Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6JT7

Crystal structure of 452-453_deletion mutant of FGAM Synthetase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004642	molecular_function	phosphoribosylformylglycinamidine synthase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0006189	biological_process	'de novo' IMP biosynthetic process
A	0006541	biological_process	glutamine metabolic process
A	0016874	molecular_function	ligase activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue EDO A 1501

Chain	Residue
A	ASP914
A	ASP915
A	HIS916
A	LEU917
A	EDO1513

site_id	AC2
Number of Residues	3
Details	binding site for residue EDO A 1502

Chain	Residue
A	HIS813
A	ARG877
A	EDO1593

site_id	AC3
Number of Residues	8
Details	binding site for residue EDO A 1503

Chain	Residue
A	ALA273
A	ASP274
A	ARG279
A	HIS283
A	HOH1601
A	HOH1634
A	HOH2559
A	PHE272

site_id	AC4
Number of Residues	4
Details	binding site for residue EDO A 1504

Chain	Residue
A	ARG936
A	TYR954
A	HOH1944
A	HOH2209

site_id	AC5
Number of Residues	2
Details	binding site for residue EDO A 1505

Chain	Residue
A	PRO348
A	ARG639

site_id	AC6
Number of Residues	6
Details	binding site for residue EDO A 1506

Chain	Residue
A	ASP624
A	ALA625
A	GLN849
A	LEU850
A	GLY851
A	HOH1875

site_id	AC7
Number of Residues	10
Details	binding site for residue EDO A 1507

Chain	Residue
A	ASP730
A	LYS732
A	LYS864
A	ASP962
A	SER977
A	THR980
A	GOL1564
A	HOH1607
A	HOH1866
A	HOH2438

site_id	AC8
Number of Residues	2
Details	binding site for residue EDO A 1508

Chain	Residue
A	THR632
A	HOH1627

site_id	AC9
Number of Residues	1
Details	binding site for residue EDO A 1509

Chain	Residue
A	PRO1032

site_id	AD1
Number of Residues	4
Details	binding site for residue EDO A 1510

Chain	Residue
A	PRO1274
A	GLU1275
A	HOH2056
A	HOH2314

site_id	AD2
Number of Residues	6
Details	binding site for residue EDO A 1511

Chain	Residue
A	LYS435
A	ASP529
A	VAL576
A	ILE577
A	GLY578
A	ASP579

site_id	AD3
Number of Residues	6
Details	binding site for residue EDO A 1512

Chain	Residue
A	ARG1039
A	PRO1040
A	ARG1291
A	SO41534
A	HOH1631
A	HOH2238

site_id	AD4
Number of Residues	6
Details	binding site for residue EDO A 1513

Chain	Residue
A	ARG628
A	ILE631
A	ILE633
A	EDO1501
A	SO41541
A	HOH1632

site_id	AD5
Number of Residues	5
Details	binding site for residue EDO A 1514

Chain	Residue
A	GLU215
A	SER778
A	MET779
A	SER780
A	HOH1637

site_id	AD6
Number of Residues	3
Details	binding site for residue EDO A 1515

Chain	Residue
A	ARG358
A	THR783
A	ARG784

site_id	AD7
Number of Residues	3
Details	binding site for residue EDO A 1516

Chain	Residue
A	ARG1285
A	HOH2029
A	HOH2427

site_id	AD8
Number of Residues	1
Details	binding site for residue EDO A 1517

Chain	Residue
A	GLU787

site_id	AD9
Number of Residues	8
Details	binding site for residue EDO A 1518

Chain	Residue
A	GLN862
A	GLY947
A	LEU948
A	ALA949
A	ASP950
A	CYS951
A	HOH1622
A	HOH2403

site_id	AE1
Number of Residues	5
Details	binding site for residue EDO A 1519

Chain	Residue
A	HIS1125
A	HOH1609
A	HOH1638
A	HOH1881
A	HOH1990

site_id	AE2
Number of Residues	5
Details	binding site for residue EDO A 1520

Chain	Residue
A	ASP493
A	ASN495
A	HOH1642
A	HOH1761
A	HOH2285

site_id	AE3
Number of Residues	2
Details	binding site for residue EDO A 1521

Chain	Residue
A	ARG994
A	HOH2568

site_id	AE4
Number of Residues	3
Details	binding site for residue EDO A 1522

Chain	Residue
A	PRO63
A	ARG1200
A	GLU1202

site_id	AE5
Number of Residues	4
Details	binding site for residue EDO A 1523

Chain	Residue
A	TYR574
A	EDO1595
A	HOH1653
A	PRO573

site_id	AE6
Number of Residues	7
Details	binding site for residue EDO A 1524

Chain	Residue
A	ASP688
A	GLU1231
A	ASN1242
A	GOL1555
A	GOL1569
A	GOL1575
A	HOH2145

site_id	AE7
Number of Residues	6
Details	binding site for residue EDO A 1525

Chain	Residue
A	VAL774
A	GLY775
A	GOL1570
A	HOH1913
A	HOH2149
A	HOH2349

site_id	AE8
Number of Residues	4
Details	binding site for residue EDO A 1526

Chain	Residue
A	GLU192
A	LYS196
A	ARG1079
A	HOH2602

site_id	AE9
Number of Residues	8
Details	binding site for residue EDO A 1527

Chain	Residue
A	ALA910
A	GLY913
A	ASP914
A	HIS916
A	ALA968
A	ASN969
A	GLN971
A	HOH1605

site_id	AF1
Number of Residues	3
Details	binding site for residue EDO A 1528

Chain	Residue
A	HIS275
A	HOH2129
A	HOH2367

site_id	AF2
Number of Residues	5
Details	binding site for residue EDO A 1529

Chain	Residue
A	TYR251
A	VAL252
A	GLU264
A	GLU1007
A	GOL1566

site_id	AF3
Number of Residues	7
Details	binding site for residue EDO A 1530

Chain	Residue
A	ARG270
A	LYS327
A	ASN419
A	HOH1860
A	HOH2241
A	HOH2372
A	HOH2462

site_id	AF4
Number of Residues	3
Details	binding site for residue IMD A 1531

Chain	Residue
A	ASN1251
A	ARG1253
A	HOH1677

site_id	AF5
Number of Residues	33
Details	binding site for residue ADP A 1532

Chain	Residue
A	VAL333
A	THR386
A	GLY387
A	TYR388
A	PHE389
A	LYS649
A	LEU652
A	VAL653
A	GLN668
A	PRO676
A	ALA678
A	ASP679
A	GLU718
A	ASN722
A	SER886
A	MG1552
A	MG1553
A	MG1554
A	HOH1676
A	HOH1680
A	HOH1700
A	HOH1755
A	HOH1820
A	HOH1822
A	HOH1846
A	HOH1915
A	HOH1974
A	HOH2083
A	HOH2132
A	HOH2169
A	HOH2173
A	HOH2240
A	HOH2260

site_id	AF6
Number of Residues	8
Details	binding site for residue SO4 A 1533

Chain	Residue
A	HIS1086
A	ARG1126
A	PRO1127
A	GLN1128
A	THR1129
A	HOH1629
A	HOH1810
A	HOH2360

site_id	AF7
Number of Residues	8
Details	binding site for residue SO4 A 1534

Chain	Residue
A	PRO1040
A	LYS1041
A	ASN1084
A	HIS1086
A	EDO1512
A	HOH1683
A	HOH1746
A	HOH2298

site_id	AF8
Number of Residues	8
Details	binding site for residue SO4 A 1535

Chain	Residue
A	GLN1176
A	GLY1184
A	MET1185
A	VAL1186
A	HOH1723
A	HOH1768
A	HOH1796
A	HOH2009

site_id	AF9
Number of Residues	7
Details	binding site for residue SO4 A 1536

Chain	Residue
A	TRP305
A	ARG1159
A	ARG1164
A	HOH1646
A	HOH1880
A	HOH1981
A	HOH2101

site_id	AG1
Number of Residues	8
Details	binding site for residue SO4 A 1537

Chain	Residue
A	ARG812
A	GLY1227
A	LYS1228
A	VAL1229
A	HOH1614
A	HOH1657
A	HOH1661
A	HOH1730

site_id	AG2
Number of Residues	7
Details	binding site for residue SO4 A 1538

Chain	Residue
A	ARG57
A	GLU1104
A	LYS1108
A	ARG1156
A	SO41547
A	GOL1573
A	GOL1574

site_id	AG3
Number of Residues	6
Details	binding site for residue SO4 A 1539

Chain	Residue
A	THR295
A	HIS296
A	ASN297
A	HIS298
A	SER778
A	HOH1751

site_id	AG4
Number of Residues	3
Details	binding site for residue SO4 A 1540

Chain	Residue
A	ASN1113
A	ARG1115
A	HOH2273

site_id	AG5
Number of Residues	5
Details	binding site for residue SO4 A 1541

Chain	Residue
A	THR632
A	ILE633
A	EDO1513
A	HOH1627
A	HOH2096

site_id	AG6
Number of Residues	5
Details	binding site for residue SO4 A 1542

Chain	Residue
A	LYS833
A	HIS835
A	ARG858
A	HOH1921
A	HOH1931

site_id	AG7
Number of Residues	7
Details	binding site for residue SO4 A 1543

Chain	Residue
A	SER12
A	ALA13
A	PHE14
A	ASN998
A	GLN1000
A	HIS1161
A	HOH2192

site_id	AG8
Number of Residues	5
Details	binding site for residue SO4 A 1544

Chain	Residue
A	VAL432
A	THR581
A	GLU582
A	GLU583
A	HOH1845

site_id	AG9
Number of Residues	4
Details	binding site for residue SO4 A 1545

Chain	Residue
A	THR1175
A	ARG1221
A	GOL1569
A	HOH1993

site_id	AH1
Number of Residues	4
Details	binding site for residue SO4 A 1546

Chain	Residue
A	ALA911
A	HIS953
A	HOH1616
A	HOH1975

site_id	AH2
Number of Residues	7
Details	binding site for residue SO4 A 1547

Chain	Residue
A	ARG1145
A	ARG1156
A	ARG1204
A	SO41538
A	HOH1669
A	HOH1781
A	HOH1888

site_id	AH3
Number of Residues	2
Details	binding site for residue SO4 A 1548

Chain	Residue
A	HIS68
A	THR69

site_id	AH4
Number of Residues	2
Details	binding site for residue SO4 A 1549

Chain	Residue
A	HIS153
A	GLN154

site_id	AH5
Number of Residues	5
Details	binding site for residue SO4 A 1550

Chain	Residue
A	PRO356
A	GLU357
A	ARG358
A	HOH1624
A	HOH1674

site_id	AH6
Number of Residues	6
Details	binding site for residue SO4 A 1551

Chain	Residue
A	GLN54
A	PHE1112
A	HIS1114
A	HOH1626
A	HOH1658
A	HOH2261

site_id	AH7
Number of Residues	6
Details	binding site for residue MG A 1552

Chain	Residue
A	ASP679
A	ASN722
A	ASP884
A	ADP1532
A	HOH1846
A	HOH2173

site_id	AH8
Number of Residues	6
Details	binding site for residue MG A 1553

Chain	Residue
A	GLU718
A	ADP1532
A	HOH1725
A	HOH1755
A	HOH1822
A	HOH1974

site_id	AH9
Number of Residues	5
Details	binding site for residue MG A 1554

Chain	Residue
A	ADP1532
A	HOH1676
A	HOH1700
A	HOH1915
A	HOH2083

site_id	AI1
Number of Residues	9
Details	binding site for residue GOL A 1555

Chain	Residue
A	SER689
A	TYR690
A	TYR691
A	VAL1229
A	THR1230
A	GLU1231
A	EDO1524
A	HOH1730
A	HOH1832

site_id	AI2
Number of Residues	9
Details	binding site for residue GOL A 1556

Chain	Residue
A	GLU648
A	THR650
A	TRP673
A	GLN674
A	GLU1005
A	LYS1009
A	HOH1667
A	HOH1709
A	HOH1971

site_id	AI3
Number of Residues	8
Details	binding site for residue GOL A 1557

Chain	Residue
A	HIS902
A	CYS903
A	GLY961
A	ARG978
A	ASP1012
A	HOH1666
A	HOH1813
A	HOH2448

site_id	AI4
Number of Residues	5
Details	binding site for residue GOL A 1558

Chain	Residue
A	GLN767
A	ASP859
A	VAL860
A	ALA861
A	HOH1983

site_id	AI5
Number of Residues	5
Details	binding site for residue GOL A 1559

Chain	Residue
A	SER85
A	GLU107
A	ARG108
A	GOL1572
A	EDO1594

site_id	AI6
Number of Residues	10
Details	binding site for residue GOL A 1560

Chain	Residue
A	GLU264
A	ALA267
A	PRO286
A	HIS288
A	GLN1004
A	GLU1007
A	HOH1650
A	HOH1668
A	HOH1780
A	HOH2330

site_id	AI7
Number of Residues	7
Details	binding site for residue GOL A 1561

Chain	Residue
A	HIS296
A	ARG317
A	GLN471
A	GLY504
A	GLN548
A	HOH1678
A	HOH1753

site_id	AI8
Number of Residues	9
Details	binding site for residue GOL A 1562

Chain	Residue
A	ALA709
A	ARG713
A	ASP755
A	LYS758
A	GLU763
A	HOH1613
A	HOH1722
A	HOH1836
A	HOH2152

site_id	AI9
Number of Residues	6
Details	binding site for residue GOL A 1563

Chain	Residue
A	ALA665
A	VAL811
A	ARG812
A	VAL1268
A	HIS1273
A	HOH1925

site_id	AJ1
Number of Residues	10
Details	binding site for residue GOL A 1564

Chain	Residue
A	ASP250
A	LYS732
A	THR980
A	TRP984
A	GLU987
A	EDO1507
A	GOL1566
A	HOH1603
A	HOH1607
A	HOH1792

site_id	AJ2
Number of Residues	8
Details	binding site for residue GOL A 1565

Chain	Residue
A	ALA743
A	ALA744
A	GLY745
A	HIS746
A	LYS782
A	ARG784
A	HOH1868
A	HOH2050

site_id	AJ3
Number of Residues	7
Details	binding site for residue GOL A 1566

Chain	Residue
A	ASP250
A	TYR251
A	ALA1010
A	EDO1529
A	GOL1564
A	HOH1714
A	HOH2229

site_id	AJ4
Number of Residues	5
Details	binding site for residue GOL A 1567

Chain	Residue
A	GLY913
A	ASP914
A	ASP915
A	HOH1837
A	HOH2184

site_id	AJ5
Number of Residues	7
Details	binding site for residue GOL A 1568

Chain	Residue
A	GLN347
A	LYS638
A	ARG639
A	HIS642
A	HOH1686
A	HOH2165
A	HOH2361

site_id	AJ6
Number of Residues	5
Details	binding site for residue GOL A 1569

Chain	Residue
A	ARG1221
A	ASN1242
A	EDO1524
A	SO41545
A	HOH1614

site_id	AJ7
Number of Residues	6
Details	binding site for residue GOL A 1570

Chain	Residue
A	PHE222
A	LYS776
A	ASP777
A	EDO1525
A	HOH1713
A	HOH2280

site_id	AJ8
Number of Residues	5
Details	binding site for residue GOL A 1571

Chain	Residue
A	ARG15
A	THR367
A	GLU368
A	ARG996
A	ARG1164

site_id	AJ9
Number of Residues	7
Details	binding site for residue GOL A 1572

Chain	Residue
A	SER85
A	GLU137
A	GOL1559
A	GOL1576
A	EDO1594
A	HOH1893
A	HOH2256

site_id	AK1
Number of Residues	7
Details	binding site for residue GOL A 1573

Chain	Residue
A	SER8
A	GLN60
A	TYR61
A	GLY62
A	SO41538
A	HOH1769
A	HOH2341

site_id	AK2
Number of Residues	7
Details	binding site for residue GOL A 1574

Chain	Residue
A	SER1142
A	ASN1143
A	LEU1144
A	ARG1145
A	GLU1146
A	ARG1156
A	SO41538

site_id	AK3
Number of Residues	6
Details	binding site for residue GOL A 1575

Chain	Residue
A	ASP688
A	TYR690
A	ARG1266
A	GLU1279
A	EDO1524
A	HOH1730

site_id	AK4
Number of Residues	6
Details	binding site for residue GOL A 1576

Chain	Residue
A	MET136
A	TRP305
A	ARG472
A	ASP473
A	GOL1572
A	HOH1697

site_id	AK5
Number of Residues	8
Details	binding site for residue GOL A 1577

Chain	Residue
A	GLN767
A	ALA861
A	ARG963
A	HOH1602
A	HOH1710
A	HOH1800
A	HOH2020
A	HOH2156

site_id	AK6
Number of Residues	6
Details	binding site for residue GOL A 1578

Chain	Residue
A	GLY278
A	ASP1069
A	ASP1074
A	ARG1079
A	HOH1640
A	HOH1976

site_id	AK7
Number of Residues	8
Details	binding site for residue GOL A 1579

Chain	Residue
A	VAL616
A	GLN617
A	PRO747
A	GLY748
A	ASP750
A	HOH2025
A	HOH2098
A	HOH2423

site_id	AK8
Number of Residues	5
Details	binding site for residue GOL A 1580

Chain	Residue
A	PHE282
A	ASP688
A	ASP1206
A	HOH1618
A	HOH2247

site_id	AK9
Number of Residues	4
Details	binding site for residue GOL A 1581

Chain	Residue
A	ARG1117
A	GLU1121
A	GLU1146
A	HOH1641

site_id	AL1
Number of Residues	6
Details	binding site for residue GOL A 1582

Chain	Residue
A	LEU1021
A	ASN1026
A	ASN1276
A	GLY1278
A	HOH1952
A	HOH2162

site_id	AL2
Number of Residues	4
Details	binding site for residue EDO A 1583

Chain	Residue
A	MET1
A	LYS620
A	EDO1587
A	HOH1803

site_id	AL3
Number of Residues	6
Details	binding site for residue EDO A 1584

Chain	Residue
A	ARG105
A	LEU149
A	PHE150
A	GLU534
A	HOH1679
A	HOH1685

site_id	AL4
Number of Residues	5
Details	binding site for residue EDO A 1585

Chain	Residue
A	ILE228
A	GLN233
A	LYS758
A	HOH1625
A	HOH1636

site_id	AL5
Number of Residues	3
Details	binding site for residue EDO A 1586

Chain	Residue
A	ALA941
A	HOH1729
A	HOH1905

site_id	AL6
Number of Residues	6
Details	binding site for residue EDO A 1587

Chain	Residue
A	THR618
A	LEU619
A	LYS620
A	EDO1583
A	HOH1630
A	HOH1889

site_id	AL7
Number of Residues	2
Details	binding site for residue EDO A 1588

Chain	Residue
A	TYR207
A	GLU541

site_id	AL8
Number of Residues	3
Details	binding site for residue EDO A 1589

Chain	Residue
A	HIS132
A	ARG134
A	HOH2534

site_id	AL9
Number of Residues	2
Details	binding site for residue EDO A 1590

Chain	Residue
A	LYS1041
A	HOH2435

site_id	AM1
Number of Residues	4
Details	binding site for residue EDO A 1591

Chain	Residue
A	ARG1204
A	HIS1208
A	HOH1654
A	HOH2310

site_id	AM2
Number of Residues	4
Details	binding site for residue EDO A 1592

Chain	Residue
A	HIS283
A	ARG421
A	GLN490
A	HOH1634

site_id	AM3
Number of Residues	5
Details	binding site for residue EDO A 1593

Chain	Residue
A	TYR690
A	ARG812
A	TRP1277
A	EDO1502
A	HOH2388

site_id	AM4
Number of Residues	8
Details	binding site for residue EDO A 1594

Chain	Residue
A	VAL77
A	THR78
A	PRO79
A	VAL110
A	GLU137
A	GOL1559
A	GOL1572
A	HOH2107

site_id	AM5
Number of Residues	4
Details	binding site for residue EDO A 1595

Chain	Residue
A	ARG571
A	EDO1523
A	HOH1653
A	HOH1954

site_id	AM6
Number of Residues	2
Details	binding site for residue CL A 1596

Chain	Residue
A	GLN818
A	TRP1272

site_id	AM7
Number of Residues	2
Details	binding site for residue CL A 1597

Chain	Residue
A	HIS298
A	LYS409

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Nucleophile => ECO:0000255\|HAMAP-Rule:MF_00419

Chain	Residue	Details
A	GLY1137

site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000255\|HAMAP-Rule:MF_00419

Chain	Residue	Details
A	GLU1262
A	VAL1264

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00419

Chain	Residue	Details
A	GLY307

site_id	SWS_FT_FI4
Number of Residues	3
Details	BINDING:

Chain	Residue	Details
A	THR386
A	CYS680
A	GLY888

site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00419, ECO:0000269\|PubMed:15301531, ECO:0000269\|PubMed:22683785, ECO:0000269\|PubMed:24223728

Chain	Residue	Details
A	ALA681
A	LEU720
A	ALA724
A	SER886

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)