6JKR

Crystal structure of aspartate transcarbamoylase from Trypanosoma cruzi in complex with carbamoyl phosphate (CP)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004070	molecular_function	aspartate carbamoyltransferase activity
A	0005829	cellular_component	cytosol
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006520	biological_process	amino acid metabolic process
A	0016597	molecular_function	amino acid binding
A	0016740	molecular_function	transferase activity
A	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
A	0044205	biological_process	'de novo' UMP biosynthetic process
B	0004070	molecular_function	aspartate carbamoyltransferase activity
B	0005829	cellular_component	cytosol
B	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006520	biological_process	amino acid metabolic process
B	0016597	molecular_function	amino acid binding
B	0016740	molecular_function	transferase activity
B	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
B	0044205	biological_process	'de novo' UMP biosynthetic process
C	0004070	molecular_function	aspartate carbamoyltransferase activity
C	0005829	cellular_component	cytosol
C	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006520	biological_process	amino acid metabolic process
C	0016597	molecular_function	amino acid binding
C	0016740	molecular_function	transferase activity
C	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
C	0044205	biological_process	'de novo' UMP biosynthetic process
D	0004070	molecular_function	aspartate carbamoyltransferase activity
D	0005829	cellular_component	cytosol
D	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
D	0006221	biological_process	pyrimidine nucleotide biosynthetic process
D	0006520	biological_process	amino acid metabolic process
D	0016597	molecular_function	amino acid binding
D	0016740	molecular_function	transferase activity
D	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
D	0044205	biological_process	'de novo' UMP biosynthetic process
E	0004070	molecular_function	aspartate carbamoyltransferase activity
E	0005829	cellular_component	cytosol
E	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
E	0006221	biological_process	pyrimidine nucleotide biosynthetic process
E	0006520	biological_process	amino acid metabolic process
E	0016597	molecular_function	amino acid binding
E	0016740	molecular_function	transferase activity
E	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
E	0044205	biological_process	'de novo' UMP biosynthetic process
F	0004070	molecular_function	aspartate carbamoyltransferase activity
F	0005829	cellular_component	cytosol
F	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
F	0006221	biological_process	pyrimidine nucleotide biosynthetic process
F	0006520	biological_process	amino acid metabolic process
F	0016597	molecular_function	amino acid binding
F	0016740	molecular_function	transferase activity
F	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
F	0044205	biological_process	'de novo' UMP biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue CP A 401

Chain	Residue
A	SER62
A	HOH558
A	HOH570
B	SER89
A	SER63
A	ARG64
A	THR65
A	ARG113
A	HIS141
A	GLN144
A	PRO287
A	LEU288

---

site_id	AC2
Number of Residues	6
Details	binding site for residue GOL A 402

Chain	Residue
A	SER9
A	GLN20
A	ASP25
A	HOH562
A	HOH566
A	HOH599

---

site_id	AC3
Number of Residues	7
Details	binding site for residue GOL A 403

Chain	Residue
A	GLY12
A	LYS13
A	SER14
A	GLN128
A	HIS129
A	PRO130
A	HOH519

---

site_id	AC4
Number of Residues	11
Details	binding site for residue CP B 401

Chain	Residue
B	SER62
B	SER63
B	ARG64
B	THR65
B	ARG113
B	HIS141
B	GLN144
B	PRO287
B	LEU288
C	SER89
C	HOH545

---

site_id	AC5
Number of Residues	6
Details	binding site for residue GOL B 402

Chain	Residue
B	SER9
B	LEU10
B	LYS13
B	GLN20
B	ASP25
B	HOH612

---

site_id	AC6
Number of Residues	12
Details	binding site for residue CP C 401

Chain	Residue
A	SER89
C	SER62
C	SER63
C	ARG64
C	THR65
C	ARG113
C	HIS141
C	GLN144
C	PRO287
C	LEU288
C	HOH531
C	HOH554

---

site_id	AC7
Number of Residues	7
Details	binding site for residue GOL C 402

Chain	Residue
C	SER9
C	LEU10
C	LYS13
C	GLN20
C	ASP25
C	HOH538
C	HOH594

---

site_id	AC8
Number of Residues	4
Details	binding site for residue GOL C 403

Chain	Residue
C	SER14
C	LEU124
C	ALA127
C	HIS129

---

site_id	AC9
Number of Residues	12
Details	binding site for residue CP D 401

Chain	Residue
D	SER62
D	SER63
D	ARG64
D	THR65
D	ARG113
D	HIS141
D	GLN144
D	PRO287
D	LEU288
D	HOH616
E	SER89
E	HOH543

---

site_id	AD1
Number of Residues	7
Details	binding site for residue GOL D 402

Chain	Residue
D	SER9
D	LEU10
D	GLN20
D	ASP25
D	HOH571
D	HOH607
D	HOH630

---

site_id	AD2
Number of Residues	5
Details	binding site for residue GOL D 403

Chain	Residue
D	GLY12
D	LYS13
D	SER14
D	GLN128
D	HOH529

---

site_id	AD3
Number of Residues	12
Details	binding site for residue CP E 401

Chain	Residue
F	SER89
F	HOH519
E	SER62
E	SER63
E	ARG64
E	THR65
E	ARG113
E	HIS141
E	GLN144
E	PRO287
E	LEU288
E	HOH538

---

site_id	AD4
Number of Residues	4
Details	binding site for residue GOL E 402

Chain	Residue
E	SER9
E	LYS13
E	GLN20
E	ASP25

---

site_id	AD5
Number of Residues	11
Details	binding site for residue CP F 401

Chain	Residue
D	SER89
D	HOH509
F	SER62
F	SER63
F	ARG64
F	THR65
F	ARG113
F	HIS141
F	GLN144
F	PRO287
F	LEU288

---

site_id	AD6
Number of Residues	6
Details	binding site for residue GOL F 402

Chain	Residue
F	SER9
F	LEU10
F	GLN20
F	ASP25
F	HOH583
F	HOH612

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