6JRS

Structure of RyR2 (*F/A/C/L-Ca2+/Ca2+-CaM dataset)

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
A	0005262	molecular_function	calcium channel activity
A	0005509	molecular_function	calcium ion binding
A	0006811	biological_process	monoatomic ion transport
A	0006816	biological_process	calcium ion transport
A	0006874	biological_process	intracellular calcium ion homeostasis
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
A	0070588	biological_process	calcium ion transmembrane transport
B	0002027	biological_process	regulation of heart rate
B	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
B	0005102	molecular_function	signaling receptor binding
B	0005246	molecular_function	calcium channel regulator activity
B	0005515	molecular_function	protein binding
B	0005528	molecular_function	FK506 binding
B	0005737	cellular_component	cytoplasm
B	0006458	biological_process	'de novo' protein folding
B	0006939	biological_process	smooth muscle contraction
B	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
B	0009749	biological_process	response to glucose
B	0010459	biological_process	negative regulation of heart rate
B	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
B	0016020	cellular_component	membrane
B	0016529	cellular_component	sarcoplasmic reticulum
B	0016853	molecular_function	isomerase activity
B	0019227	biological_process	neuronal action potential propagation
B	0019722	biological_process	calcium-mediated signaling
B	0019855	molecular_function	calcium channel inhibitor activity
B	0030018	cellular_component	Z disc
B	0030073	biological_process	insulin secretion
B	0033017	cellular_component	sarcoplasmic reticulum membrane
B	0034704	cellular_component	calcium channel complex
B	0035773	biological_process	insulin secretion involved in cellular response to glucose stimulus
B	0042026	biological_process	protein refolding
B	0042098	biological_process	T cell proliferation
B	0044325	molecular_function	transmembrane transporter binding
B	0050849	biological_process	negative regulation of calcium-mediated signaling
B	0051209	biological_process	release of sequestered calcium ion into cytosol
B	0051280	biological_process	negative regulation of release of sequestered calcium ion into cytosol
B	0051284	biological_process	positive regulation of sequestering of calcium ion
B	0051604	biological_process	protein maturation
B	0051775	biological_process	response to redox state
B	0061179	biological_process	negative regulation of insulin secretion involved in cellular response to glucose stimulus
C	0000086	biological_process	G2/M transition of mitotic cell cycle
C	0000922	cellular_component	spindle pole
C	0002027	biological_process	regulation of heart rate
C	0005246	molecular_function	calcium channel regulator activity
C	0005509	molecular_function	calcium ion binding
C	0005513	biological_process	detection of calcium ion
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005813	cellular_component	centrosome
C	0005819	cellular_component	spindle
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005876	cellular_component	spindle microtubule
C	0005886	cellular_component	plasma membrane
C	0005929	cellular_component	cilium
C	0007186	biological_process	G protein-coupled receptor signaling pathway
C	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
C	0008076	cellular_component	voltage-gated potassium channel complex
C	0010856	molecular_function	adenylate cyclase activator activity
C	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
C	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
C	0016020	cellular_component	membrane
C	0016240	biological_process	autophagosome membrane docking
C	0019855	molecular_function	calcium channel inhibitor activity
C	0019901	molecular_function	protein kinase binding
C	0021762	biological_process	substantia nigra development
C	0030017	cellular_component	sarcomere
C	0030672	cellular_component	synaptic vesicle membrane
C	0031432	molecular_function	titin binding
C	0031514	cellular_component	motile cilium
C	0031982	cellular_component	vesicle
C	0032465	biological_process	regulation of cytokinesis
C	0032991	cellular_component	protein-containing complex
C	0034704	cellular_component	calcium channel complex
C	0035458	biological_process	cellular response to interferon-beta
C	0042995	cellular_component	cell projection
C	0043209	cellular_component	myelin sheath
C	0043539	molecular_function	protein serine/threonine kinase activator activity
C	0044305	cellular_component	calyx of Held
C	0044325	molecular_function	transmembrane transporter binding
C	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
C	0046872	molecular_function	metal ion binding
C	0048306	molecular_function	calcium-dependent protein binding
C	0050848	biological_process	regulation of calcium-mediated signaling
C	0051592	biological_process	response to calcium ion
C	0055117	biological_process	regulation of cardiac muscle contraction
C	0060291	biological_process	long-term synaptic potentiation
C	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
C	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
C	0071346	biological_process	cellular response to type II interferon
C	0072542	molecular_function	protein phosphatase activator activity
C	0097225	cellular_component	sperm midpiece
C	0097720	biological_process	calcineurin-mediated signaling
C	0098901	biological_process	regulation of cardiac muscle cell action potential
C	0099523	cellular_component	presynaptic cytosol
C	0140056	biological_process	organelle localization by membrane tethering
C	0140238	biological_process	presynaptic endocytosis
C	0141110	molecular_function	transporter inhibitor activity
C	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
C	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
C	1902494	cellular_component	catalytic complex
C	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
C	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
D	0005216	molecular_function	monoatomic ion channel activity
D	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
D	0005262	molecular_function	calcium channel activity
D	0005509	molecular_function	calcium ion binding
D	0006811	biological_process	monoatomic ion transport
D	0006816	biological_process	calcium ion transport
D	0006874	biological_process	intracellular calcium ion homeostasis
D	0016020	cellular_component	membrane
D	0055085	biological_process	transmembrane transport
D	0070588	biological_process	calcium ion transmembrane transport
E	0002027	biological_process	regulation of heart rate
E	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
E	0005102	molecular_function	signaling receptor binding
E	0005246	molecular_function	calcium channel regulator activity
E	0005515	molecular_function	protein binding
E	0005528	molecular_function	FK506 binding
E	0005737	cellular_component	cytoplasm
E	0006458	biological_process	'de novo' protein folding
E	0006939	biological_process	smooth muscle contraction
E	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
E	0009749	biological_process	response to glucose
E	0010459	biological_process	negative regulation of heart rate
E	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
E	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
E	0016020	cellular_component	membrane
E	0016529	cellular_component	sarcoplasmic reticulum
E	0016853	molecular_function	isomerase activity
E	0019227	biological_process	neuronal action potential propagation
E	0019722	biological_process	calcium-mediated signaling
E	0019855	molecular_function	calcium channel inhibitor activity
E	0030018	cellular_component	Z disc
E	0030073	biological_process	insulin secretion
E	0033017	cellular_component	sarcoplasmic reticulum membrane
E	0034704	cellular_component	calcium channel complex
E	0035773	biological_process	insulin secretion involved in cellular response to glucose stimulus
E	0042026	biological_process	protein refolding
E	0042098	biological_process	T cell proliferation
E	0044325	molecular_function	transmembrane transporter binding
E	0050849	biological_process	negative regulation of calcium-mediated signaling
E	0051209	biological_process	release of sequestered calcium ion into cytosol
E	0051280	biological_process	negative regulation of release of sequestered calcium ion into cytosol
E	0051284	biological_process	positive regulation of sequestering of calcium ion
E	0051604	biological_process	protein maturation
E	0051775	biological_process	response to redox state
E	0061179	biological_process	negative regulation of insulin secretion involved in cellular response to glucose stimulus
F	0000086	biological_process	G2/M transition of mitotic cell cycle
F	0000922	cellular_component	spindle pole
F	0002027	biological_process	regulation of heart rate
F	0005246	molecular_function	calcium channel regulator activity
F	0005509	molecular_function	calcium ion binding
F	0005513	biological_process	detection of calcium ion
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005813	cellular_component	centrosome
F	0005819	cellular_component	spindle
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0005876	cellular_component	spindle microtubule
F	0005886	cellular_component	plasma membrane
F	0005929	cellular_component	cilium
F	0007186	biological_process	G protein-coupled receptor signaling pathway
F	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
F	0008076	cellular_component	voltage-gated potassium channel complex
F	0010856	molecular_function	adenylate cyclase activator activity
F	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
F	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
F	0016020	cellular_component	membrane
F	0016240	biological_process	autophagosome membrane docking
F	0019855	molecular_function	calcium channel inhibitor activity
F	0019901	molecular_function	protein kinase binding
F	0021762	biological_process	substantia nigra development
F	0030017	cellular_component	sarcomere
F	0030672	cellular_component	synaptic vesicle membrane
F	0031432	molecular_function	titin binding
F	0031514	cellular_component	motile cilium
F	0031982	cellular_component	vesicle
F	0032465	biological_process	regulation of cytokinesis
F	0032991	cellular_component	protein-containing complex
F	0034704	cellular_component	calcium channel complex
F	0035458	biological_process	cellular response to interferon-beta
F	0042995	cellular_component	cell projection
F	0043209	cellular_component	myelin sheath
F	0043539	molecular_function	protein serine/threonine kinase activator activity
F	0044305	cellular_component	calyx of Held
F	0044325	molecular_function	transmembrane transporter binding
F	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
F	0046872	molecular_function	metal ion binding
F	0048306	molecular_function	calcium-dependent protein binding
F	0050848	biological_process	regulation of calcium-mediated signaling
F	0051592	biological_process	response to calcium ion
F	0055117	biological_process	regulation of cardiac muscle contraction
F	0060291	biological_process	long-term synaptic potentiation
F	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
F	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
F	0071346	biological_process	cellular response to type II interferon
F	0072542	molecular_function	protein phosphatase activator activity
F	0097225	cellular_component	sperm midpiece
F	0097720	biological_process	calcineurin-mediated signaling
F	0098901	biological_process	regulation of cardiac muscle cell action potential
F	0099523	cellular_component	presynaptic cytosol
F	0140056	biological_process	organelle localization by membrane tethering
F	0140238	biological_process	presynaptic endocytosis
F	0141110	molecular_function	transporter inhibitor activity
F	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
F	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
F	1902494	cellular_component	catalytic complex
F	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
F	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
G	0005216	molecular_function	monoatomic ion channel activity
G	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
G	0005262	molecular_function	calcium channel activity
G	0005509	molecular_function	calcium ion binding
G	0006811	biological_process	monoatomic ion transport
G	0006816	biological_process	calcium ion transport
G	0006874	biological_process	intracellular calcium ion homeostasis
G	0016020	cellular_component	membrane
G	0055085	biological_process	transmembrane transport
G	0070588	biological_process	calcium ion transmembrane transport
H	0002027	biological_process	regulation of heart rate
H	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
H	0005102	molecular_function	signaling receptor binding
H	0005246	molecular_function	calcium channel regulator activity
H	0005515	molecular_function	protein binding
H	0005528	molecular_function	FK506 binding
H	0005737	cellular_component	cytoplasm
H	0006458	biological_process	'de novo' protein folding
H	0006939	biological_process	smooth muscle contraction
H	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
H	0009749	biological_process	response to glucose
H	0010459	biological_process	negative regulation of heart rate
H	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
H	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
H	0016020	cellular_component	membrane
H	0016529	cellular_component	sarcoplasmic reticulum
H	0016853	molecular_function	isomerase activity
H	0019227	biological_process	neuronal action potential propagation
H	0019722	biological_process	calcium-mediated signaling
H	0019855	molecular_function	calcium channel inhibitor activity
H	0030018	cellular_component	Z disc
H	0030073	biological_process	insulin secretion
H	0033017	cellular_component	sarcoplasmic reticulum membrane
H	0034704	cellular_component	calcium channel complex
H	0035773	biological_process	insulin secretion involved in cellular response to glucose stimulus
H	0042026	biological_process	protein refolding
H	0042098	biological_process	T cell proliferation
H	0044325	molecular_function	transmembrane transporter binding
H	0050849	biological_process	negative regulation of calcium-mediated signaling
H	0051209	biological_process	release of sequestered calcium ion into cytosol
H	0051280	biological_process	negative regulation of release of sequestered calcium ion into cytosol
H	0051284	biological_process	positive regulation of sequestering of calcium ion
H	0051604	biological_process	protein maturation
H	0051775	biological_process	response to redox state
H	0061179	biological_process	negative regulation of insulin secretion involved in cellular response to glucose stimulus
I	0000086	biological_process	G2/M transition of mitotic cell cycle
I	0000922	cellular_component	spindle pole
I	0002027	biological_process	regulation of heart rate
I	0005246	molecular_function	calcium channel regulator activity
I	0005509	molecular_function	calcium ion binding
I	0005513	biological_process	detection of calcium ion
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0005813	cellular_component	centrosome
I	0005819	cellular_component	spindle
I	0005829	cellular_component	cytosol
I	0005856	cellular_component	cytoskeleton
I	0005876	cellular_component	spindle microtubule
I	0005886	cellular_component	plasma membrane
I	0005929	cellular_component	cilium
I	0007186	biological_process	G protein-coupled receptor signaling pathway
I	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
I	0008076	cellular_component	voltage-gated potassium channel complex
I	0010856	molecular_function	adenylate cyclase activator activity
I	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
I	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
I	0016020	cellular_component	membrane
I	0016240	biological_process	autophagosome membrane docking
I	0019855	molecular_function	calcium channel inhibitor activity
I	0019901	molecular_function	protein kinase binding
I	0021762	biological_process	substantia nigra development
I	0030017	cellular_component	sarcomere
I	0030672	cellular_component	synaptic vesicle membrane
I	0031432	molecular_function	titin binding
I	0031514	cellular_component	motile cilium
I	0031982	cellular_component	vesicle
I	0032465	biological_process	regulation of cytokinesis
I	0032991	cellular_component	protein-containing complex
I	0034704	cellular_component	calcium channel complex
I	0035458	biological_process	cellular response to interferon-beta
I	0042995	cellular_component	cell projection
I	0043209	cellular_component	myelin sheath
I	0043539	molecular_function	protein serine/threonine kinase activator activity
I	0044305	cellular_component	calyx of Held
I	0044325	molecular_function	transmembrane transporter binding
I	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
I	0046872	molecular_function	metal ion binding
I	0048306	molecular_function	calcium-dependent protein binding
I	0050848	biological_process	regulation of calcium-mediated signaling
I	0051592	biological_process	response to calcium ion
I	0055117	biological_process	regulation of cardiac muscle contraction
I	0060291	biological_process	long-term synaptic potentiation
I	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
I	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
I	0071346	biological_process	cellular response to type II interferon
I	0072542	molecular_function	protein phosphatase activator activity
I	0097225	cellular_component	sperm midpiece
I	0097720	biological_process	calcineurin-mediated signaling
I	0098901	biological_process	regulation of cardiac muscle cell action potential
I	0099523	cellular_component	presynaptic cytosol
I	0140056	biological_process	organelle localization by membrane tethering
I	0140238	biological_process	presynaptic endocytosis
I	0141110	molecular_function	transporter inhibitor activity
I	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
I	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
I	1902494	cellular_component	catalytic complex
I	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
I	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
J	0005216	molecular_function	monoatomic ion channel activity
J	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
J	0005262	molecular_function	calcium channel activity
J	0005509	molecular_function	calcium ion binding
J	0006811	biological_process	monoatomic ion transport
J	0006816	biological_process	calcium ion transport
J	0006874	biological_process	intracellular calcium ion homeostasis
J	0016020	cellular_component	membrane
J	0055085	biological_process	transmembrane transport
J	0070588	biological_process	calcium ion transmembrane transport
K	0002027	biological_process	regulation of heart rate
K	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
K	0005102	molecular_function	signaling receptor binding
K	0005246	molecular_function	calcium channel regulator activity
K	0005515	molecular_function	protein binding
K	0005528	molecular_function	FK506 binding
K	0005737	cellular_component	cytoplasm
K	0006458	biological_process	'de novo' protein folding
K	0006939	biological_process	smooth muscle contraction
K	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
K	0009749	biological_process	response to glucose
K	0010459	biological_process	negative regulation of heart rate
K	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
K	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
K	0016020	cellular_component	membrane
K	0016529	cellular_component	sarcoplasmic reticulum
K	0016853	molecular_function	isomerase activity
K	0019227	biological_process	neuronal action potential propagation
K	0019722	biological_process	calcium-mediated signaling
K	0019855	molecular_function	calcium channel inhibitor activity
K	0030018	cellular_component	Z disc
K	0030073	biological_process	insulin secretion
K	0033017	cellular_component	sarcoplasmic reticulum membrane
K	0034704	cellular_component	calcium channel complex
K	0035773	biological_process	insulin secretion involved in cellular response to glucose stimulus
K	0042026	biological_process	protein refolding
K	0042098	biological_process	T cell proliferation
K	0044325	molecular_function	transmembrane transporter binding
K	0050849	biological_process	negative regulation of calcium-mediated signaling
K	0051209	biological_process	release of sequestered calcium ion into cytosol
K	0051280	biological_process	negative regulation of release of sequestered calcium ion into cytosol
K	0051284	biological_process	positive regulation of sequestering of calcium ion
K	0051604	biological_process	protein maturation
K	0051775	biological_process	response to redox state
K	0061179	biological_process	negative regulation of insulin secretion involved in cellular response to glucose stimulus
L	0000086	biological_process	G2/M transition of mitotic cell cycle
L	0000922	cellular_component	spindle pole
L	0002027	biological_process	regulation of heart rate
L	0005246	molecular_function	calcium channel regulator activity
L	0005509	molecular_function	calcium ion binding
L	0005513	biological_process	detection of calcium ion
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0005813	cellular_component	centrosome
L	0005819	cellular_component	spindle
L	0005829	cellular_component	cytosol
L	0005856	cellular_component	cytoskeleton
L	0005876	cellular_component	spindle microtubule
L	0005886	cellular_component	plasma membrane
L	0005929	cellular_component	cilium
L	0007186	biological_process	G protein-coupled receptor signaling pathway
L	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
L	0008076	cellular_component	voltage-gated potassium channel complex
L	0010856	molecular_function	adenylate cyclase activator activity
L	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
L	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
L	0016020	cellular_component	membrane
L	0016240	biological_process	autophagosome membrane docking
L	0019855	molecular_function	calcium channel inhibitor activity
L	0019901	molecular_function	protein kinase binding
L	0021762	biological_process	substantia nigra development
L	0030017	cellular_component	sarcomere
L	0030672	cellular_component	synaptic vesicle membrane
L	0031432	molecular_function	titin binding
L	0031514	cellular_component	motile cilium
L	0031982	cellular_component	vesicle
L	0032465	biological_process	regulation of cytokinesis
L	0032991	cellular_component	protein-containing complex
L	0034704	cellular_component	calcium channel complex
L	0035458	biological_process	cellular response to interferon-beta
L	0042995	cellular_component	cell projection
L	0043209	cellular_component	myelin sheath
L	0043539	molecular_function	protein serine/threonine kinase activator activity
L	0044305	cellular_component	calyx of Held
L	0044325	molecular_function	transmembrane transporter binding
L	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
L	0046872	molecular_function	metal ion binding
L	0048306	molecular_function	calcium-dependent protein binding
L	0050848	biological_process	regulation of calcium-mediated signaling
L	0051592	biological_process	response to calcium ion
L	0055117	biological_process	regulation of cardiac muscle contraction
L	0060291	biological_process	long-term synaptic potentiation
L	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
L	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
L	0071346	biological_process	cellular response to type II interferon
L	0072542	molecular_function	protein phosphatase activator activity
L	0097225	cellular_component	sperm midpiece
L	0097720	biological_process	calcineurin-mediated signaling
L	0098901	biological_process	regulation of cardiac muscle cell action potential
L	0099523	cellular_component	presynaptic cytosol
L	0140056	biological_process	organelle localization by membrane tethering
L	0140238	biological_process	presynaptic endocytosis
L	0141110	molecular_function	transporter inhibitor activity
L	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
L	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
L	1902494	cellular_component	catalytic complex
L	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
L	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 6000

Chain	Residue
A	CYS4889
A	CYS4892
A	HIS4909
A	HIS4914

---

site_id	AC2
Number of Residues	3
Details	binding site for residue CA A 6001

Chain	Residue
A	GLU3923
A	GLN3926
A	THR4932

---

site_id	AC3
Number of Residues	7
Details	binding site for residue ATP A 6002

Chain	Residue
A	LYS4888
A	PHE4890
A	ILE4891
A	THR4910
A	LEU4916
A	LYS4170
A	MET4885

---

site_id	AC4
Number of Residues	4
Details	binding site for residue CFF A 6003

Chain	Residue
A	PHE3715
A	TRP4646
A	ILE4927
A	TYR4945

---

site_id	AC5
Number of Residues	4
Details	binding site for residue CA C 201

Chain	Residue
C	ASP23
C	ASP25
C	THR29
C	GLU32

---

site_id	AC6
Number of Residues	1
Details	binding site for residue CA C 202

Chain	Residue
C	ASN61

---

site_id	AC7
Number of Residues	4
Details	binding site for residue ZN D 6000

Chain	Residue
D	CYS4889
D	CYS4892
D	HIS4909
D	HIS4914

---

site_id	AC8
Number of Residues	3
Details	binding site for residue CA D 6001

Chain	Residue
D	GLU3923
D	GLN3926
D	THR4932

---

site_id	AC9
Number of Residues	7
Details	binding site for residue ATP D 6002

Chain	Residue
D	LYS4170
D	MET4885
D	LYS4888
D	PHE4890
D	ILE4891
D	THR4910
D	LEU4916

---

site_id	AD1
Number of Residues	4
Details	binding site for residue CFF D 6003

Chain	Residue
D	PHE3715
D	TRP4646
D	ILE4927
D	TYR4945

---

site_id	AD2
Number of Residues	4
Details	binding site for residue CA F 201

Chain	Residue
F	ASP23
F	ASP25
F	THR29
F	GLU32

---

site_id	AD3
Number of Residues	1
Details	binding site for residue CA F 202

Chain	Residue
F	ASN61

---

site_id	AD4
Number of Residues	4
Details	binding site for residue ZN G 6000

Chain	Residue
G	CYS4889
G	CYS4892
G	HIS4909
G	HIS4914

---

site_id	AD5
Number of Residues	3
Details	binding site for residue CA G 6001

Chain	Residue
G	GLU3923
G	GLN3926
G	THR4932

---

site_id	AD6
Number of Residues	7
Details	binding site for residue ATP G 6002

Chain	Residue
G	LYS4170
G	MET4885
G	LYS4888
G	PHE4890
G	ILE4891
G	THR4910
G	LEU4916

---

site_id	AD7
Number of Residues	4
Details	binding site for residue CFF G 6003

Chain	Residue
G	PHE3715
G	TRP4646
G	ILE4927
G	TYR4945

---

site_id	AD8
Number of Residues	4
Details	binding site for residue CA I 201

Chain	Residue
I	ASP23
I	ASP25
I	THR29
I	GLU32

---

site_id	AD9
Number of Residues	1
Details	binding site for residue CA I 202

Chain	Residue
I	ASN61

---

site_id	AE1
Number of Residues	4
Details	binding site for residue ZN J 6000

Chain	Residue
J	CYS4889
J	CYS4892
J	HIS4909
J	HIS4914

---

site_id	AE2
Number of Residues	3
Details	binding site for residue CA J 6001

Chain	Residue
J	GLU3923
J	GLN3926
J	THR4932

---

site_id	AE3
Number of Residues	7
Details	binding site for residue ATP J 6002

Chain	Residue
J	LYS4170
J	MET4885
J	LYS4888
J	PHE4890
J	ILE4891
J	THR4910
J	LEU4916

---

site_id	AE4
Number of Residues	4
Details	binding site for residue CFF J 6003

Chain	Residue
J	PHE3715
J	TRP4646
J	ILE4927
J	TYR4945

---

site_id	AE5
Number of Residues	4
Details	binding site for residue CA L 201

Chain	Residue
L	ASP23
L	ASP25
L	THR29
L	GLU32

---

site_id	AE6
Number of Residues	1
Details	binding site for residue CA L 202

Chain	Residue
L	ASN61

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL

Chain	Residue	Details
C	ASP21-LEU33
C	ASP57-PHE69
C	ASP94-LEU106
C	ASP130-PHE142

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	352
Details	Domain: {"description":"PPIase FKBP-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00277","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	40
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1474585","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25441029","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27564677","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UMO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4V0C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5J03","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine; by CaMK4","evidences":[{"source":"UniProtKB","id":"P0DP29","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P62157","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---