Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6JNF

Cryo-EM structure of the translocator of the outer mitochondrial membrane

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005741	cellular_component	mitochondrial outer membrane
A	0005742	cellular_component	mitochondrial outer membrane translocase complex
A	0005758	cellular_component	mitochondrial intermembrane space
A	0005829	cellular_component	cytosol
A	0006811	biological_process	monoatomic ion transport
A	0008320	molecular_function	protein transmembrane transporter activity
A	0015031	biological_process	protein transport
A	0015288	molecular_function	porin activity
A	0030150	biological_process	protein import into mitochondrial matrix
A	0045040	biological_process	protein insertion into mitochondrial outer membrane
A	0046930	cellular_component	pore complex
A	0055085	biological_process	transmembrane transport
B	0005739	cellular_component	mitochondrion
B	0005741	cellular_component	mitochondrial outer membrane
B	0005742	cellular_component	mitochondrial outer membrane translocase complex
B	0008320	molecular_function	protein transmembrane transporter activity
B	0015031	biological_process	protein transport
B	0030150	biological_process	protein import into mitochondrial matrix
B	0045040	biological_process	protein insertion into mitochondrial outer membrane
C	0005515	molecular_function	protein binding
C	0005739	cellular_component	mitochondrion
C	0005741	cellular_component	mitochondrial outer membrane
C	0005742	cellular_component	mitochondrial outer membrane translocase complex
C	0006886	biological_process	intracellular protein transport
C	0008320	molecular_function	protein transmembrane transporter activity
C	0015031	biological_process	protein transport
C	0030150	biological_process	protein import into mitochondrial matrix
C	0045040	biological_process	protein insertion into mitochondrial outer membrane
D	0005515	molecular_function	protein binding
D	0005739	cellular_component	mitochondrion
D	0005741	cellular_component	mitochondrial outer membrane
D	0005742	cellular_component	mitochondrial outer membrane translocase complex
D	0006626	biological_process	protein targeting to mitochondrion
D	0008320	molecular_function	protein transmembrane transporter activity
D	0015031	biological_process	protein transport
D	0045040	biological_process	protein insertion into mitochondrial outer membrane
D	0070096	biological_process	mitochondrial outer membrane translocase complex assembly
D	0071806	biological_process	protein transmembrane transport
E	0005739	cellular_component	mitochondrion
E	0005741	cellular_component	mitochondrial outer membrane
E	0005742	cellular_component	mitochondrial outer membrane translocase complex
E	0008320	molecular_function	protein transmembrane transporter activity
E	0015031	biological_process	protein transport
E	0030150	biological_process	protein import into mitochondrial matrix
E	0045040	biological_process	protein insertion into mitochondrial outer membrane
E	0070096	biological_process	mitochondrial outer membrane translocase complex assembly
F	0005515	molecular_function	protein binding
F	0005739	cellular_component	mitochondrion
F	0005741	cellular_component	mitochondrial outer membrane
F	0005742	cellular_component	mitochondrial outer membrane translocase complex
F	0005758	cellular_component	mitochondrial intermembrane space
F	0005829	cellular_component	cytosol
F	0006811	biological_process	monoatomic ion transport
F	0008320	molecular_function	protein transmembrane transporter activity
F	0015031	biological_process	protein transport
F	0015288	molecular_function	porin activity
F	0030150	biological_process	protein import into mitochondrial matrix
F	0045040	biological_process	protein insertion into mitochondrial outer membrane
F	0046930	cellular_component	pore complex
F	0055085	biological_process	transmembrane transport
G	0005739	cellular_component	mitochondrion
G	0005741	cellular_component	mitochondrial outer membrane
G	0005742	cellular_component	mitochondrial outer membrane translocase complex
G	0008320	molecular_function	protein transmembrane transporter activity
G	0015031	biological_process	protein transport
G	0030150	biological_process	protein import into mitochondrial matrix
G	0045040	biological_process	protein insertion into mitochondrial outer membrane
H	0005515	molecular_function	protein binding
H	0005739	cellular_component	mitochondrion
H	0005741	cellular_component	mitochondrial outer membrane
H	0005742	cellular_component	mitochondrial outer membrane translocase complex
H	0006886	biological_process	intracellular protein transport
H	0008320	molecular_function	protein transmembrane transporter activity
H	0015031	biological_process	protein transport
H	0030150	biological_process	protein import into mitochondrial matrix
H	0045040	biological_process	protein insertion into mitochondrial outer membrane
I	0005515	molecular_function	protein binding
I	0005739	cellular_component	mitochondrion
I	0005741	cellular_component	mitochondrial outer membrane
I	0005742	cellular_component	mitochondrial outer membrane translocase complex
I	0006626	biological_process	protein targeting to mitochondrion
I	0008320	molecular_function	protein transmembrane transporter activity
I	0015031	biological_process	protein transport
I	0045040	biological_process	protein insertion into mitochondrial outer membrane
I	0070096	biological_process	mitochondrial outer membrane translocase complex assembly
I	0071806	biological_process	protein transmembrane transport
J	0005739	cellular_component	mitochondrion
J	0005741	cellular_component	mitochondrial outer membrane
J	0005742	cellular_component	mitochondrial outer membrane translocase complex
J	0008320	molecular_function	protein transmembrane transporter activity
J	0015031	biological_process	protein transport
J	0030150	biological_process	protein import into mitochondrial matrix
J	0045040	biological_process	protein insertion into mitochondrial outer membrane
J	0070096	biological_process	mitochondrial outer membrane translocase complex assembly

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue 46E A 401

Chain	Residue
A	LEU84
F	VAL332
H	LEU107
H	GLN122
A	LEU328
A	ARG330
A	VAL332
A	VAL338
C	THR104
F	LEU84
F	LEU328
F	ARG330

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	60
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
E	MET1-PRO31
J	MET1-PRO31

site_id	SWS_FT_FI2
Number of Residues	40
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
E	LEU32-PRO52
J	LEU32-PRO52

site_id	SWS_FT_FI3
Number of Residues	16
Details	TOPO_DOM: Mitochondrial intermembrane => ECO:0000255

Chain	Residue	Details
E	LEU53-LEU61
J	LEU53-LEU61

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N-acetylmethionine => ECO:0007744\|PubMed:22814378

Chain	Residue	Details
E	MET1
J	MET1
H	SER44
H	SER46

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)