6JNN

REF6 ZnF2-4-NAC004-mC1 complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 1401

Chain	Residue
A	CYS1298
A	CYS1303
A	HIS1316
A	HIS1320

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 1402

Chain	Residue
A	CYS1328
A	CYS1333
A	HIS1346
A	HIS1352

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 1403

Chain	Residue
A	CYS1273
A	HIS1286
A	HIS1290
A	CYS1268

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN B 1401

Chain	Residue
B	CYS1268
B	CYS1273
B	HIS1286
B	HIS1290

---

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN B 1402

Chain	Residue
B	CYS1298
B	CYS1303
B	HIS1316
B	HIS1320

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN B 1403

Chain	Residue
B	CYS1328
B	CYS1333
B	HIS1346
B	HIS1352

---

site_id	AC7
Number of Residues	4
Details	binding site for residue ZN N 1401

Chain	Residue
N	CYS1298
N	CYS1303
N	HIS1316
N	HIS1320

---

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN N 1402

Chain	Residue
N	CYS1328
N	CYS1333
N	HIS1346
N	HIS1352

---

site_id	AC9
Number of Residues	6
Details	binding site for residue ZN N 1403

Chain	Residue
N	CYS1268
N	ILE1270
N	CYS1273
N	HIS1286
N	GLN1287
N	HIS1290

---

site_id	AD1
Number of Residues	4
Details	binding site for residue ZN G 1401

Chain	Residue
G	CYS1298
G	CYS1303
G	HIS1316
G	HIS1320

---

site_id	AD2
Number of Residues	4
Details	binding site for residue ZN G 1402

Chain	Residue
G	CYS1328
G	CYS1333
G	HIS1346
G	HIS1352

---

site_id	AD3
Number of Residues	6
Details	binding site for residue ZN G 1403

Chain	Residue
G	CYS1268
G	ILE1270
G	CYS1273
G	HIS1286
G	GLN1287
G	HIS1290

---

site_id	AD4
Number of Residues	7
Details	binding site for Di-nucleotide DT F 2 and 5CM F 3

Chain	Residue
A	ARG1265
B	PHE1339
B	ASP1342
E	DG10
E	DA11
F	DT1
F	DT4

---

site_id	AD5
Number of Residues	12
Details	binding site for Di-nucleotide 5CM F 3 and DT F 4

Chain	Residue
A	ARG1265
B	SER1312
B	GLU1315
B	HIS1316
B	PHE1339
B	ASP1342
E	DG8
E	DA9
E	DG10
E	DA11
F	DT2
F	DC5

---

site_id	AD6
Number of Residues	6
Details	binding site for Di-nucleotide DT I 2 and 5CM I 3

Chain	Residue
H	DG10
H	DA11
I	DT1
I	DT4
N	ARG1338
N	PHE1339

---

site_id	AD7
Number of Residues	9
Details	binding site for Di-nucleotide 5CM I 3 and DT I 4

Chain	Residue
H	DG8
H	DA9
H	DG10
I	DT2
I	DC5
N	GLU1315
N	HIS1316
N	ARG1338
N	PHE1339

---

site_id	AD8
Number of Residues	6
Details	binding site for Di-nucleotide DT L 2 and 5CM L 3

Chain	Residue
G	PHE1339
G	ASP1342
K	DG10
K	DA11
L	DT1
L	DT4

---

site_id	AD9
Number of Residues	7
Details	binding site for Di-nucleotide 5CM L 3 and DT L 4

Chain	Residue
G	HIS1316
G	PHE1339
G	ASP1342
K	DA9
K	DG10
L	DT2
L	DC5

---

Functional Information from PROSITE/UniProt

site_id	PS00028
Number of Residues	23
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. CpikgCgknFfshkylvqHqrv..H

Chain	Residue	Details
A	CYS1268-HIS1290
A	CYS1298-HIS1320
A	CYS1328-HIS1352

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	96
Details	Zinc finger: {"description":"C2H2-type 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	96
Details	Zinc finger: {"description":"C2H2-type 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	104
Details	Zinc finger: {"description":"C2H2-type 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	292
Details	Region: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"31048693","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32257379","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6A57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JNL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JNM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JNN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31048693","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32257379","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6A57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6A58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6A59","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JNL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JNN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32257379","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6A57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6A58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6A59","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31048693","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32257379","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6A57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6A58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6A59","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JNL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JNM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JNN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---