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6JH6

Structure of RyR2 (F/A/Ca2+ dataset)

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0002027biological_processregulation of heart rate
A0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
A0005102molecular_functionsignaling receptor binding
A0005219molecular_functionryanodine-sensitive calcium-release channel activity
A0005515molecular_functionprotein binding
A0005528molecular_functionFK506 binding
A0005737cellular_componentcytoplasm
A0006458biological_process'de novo' protein folding
A0006939biological_processsmooth muscle contraction
A0007204biological_processpositive regulation of cytosolic calcium ion concentration
A0009749biological_processresponse to glucose
A0010459biological_processnegative regulation of heart rate
A0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
A0016020cellular_componentmembrane
A0016247molecular_functionchannel regulator activity
A0016529cellular_componentsarcoplasmic reticulum
A0019227biological_processneuronal action potential propagation
A0019722biological_processcalcium-mediated signaling
A0019855molecular_functioncalcium channel inhibitor activity
A0022417biological_processprotein maturation by protein folding
A0030018cellular_componentZ disc
A0030073biological_processinsulin secretion
A0030551molecular_functioncyclic nucleotide binding
A0033017cellular_componentsarcoplasmic reticulum membrane
A0033197biological_processresponse to vitamin E
A0034704cellular_componentcalcium channel complex
A0035773biological_processinsulin secretion involved in cellular response to glucose stimulus
A0042026biological_processprotein refolding
A0042098biological_processT cell proliferation
A0042542biological_processresponse to hydrogen peroxide
A0044325molecular_functiontransmembrane transporter binding
A0048680biological_processpositive regulation of axon regeneration
A0050849biological_processnegative regulation of calcium-mediated signaling
A0051209biological_processrelease of sequestered calcium ion into cytosol
A0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
A0051284biological_processpositive regulation of sequestering of calcium ion
A0051775biological_processresponse to redox state
A0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
A0061179biological_processnegative regulation of insulin secretion involved in cellular response to glucose stimulus
B0005216molecular_functionmonoatomic ion channel activity
B0005219molecular_functionryanodine-sensitive calcium-release channel activity
B0005262molecular_functioncalcium channel activity
B0005509molecular_functioncalcium ion binding
B0006811biological_processmonoatomic ion transport
B0006816biological_processcalcium ion transport
B0006874biological_processintracellular calcium ion homeostasis
B0016020cellular_componentmembrane
B0055085biological_processtransmembrane transport
B0070588biological_processcalcium ion transmembrane transport
C0002027biological_processregulation of heart rate
C0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
C0005102molecular_functionsignaling receptor binding
C0005219molecular_functionryanodine-sensitive calcium-release channel activity
C0005515molecular_functionprotein binding
C0005528molecular_functionFK506 binding
C0005737cellular_componentcytoplasm
C0006458biological_process'de novo' protein folding
C0006939biological_processsmooth muscle contraction
C0007204biological_processpositive regulation of cytosolic calcium ion concentration
C0009749biological_processresponse to glucose
C0010459biological_processnegative regulation of heart rate
C0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
C0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
C0016020cellular_componentmembrane
C0016247molecular_functionchannel regulator activity
C0016529cellular_componentsarcoplasmic reticulum
C0019227biological_processneuronal action potential propagation
C0019722biological_processcalcium-mediated signaling
C0019855molecular_functioncalcium channel inhibitor activity
C0022417biological_processprotein maturation by protein folding
C0030018cellular_componentZ disc
C0030073biological_processinsulin secretion
C0030551molecular_functioncyclic nucleotide binding
C0033017cellular_componentsarcoplasmic reticulum membrane
C0033197biological_processresponse to vitamin E
C0034704cellular_componentcalcium channel complex
C0035773biological_processinsulin secretion involved in cellular response to glucose stimulus
C0042026biological_processprotein refolding
C0042098biological_processT cell proliferation
C0042542biological_processresponse to hydrogen peroxide
C0044325molecular_functiontransmembrane transporter binding
C0048680biological_processpositive regulation of axon regeneration
C0050849biological_processnegative regulation of calcium-mediated signaling
C0051209biological_processrelease of sequestered calcium ion into cytosol
C0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
C0051284biological_processpositive regulation of sequestering of calcium ion
C0051775biological_processresponse to redox state
C0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
C0061179biological_processnegative regulation of insulin secretion involved in cellular response to glucose stimulus
D0005216molecular_functionmonoatomic ion channel activity
D0005219molecular_functionryanodine-sensitive calcium-release channel activity
D0005262molecular_functioncalcium channel activity
D0005509molecular_functioncalcium ion binding
D0006811biological_processmonoatomic ion transport
D0006816biological_processcalcium ion transport
D0006874biological_processintracellular calcium ion homeostasis
D0016020cellular_componentmembrane
D0055085biological_processtransmembrane transport
D0070588biological_processcalcium ion transmembrane transport
E0002027biological_processregulation of heart rate
E0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
E0005102molecular_functionsignaling receptor binding
E0005219molecular_functionryanodine-sensitive calcium-release channel activity
E0005515molecular_functionprotein binding
E0005528molecular_functionFK506 binding
E0005737cellular_componentcytoplasm
E0006458biological_process'de novo' protein folding
E0006939biological_processsmooth muscle contraction
E0007204biological_processpositive regulation of cytosolic calcium ion concentration
E0009749biological_processresponse to glucose
E0010459biological_processnegative regulation of heart rate
E0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
E0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
E0016020cellular_componentmembrane
E0016247molecular_functionchannel regulator activity
E0016529cellular_componentsarcoplasmic reticulum
E0019227biological_processneuronal action potential propagation
E0019722biological_processcalcium-mediated signaling
E0019855molecular_functioncalcium channel inhibitor activity
E0022417biological_processprotein maturation by protein folding
E0030018cellular_componentZ disc
E0030073biological_processinsulin secretion
E0030551molecular_functioncyclic nucleotide binding
E0033017cellular_componentsarcoplasmic reticulum membrane
E0033197biological_processresponse to vitamin E
E0034704cellular_componentcalcium channel complex
E0035773biological_processinsulin secretion involved in cellular response to glucose stimulus
E0042026biological_processprotein refolding
E0042098biological_processT cell proliferation
E0042542biological_processresponse to hydrogen peroxide
E0044325molecular_functiontransmembrane transporter binding
E0048680biological_processpositive regulation of axon regeneration
E0050849biological_processnegative regulation of calcium-mediated signaling
E0051209biological_processrelease of sequestered calcium ion into cytosol
E0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
E0051284biological_processpositive regulation of sequestering of calcium ion
E0051775biological_processresponse to redox state
E0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
E0061179biological_processnegative regulation of insulin secretion involved in cellular response to glucose stimulus
F0005216molecular_functionmonoatomic ion channel activity
F0005219molecular_functionryanodine-sensitive calcium-release channel activity
F0005262molecular_functioncalcium channel activity
F0005509molecular_functioncalcium ion binding
F0006811biological_processmonoatomic ion transport
F0006816biological_processcalcium ion transport
F0006874biological_processintracellular calcium ion homeostasis
F0016020cellular_componentmembrane
F0055085biological_processtransmembrane transport
F0070588biological_processcalcium ion transmembrane transport
G0002027biological_processregulation of heart rate
G0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
G0005102molecular_functionsignaling receptor binding
G0005219molecular_functionryanodine-sensitive calcium-release channel activity
G0005515molecular_functionprotein binding
G0005528molecular_functionFK506 binding
G0005737cellular_componentcytoplasm
G0006458biological_process'de novo' protein folding
G0006939biological_processsmooth muscle contraction
G0007204biological_processpositive regulation of cytosolic calcium ion concentration
G0009749biological_processresponse to glucose
G0010459biological_processnegative regulation of heart rate
G0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
G0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
G0016020cellular_componentmembrane
G0016247molecular_functionchannel regulator activity
G0016529cellular_componentsarcoplasmic reticulum
G0019227biological_processneuronal action potential propagation
G0019722biological_processcalcium-mediated signaling
G0019855molecular_functioncalcium channel inhibitor activity
G0022417biological_processprotein maturation by protein folding
G0030018cellular_componentZ disc
G0030073biological_processinsulin secretion
G0030551molecular_functioncyclic nucleotide binding
G0033017cellular_componentsarcoplasmic reticulum membrane
G0033197biological_processresponse to vitamin E
G0034704cellular_componentcalcium channel complex
G0035773biological_processinsulin secretion involved in cellular response to glucose stimulus
G0042026biological_processprotein refolding
G0042098biological_processT cell proliferation
G0042542biological_processresponse to hydrogen peroxide
G0044325molecular_functiontransmembrane transporter binding
G0048680biological_processpositive regulation of axon regeneration
G0050849biological_processnegative regulation of calcium-mediated signaling
G0051209biological_processrelease of sequestered calcium ion into cytosol
G0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
G0051284biological_processpositive regulation of sequestering of calcium ion
G0051775biological_processresponse to redox state
G0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
G0061179biological_processnegative regulation of insulin secretion involved in cellular response to glucose stimulus
H0005216molecular_functionmonoatomic ion channel activity
H0005219molecular_functionryanodine-sensitive calcium-release channel activity
H0005262molecular_functioncalcium channel activity
H0005509molecular_functioncalcium ion binding
H0006811biological_processmonoatomic ion transport
H0006816biological_processcalcium ion transport
H0006874biological_processintracellular calcium ion homeostasis
H0016020cellular_componentmembrane
H0055085biological_processtransmembrane transport
H0070588biological_processcalcium ion transmembrane transport
Functional Information from PDB Data
site_idAC1
Number of Residues8
Detailsbinding site for residue ATP B 5101
ChainResidue
BLYS4167
BARG4171
BMET4885
BCYS4889
BPHE4890
BTHR4910
BASN4915
BLEU4916

site_idAC2
Number of Residues5
Detailsbinding site for residue ZN B 5102
ChainResidue
BPHE4890
BILE4891
BCYS4892
BHIS4914
BCYS4889

site_idAC3
Number of Residues8
Detailsbinding site for residue ATP D 5101
ChainResidue
DLYS4167
DARG4171
DMET4885
DCYS4889
DPHE4890
DTHR4910
DASN4915
DLEU4916

site_idAC4
Number of Residues5
Detailsbinding site for residue ZN D 5102
ChainResidue
DCYS4889
DPHE4890
DILE4891
DCYS4892
DHIS4914

site_idAC5
Number of Residues8
Detailsbinding site for residue ATP F 5101
ChainResidue
FLYS4167
FARG4171
FMET4885
FCYS4889
FPHE4890
FTHR4910
FASN4915
FLEU4916

site_idAC6
Number of Residues5
Detailsbinding site for residue ZN F 5102
ChainResidue
FCYS4889
FPHE4890
FILE4891
FCYS4892
FHIS4914

site_idAC7
Number of Residues8
Detailsbinding site for residue ATP H 5101
ChainResidue
HLYS4167
HARG4171
HMET4885
HCYS4889
HPHE4890
HTHR4910
HASN4915
HLEU4916

site_idAC8
Number of Residues5
Detailsbinding site for residue ZN H 5102
ChainResidue
HCYS4889
HPHE4890
HILE4891
HCYS4892
HHIS4914

226707

PDB entries from 2024-10-30

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