6JSI

Co-purified Fatty Acid Synthase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
A	0006633	biological_process	fatty acid biosynthetic process
A	0016746	molecular_function	acyltransferase activity
B	0004312	molecular_function	fatty acid synthase activity
B	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
B	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
B	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B	0004321	molecular_function	fatty-acyl-CoA synthase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005811	cellular_component	lipid droplet
B	0005829	cellular_component	cytosol
B	0005835	cellular_component	fatty acid synthase complex
B	0006633	biological_process	fatty acid biosynthetic process
B	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
B	0016409	molecular_function	palmitoyltransferase activity
B	0016491	molecular_function	oxidoreductase activity
B	0016740	molecular_function	transferase activity
B	0016787	molecular_function	hydrolase activity
B	0016829	molecular_function	lyase activity
B	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
B	0042759	biological_process	long-chain fatty acid biosynthetic process
B	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
D	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
D	0006633	biological_process	fatty acid biosynthetic process
D	0016746	molecular_function	acyltransferase activity
E	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
E	0006633	biological_process	fatty acid biosynthetic process
E	0016746	molecular_function	acyltransferase activity
F	0004312	molecular_function	fatty acid synthase activity
F	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
F	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
F	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
F	0004321	molecular_function	fatty-acyl-CoA synthase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005811	cellular_component	lipid droplet
F	0005829	cellular_component	cytosol
F	0005835	cellular_component	fatty acid synthase complex
F	0006633	biological_process	fatty acid biosynthetic process
F	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
F	0016409	molecular_function	palmitoyltransferase activity
F	0016491	molecular_function	oxidoreductase activity
F	0016740	molecular_function	transferase activity
F	0016787	molecular_function	hydrolase activity
F	0016829	molecular_function	lyase activity
F	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
F	0042759	biological_process	long-chain fatty acid biosynthetic process
F	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
G	0004312	molecular_function	fatty acid synthase activity
G	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
G	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
G	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
G	0004321	molecular_function	fatty-acyl-CoA synthase activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005811	cellular_component	lipid droplet
G	0005829	cellular_component	cytosol
G	0005835	cellular_component	fatty acid synthase complex
G	0006633	biological_process	fatty acid biosynthetic process
G	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
G	0016409	molecular_function	palmitoyltransferase activity
G	0016491	molecular_function	oxidoreductase activity
G	0016740	molecular_function	transferase activity
G	0016787	molecular_function	hydrolase activity
G	0016829	molecular_function	lyase activity
G	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
G	0042759	biological_process	long-chain fatty acid biosynthetic process
G	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity

Functional Information from PROSITE/UniProt

site_id	PS00606
Number of Residues	17
Details	KS3_1 Ketosynthase family 3 (KS3) active site signature. GPIktPVgACATSveSV

Chain	Residue	Details
A	GLY1296-VAL1312

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: For acetyltransferase activity => ECO:0000250

Chain	Residue	Details
B	SER274
F	SER274
G	SER274

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site_id	SWS_FT_FI2
Number of Residues	3
Details	ACT_SITE: For malonyltransferase activity => ECO:0000250

Chain	Residue	Details
B	SER1808
F	SER1808
G	SER1808

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site_id	SWS_FT_FI3
Number of Residues	3
Details	MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378

Chain	Residue	Details
B	MET1
F	MET1
G	MET1
D	SER1440
E	SER958
E	SER1440

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site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19779198

Chain	Residue	Details
B	UNK733
F	UNK733
G	UNK733

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site_id	SWS_FT_FI5
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198

Chain	Residue	Details
B	UNK1121
F	UNK1121
G	UNK1121

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site_id	SWS_FT_FI6
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047

Chain	Residue	Details
B	UNK1364
F	UNK1364
G	UNK1364

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