6JRD

ZHD complex with hydrolyzed beta-ZOL

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0009636	biological_process	response to toxic substance
A	0016787	molecular_function	hydrolase activity
B	0009636	biological_process	response to toxic substance
B	0016787	molecular_function	hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue C1U A 301

Chain	Residue
A	SER102
A	HOH424
A	HOH452
A	HOH490
A	PRO128
A	LEU132
A	LEU135
A	VAL158
A	PRO188
A	ILE191
A	PRO192
A	SER220

---

site_id	AC2
Number of Residues	7
Details	binding site for residue GOL A 302

Chain	Residue
A	PRO128
A	THR129
A	LYS130
A	SER220
A	PHE221
A	HOH403
A	HOH406

---

site_id	AC3
Number of Residues	7
Details	binding site for residue GOL A 303

Chain	Residue
A	GLN19
A	ARG52
A	LEU91
A	HOH421
A	HOH478
B	SER162
B	GLU163

---

site_id	AC4
Number of Residues	6
Details	binding site for residue GOL A 304

Chain	Residue
A	THR6
A	ARG63
A	LYS66
A	HOH444
A	HOH492
A	HOH586

---

site_id	AC5
Number of Residues	9
Details	binding site for residue GOL A 305

Chain	Residue
A	GLN78
A	PRO193
A	SER194
A	ALA195
A	GLN198
A	HOH427
A	HOH433
B	ARG189
B	PRO193

---

site_id	AC6
Number of Residues	4
Details	binding site for residue K A 306

Chain	Residue
A	HIS248
A	PRO249
A	ASP250
A	VAL251

---

site_id	AC7
Number of Residues	14
Details	binding site for residue C1U B 301

Chain	Residue
B	SER102
B	SER103
B	VAL158
B	TRP183
B	TYR187
B	PRO188
B	ILE191
B	PRO192
B	GLU219
B	SER220
B	GOL302
B	HOH406
B	HOH498
B	HOH574

---

site_id	AC8
Number of Residues	7
Details	binding site for residue GOL B 302

Chain	Residue
B	PRO128
B	THR129
B	LYS130
B	SER220
B	PHE221
B	C1U301
B	HOH439

---

site_id	AC9
Number of Residues	6
Details	binding site for residue GOL B 303

Chain	Residue
A	LYS79
A	HOH461
B	GLU70
B	GLU74
B	LYS79
B	HOH457

---

site_id	AD1
Number of Residues	8
Details	binding site for residue GOL B 304

Chain	Residue
B	LEU155
B	ASN156
B	ASP157
B	SER159
B	GLY160
B	GLY161
B	MET241
B	HOH544

---

site_id	AD2
Number of Residues	4
Details	binding site for residue GOL B 305

Chain	Residue
B	GLY60
B	ALA65
B	TYR72
B	VAL182

---

site_id	AD3
Number of Residues	4
Details	binding site for residue K B 306

Chain	Residue
B	HIS248
B	PRO249
B	ASP250
B	VAL251

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	360
Details	Domain: {"description":"AB hydrolase-1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PubMed","id":"28695844","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2014","firstPage":"62321","lastPage":"62325","volume":"4","journal":"RSC Adv.","title":"Crystal structure and substrate-binding mode of the mycoestrogen-detoxifying lactonase ZHD from Clonostachys rosea.","authors":["Peng W.","Ko T.P.","Yang Y.","Zheng Y.","Chen C.C.","Zhu Z.","Huang C.H.","Zeng Y.F.","Huang J.W.","Wand A.H.-J.","Liu J.R.","Guo R.T."],"citationCrossReferences":[{"database":"DOI","id":"10.1039/c4ra12111b"}]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Active site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2014","firstPage":"62321","lastPage":"62325","volume":"4","journal":"RSC Adv.","title":"Crystal structure and substrate-binding mode of the mycoestrogen-detoxifying lactonase ZHD from Clonostachys rosea.","authors":["Peng W.","Ko T.P.","Yang Y.","Zheng Y.","Chen C.C.","Zhu Z.","Huang C.H.","Zeng Y.F.","Huang J.W.","Wand A.H.-J.","Liu J.R.","Guo R.T."],"citationCrossReferences":[{"database":"DOI","id":"10.1039/c4ra12111b"}]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28695844","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2014","firstPage":"62321","lastPage":"62325","volume":"4","journal":"RSC Adv.","title":"Crystal structure and substrate-binding mode of the mycoestrogen-detoxifying lactonase ZHD from Clonostachys rosea.","authors":["Peng W.","Ko T.P.","Yang Y.","Zheng Y.","Chen C.C.","Zhu Z.","Huang C.H.","Zeng Y.F.","Huang J.W.","Wand A.H.-J.","Liu J.R.","Guo R.T."],"citationCrossReferences":[{"database":"DOI","id":"10.1039/c4ra12111b"}]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2016","firstPage":"7657","lastPage":"7663","volume":"6","journal":"ACS Catal.","title":"Enhanced alpha-zearalenol hydrolyzing activity of a mycoestrogen-detoxifying lactonase by structure-based engineering.","authors":["Xu Z.X.","Liu W.D.","Chen C.C.","Li Q.","Huang J.W.","Ko T.P.","Liu G.","Liu W.","Peng W.","Cheng Y.S.","Chen Y.","Jin J.","Li H.","Zheng Y.Y.","Guo R.T."],"citationCrossReferences":[{"database":"DOI","id":"10.1021/acscatal.6b01826"}]}},{"source":"PDB","id":"3WZM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5C7Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IE4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IE5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IE6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IE7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-2015","submissionDatabase":"PDB data bank","title":"A case study of lactonase ZHD.","authors":["Ming D.-M.","Qi Q.","Yang W.-J.","Sun K.-L.","Xu T.-Y.","Huang Q.","Hu X.-J.","Lv H."]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"APR-2019","submissionDatabase":"PDB data bank","title":"Structure of ZHD complex.","authors":["Hu X.J.","Zhou H.J.","Li L."]}},{"source":"PDB","id":"5C7Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JRD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2014","firstPage":"62321","lastPage":"62325","volume":"4","journal":"RSC Adv.","title":"Crystal structure and substrate-binding mode of the mycoestrogen-detoxifying lactonase ZHD from Clonostachys rosea.","authors":["Peng W.","Ko T.P.","Yang Y.","Zheng Y.","Chen C.C.","Zhu Z.","Huang C.H.","Zeng Y.F.","Huang J.W.","Wand A.H.-J.","Liu J.R.","Guo R.T."],"citationCrossReferences":[{"database":"DOI","id":"10.1039/c4ra12111b"}]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2016","firstPage":"7657","lastPage":"7663","volume":"6","journal":"ACS Catal.","title":"Enhanced alpha-zearalenol hydrolyzing activity of a mycoestrogen-detoxifying lactonase by structure-based engineering.","authors":["Xu Z.X.","Liu W.D.","Chen C.C.","Li Q.","Huang J.W.","Ko T.P.","Liu G.","Liu W.","Peng W.","Cheng Y.S.","Chen Y.","Jin J.","Li H.","Zheng Y.Y.","Guo R.T."],"citationCrossReferences":[{"database":"DOI","id":"10.1021/acscatal.6b01826"}]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"APR-2019","submissionDatabase":"PDB data bank","title":"Structure of ZHD complex.","authors":["Hu X.J.","Zhou H.J.","Li L."]}},{"source":"PDB","id":"3WZM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IE4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IE5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IE6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IE7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JRD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-2015","submissionDatabase":"PDB data bank","title":"A case study of lactonase ZHD.","authors":["Ming D.-M.","Qi Q.","Yang W.-J.","Sun K.-L.","Xu T.-Y.","Huang Q.","Hu X.-J.","Lv H."]}},{"source":"PDB","id":"5C7Y","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"APR-2019","submissionDatabase":"PDB data bank","title":"Structure of ZHD complex.","authors":["Hu X.J.","Zhou H.J.","Li L."]}},{"source":"PDB","id":"6JRD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2014","firstPage":"62321","lastPage":"62325","volume":"4","journal":"RSC Adv.","title":"Crystal structure and substrate-binding mode of the mycoestrogen-detoxifying lactonase ZHD from Clonostachys rosea.","authors":["Peng W.","Ko T.P.","Yang Y.","Zheng Y.","Chen C.C.","Zhu Z.","Huang C.H.","Zeng Y.F.","Huang J.W.","Wand A.H.-J.","Liu J.R.","Guo R.T."],"citationCrossReferences":[{"database":"DOI","id":"10.1039/c4ra12111b"}]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2016","firstPage":"7657","lastPage":"7663","volume":"6","journal":"ACS Catal.","title":"Enhanced alpha-zearalenol hydrolyzing activity of a mycoestrogen-detoxifying lactonase by structure-based engineering.","authors":["Xu Z.X.","Liu W.D.","Chen C.C.","Li Q.","Huang J.W.","Ko T.P.","Liu G.","Liu W.","Peng W.","Cheng Y.S.","Chen Y.","Jin J.","Li H.","Zheng Y.Y.","Guo R.T."],"citationCrossReferences":[{"database":"DOI","id":"10.1021/acscatal.6b01826"}]}},{"source":"PDB","id":"3WZM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IE5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IE6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---