOH2568 |
| site_id | AE4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 1522 |
| Chain | Residue |
| A | PRO63 |
| A | ARG1200 |
| A | GLU1202 |
| site_id | AE5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 1523 |
| Chain | Residue |
| A | TYR574 |
| A | EDO1595 |
| A | HOH1653 |
| A | PRO573 |
| site_id | AE6 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 1524 |
| Chain | Residue |
| A | ASP688 |
| A | GLU1231 |
| A | ASN1242 |
| A | GOL1555 |
| A | GOL1569 |
| A | GOL1575 |
| A | HOH2145 |
| site_id | AE7 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 1525 |
| Chain | Residue |
| A | VAL774 |
| A | GLY775 |
| A | GOL1570 |
| A | HOH1913 |
| A | HOH2149 |
| A | HOH2349 |
| site_id | AE8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 1526 |
| Chain | Residue |
| A | GLU192 |
| A | LYS196 |
| A | ARG1079 |
| A | HOH2602 |
| site_id | AE9 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 1527 |
| Chain | Residue |
| A | ALA910 |
| A | GLY913 |
| A | ASP914 |
| A | HIS916 |
| A | ALA968 |
| A | ASN969 |
| A | GLN971 |
| A | HOH1605 |
| site_id | AF1 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 1528 |
| Chain | Residue |
| A | HIS275 |
| A | HOH2129 |
| A | HOH2367 |
| site_id | AF2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 1529 |
| Chain | Residue |
| A | TYR251 |
| A | VAL252 |
| A | GLU264 |
| A | GLU1007 |
| A | GOL1566 |
| site_id | AF3 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 1530 |
| Chain | Residue |
| A | ARG270 |
| A | LYS327 |
| A | ASN419 |
| A | HOH1860 |
| A | HOH2241 |
| A | HOH2372 |
| A | HOH2462 |
| site_id | AF4 |
| Number of Residues | 3 |
| Details | binding site for residue IMD A 1531 |
| Chain | Residue |
| A | ASN1251 |
| A | ARG1253 |
| A | HOH1677 |
| site_id | AF5 |
| Number of Residues | 33 |
| Details | binding site for residue ADP A 1532 |
| Chain | Residue |
| A | VAL333 |
| A | THR386 |
| A | GLY387 |
| A | TYR388 |
| A | PHE389 |
| A | LYS649 |
| A | LEU652 |
| A | VAL653 |
| A | GLN668 |
| A | PRO676 |
| A | ALA678 |
| A | ASP679 |
| A | GLU718 |
| A | ASN722 |
| A | SER886 |
| A | MG1552 |
| A | MG1553 |
| A | MG1554 |
| A | HOH1676 |
| A | HOH1680 |
| A | HOH1700 |
| A | HOH1755 |
| A | HOH1820 |
| A | HOH1822 |
| A | HOH1846 |
| A | HOH1915 |
| A | HOH1974 |
| A | HOH2083 |
| A | HOH2132 |
| A | HOH2169 |
| A | HOH2173 |
| A | HOH2240 |
| A | HOH2260 |
| site_id | AF6 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 1533 |
| Chain | Residue |
| A | HIS1086 |
| A | ARG1126 |
| A | PRO1127 |
| A | GLN1128 |
| A | THR1129 |
| A | HOH1629 |
| A | HOH1810 |
| A | HOH2360 |
| site_id | AF7 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 1534 |
| Chain | Residue |
| A | PRO1040 |
| A | LYS1041 |
| A | ASN1084 |
| A | HIS1086 |
| A | EDO1512 |
| A | HOH1683 |
| A | HOH1746 |
| A | HOH2298 |
| site_id | AF8 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 1535 |
| Chain | Residue |
| A | GLN1176 |
| A | GLY1184 |
| A | MET1185 |
| A | VAL1186 |
| A | HOH1723 |
| A | HOH1768 |
| A | HOH1796 |
| A | HOH2009 |
| site_id | AF9 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 1536 |
| Chain | Residue |
| A | TRP305 |
| A | ARG1159 |
| A | ARG1164 |
| A | HOH1646 |
| A | HOH1880 |
| A | HOH1981 |
| A | HOH2101 |
| site_id | AG1 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 1537 |
| Chain | Residue |
| A | ARG812 |
| A | GLY1227 |
| A | LYS1228 |
| A | VAL1229 |
| A | HOH1614 |
| A | HOH1657 |
| A | HOH1661 |
| A | HOH1730 |
| site_id | AG2 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 1538 |
| Chain | Residue |
| A | ARG57 |
| A | GLU1104 |
| A | LYS1108 |
| A | ARG1156 |
| A | SO41547 |
| A | GOL1573 |
| A | GOL1574 |
| site_id | AG3 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 1539 |
| Chain | Residue |
| A | THR295 |
| A | HIS296 |
| A | ASN297 |
| A | HIS298 |
| A | SER778 |
| A | HOH1751 |
| site_id | AG4 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 1540 |
| Chain | Residue |
| A | ASN1113 |
| A | ARG1115 |
| A | HOH2273 |
| site_id | AG5 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 1541 |
| Chain | Residue |
| A | THR632 |
| A | ILE633 |
| A | EDO1513 |
| A | HOH1627 |
| A | HOH2096 |
| site_id | AG6 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 1542 |
| Chain | Residue |
| A | LYS833 |
| A | HIS835 |
| A | ARG858 |
| A | HOH1921 |
| A | HOH1931 |
| site_id | AG7 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 1543 |
| Chain | Residue |
| A | SER12 |
| A | ALA13 |
| A | PHE14 |
| A | ASN998 |
| A | GLN1000 |
| A | HIS1161 |
| A | HOH2192 |
| site_id | AG8 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 1544 |
| Chain | Residue |
| A | VAL432 |
| A | THR581 |
| A | GLU582 |
| A | GLU583 |
| A | HOH1845 |
| site_id | AG9 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 1545 |
| Chain | Residue |
| A | THR1175 |
| A | ARG1221 |
| A | GOL1569 |
| A | HOH1993 |
| site_id | AH1 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 1546 |
| Chain | Residue |
| A | ALA911 |
| A | HIS953 |
| A | HOH1616 |
| A | HOH1975 |
| site_id | AH2 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 1547 |
| Chain | Residue |
| A | ARG1145 |
| A | ARG1156 |
| A | ARG1204 |
| A | SO41538 |
| A | HOH1669 |
| A | HOH1781 |
| A | HOH1888 |
| site_id | AH3 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 1548 |
| Chain | Residue |
| A | HIS68 |
| A | THR69 |
| site_id | AH4 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 1549 |
| Chain | Residue |
| A | HIS153 |
| A | GLN154 |
| site_id | AH5 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 1550 |
| Chain | Residue |
| A | PRO356 |
| A | GLU357 |
| A | ARG358 |
| A | HOH1624 |
| A | HOH1674 |
| site_id | AH6 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 1551 |
| Chain | Residue |
| A | GLN54 |
| A | PHE1112 |
| A | HIS1114 |
| A | HOH1626 |
| A | HOH1658 |
| A | HOH2261 |
| site_id | AH7 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 1552 |
| Chain | Residue |
| A | ASP679 |
| A | ASN722 |
| A | ASP884 |
| A | ADP1532 |
| A | HOH1846 |
| A | HOH2173 |
| site_id | AH8 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 1553 |
| Chain | Residue |
| A | GLU718 |
| A | ADP1532 |
| A | HOH1725 |
| A | HOH1755 |
| A | HOH1822 |
| A | HOH1974 |
| site_id | AH9 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 1554 |
| Chain | Residue |
| A | ADP1532 |
| A | HOH1676 |
| A | HOH1700 |
| A | HOH1915 |
| A | HOH2083 |
| site_id | AI1 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 1555 |
| Chain | Residue |
| A | SER689 |
| A | TYR690 |
| A | TYR691 |
| A | VAL1229 |
| A | THR1230 |
| A | GLU1231 |
| A | EDO1524 |
| A | HOH1730 |
| A | HOH1832 |
| site_id | AI2 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 1556 |
| Chain | Residue |
| A | GLU648 |
| A | THR650 |
| A | TRP673 |
| A | GLN674 |
| A | GLU1005 |
| A | LYS1009 |
| A | HOH1667 |
| A | HOH1709 |
| A | HOH1971 |
| site_id | AI3 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 1557 |
| Chain | Residue |
| A | HIS902 |
| A | CYS903 |
| A | GLY961 |
| A | ARG978 |
| A | ASP1012 |
| A | HOH1666 |
| A | HOH1813 |
| A | HOH2448 |
| site_id | AI4 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 1558 |
| Chain | Residue |
| A | GLN767 |
| A | ASP859 |
| A | VAL860 |
| A | ALA861 |
| A | HOH1983 |
| site_id | AI5 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 1559 |
| Chain | Residue |
| A | SER85 |
| A | GLU107 |
| A | ARG108 |
| A | GOL1572 |
| A | EDO1594 |
| site_id | AI6 |
| Number of Residues | 10 |
| Details | binding site for residue GOL A 1560 |
| Chain | Residue |
| A | GLU264 |
| A | ALA267 |
| A | PRO286 |
| A | HIS288 |
| A | GLN1004 |
| A | GLU1007 |
| A | HOH1650 |
| A | HOH1668 |
| A | HOH1780 |
| A | HOH2330 |
| site_id | AI7 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 1561 |
| Chain | Residue |
| A | HIS296 |
| A | ARG317 |
| A | GLN471 |
| A | GLY504 |
| A | GLN548 |
| A | HOH1678 |
| A | HOH1753 |
| site_id | AI8 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 1562 |
| Chain | Residue |
| A | ALA709 |
| A | ARG713 |
| A | ASP755 |
| A | LYS758 |
| A | GLU763 |
| A | HOH1613 |
| A | HOH1722 |
| A | HOH1836 |
| A | HOH2152 |
| site_id | AI9 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 1563 |
| Chain | Residue |
| A | ALA665 |
| A | VAL811 |
| A | ARG812 |
| A | VAL1268 |
| A | HIS1273 |
| A | HOH1925 |
| site_id | AJ1 |
| Number of Residues | 10 |
| Details | binding site for residue GOL A 1564 |
| Chain | Residue |
| A | ASP250 |
| A | LYS732 |
| A | THR980 |
| A | TRP984 |
| A | GLU987 |
| A | EDO1507 |
| A | GOL1566 |
| A | HOH1603 |
| A | HOH1607 |
| A | HOH1792 |
| site_id | AJ2 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 1565 |
| Chain | Residue |
| A | ALA743 |
| A | ALA744 |
| A | GLY745 |
| A | HIS746 |
| A | LYS782 |
| A | ARG784 |
| A | HOH1868 |
| A | HOH2050 |
| site_id | AJ3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 1566 |
| Chain | Residue |
| A | ASP250 |
| A | TYR251 |
| A | ALA1010 |
| A | EDO1529 |
| A | GOL1564 |
| A | HOH1714 |
| A | HOH2229 |
| site_id | AJ4 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 1567 |
| Chain | Residue |
| A | GLY913 |
| A | ASP914 |
| A | ASP915 |
| A | HOH1837 |
| A | HOH2184 |
| site_id | AJ5 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 1568 |
| Chain | Residue |
| A | GLN347 |
| A | LYS638 |
| A | ARG639 |
| A | HIS642 |
| A | HOH1686 |
| A | HOH2165 |
| A | HOH2361 |
| site_id | AJ6 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 1569 |
| Chain | Residue |
| A | ARG1221 |
| A | ASN1242 |
| A | EDO1524 |
| A | SO41545 |
| A | HOH1614 |
| site_id | AJ7 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 1570 |
| Chain | Residue |
| A | PHE222 |
| A | LYS776 |
| A | ASP777 |
| A | EDO1525 |
| A | HOH1713 |
| A | HOH2280 |
| site_id | AJ8 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 1571 |
| Chain | Residue |
| A | ARG15 |
| A | THR367 |
| A | GLU368 |
| A | ARG996 |
| A | ARG1164 |
| site_id | AJ9 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 1572 |
| Chain | Residue |
| A | SER85 |
| A | GLU137 |
| A | GOL1559 |
| A | GOL1576 |
| A | EDO1594 |
| A | HOH1893 |
| A | HOH2256 |
| site_id | AK1 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 1573 |
| Chain | Residue |
| A | SER8 |
| A | GLN60 |
| A | TYR61 |
| A | GLY62 |
| A | SO41538 |
| A | HOH1769 |
| A | HOH2341 |
| site_id | AK2 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 1574 |
| Chain | Residue |
| A | SER1142 |
| A | ASN1143 |
| A | LEU1144 |
| A | ARG1145 |
| A | GLU1146 |
| A | ARG1156 |
| A | SO41538 |
| site_id | AK3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 1575 |
| Chain | Residue |
| A | ASP688 |
| A | TYR690 |
| A | ARG1266 |
| A | GLU1279 |
| A | EDO1524 |
| A | HOH1730 |
| site_id | AK4 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 1576 |
| Chain | Residue |
| A | MET136 |
| A | TRP305 |
| A | ARG472 |
| A | ASP473 |
| A | GOL1572 |
| A | HOH1697 |
| site_id | AK5 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 1577 |
| Chain | Residue |
| A | GLN767 |
| A | ALA861 |
| A | ARG963 |
| A | HOH1602 |
| A | HOH1710 |
| A | HOH1800 |
| A | HOH2020 |
| A | HOH2156 |
| site_id | AK6 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 1578 |
| Chain | Residue |
| A | GLY278 |
| A | ASP1069 |
| A | ASP1074 |
| A | ARG1079 |
| A | HOH1640 |
| A | HOH1976 |
| site_id | AK7 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 1579 |
| Chain | Residue |
| A | VAL616 |
| A | GLN617 |
| A | PRO747 |
| A | GLY748 |
| A | ASP750 |
| A | HOH2025 |
| A | HOH2098 |
| A | HOH2423 |
| site_id | AK8 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 1580 |
| Chain | Residue |
| A | PHE282 |
| A | ASP688 |
| A | ASP1206 |
| A | HOH1618 |
| A | HOH2247 |
| site_id | AK9 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 1581 |
| Chain | Residue |
| A | ARG1117 |
| A | GLU1121 |
| A | GLU1146 |
| A | HOH1641 |
| site_id | AL1 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 1582 |
| Chain | Residue |
| A | LEU1021 |
| A | ASN1026 |
| A | ASN1276 |
| A | GLY1278 |
| A | HOH1952 |
| A | HOH2162 |
| site_id | AL2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 1583 |
| Chain | Residue |
| A | MET1 |
| A | LYS620 |
| A | EDO1587 |
| A | HOH1803 |
| site_id | AL3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 1584 |
| Chain | Residue |
| A | ARG105 |
| A | LEU149 |
| A | PHE150 |
| A | GLU534 |
| A | HOH1679 |
| A | HOH1685 |
| site_id | AL4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 1585 |
| Chain | Residue |
| A | ILE228 |
| A | GLN233 |
| A | LYS758 |
| A | HOH1625 |
| A | HOH1636 |
| site_id | AL5 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 1586 |
| Chain | Residue |
| A | ALA941 |
| A | HOH1729 |
| A | HOH1905 |
| site_id | AL6 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 1587 |
| Chain | Residue |
| A | THR618 |
| A | LEU619 |
| A | LYS620 |
| A | EDO1583 |
| A | HOH1630 |
| A | HOH1889 |
| site_id | AL7 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 1588 |
| Chain | Residue |
| A | TYR207 |
| A | GLU541 |
| site_id | AL8 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 1589 |
| Chain | Residue |
| A | HIS132 |
| A | ARG134 |
| A | HOH2534 |
| site_id | AL9 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 1590 |
| Chain | Residue |
| A | LYS1041 |
| A | HOH2435 |
| site_id | AM1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 1591 |
| Chain | Residue |
| A | ARG1204 |
| A | HIS1208 |
| A | HOH1654 |
| A | HOH2310 |
| site_id | AM2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 1592 |
| Chain | Residue |
| A | HIS283 |
| A | ARG421 |
| A | GLN490 |
| A | HOH1634 |
| site_id | AM3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 1593 |
| Chain | Residue |
| A | TYR690 |
| A | ARG812 |
| A | TRP1277 |
| A | EDO1502 |
| A | HOH2388 |
| site_id | AM4 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 1594 |
| Chain | Residue |
| A | VAL77 |
| A | THR78 |
| A | PRO79 |
| A | VAL110 |
| A | GLU137 |
| A | GOL1559 |
| A | GOL1572 |
| A | HOH2107 |
| site_id | AM5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 1595 |
| Chain | Residue |
| A | ARG571 |
| A | EDO1523 |
| A | HOH1653 |
| A | HOH1954 |
| site_id | AM6 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 1596 |
| Chain | Residue |
| A | GLN818 |
| A | TRP1272 |
| site_id | AM7 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 1597 |
| Chain | Residue |
| A | HIS298 |
| A | LYS409 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI5 |
| Number of Residues | 22 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_00419","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00419","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 11 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00419","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00419","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15301531","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22683785","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24223728","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
