6JKS
Crystal structure of aspartate transcarbamoylase from Trypanosoma cruzi in complex with carbamoyl phosphate (CP) and aspartate (Asp)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004070 | molecular_function | aspartate carbamoyltransferase activity |
| A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0016597 | molecular_function | amino acid binding |
| A | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| B | 0004070 | molecular_function | aspartate carbamoyltransferase activity |
| B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0016597 | molecular_function | amino acid binding |
| B | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| C | 0004070 | molecular_function | aspartate carbamoyltransferase activity |
| C | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| C | 0006520 | biological_process | amino acid metabolic process |
| C | 0016597 | molecular_function | amino acid binding |
| C | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| C | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| D | 0004070 | molecular_function | aspartate carbamoyltransferase activity |
| D | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| D | 0006520 | biological_process | amino acid metabolic process |
| D | 0016597 | molecular_function | amino acid binding |
| D | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| D | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| E | 0004070 | molecular_function | aspartate carbamoyltransferase activity |
| E | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| E | 0006520 | biological_process | amino acid metabolic process |
| E | 0016597 | molecular_function | amino acid binding |
| E | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| E | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| F | 0004070 | molecular_function | aspartate carbamoyltransferase activity |
| F | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| F | 0006520 | biological_process | amino acid metabolic process |
| F | 0016597 | molecular_function | amino acid binding |
| F | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| F | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue CP A 401 |
| Chain | Residue |
| A | SER62 |
| A | ASP402 |
| B | SER89 |
| B | LYS92 |
| A | SER63 |
| A | ARG64 |
| A | THR65 |
| A | ARG113 |
| A | HIS141 |
| A | GLN144 |
| A | PRO287 |
| A | LEU288 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue ASP A 402 |
| Chain | Residue |
| A | ARG113 |
| A | ARG174 |
| A | ARG242 |
| A | GLN244 |
| A | LEU288 |
| A | PRO289 |
| A | CP401 |
| A | HOH543 |
| A | HOH549 |
| B | LYS92 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | binding site for residue CP B 401 |
| Chain | Residue |
| B | SER62 |
| B | SER63 |
| B | ARG64 |
| B | THR65 |
| B | ARG113 |
| B | HIS141 |
| B | GLN144 |
| B | PRO287 |
| B | LEU288 |
| B | ASP402 |
| C | SER89 |
| C | LYS92 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue ASP B 402 |
| Chain | Residue |
| B | ARG113 |
| B | ARG174 |
| B | THR175 |
| B | ARG242 |
| B | LEU288 |
| B | PRO289 |
| B | CP401 |
| B | HOH569 |
| C | LYS92 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | binding site for residue CP C 401 |
| Chain | Residue |
| A | SER89 |
| C | SER62 |
| C | SER63 |
| C | ARG64 |
| C | THR65 |
| C | ARG113 |
| C | HIS141 |
| C | GLN144 |
| C | PRO287 |
| C | LEU288 |
| C | ASP402 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | binding site for residue ASP C 402 |
| Chain | Residue |
| A | LYS92 |
| C | ARG113 |
| C | HIS141 |
| C | ARG174 |
| C | ARG242 |
| C | GLN244 |
| C | LEU288 |
| C | PRO289 |
| C | CP401 |
| site_id | AC7 |
| Number of Residues | 12 |
| Details | binding site for residue CP D 401 |
| Chain | Residue |
| D | SER62 |
| D | SER63 |
| D | ARG64 |
| D | THR65 |
| D | ARG113 |
| D | HIS141 |
| D | GLN144 |
| D | PRO287 |
| D | LEU288 |
| D | ASP402 |
| E | SER89 |
| E | HOH502 |
| site_id | AC8 |
| Number of Residues | 11 |
| Details | binding site for residue ASP D 402 |
| Chain | Residue |
| D | ARG113 |
| D | ARG174 |
| D | THR175 |
| D | ARG242 |
| D | GLN244 |
| D | LEU288 |
| D | PRO289 |
| D | CP401 |
| D | HOH502 |
| D | HOH538 |
| E | LYS92 |
| site_id | AC9 |
| Number of Residues | 12 |
| Details | binding site for residue CP E 401 |
| Chain | Residue |
| E | SER62 |
| E | SER63 |
| E | ARG64 |
| E | THR65 |
| E | ARG113 |
| E | HIS141 |
| E | GLN144 |
| E | PRO287 |
| E | LEU288 |
| E | ASP402 |
| F | SER89 |
| F | LYS92 |
| site_id | AD1 |
| Number of Residues | 10 |
| Details | binding site for residue ASP E 402 |
| Chain | Residue |
| E | HIS141 |
| E | ARG174 |
| E | THR175 |
| E | ARG242 |
| E | GLN244 |
| E | LEU288 |
| E | PRO289 |
| E | CP401 |
| E | HOH567 |
| E | ARG113 |
| site_id | AD2 |
| Number of Residues | 12 |
| Details | binding site for residue CP F 401 |
| Chain | Residue |
| D | SER89 |
| D | LYS92 |
| F | SER62 |
| F | SER63 |
| F | ARG64 |
| F | THR65 |
| F | ARG113 |
| F | HIS141 |
| F | GLN144 |
| F | PRO287 |
| F | LEU288 |
| F | ASP402 |
| site_id | AD3 |
| Number of Residues | 9 |
| Details | binding site for residue ASP F 402 |
| Chain | Residue |
| F | ARG113 |
| F | HIS141 |
| F | ARG174 |
| F | THR175 |
| F | ARG242 |
| F | GLN244 |
| F | LEU288 |
| F | PRO289 |
| F | CP401 |
