6JL5
Crystal structure of aspartate transcarbamoylase from Trypanosoma cruzi in complex with aspartate (Asp) and phosphate (Pi).
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004070 | molecular_function | aspartate carbamoyltransferase activity |
| A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0016597 | molecular_function | amino acid binding |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| B | 0004070 | molecular_function | aspartate carbamoyltransferase activity |
| B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0016597 | molecular_function | amino acid binding |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| C | 0004070 | molecular_function | aspartate carbamoyltransferase activity |
| C | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| C | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| C | 0006520 | biological_process | amino acid metabolic process |
| C | 0016597 | molecular_function | amino acid binding |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| C | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| D | 0004070 | molecular_function | aspartate carbamoyltransferase activity |
| D | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| D | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| D | 0006520 | biological_process | amino acid metabolic process |
| D | 0016597 | molecular_function | amino acid binding |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| D | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| E | 0004070 | molecular_function | aspartate carbamoyltransferase activity |
| E | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| E | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| E | 0006520 | biological_process | amino acid metabolic process |
| E | 0016597 | molecular_function | amino acid binding |
| E | 0016740 | molecular_function | transferase activity |
| E | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| E | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| F | 0004070 | molecular_function | aspartate carbamoyltransferase activity |
| F | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| F | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| F | 0006520 | biological_process | amino acid metabolic process |
| F | 0016597 | molecular_function | amino acid binding |
| F | 0016740 | molecular_function | transferase activity |
| F | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| F | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue PO4 A 401 |
| Chain | Residue |
| A | SER62 |
| B | LYS92 |
| A | SER63 |
| A | ARG64 |
| A | THR65 |
| A | ARG113 |
| A | LEU288 |
| A | ASP402 |
| A | HOH517 |
| B | SER89 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue ASP A 402 |
| Chain | Residue |
| A | ARG113 |
| A | ARG174 |
| A | ARG242 |
| A | GLN244 |
| A | LEU288 |
| A | PRO289 |
| A | PO4401 |
| A | HOH501 |
| A | HOH517 |
| A | HOH525 |
| B | LYS92 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 403 |
| Chain | Residue |
| A | SER9 |
| A | LEU10 |
| A | LYS13 |
| A | GLN20 |
| A | PHE21 |
| A | ASP25 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | binding site for residue PO4 B 401 |
| Chain | Residue |
| B | SER62 |
| B | SER63 |
| B | ARG64 |
| B | THR65 |
| B | ARG113 |
| B | LEU288 |
| B | ASP402 |
| B | HOH538 |
| C | SER89 |
| C | LYS92 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | binding site for residue ASP B 402 |
| Chain | Residue |
| B | ARG113 |
| B | ARG174 |
| B | THR175 |
| B | ARG242 |
| B | GLN244 |
| B | LEU288 |
| B | PRO289 |
| B | PO4401 |
| B | HOH506 |
| B | HOH538 |
| B | HOH541 |
| C | LYS92 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 403 |
| Chain | Residue |
| B | SER9 |
| B | LYS13 |
| B | GLN20 |
| B | ASP25 |
| B | HOH530 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | binding site for residue PO4 C 401 |
| Chain | Residue |
| A | SER89 |
| A | LYS92 |
| C | SER62 |
| C | SER63 |
| C | ARG64 |
| C | THR65 |
| C | ARG113 |
| C | LEU288 |
| C | ASP402 |
| C | HOH522 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | binding site for residue ASP C 402 |
| Chain | Residue |
| A | LYS92 |
| C | ARG113 |
| C | ARG174 |
| C | ARG242 |
| C | GLN244 |
| C | LEU288 |
| C | PO4401 |
| C | HOH502 |
| C | HOH522 |
| C | HOH540 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue GOL C 403 |
| Chain | Residue |
| C | SER9 |
| C | LEU10 |
| C | LYS13 |
| C | GLN20 |
| C | ASP25 |
| site_id | AD1 |
| Number of Residues | 10 |
| Details | binding site for residue PO4 D 401 |
| Chain | Residue |
| D | SER62 |
| D | SER63 |
| D | ARG64 |
| D | THR65 |
| D | ARG113 |
| D | LEU288 |
| D | ASP402 |
| D | HOH507 |
| E | SER89 |
| E | LYS92 |
| site_id | AD2 |
| Number of Residues | 10 |
| Details | binding site for residue ASP D 402 |
| Chain | Residue |
| D | ARG113 |
| D | ARG174 |
| D | ARG242 |
| D | GLN244 |
| D | LEU288 |
| D | PO4401 |
| D | HOH504 |
| D | HOH507 |
| D | HOH562 |
| E | LYS92 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue GOL D 403 |
| Chain | Residue |
| D | SER9 |
| D | GLN20 |
| D | ASP25 |
| D | HOH579 |
| site_id | AD4 |
| Number of Residues | 10 |
| Details | binding site for residue PO4 E 401 |
| Chain | Residue |
| E | SER62 |
| E | SER63 |
| E | ARG64 |
| E | THR65 |
| E | ARG113 |
| E | LEU288 |
| E | ASP402 |
| E | HOH510 |
| F | SER89 |
| F | LYS92 |
| site_id | AD5 |
| Number of Residues | 11 |
| Details | binding site for residue ASP E 402 |
| Chain | Residue |
| E | ARG113 |
| E | ARG174 |
| E | THR175 |
| E | ARG242 |
| E | GLN244 |
| E | LEU288 |
| E | PO4401 |
| E | HOH510 |
| E | HOH513 |
| E | HOH527 |
| F | LYS92 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue GOL E 403 |
| Chain | Residue |
| E | SER9 |
| E | LYS13 |
| E | GLN20 |
| E | ASP25 |
| site_id | AD7 |
| Number of Residues | 10 |
| Details | binding site for residue PO4 F 401 |
| Chain | Residue |
| D | SER89 |
| D | LYS92 |
| F | SER62 |
| F | SER63 |
| F | ARG64 |
| F | THR65 |
| F | ARG113 |
| F | LEU288 |
| F | ASP402 |
| F | HOH535 |
| site_id | AD8 |
| Number of Residues | 11 |
| Details | binding site for residue ASP F 402 |
| Chain | Residue |
| D | LYS92 |
| F | ARG113 |
| F | HIS141 |
| F | ARG174 |
| F | ARG242 |
| F | GLN244 |
| F | LEU288 |
| F | PO4401 |
| F | HOH530 |
| F | HOH535 |
| F | HOH576 |
| site_id | AD9 |
| Number of Residues | 3 |
| Details | binding site for residue GOL F 403 |
| Chain | Residue |
| F | LYS13 |
| F | GLN20 |
| F | ASP25 |
