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6JIY

Structure of RyR2 (F/A/C/H-Ca2+/Ca2+CaM dataset)

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0005216molecular_functionmonoatomic ion channel activity
A0005219molecular_functionryanodine-sensitive calcium-release channel activity
A0005262molecular_functioncalcium channel activity
A0005509molecular_functioncalcium ion binding
A0006811biological_processmonoatomic ion transport
A0006816biological_processcalcium ion transport
A0006874biological_processintracellular calcium ion homeostasis
A0016020cellular_componentmembrane
A0055085biological_processtransmembrane transport
A0070588biological_processcalcium ion transmembrane transport
B0000413biological_processprotein peptidyl-prolyl isomerization
B0002027biological_processregulation of heart rate
B0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
B0005102molecular_functionsignaling receptor binding
B0005219molecular_functionryanodine-sensitive calcium-release channel activity
B0005515molecular_functionprotein binding
B0005528molecular_functionFK506 binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006458biological_process'de novo' protein folding
B0006939biological_processsmooth muscle contraction
B0007204biological_processpositive regulation of cytosolic calcium ion concentration
B0009749biological_processresponse to glucose
B0010033biological_processresponse to organic substance
B0010459biological_processnegative regulation of heart rate
B0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
B0016020cellular_componentmembrane
B0016529cellular_componentsarcoplasmic reticulum
B0016853molecular_functionisomerase activity
B0019227biological_processneuronal action potential propagation
B0019855molecular_functioncalcium channel inhibitor activity
B0022417biological_processprotein maturation by protein folding
B0030018cellular_componentZ disc
B0030073biological_processinsulin secretion
B0030551molecular_functioncyclic nucleotide binding
B0032515biological_processnegative regulation of phosphoprotein phosphatase activity
B0033017cellular_componentsarcoplasmic reticulum membrane
B0033197biological_processresponse to vitamin E
B0034704cellular_componentcalcium channel complex
B0035584biological_processcalcium-mediated signaling using intracellular calcium source
B0035773biological_processinsulin secretion involved in cellular response to glucose stimulus
B0042026biological_processprotein refolding
B0042098biological_processT cell proliferation
B0042542biological_processresponse to hydrogen peroxide
B0044325molecular_functiontransmembrane transporter binding
B0048680biological_processpositive regulation of axon regeneration
B0051209biological_processrelease of sequestered calcium ion into cytosol
B0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
B0051284biological_processpositive regulation of sequestering of calcium ion
B0051480biological_processregulation of cytosolic calcium ion concentration
B0051775biological_processresponse to redox state
B0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
B0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
B0061179biological_processnegative regulation of insulin secretion involved in cellular response to glucose stimulus
B0086064biological_processcell communication by electrical coupling involved in cardiac conduction
C0000086biological_processG2/M transition of mitotic cell cycle
C0000922cellular_componentspindle pole
C0002027biological_processregulation of heart rate
C0005509molecular_functioncalcium ion binding
C0005513biological_processdetection of calcium ion
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005813cellular_componentcentrosome
C0005819cellular_componentspindle
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005876cellular_componentspindle microtubule
C0005886cellular_componentplasma membrane
C0005929cellular_componentcilium
C0007186biological_processG protein-coupled receptor signaling pathway
C0008076cellular_componentvoltage-gated potassium channel complex
C0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
C0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
C0010856molecular_functionadenylate cyclase activator activity
C0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
C0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
C0016020cellular_componentmembrane
C0016240biological_processautophagosome membrane docking
C0019855molecular_functioncalcium channel inhibitor activity
C0019901molecular_functionprotein kinase binding
C0021762biological_processsubstantia nigra development
C0030017cellular_componentsarcomere
C0030234molecular_functionenzyme regulator activity
C0031432molecular_functiontitin binding
C0031514cellular_componentmotile cilium
C0031954biological_processpositive regulation of protein autophosphorylation
C0031982cellular_componentvesicle
C0032465biological_processregulation of cytokinesis
C0032516biological_processpositive regulation of phosphoprotein phosphatase activity
C0032991cellular_componentprotein-containing complex
C0034704cellular_componentcalcium channel complex
C0035307biological_processpositive regulation of protein dephosphorylation
C0035458biological_processcellular response to interferon-beta
C0042995cellular_componentcell projection
C0043209cellular_componentmyelin sheath
C0043539molecular_functionprotein serine/threonine kinase activator activity
C0044325molecular_functiontransmembrane transporter binding
C0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
C0046872molecular_functionmetal ion binding
C0048306molecular_functioncalcium-dependent protein binding
C0050848biological_processregulation of calcium-mediated signaling
C0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
C0051592biological_processresponse to calcium ion
C0055117biological_processregulation of cardiac muscle contraction
C0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
C0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
C0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
C0071346biological_processcellular response to type II interferon
C0071902biological_processpositive regulation of protein serine/threonine kinase activity
C0072542molecular_functionprotein phosphatase activator activity
C0097225cellular_componentsperm midpiece
C0098901biological_processregulation of cardiac muscle cell action potential
C0140056biological_processorganelle localization by membrane tethering
C1901842biological_processnegative regulation of high voltage-gated calcium channel activity
C1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
C1902494cellular_componentcatalytic complex
C1905913biological_processnegative regulation of calcium ion export across plasma membrane
C1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
D0005216molecular_functionmonoatomic ion channel activity
D0005219molecular_functionryanodine-sensitive calcium-release channel activity
D0005262molecular_functioncalcium channel activity
D0005509molecular_functioncalcium ion binding
D0006811biological_processmonoatomic ion transport
D0006816biological_processcalcium ion transport
D0006874biological_processintracellular calcium ion homeostasis
D0016020cellular_componentmembrane
D0055085biological_processtransmembrane transport
D0070588biological_processcalcium ion transmembrane transport
E0000413biological_processprotein peptidyl-prolyl isomerization
E0002027biological_processregulation of heart rate
E0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
E0005102molecular_functionsignaling receptor binding
E0005219molecular_functionryanodine-sensitive calcium-release channel activity
E0005515molecular_functionprotein binding
E0005528molecular_functionFK506 binding
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0006458biological_process'de novo' protein folding
E0006939biological_processsmooth muscle contraction
E0007204biological_processpositive regulation of cytosolic calcium ion concentration
E0009749biological_processresponse to glucose
E0010033biological_processresponse to organic substance
E0010459biological_processnegative regulation of heart rate
E0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
E0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
E0016020cellular_componentmembrane
E0016529cellular_componentsarcoplasmic reticulum
E0016853molecular_functionisomerase activity
E0019227biological_processneuronal action potential propagation
E0019855molecular_functioncalcium channel inhibitor activity
E0022417biological_processprotein maturation by protein folding
E0030018cellular_componentZ disc
E0030073biological_processinsulin secretion
E0030551molecular_functioncyclic nucleotide binding
E0032515biological_processnegative regulation of phosphoprotein phosphatase activity
E0033017cellular_componentsarcoplasmic reticulum membrane
E0033197biological_processresponse to vitamin E
E0034704cellular_componentcalcium channel complex
E0035584biological_processcalcium-mediated signaling using intracellular calcium source
E0035773biological_processinsulin secretion involved in cellular response to glucose stimulus
E0042026biological_processprotein refolding
E0042098biological_processT cell proliferation
E0042542biological_processresponse to hydrogen peroxide
E0044325molecular_functiontransmembrane transporter binding
E0048680biological_processpositive regulation of axon regeneration
E0051209biological_processrelease of sequestered calcium ion into cytosol
E0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
E0051284biological_processpositive regulation of sequestering of calcium ion
E0051480biological_processregulation of cytosolic calcium ion concentration
E0051775biological_processresponse to redox state
E0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
E0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
E0061179biological_processnegative regulation of insulin secretion involved in cellular response to glucose stimulus
E0086064biological_processcell communication by electrical coupling involved in cardiac conduction
F0000086biological_processG2/M transition of mitotic cell cycle
F0000922cellular_componentspindle pole
F0002027biological_processregulation of heart rate
F0005509molecular_functioncalcium ion binding
F0005513biological_processdetection of calcium ion
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005813cellular_componentcentrosome
F0005819cellular_componentspindle
F0005829cellular_componentcytosol
F0005856cellular_componentcytoskeleton
F0005876cellular_componentspindle microtubule
F0005886cellular_componentplasma membrane
F0005929cellular_componentcilium
F0007186biological_processG protein-coupled receptor signaling pathway
F0008076cellular_componentvoltage-gated potassium channel complex
F0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
F0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
F0010856molecular_functionadenylate cyclase activator activity
F0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
F0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
F0016020cellular_componentmembrane
F0016240biological_processautophagosome membrane docking
F0019855molecular_functioncalcium channel inhibitor activity
F0019901molecular_functionprotein kinase binding
F0021762biological_processsubstantia nigra development
F0030017cellular_componentsarcomere
F0030234molecular_functionenzyme regulator activity
F0031432molecular_functiontitin binding
F0031514cellular_componentmotile cilium
F0031954biological_processpositive regulation of protein autophosphorylation
F0031982cellular_componentvesicle
F0032465biological_processregulation of cytokinesis
F0032516biological_processpositive regulation of phosphoprotein phosphatase activity
F0032991cellular_componentprotein-containing complex
F0034704cellular_componentcalcium channel complex
F0035307biological_processpositive regulation of protein dephosphorylation
F0035458biological_processcellular response to interferon-beta
F0042995cellular_componentcell projection
F0043209cellular_componentmyelin sheath
F0043539molecular_functionprotein serine/threonine kinase activator activity
F0044325molecular_functiontransmembrane transporter binding
F0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
F0046872molecular_functionmetal ion binding
F0048306molecular_functioncalcium-dependent protein binding
F0050848biological_processregulation of calcium-mediated signaling
F0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
F0051592biological_processresponse to calcium ion
F0055117biological_processregulation of cardiac muscle contraction
F0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
F0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
F0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
F0071346biological_processcellular response to type II interferon
F0071902biological_processpositive regulation of protein serine/threonine kinase activity
F0072542molecular_functionprotein phosphatase activator activity
F0097225cellular_componentsperm midpiece
F0098901biological_processregulation of cardiac muscle cell action potential
F0140056biological_processorganelle localization by membrane tethering
F1901842biological_processnegative regulation of high voltage-gated calcium channel activity
F1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
F1902494cellular_componentcatalytic complex
F1905913biological_processnegative regulation of calcium ion export across plasma membrane
F1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
G0005216molecular_functionmonoatomic ion channel activity
G0005219molecular_functionryanodine-sensitive calcium-release channel activity
G0005262molecular_functioncalcium channel activity
G0005509molecular_functioncalcium ion binding
G0006811biological_processmonoatomic ion transport
G0006816biological_processcalcium ion transport
G0006874biological_processintracellular calcium ion homeostasis
G0016020cellular_componentmembrane
G0055085biological_processtransmembrane transport
G0070588biological_processcalcium ion transmembrane transport
H0000413biological_processprotein peptidyl-prolyl isomerization
H0002027biological_processregulation of heart rate
H0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
H0005102molecular_functionsignaling receptor binding
H0005219molecular_functionryanodine-sensitive calcium-release channel activity
H0005515molecular_functionprotein binding
H0005528molecular_functionFK506 binding
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0006458biological_process'de novo' protein folding
H0006939biological_processsmooth muscle contraction
H0007204biological_processpositive regulation of cytosolic calcium ion concentration
H0009749biological_processresponse to glucose
H0010033biological_processresponse to organic substance
H0010459biological_processnegative regulation of heart rate
H0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
H0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
H0016020cellular_componentmembrane
H0016529cellular_componentsarcoplasmic reticulum
H0016853molecular_functionisomerase activity
H0019227biological_processneuronal action potential propagation
H0019855molecular_functioncalcium channel inhibitor activity
H0022417biological_processprotein maturation by protein folding
H0030018cellular_componentZ disc
H0030073biological_processinsulin secretion
H0030551molecular_functioncyclic nucleotide binding
H0032515biological_processnegative regulation of phosphoprotein phosphatase activity
H0033017cellular_componentsarcoplasmic reticulum membrane
H0033197biological_processresponse to vitamin E
H0034704cellular_componentcalcium channel complex
H0035584biological_processcalcium-mediated signaling using intracellular calcium source
H0035773biological_processinsulin secretion involved in cellular response to glucose stimulus
H0042026biological_processprotein refolding
H0042098biological_processT cell proliferation
H0042542biological_processresponse to hydrogen peroxide
H0044325molecular_functiontransmembrane transporter binding
H0048680biological_processpositive regulation of axon regeneration
H0051209biological_processrelease of sequestered calcium ion into cytosol
H0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
H0051284biological_processpositive regulation of sequestering of calcium ion
H0051480biological_processregulation of cytosolic calcium ion concentration
H0051775biological_processresponse to redox state
H0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
H0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
H0061179biological_processnegative regulation of insulin secretion involved in cellular response to glucose stimulus
H0086064biological_processcell communication by electrical coupling involved in cardiac conduction
I0000086biological_processG2/M transition of mitotic cell cycle
I0000922cellular_componentspindle pole
I0002027biological_processregulation of heart rate
I0005509molecular_functioncalcium ion binding
I0005513biological_processdetection of calcium ion
I0005515molecular_functionprotein binding
I0005576cellular_componentextracellular region
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005737cellular_componentcytoplasm
I0005813cellular_componentcentrosome
I0005819cellular_componentspindle
I0005829cellular_componentcytosol
I0005856cellular_componentcytoskeleton
I0005876cellular_componentspindle microtubule
I0005886cellular_componentplasma membrane
I0005929cellular_componentcilium
I0007186biological_processG protein-coupled receptor signaling pathway
I0008076cellular_componentvoltage-gated potassium channel complex
I0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
I0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
I0010856molecular_functionadenylate cyclase activator activity
I0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
I0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
I0016020cellular_componentmembrane
I0016240biological_processautophagosome membrane docking
I0019855molecular_functioncalcium channel inhibitor activity
I0019901molecular_functionprotein kinase binding
I0021762biological_processsubstantia nigra development
I0030017cellular_componentsarcomere
I0030234molecular_functionenzyme regulator activity
I0031432molecular_functiontitin binding
I0031514cellular_componentmotile cilium
I0031954biological_processpositive regulation of protein autophosphorylation
I0031982cellular_componentvesicle
I0032465biological_processregulation of cytokinesis
I0032516biological_processpositive regulation of phosphoprotein phosphatase activity
I0032991cellular_componentprotein-containing complex
I0034704cellular_componentcalcium channel complex
I0035307biological_processpositive regulation of protein dephosphorylation
I0035458biological_processcellular response to interferon-beta
I0042995cellular_componentcell projection
I0043209cellular_componentmyelin sheath
I0043539molecular_functionprotein serine/threonine kinase activator activity
I0044325molecular_functiontransmembrane transporter binding
I0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
I0046872molecular_functionmetal ion binding
I0048306molecular_functioncalcium-dependent protein binding
I0050848biological_processregulation of calcium-mediated signaling
I0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
I0051592biological_processresponse to calcium ion
I0055117biological_processregulation of cardiac muscle contraction
I0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
I0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
I0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
I0071346biological_processcellular response to type II interferon
I0071902biological_processpositive regulation of protein serine/threonine kinase activity
I0072542molecular_functionprotein phosphatase activator activity
I0097225cellular_componentsperm midpiece
I0098901biological_processregulation of cardiac muscle cell action potential
I0140056biological_processorganelle localization by membrane tethering
I1901842biological_processnegative regulation of high voltage-gated calcium channel activity
I1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
I1902494cellular_componentcatalytic complex
I1905913biological_processnegative regulation of calcium ion export across plasma membrane
I1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
J0005216molecular_functionmonoatomic ion channel activity
J0005219molecular_functionryanodine-sensitive calcium-release channel activity
J0005262molecular_functioncalcium channel activity
J0005509molecular_functioncalcium ion binding
J0006811biological_processmonoatomic ion transport
J0006816biological_processcalcium ion transport
J0006874biological_processintracellular calcium ion homeostasis
J0016020cellular_componentmembrane
J0055085biological_processtransmembrane transport
J0070588biological_processcalcium ion transmembrane transport
K0000413biological_processprotein peptidyl-prolyl isomerization
K0002027biological_processregulation of heart rate
K0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
K0005102molecular_functionsignaling receptor binding
K0005219molecular_functionryanodine-sensitive calcium-release channel activity
K0005515molecular_functionprotein binding
K0005528molecular_functionFK506 binding
K0005737cellular_componentcytoplasm
K0005829cellular_componentcytosol
K0006458biological_process'de novo' protein folding
K0006939biological_processsmooth muscle contraction
K0007204biological_processpositive regulation of cytosolic calcium ion concentration
K0009749biological_processresponse to glucose
K0010033biological_processresponse to organic substance
K0010459biological_processnegative regulation of heart rate
K0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
K0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
K0016020cellular_componentmembrane
K0016529cellular_componentsarcoplasmic reticulum
K0016853molecular_functionisomerase activity
K0019227biological_processneuronal action potential propagation
K0019855molecular_functioncalcium channel inhibitor activity
K0022417biological_processprotein maturation by protein folding
K0030018cellular_componentZ disc
K0030073biological_processinsulin secretion
K0030551molecular_functioncyclic nucleotide binding
K0032515biological_processnegative regulation of phosphoprotein phosphatase activity
K0033017cellular_componentsarcoplasmic reticulum membrane
K0033197biological_processresponse to vitamin E
K0034704cellular_componentcalcium channel complex
K0035584biological_processcalcium-mediated signaling using intracellular calcium source
K0035773biological_processinsulin secretion involved in cellular response to glucose stimulus
K0042026biological_processprotein refolding
K0042098biological_processT cell proliferation
K0042542biological_processresponse to hydrogen peroxide
K0044325molecular_functiontransmembrane transporter binding
K0048680biological_processpositive regulation of axon regeneration
K0051209biological_processrelease of sequestered calcium ion into cytosol
K0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
K0051284biological_processpositive regulation of sequestering of calcium ion
K0051480biological_processregulation of cytosolic calcium ion concentration
K0051775biological_processresponse to redox state
K0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
K0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
K0061179biological_processnegative regulation of insulin secretion involved in cellular response to glucose stimulus
K0086064biological_processcell communication by electrical coupling involved in cardiac conduction
L0000086biological_processG2/M transition of mitotic cell cycle
L0000922cellular_componentspindle pole
L0002027biological_processregulation of heart rate
L0005509molecular_functioncalcium ion binding
L0005513biological_processdetection of calcium ion
L0005515molecular_functionprotein binding
L0005576cellular_componentextracellular region
L0005634cellular_componentnucleus
L0005654cellular_componentnucleoplasm
L0005737cellular_componentcytoplasm
L0005813cellular_componentcentrosome
L0005819cellular_componentspindle
L0005829cellular_componentcytosol
L0005856cellular_componentcytoskeleton
L0005876cellular_componentspindle microtubule
L0005886cellular_componentplasma membrane
L0005929cellular_componentcilium
L0007186biological_processG protein-coupled receptor signaling pathway
L0008076cellular_componentvoltage-gated potassium channel complex
L0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
L0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
L0010856molecular_functionadenylate cyclase activator activity
L0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
L0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
L0016020cellular_componentmembrane
L0016240biological_processautophagosome membrane docking
L0019855molecular_functioncalcium channel inhibitor activity
L0019901molecular_functionprotein kinase binding
L0021762biological_processsubstantia nigra development
L0030017cellular_componentsarcomere
L0030234molecular_functionenzyme regulator activity
L0031432molecular_functiontitin binding
L0031514cellular_componentmotile cilium
L0031954biological_processpositive regulation of protein autophosphorylation
L0031982cellular_componentvesicle
L0032465biological_processregulation of cytokinesis
L0032516biological_processpositive regulation of phosphoprotein phosphatase activity
L0032991cellular_componentprotein-containing complex
L0034704cellular_componentcalcium channel complex
L0035307biological_processpositive regulation of protein dephosphorylation
L0035458biological_processcellular response to interferon-beta
L0042995cellular_componentcell projection
L0043209cellular_componentmyelin sheath
L0043539molecular_functionprotein serine/threonine kinase activator activity
L0044325molecular_functiontransmembrane transporter binding
L0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
L0046872molecular_functionmetal ion binding
L0048306molecular_functioncalcium-dependent protein binding
L0050848biological_processregulation of calcium-mediated signaling
L0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
L0051592biological_processresponse to calcium ion
L0055117biological_processregulation of cardiac muscle contraction
L0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
L0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
L0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
L0071346biological_processcellular response to type II interferon
L0071902biological_processpositive regulation of protein serine/threonine kinase activity
L0072542molecular_functionprotein phosphatase activator activity
L0097225cellular_componentsperm midpiece
L0098901biological_processregulation of cardiac muscle cell action potential
L0140056biological_processorganelle localization by membrane tethering
L1901842biological_processnegative regulation of high voltage-gated calcium channel activity
L1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
L1902494cellular_componentcatalytic complex
L1905913biological_processnegative regulation of calcium ion export across plasma membrane
L1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue ZN A 6000
ChainResidue
ACYS4889
ACYS4892
AHIS4909
AHIS4914

site_idAC2
Number of Residues3
Detailsbinding site for residue CA A 6001
ChainResidue
AGLU3849
AGLU3923
ATHR4932

site_idAC3
Number of Residues8
Detailsbinding site for residue ATP A 6002
ChainResidue
AARG4171
AMET4885
ACYS4889
APHE4890
ATHR4910
ALEU4916
ALYS4167
ALYS4170

site_idAC4
Number of Residues4
Detailsbinding site for residue CFF A 6003
ChainResidue
ATRP4646
AILE4927
ATRP4942
ATYR4945

site_idAC5
Number of Residues6
Detailsbinding site for residue CA C 201
ChainResidue
CASP21
CASP23
CTHR27
CILE28
CTHR29
CGLU32

site_idAC6
Number of Residues5
Detailsbinding site for residue CA C 202
ChainResidue
CASP59
CASN61
CTHR63
CILE64
CASP65

site_idAC7
Number of Residues4
Detailsbinding site for residue CA C 204
ChainResidue
CASP130
CILE131
CASP134
CASN138

site_idAC8
Number of Residues4
Detailsbinding site for residue ZN D 6000
ChainResidue
DCYS4889
DCYS4892
DHIS4909
DHIS4914

site_idAC9
Number of Residues3
Detailsbinding site for residue CA D 6001
ChainResidue
DGLU3849
DGLU3923
DTHR4932

site_idAD1
Number of Residues8
Detailsbinding site for residue ATP D 6002
ChainResidue
DLYS4167
DLYS4170
DARG4171
DMET4885
DCYS4889
DPHE4890
DTHR4910
DLEU4916

site_idAD2
Number of Residues4
Detailsbinding site for residue CFF D 6003
ChainResidue
DTRP4646
DILE4927
DTRP4942
DTYR4945

site_idAD3
Number of Residues6
Detailsbinding site for residue CA F 201
ChainResidue
FASP21
FASP23
FTHR27
FILE28
FTHR29
FGLU32

site_idAD4
Number of Residues5
Detailsbinding site for residue CA F 202
ChainResidue
FASP59
FASN61
FTHR63
FILE64
FASP65

site_idAD5
Number of Residues4
Detailsbinding site for residue CA F 204
ChainResidue
FASP130
FILE131
FASP134
FASN138

site_idAD6
Number of Residues4
Detailsbinding site for residue ZN G 6000
ChainResidue
GCYS4889
GCYS4892
GHIS4909
GHIS4914

site_idAD7
Number of Residues3
Detailsbinding site for residue CA G 6001
ChainResidue
GGLU3849
GGLU3923
GTHR4932

site_idAD8
Number of Residues8
Detailsbinding site for residue ATP G 6002
ChainResidue
GLYS4167
GLYS4170
GARG4171
GMET4885
GCYS4889
GPHE4890
GTHR4910
GLEU4916

site_idAD9
Number of Residues4
Detailsbinding site for residue CFF G 6003
ChainResidue
GTRP4646
GILE4927
GTRP4942
GTYR4945

site_idAE1
Number of Residues6
Detailsbinding site for residue CA I 201
ChainResidue
IASP21
IASP23
ITHR27
IILE28
ITHR29
IGLU32

site_idAE2
Number of Residues5
Detailsbinding site for residue CA I 202
ChainResidue
IASP59
IASN61
ITHR63
IILE64
IASP65

site_idAE3
Number of Residues4
Detailsbinding site for residue CA I 204
ChainResidue
IILE131
IASP134
IASN138
IASP130

site_idAE4
Number of Residues4
Detailsbinding site for residue ZN J 6000
ChainResidue
JCYS4889
JCYS4892
JHIS4909
JHIS4914

site_idAE5
Number of Residues3
Detailsbinding site for residue CA J 6001
ChainResidue
JGLU3849
JGLU3923
JTHR4932

site_idAE6
Number of Residues8
Detailsbinding site for residue ATP J 6002
ChainResidue
JLYS4167
JLYS4170
JARG4171
JMET4885
JCYS4889
JPHE4890
JTHR4910
JLEU4916

site_idAE7
Number of Residues4
Detailsbinding site for residue CFF J 6003
ChainResidue
JTRP4646
JILE4927
JTRP4942
JTYR4945

site_idAE8
Number of Residues6
Detailsbinding site for residue CA L 201
ChainResidue
LASP21
LASP23
LTHR27
LILE28
LTHR29
LGLU32

site_idAE9
Number of Residues5
Detailsbinding site for residue CA L 202
ChainResidue
LASP59
LASN61
LTHR63
LILE64
LASP65

site_idAF1
Number of Residues4
Detailsbinding site for residue CA L 204
ChainResidue
LASP130
LILE131
LASP134
LASN138

Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL
ChainResidueDetails
CASP21-LEU33
CASP57-PHE69
CASP94-LEU106
CASP130-PHE142

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues40
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:25441029, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:4UMO, ECO:0007744|PDB:4V0C, ECO:0007744|PDB:5J03
ChainResidueDetails
CGLU32
CASP21
CASP23
CASP25
CTHR27
IASP21
IASP23
IASP25
ITHR27
IGLU32
IASP57
IASP59
IASN61
ITHR63
IGLU68
LASP21
LASP23
LASP25
LTHR27
LGLU32
LASP57
LASP59
LASN61
LTHR63
LGLU68
CASP57
CASP59
CASN61
CTHR63
CGLU68
FASP21
FASP23
FASP25
FTHR27
FGLU32
FASP57
FASP59
FASN61
FTHR63
FGLU68

site_idSWS_FT_FI2
Number of Residues40
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:5J03
ChainResidueDetails
IASP94
IASP96
IASN98
ITYR100
IGLU105
IASP130
IASP132
IASP134
IGLN136
IGLU141
LASP94
LASP96
LASN98
LTYR100
LGLU105
LASP130
LASP132
LASP134
LGLN136
LGLU141
CASP94
CASP96
CASN98
CTYR100
CGLU105
CASP130
CASP132
CASP134
CGLN136
CGLU141
FASP94
FASP96
FASN98
FTYR100
FGLU105
FASP130
FASP132
FASP134
FGLN136
FGLU141

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: N-acetylalanine => ECO:0000269|PubMed:7093203, ECO:0000269|Ref.7, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712
ChainResidueDetails
CALA2
FALA2
IALA2
LALA2

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861
ChainResidueDetails
CLYS22
FLYS22
ILYS22
LLYS22

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: Phosphothreonine; by CaMK4 => ECO:0000250|UniProtKB:P0DP29
ChainResidueDetails
CTHR45
FTHR45
ITHR45
LTHR45

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
CSER82
FSER82
ISER82
LSER82

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
CLYS95
FLYS95
ILYS95
LLYS95

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332
ChainResidueDetails
CTYR100
FTYR100
ITYR100
LTYR100

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
CSER102
FSER102
ISER102
LSER102

site_idSWS_FT_FI10
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569
ChainResidueDetails
CTHR111
FTHR111
ITHR111
LTHR111

site_idSWS_FT_FI11
Number of Residues4
DetailsMOD_RES: N6-methyllysine; alternate => ECO:0007744|PubMed:24129315
ChainResidueDetails
CLYS116
FLYS116
ILYS116
LLYS116

site_idSWS_FT_FI12
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332
ChainResidueDetails
CTYR139
FTYR139
ITYR139
LTYR139

site_idSWS_FT_FI13
Number of Residues8
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62157
ChainResidueDetails
ILYS22
LLYS22
CLYS22
FLYS22

218500

PDB entries from 2024-04-17

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