6JS8
Structure of the CYP102A1 Haem Domain with N-Dehydroabietoyl-L-Tryptophan
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004497 | molecular_function | monooxygenase activity |
A | 0005506 | molecular_function | iron ion binding |
A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
A | 0020037 | molecular_function | heme binding |
B | 0004497 | molecular_function | monooxygenase activity |
B | 0005506 | molecular_function | iron ion binding |
B | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
B | 0020037 | molecular_function | heme binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 28 |
Details | binding site for residue HEM A 501 |
Chain | Residue |
A | LYS69 |
A | THR327 |
A | ALA328 |
A | PHE331 |
A | PRO392 |
A | PHE393 |
A | GLY394 |
A | ARG398 |
A | ALA399 |
A | CYS400 |
A | ILE401 |
A | LEU86 |
A | GLY402 |
A | PHE405 |
A | DMS502 |
A | HOH644 |
A | HOH648 |
A | HOH697 |
A | HOH736 |
A | HOH766 |
A | HOH788 |
A | PHE87 |
A | TRP96 |
A | ILE153 |
A | ALA264 |
A | THR268 |
A | THR269 |
A | LEU322 |
site_id | AC2 |
Number of Residues | 4 |
Details | binding site for residue DMS A 502 |
Chain | Residue |
A | PHE87 |
A | ALA264 |
A | THR268 |
A | HEM501 |
site_id | AC3 |
Number of Residues | 13 |
Details | binding site for residue C5R A 503 |
Chain | Residue |
A | LEU20 |
A | VAL26 |
A | LEU29 |
A | ARG47 |
A | TYR51 |
A | SER72 |
A | GLN73 |
A | ALA74 |
A | LEU75 |
A | PHE87 |
A | LEU188 |
A | LEU437 |
A | HOH636 |
site_id | AC4 |
Number of Residues | 5 |
Details | binding site for residue GOL A 504 |
Chain | Residue |
A | HIS100 |
A | GLY396 |
A | GLN397 |
A | ALA399 |
A | HOH644 |
site_id | AC5 |
Number of Residues | 6 |
Details | binding site for residue GOL A 505 |
Chain | Residue |
A | ASP68 |
A | THR91 |
A | HIS92 |
A | TYR334 |
A | LYS336 |
A | HOH609 |
site_id | AC6 |
Number of Residues | 4 |
Details | binding site for residue GOL A 506 |
Chain | Residue |
A | GLN128 |
A | ARG132 |
B | ASP121 |
B | ARG161 |
site_id | AC7 |
Number of Residues | 8 |
Details | binding site for residue GOL A 507 |
Chain | Residue |
A | TRP130 |
A | LEU133 |
A | ASN134 |
A | ALA135 |
A | ALA448 |
A | LYS449 |
A | SER450 |
A | HOH602 |
site_id | AC8 |
Number of Residues | 6 |
Details | binding site for residue GOL A 508 |
Chain | Residue |
A | LYS391 |
A | GLY394 |
A | ASN395 |
A | GLY396 |
A | GLN403 |
A | HOH700 |
site_id | AC9 |
Number of Residues | 8 |
Details | binding site for residue GOL A 509 |
Chain | Residue |
A | ARG47 |
A | ASN70 |
A | LEU71 |
A | SER72 |
A | GLN73 |
A | LYS76 |
A | GLU352 |
A | HOH730 |
site_id | AD1 |
Number of Residues | 6 |
Details | binding site for residue GOL A 510 |
Chain | Residue |
A | THR22 |
A | LYS24 |
A | GLN27 |
A | ALA28 |
A | LYS31 |
A | HOH604 |
site_id | AD2 |
Number of Residues | 3 |
Details | binding site for residue GOL A 511 |
Chain | Residue |
A | GLU137 |
A | HIS138 |
A | HOH805 |
site_id | AD3 |
Number of Residues | 5 |
Details | binding site for residue GOL A 512 |
Chain | Residue |
A | ILE366 |
A | ARG378 |
A | ASN381 |
A | HOH647 |
A | HOH693 |
site_id | AD4 |
Number of Residues | 28 |
Details | binding site for residue HEM B 501 |
Chain | Residue |
B | TRP96 |
B | ILE153 |
B | ALA264 |
B | THR268 |
B | THR269 |
B | LEU322 |
B | THR327 |
B | ALA328 |
B | PHE331 |
B | PRO392 |
B | PHE393 |
B | GLY394 |
B | ARG398 |
B | ALA399 |
B | CYS400 |
B | ILE401 |
B | GLY402 |
B | PHE405 |
B | DMS502 |
B | HOH639 |
B | HOH676 |
B | HOH694 |
B | HOH711 |
B | HOH760 |
B | HOH789 |
B | LYS69 |
B | LEU86 |
B | PHE87 |
site_id | AD5 |
Number of Residues | 4 |
Details | binding site for residue DMS B 502 |
Chain | Residue |
B | PHE87 |
B | ALA264 |
B | THR268 |
B | HEM501 |
site_id | AD6 |
Number of Residues | 14 |
Details | binding site for residue C5R B 503 |
Chain | Residue |
B | LEU20 |
B | PRO25 |
B | VAL26 |
B | LEU29 |
B | ARG47 |
B | TYR51 |
B | SER72 |
B | GLN73 |
B | ALA74 |
B | LEU75 |
B | PHE87 |
B | LEU188 |
B | MET354 |
B | LEU437 |
site_id | AD7 |
Number of Residues | 7 |
Details | binding site for residue GOL B 504 |
Chain | Residue |
B | LYS391 |
B | GLY394 |
B | ASN395 |
B | GLY396 |
B | GLN403 |
B | HOH678 |
B | HOH775 |
site_id | AD8 |
Number of Residues | 4 |
Details | binding site for residue GOL B 505 |
Chain | Residue |
B | THR91 |
B | LYS97 |
B | GLN397 |
B | GOL509 |
site_id | AD9 |
Number of Residues | 4 |
Details | binding site for residue GOL B 506 |
Chain | Residue |
B | HIS285 |
B | GLN288 |
B | LYS289 |
B | HOH707 |
site_id | AE1 |
Number of Residues | 8 |
Details | binding site for residue GOL B 507 |
Chain | Residue |
B | HIS100 |
B | LEU104 |
B | GLN397 |
B | ALA399 |
B | CYS400 |
B | ILE401 |
B | HOH676 |
B | HOH703 |
site_id | AE2 |
Number of Residues | 4 |
Details | binding site for residue GOL B 508 |
Chain | Residue |
B | ILE366 |
B | ARG378 |
B | PRO386 |
B | HOH747 |
site_id | AE3 |
Number of Residues | 5 |
Details | binding site for residue GOL B 509 |
Chain | Residue |
B | ASP68 |
B | HIS92 |
B | LYS336 |
B | GOL505 |
B | HOH603 |
site_id | AE4 |
Number of Residues | 8 |
Details | binding site for residue GOL B 510 |
Chain | Residue |
B | TRP130 |
B | LEU133 |
B | ASN134 |
B | ALA135 |
B | ALA448 |
B | LYS449 |
B | SER450 |
B | HOH601 |
site_id | AE5 |
Number of Residues | 1 |
Details | binding site for residue GOL B 511 |
Chain | Residue |
B | LYS9 |
site_id | AE6 |
Number of Residues | 5 |
Details | binding site for residue GOL B 512 |
Chain | Residue |
B | GLN288 |
B | ALA291 |
B | GLU292 |
B | ASP422 |
B | LYS451 |
site_id | AE7 |
Number of Residues | 3 |
Details | binding site for residue GOL B 513 |
Chain | Residue |
B | ARG79 |
B | GLY83 |
B | TYR256 |
site_id | AE8 |
Number of Residues | 4 |
Details | binding site for residue GOL B 514 |
Chain | Residue |
A | ASP121 |
A | ARG161 |
B | GLN128 |
B | ARG132 |
Functional Information from PROSITE/UniProt
site_id | PS00086 |
Number of Residues | 10 |
Details | CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGnGQRACIG |
Chain | Residue | Details |
A | PHE393-GLY402 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15020590, ECO:0007744|PDB:1SMJ |
Chain | Residue | Details |
A | TYR51 | |
B | TYR51 |
Chain | Residue | Details |
A | CYS400 | |
B | CYS400 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | SITE: Important for catalytic activity => ECO:0000305|PubMed:16403573, ECO:0000305|PubMed:7578081 |
Chain | Residue | Details |
A | THR268 | |
B | THR268 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 3 |
Details | M-CSA 699 |
Chain | Residue | Details |
A | THR268 | electrostatic stabiliser, steric role |
A | PHE393 | electrostatic stabiliser, steric role |
A | CYS400 | electrostatic stabiliser |
site_id | MCSA2 |
Number of Residues | 3 |
Details | M-CSA 699 |
Chain | Residue | Details |
B | THR268 | electrostatic stabiliser, steric role |
B | PHE393 | electrostatic stabiliser, steric role |
B | CYS400 | electrostatic stabiliser |