Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6JJ8

Crystal structure of OsHXK6-ATP-Mg2+ complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001678	biological_process	intracellular glucose homeostasis
A	0004340	molecular_function	glucokinase activity
A	0004396	molecular_function	hexokinase activity
A	0005524	molecular_function	ATP binding
A	0005536	molecular_function	D-glucose binding
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0005975	biological_process	carbohydrate metabolic process
A	0006006	biological_process	glucose metabolic process
A	0006096	biological_process	glycolytic process
A	0008865	molecular_function	fructokinase activity
A	0009707	cellular_component	chloroplast outer membrane
A	0009749	biological_process	response to glucose
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
A	0019318	biological_process	hexose metabolic process
A	0046835	biological_process	carbohydrate phosphorylation
A	0051156	biological_process	glucose 6-phosphate metabolic process
B	0000166	molecular_function	nucleotide binding
B	0001678	biological_process	intracellular glucose homeostasis
B	0004340	molecular_function	glucokinase activity
B	0004396	molecular_function	hexokinase activity
B	0005524	molecular_function	ATP binding
B	0005536	molecular_function	D-glucose binding
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0005975	biological_process	carbohydrate metabolic process
B	0006006	biological_process	glucose metabolic process
B	0006096	biological_process	glycolytic process
B	0008865	molecular_function	fructokinase activity
B	0009707	cellular_component	chloroplast outer membrane
B	0009749	biological_process	response to glucose
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
B	0019318	biological_process	hexose metabolic process
B	0046835	biological_process	carbohydrate phosphorylation
B	0051156	biological_process	glucose 6-phosphate metabolic process
C	0000166	molecular_function	nucleotide binding
C	0001678	biological_process	intracellular glucose homeostasis
C	0004340	molecular_function	glucokinase activity
C	0004396	molecular_function	hexokinase activity
C	0005524	molecular_function	ATP binding
C	0005536	molecular_function	D-glucose binding
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0005975	biological_process	carbohydrate metabolic process
C	0006006	biological_process	glucose metabolic process
C	0006096	biological_process	glycolytic process
C	0008865	molecular_function	fructokinase activity
C	0009707	cellular_component	chloroplast outer membrane
C	0009749	biological_process	response to glucose
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
C	0019318	biological_process	hexose metabolic process
C	0046835	biological_process	carbohydrate phosphorylation
C	0051156	biological_process	glucose 6-phosphate metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue ADP C 601

Chain	Residue
C	GLY112
C	GLY450
C	GLY451
C	LEU452
C	HIS455
C	PO4602
C	MG603
C	THR113
C	ASN114
C	GLY260
C	THR261
C	GLY328
C	THR365
C	PRO366
C	SER369

site_id	AC2
Number of Residues	7
Details	binding site for residue PO4 C 602

Chain	Residue
C	ASP109
C	SER185
C	ASP238
C	ASP449
C	ASP486
C	SER488
C	ADP601

site_id	AC3
Number of Residues	3
Details	binding site for residue MG C 603

Chain	Residue
C	GLU136
C	ASP486
C	ADP601

site_id	AC4
Number of Residues	13
Details	binding site for residue ADP A 601

Chain	Residue
A	GLY112
A	THR113
A	ASN114
A	THR261
A	GLY328
A	PRO366
A	SER369
A	GLY450
A	GLY451
A	LEU452
A	HIS455
A	PO4602
A	MG603

site_id	AC5
Number of Residues	7
Details	binding site for residue PO4 A 602

Chain	Residue
A	ASP109
A	SER185
A	ASP238
A	ASP449
A	ASP486
A	SER488
A	ADP601

site_id	AC6
Number of Residues	3
Details	binding site for residue MG A 603

Chain	Residue
A	GLU136
A	ASP486
A	ADP601

site_id	AC7
Number of Residues	13
Details	binding site for residue ADP B 601

Chain	Residue
B	GLY112
B	THR113
B	ASN114
B	GLY260
B	THR261
B	GLY328
B	SER369
B	GLY450
B	GLY451
B	LEU452
B	HIS455
B	PO4602
B	MG603

site_id	AC8
Number of Residues	7
Details	binding site for residue PO4 B 602

Chain	Residue
B	ASP109
B	SER185
B	ASP238
B	ASP449
B	ASP486
B	SER488
B	ADP601

site_id	AC9
Number of Residues	2
Details	binding site for residue MG B 603

Chain	Residue
B	ASP486
B	ADP601

Functional Information from PROSITE/UniProt

site_id	PS00378
Number of Residues	26
Details	HEXOKINASE_1 Hexokinase domain signature. LGFTFSFPvhqtsISsgtLikWTKgF

Chain	Residue	Details
C	LEU180-PHE205

site_id	PS00782
Number of Residues	16
Details	TFIIB Transcription factor TFIIB repeat signature. GRyvdNDVAAAVILGT

Chain	Residue	Details
C	GLY246-THR261

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1362
Details	Domain: {"description":"Hexokinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU01084","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	414
Details	Region: {"description":"Hexokinase small subdomain","evidences":[{"source":"PROSITE-ProRule","id":"PRU01084","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	747
Details	Region: {"description":"Hexokinase large subdomain","evidences":[{"source":"PROSITE-ProRule","id":"PRU01084","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31176485","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6JJ8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JJ9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31176485","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6JJ8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	21
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31176485","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"APR-2018","submissionDatabase":"PDB data bank","title":"Crystal structure of Oryza sativa hexokinase 6.","authors":["Matsudaira K.","Mochizuki S.","Yoshida H.","Kamitori S.","Akimitsu K."]}},{"source":"PDB","id":"5ZQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JJ7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)