6JL4

Crystal structure of aspartate transcarbamoylase from Trypanosoma cruzi in complex with carbamoyl aspartate (CA) and phosphate (Pi)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004070	molecular_function	aspartate carbamoyltransferase activity
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006520	biological_process	amino acid metabolic process
A	0016597	molecular_function	amino acid binding
A	0016740	molecular_function	transferase activity
A	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
A	0044205	biological_process	'de novo' UMP biosynthetic process
B	0004070	molecular_function	aspartate carbamoyltransferase activity
B	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006520	biological_process	amino acid metabolic process
B	0016597	molecular_function	amino acid binding
B	0016740	molecular_function	transferase activity
B	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
B	0044205	biological_process	'de novo' UMP biosynthetic process
C	0004070	molecular_function	aspartate carbamoyltransferase activity
C	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006520	biological_process	amino acid metabolic process
C	0016597	molecular_function	amino acid binding
C	0016740	molecular_function	transferase activity
C	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
C	0044205	biological_process	'de novo' UMP biosynthetic process
D	0004070	molecular_function	aspartate carbamoyltransferase activity
D	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
D	0006221	biological_process	pyrimidine nucleotide biosynthetic process
D	0006520	biological_process	amino acid metabolic process
D	0016597	molecular_function	amino acid binding
D	0016740	molecular_function	transferase activity
D	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
D	0044205	biological_process	'de novo' UMP biosynthetic process
E	0004070	molecular_function	aspartate carbamoyltransferase activity
E	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
E	0006221	biological_process	pyrimidine nucleotide biosynthetic process
E	0006520	biological_process	amino acid metabolic process
E	0016597	molecular_function	amino acid binding
E	0016740	molecular_function	transferase activity
E	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
E	0044205	biological_process	'de novo' UMP biosynthetic process
F	0004070	molecular_function	aspartate carbamoyltransferase activity
F	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
F	0006221	biological_process	pyrimidine nucleotide biosynthetic process
F	0006520	biological_process	amino acid metabolic process
F	0016597	molecular_function	amino acid binding
F	0016740	molecular_function	transferase activity
F	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
F	0044205	biological_process	'de novo' UMP biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue NCD A 401

Chain	Residue
A	THR65
A	PO4402
B	LYS92
A	ARG113
A	HIS141
A	GLN144
A	ARG174
A	THR175
A	ARG242
A	GLN244
A	LEU288

---

site_id	AC2
Number of Residues	9
Details	binding site for residue PO4 A 402

Chain	Residue
A	SER62
A	SER63
A	ARG64
A	THR65
A	ARG113
A	LEU288
A	NCD401
B	SER89
B	LYS92

---

site_id	AC3
Number of Residues	7
Details	binding site for residue ASP B 401

Chain	Residue
B	HIS141
B	ARG174
B	THR175
B	GLN244
B	LEU288
B	PRO289
B	CP402

---

site_id	AC4
Number of Residues	12
Details	binding site for residue CP B 402

Chain	Residue
B	SER62
B	SER63
B	ARG64
B	THR65
B	ARG113
B	HIS141
B	GLN144
B	PRO287
B	LEU288
B	ASP401
C	SER89
C	LYS92

---

site_id	AC5
Number of Residues	9
Details	binding site for residue ASP C 401

Chain	Residue
A	LYS92
C	ARG113
C	HIS141
C	ARG174
C	THR175
C	ARG242
C	GLN244
C	LEU288
C	PO4402

---

site_id	AC6
Number of Residues	9
Details	binding site for residue PO4 C 402

Chain	Residue
A	SER89
A	LYS92
C	SER62
C	SER63
C	ARG64
C	THR65
C	ARG113
C	LEU288
C	ASP401

---

site_id	AC7
Number of Residues	9
Details	binding site for residue ASP D 401

Chain	Residue
D	ARG113
D	ARG174
D	ARG242
D	GLN244
D	LEU288
D	PRO289
D	PO4402
D	HOH520
E	LYS92

---

site_id	AC8
Number of Residues	9
Details	binding site for residue PO4 D 402

Chain	Residue
D	SER62
D	SER63
D	ARG64
D	THR65
D	ARG113
D	LEU288
D	ASP401
E	SER89
E	LYS92

---

site_id	AC9
Number of Residues	10
Details	binding site for residue ASP E 401

Chain	Residue
E	ARG113
E	HIS141
E	ARG174
E	ARG242
E	GLN244
E	LEU288
E	PRO289
E	PO4402
E	HOH501
F	LYS92

---

site_id	AD1
Number of Residues	8
Details	binding site for residue PO4 E 402

Chain	Residue
E	SER62
E	SER63
E	ARG64
E	THR65
E	ARG113
E	ASP401
F	SER89
F	LYS92

---

site_id	AD2
Number of Residues	9
Details	binding site for residue ASP F 401

Chain	Residue
F	LEU288
F	PRO289
F	PO4402
D	LYS92
F	ARG113
F	HIS141
F	ARG174
F	ARG242
F	GLN244

---

site_id	AD3
Number of Residues	9
Details	binding site for residue PO4 F 402

Chain	Residue
D	SER89
D	LYS92
F	SER62
F	SER63
F	ARG64
F	THR65
F	ARG113
F	LEU288
F	ASP401

---