Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005227 | molecular_function | calcium-activated cation channel activity |
| A | 0005261 | molecular_function | monoatomic cation channel activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006970 | biological_process | response to osmotic stress |
| A | 0008381 | molecular_function | mechanosensitive monoatomic ion channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0051262 | biological_process | protein tetramerization |
| A | 0071474 | biological_process | cellular hyperosmotic response |
| A | 0090279 | biological_process | regulation of calcium ion import |
| A | 0098655 | biological_process | monoatomic cation transmembrane transport |
| B | 0005227 | molecular_function | calcium-activated cation channel activity |
| B | 0005261 | molecular_function | monoatomic cation channel activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006970 | biological_process | response to osmotic stress |
| B | 0008381 | molecular_function | mechanosensitive monoatomic ion channel activity |
| B | 0016020 | cellular_component | membrane |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0051262 | biological_process | protein tetramerization |
| B | 0071474 | biological_process | cellular hyperosmotic response |
| B | 0090279 | biological_process | regulation of calcium ion import |
| B | 0098655 | biological_process | monoatomic cation transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 44 |
| Details | Transmembrane: {"description":"Helical; Name=TM0","evidences":[{"source":"PubMed","id":"30190597","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39209849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6JPF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 42 |
| Details | Transmembrane: {"description":"Helical; Name=TM1","evidences":[{"source":"PubMed","id":"30190597","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39209849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6JPF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=TM2","evidences":[{"source":"PubMed","id":"30190597","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39209849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6JPF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 50 |
| Details | Transmembrane: {"description":"Helical; Name=TM3","evidences":[{"source":"PubMed","id":"30190597","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39209849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6JPF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 50 |
| Details | Transmembrane: {"description":"Helical; Name=TM4","evidences":[{"source":"PubMed","id":"30190597","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39209849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6JPF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 54 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"39209849","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30190597","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 46 |
| Details | Transmembrane: {"description":"Helical; Name=TM5","evidences":[{"source":"PubMed","id":"30190597","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39209849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6JPF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 56 |
| Details | Transmembrane: {"description":"Helical; Name=TM6","evidences":[{"source":"PubMed","id":"30190597","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39209849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6JPF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=TM7","evidences":[{"source":"PubMed","id":"30190597","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39209849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6JPF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 12 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"39209849","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30190597","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 34 |
| Details | Transmembrane: {"description":"Helical; Name=TM8","evidences":[{"source":"PubMed","id":"30190597","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39209849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6JPF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 44 |
| Details | Transmembrane: {"description":"Helical; Name=TM9","evidences":[{"source":"PubMed","id":"30190597","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39209849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6JPF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=TM10","evidences":[{"source":"PubMed","id":"30190597","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39209849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6JPF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 14 |
| Details | Region: {"description":"Cytoplasmic region required for homodimerization","evidences":[{"source":"PubMed","id":"30190597","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
