6JMR

CD98hc extracellular domain bound to HBJ127 Fab and MEM-108 Fab

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0003723	molecular_function	RNA binding
B	0003725	molecular_function	double-stranded RNA binding
B	0005515	molecular_function	protein binding
B	0005765	cellular_component	lysosomal membrane
B	0005886	cellular_component	plasma membrane
B	0005975	biological_process	carbohydrate metabolic process
B	0006816	biological_process	calcium ion transport
B	0006865	biological_process	amino acid transport
B	0009925	cellular_component	basal plasma membrane
B	0009986	cellular_component	cell surface
B	0015173	molecular_function	aromatic amino acid transmembrane transporter activity
B	0015175	molecular_function	neutral L-amino acid transmembrane transporter activity
B	0015180	molecular_function	L-alanine transmembrane transporter activity
B	0015190	molecular_function	L-leucine transmembrane transporter activity
B	0015818	biological_process	isoleucine transport
B	0015820	biological_process	L-leucine transport
B	0015821	biological_process	methionine transport
B	0015823	biological_process	phenylalanine transport
B	0015824	biological_process	proline transport
B	0015827	biological_process	tryptophan transport
B	0015828	biological_process	tyrosine transport
B	0015829	biological_process	valine transport
B	0016020	cellular_component	membrane
B	0016323	cellular_component	basolateral plasma membrane
B	0016324	cellular_component	apical plasma membrane
B	0042470	cellular_component	melanosome
B	0042803	molecular_function	protein homodimerization activity
B	0043330	biological_process	response to exogenous dsRNA
B	0045296	molecular_function	cadherin binding
B	0046718	biological_process	symbiont entry into host cell
B	0046982	molecular_function	protein heterodimerization activity
B	0070062	cellular_component	extracellular exosome
B	0070161	cellular_component	anchoring junction
B	0070327	biological_process	thyroid hormone transport
B	0089718	biological_process	amino acid import across plasma membrane
B	0140272	molecular_function	exogenous protein binding
B	0150104	biological_process	transport across blood-brain barrier
B	1902024	biological_process	L-histidine transport
B	1902495	cellular_component	transmembrane transporter complex
B	1903801	biological_process	L-leucine import across plasma membrane
B	1904273	biological_process	L-alanine import across plasma membrane
B	1990184	cellular_component	amino acid transport complex

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
D	TYR198-HIS204
F	TYR197-HIS203

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19065266","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12754519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30867591","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33298890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33758168","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34880232","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35352032","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IRS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7CMI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EPZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7P9V","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12754519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30867591","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33298890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33758168","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34880232","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35352032","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IRS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7CMI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EPZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7P9V","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"12754519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30867591","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33298890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33758168","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34880232","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35352032","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IRS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7CMI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EPZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7P9V","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30867591","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33298890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33758168","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34880232","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35352032","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IRS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7CMH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EPZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7P9V","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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