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6JFZ

GluK3 receptor complex with UBP310

Functional Information from GO Data
ChainGOidnamespacecontents
A0001640molecular_functionadenylate cyclase inhibiting G protein-coupled glutamate receptor activity
A0004970molecular_functionglutamate-gated receptor activity
A0005216molecular_functionmonoatomic ion channel activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0007196biological_processadenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
A0007215biological_processglutamate receptor signaling pathway
A0007216biological_processG protein-coupled glutamate receptor signaling pathway
A0007268biological_processchemical synaptic transmission
A0008066molecular_functionglutamate receptor activity
A0015276molecular_functionligand-gated monoatomic ion channel activity
A0015277molecular_functionkainate selective glutamate receptor activity
A0016020cellular_componentmembrane
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0032839cellular_componentdendrite cytoplasm
A0032983cellular_componentkainate selective glutamate receptor complex
A0034220biological_processmonoatomic ion transmembrane transport
A0035235biological_processionotropic glutamate receptor signaling pathway
A0035249biological_processsynaptic transmission, glutamatergic
A0038023molecular_functionsignaling receptor activity
A0042391biological_processregulation of membrane potential
A0042734cellular_componentpresynaptic membrane
A0043195cellular_componentterminal bouton
A0043204cellular_componentperikaryon
A0045202cellular_componentsynapse
A0045211cellular_componentpostsynaptic membrane
A0050804biological_processmodulation of chemical synaptic transmission
A0051967biological_processnegative regulation of synaptic transmission, glutamatergic
A0060078biological_processregulation of postsynaptic membrane potential
A0098683cellular_componentcochlear hair cell ribbon synapse
A0098839cellular_componentpostsynaptic density membrane
A0098978cellular_componentglutamatergic synapse
A0099505biological_processregulation of presynaptic membrane potential
A0099507molecular_functionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
A1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
B0001640molecular_functionadenylate cyclase inhibiting G protein-coupled glutamate receptor activity
B0004970molecular_functionglutamate-gated receptor activity
B0005216molecular_functionmonoatomic ion channel activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0007196biological_processadenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
B0007215biological_processglutamate receptor signaling pathway
B0007216biological_processG protein-coupled glutamate receptor signaling pathway
B0007268biological_processchemical synaptic transmission
B0008066molecular_functionglutamate receptor activity
B0015276molecular_functionligand-gated monoatomic ion channel activity
B0015277molecular_functionkainate selective glutamate receptor activity
B0016020cellular_componentmembrane
B0030424cellular_componentaxon
B0030425cellular_componentdendrite
B0032839cellular_componentdendrite cytoplasm
B0032983cellular_componentkainate selective glutamate receptor complex
B0034220biological_processmonoatomic ion transmembrane transport
B0035235biological_processionotropic glutamate receptor signaling pathway
B0035249biological_processsynaptic transmission, glutamatergic
B0038023molecular_functionsignaling receptor activity
B0042391biological_processregulation of membrane potential
B0042734cellular_componentpresynaptic membrane
B0043195cellular_componentterminal bouton
B0043204cellular_componentperikaryon
B0045202cellular_componentsynapse
B0045211cellular_componentpostsynaptic membrane
B0050804biological_processmodulation of chemical synaptic transmission
B0051967biological_processnegative regulation of synaptic transmission, glutamatergic
B0060078biological_processregulation of postsynaptic membrane potential
B0098683cellular_componentcochlear hair cell ribbon synapse
B0098839cellular_componentpostsynaptic density membrane
B0098978cellular_componentglutamatergic synapse
B0099505biological_processregulation of presynaptic membrane potential
B0099507molecular_functionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
B1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
C0001640molecular_functionadenylate cyclase inhibiting G protein-coupled glutamate receptor activity
C0004970molecular_functionglutamate-gated receptor activity
C0005216molecular_functionmonoatomic ion channel activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0007196biological_processadenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
C0007215biological_processglutamate receptor signaling pathway
C0007216biological_processG protein-coupled glutamate receptor signaling pathway
C0007268biological_processchemical synaptic transmission
C0008066molecular_functionglutamate receptor activity
C0015276molecular_functionligand-gated monoatomic ion channel activity
C0015277molecular_functionkainate selective glutamate receptor activity
C0016020cellular_componentmembrane
C0030424cellular_componentaxon
C0030425cellular_componentdendrite
C0032839cellular_componentdendrite cytoplasm
C0032983cellular_componentkainate selective glutamate receptor complex
C0034220biological_processmonoatomic ion transmembrane transport
C0035235biological_processionotropic glutamate receptor signaling pathway
C0035249biological_processsynaptic transmission, glutamatergic
C0038023molecular_functionsignaling receptor activity
C0042391biological_processregulation of membrane potential
C0042734cellular_componentpresynaptic membrane
C0043195cellular_componentterminal bouton
C0043204cellular_componentperikaryon
C0045202cellular_componentsynapse
C0045211cellular_componentpostsynaptic membrane
C0050804biological_processmodulation of chemical synaptic transmission
C0051967biological_processnegative regulation of synaptic transmission, glutamatergic
C0060078biological_processregulation of postsynaptic membrane potential
C0098683cellular_componentcochlear hair cell ribbon synapse
C0098839cellular_componentpostsynaptic density membrane
C0098978cellular_componentglutamatergic synapse
C0099505biological_processregulation of presynaptic membrane potential
C0099507molecular_functionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
C1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
D0001640molecular_functionadenylate cyclase inhibiting G protein-coupled glutamate receptor activity
D0004970molecular_functionglutamate-gated receptor activity
D0005216molecular_functionmonoatomic ion channel activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0007196biological_processadenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
D0007215biological_processglutamate receptor signaling pathway
D0007216biological_processG protein-coupled glutamate receptor signaling pathway
D0007268biological_processchemical synaptic transmission
D0008066molecular_functionglutamate receptor activity
D0015276molecular_functionligand-gated monoatomic ion channel activity
D0015277molecular_functionkainate selective glutamate receptor activity
D0016020cellular_componentmembrane
D0030424cellular_componentaxon
D0030425cellular_componentdendrite
D0032839cellular_componentdendrite cytoplasm
D0032983cellular_componentkainate selective glutamate receptor complex
D0034220biological_processmonoatomic ion transmembrane transport
D0035235biological_processionotropic glutamate receptor signaling pathway
D0035249biological_processsynaptic transmission, glutamatergic
D0038023molecular_functionsignaling receptor activity
D0042391biological_processregulation of membrane potential
D0042734cellular_componentpresynaptic membrane
D0043195cellular_componentterminal bouton
D0043204cellular_componentperikaryon
D0045202cellular_componentsynapse
D0045211cellular_componentpostsynaptic membrane
D0050804biological_processmodulation of chemical synaptic transmission
D0051967biological_processnegative regulation of synaptic transmission, glutamatergic
D0060078biological_processregulation of postsynaptic membrane potential
D0098683cellular_componentcochlear hair cell ribbon synapse
D0098839cellular_componentpostsynaptic density membrane
D0098978cellular_componentglutamatergic synapse
D0099505biological_processregulation of presynaptic membrane potential
D0099507molecular_functionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
D1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2124
DetailsTOPO_DOM: Extracellular
ChainResidueDetails
AMET1-PRO532
BMET1-PRO532
DMET1-PRO532
CMET1-PRO532

site_idSWS_FT_FI2
Number of Residues160
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
AASP533-ALA553
AILE606-LEU626
BASP533-ALA553
BILE606-LEU626
DASP533-ALA553
DILE606-LEU626
CASP533-ALA553
CILE606-LEU626

site_idSWS_FT_FI3
Number of Residues204
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AARG554-ARG605
BARG554-ARG605
DARG554-ARG605
CARG554-ARG605

site_idSWS_FT_FI4
Number of Residues648
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
AALA627-LYS789
BALA627-LYS789
DALA627-LYS789
CALA627-LYS789

site_idSWS_FT_FI5
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:21907808
ChainResidueDetails
ATHR489
AARG494
AGLU708
BTHR489
BARG494
BGLU708
DTHR489
DARG494
DGLU708
CTHR489
CARG494
CGLU708

site_idSWS_FT_FI6
Number of Residues4
DetailsBINDING:
ChainResidueDetails
AGLY659
BGLY659
DGLY659
CGLY659

site_idSWS_FT_FI7
Number of Residues8
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:20951142
ChainResidueDetails
AASN39
AASN350
BASN39
BASN350
DASN39
DASN350
CASN39
CASN350

site_idSWS_FT_FI8
Number of Residues28
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN517
AASN520
AASN721
BASN45
BASN384
BASN395
BASN402
BASN517
BASN520
BASN721
DASN45
DASN384
DASN395
DASN402
DASN517
DASN520
DASN721
CASN45
CASN384
CASN395
CASN402
CASN517
CASN520
CASN721
AASN45
AASN384
AASN395
AASN402

site_idSWS_FT_FI9
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:20951142, ECO:0007744|PubMed:24090084
ChainResidueDetails
AASN247
BASN247
DASN247
CASN247

219869

PDB entries from 2024-05-15

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