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6JT0

Structure of human soluble guanylate cyclase in the unliganded state

Functional Information from GO Data
ChainGOidnamespacecontents
A0004383molecular_functionguanylate cyclase activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006182biological_processcGMP biosynthetic process
A0007263biological_processnitric oxide mediated signal transduction
A0008015biological_processblood circulation
A0008074cellular_componentguanylate cyclase complex, soluble
A0008217biological_processregulation of blood pressure
A0009190biological_processcyclic nucleotide biosynthetic process
A0010750biological_processpositive regulation of nitric oxide mediated signal transduction
A0016829molecular_functionlyase activity
A0016849molecular_functionphosphorus-oxygen lyase activity
A0019934biological_processcGMP-mediated signaling
A0020037molecular_functionheme binding
A0035556biological_processintracellular signal transduction
A0038023molecular_functionsignaling receptor activity
A0038060biological_processnitric oxide-cGMP-mediated signaling
A0060087biological_processrelaxation of vascular associated smooth muscle
A0070482biological_processresponse to oxygen levels
A0098925biological_processretrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission
A0098978cellular_componentglutamatergic synapse
A0098982cellular_componentGABA-ergic synapse
B0004016molecular_functionadenylate cyclase activity
B0004383molecular_functionguanylate cyclase activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006182biological_processcGMP biosynthetic process
B0007263biological_processnitric oxide mediated signal transduction
B0008015biological_processblood circulation
B0008074cellular_componentguanylate cyclase complex, soluble
B0009190biological_processcyclic nucleotide biosynthetic process
B0016829molecular_functionlyase activity
B0016849molecular_functionphosphorus-oxygen lyase activity
B0019934biological_processcGMP-mediated signaling
B0020037molecular_functionheme binding
B0032991cellular_componentprotein-containing complex
B0035556biological_processintracellular signal transduction
B0038023molecular_functionsignaling receptor activity
B0038060biological_processnitric oxide-cGMP-mediated signaling
B0043167molecular_functionion binding
B0044877molecular_functionprotein-containing complex binding
B0046872molecular_functionmetal ion binding
B0047805molecular_functioncytidylate cyclase activity
B0048786cellular_componentpresynaptic active zone
B0051879molecular_functionHsp90 protein binding
B0070482biological_processresponse to oxygen levels
B0071732biological_processcellular response to nitric oxide
B0098831cellular_componentpresynaptic active zone cytoplasmic component
B0098978cellular_componentglutamatergic synapse
B0099555biological_processtrans-synaptic signaling by nitric oxide, modulating synaptic transmission
Functional Information from PDB Data
site_idAC1
Number of Residues15
Detailsbinding site for residue HEM B 1000
ChainResidue
BMET1
BPRO118
BPHE120
BSER137
BARG139
BLEU142
BILE149
BTYR2
BPHE74
BLEU87
BLEU101
BHIS105
BLEU108
BMET115
BARG116

Functional Information from PROSITE/UniProt
site_idPS00452
Number of Residues24
DetailsGUANYLATE_CYCLASE_1 Guanylate cyclase signature. GVV.GvkmprYcLFGNNVTlankfE
ChainResidueDetails
AGLY585-GLU608
BGLY531-GLU554

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsBINDING: proximal binding residue => ECO:0000250|UniProtKB:P16068
ChainResidueDetails
BHIS105

222036

PDB entries from 2024-07-03

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