6JEB
crystal structure of a beta-N-acetylhexosaminidase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000272 | biological_process | polysaccharide catabolic process |
| A | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| A | 0004563 | molecular_function | beta-N-acetylhexosaminidase activity |
| A | 0005764 | cellular_component | lysosome |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006689 | biological_process | ganglioside catabolic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016231 | molecular_function | beta-N-acetylglucosaminidase activity |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0030203 | biological_process | glycosaminoglycan metabolic process |
| A | 0032428 | molecular_function | beta-N-acetylgalactosaminidase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0052781 | biological_process | chitobiose catabolic process |
| A | 0102148 | molecular_function | N-acetyl-beta-D-galactosaminidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 501 |
| Chain | Residue |
| A | CYS227 |
| A | CYS247 |
| A | CYS288 |
| A | CYS291 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue ACM A 502 |
| Chain | Residue |
| A | TRP421 |
| A | HOH617 |
| A | HOH853 |
| A | HOH975 |
| A | ASP278 |
| A | GLU279 |
| A | TRP328 |
| A | TRP345 |
| A | TYR373 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Charge relay system => ECO:0000305|PubMed:30846208, ECO:0007744|PDB:6JE8, ECO:0007744|PDB:6JEA, ECO:0007744|PDB:6JEB |
| Chain | Residue | Details |
| A | ASP151 | |
| A | HIS214 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Charge relay system => ECO:0000269|PubMed:30846208, ECO:0007744|PDB:6JEB |
| Chain | Residue | Details |
| A | GLU279 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:30846208, ECO:0007744|PDB:6JEA |
| Chain | Residue | Details |
| A | TRP421 | |
| A | TYR373 | |
| A | ARG122 | |
| A | ASP278 | |
| A | TRP345 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:30846208, ECO:0007744|PDB:6JE8, ECO:0007744|PDB:6JEA, ECO:0007744|PDB:6JEB |
| Chain | Residue | Details |
| A | CYS291 | |
| A | CYS227 | |
| A | CYS247 | |
| A | CYS288 |
