Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6JCW

Cryo-EM Structure of Sulfolobus solfataricus ketol-acid reductoisomerase (Sso-KARI) with Mg2+ at pH8.5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004455	molecular_function	ketol-acid reductoisomerase activity
A	0008652	biological_process	amino acid biosynthetic process
A	0009082	biological_process	branched-chain amino acid biosynthetic process
A	0009097	biological_process	isoleucine biosynthetic process
A	0009099	biological_process	L-valine biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
B	0004455	molecular_function	ketol-acid reductoisomerase activity
B	0008652	biological_process	amino acid biosynthetic process
B	0009082	biological_process	branched-chain amino acid biosynthetic process
B	0009097	biological_process	isoleucine biosynthetic process
B	0009099	biological_process	L-valine biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
C	0004455	molecular_function	ketol-acid reductoisomerase activity
C	0008652	biological_process	amino acid biosynthetic process
C	0009082	biological_process	branched-chain amino acid biosynthetic process
C	0009097	biological_process	isoleucine biosynthetic process
C	0009099	biological_process	L-valine biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
D	0004455	molecular_function	ketol-acid reductoisomerase activity
D	0008652	biological_process	amino acid biosynthetic process
D	0009082	biological_process	branched-chain amino acid biosynthetic process
D	0009097	biological_process	isoleucine biosynthetic process
D	0009099	biological_process	L-valine biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
E	0004455	molecular_function	ketol-acid reductoisomerase activity
E	0008652	biological_process	amino acid biosynthetic process
E	0009082	biological_process	branched-chain amino acid biosynthetic process
E	0009097	biological_process	isoleucine biosynthetic process
E	0009099	biological_process	L-valine biosynthetic process
E	0016491	molecular_function	oxidoreductase activity
F	0004455	molecular_function	ketol-acid reductoisomerase activity
F	0008652	biological_process	amino acid biosynthetic process
F	0009082	biological_process	branched-chain amino acid biosynthetic process
F	0009097	biological_process	isoleucine biosynthetic process
F	0009099	biological_process	L-valine biosynthetic process
F	0016491	molecular_function	oxidoreductase activity
G	0004455	molecular_function	ketol-acid reductoisomerase activity
G	0008652	biological_process	amino acid biosynthetic process
G	0009082	biological_process	branched-chain amino acid biosynthetic process
G	0009097	biological_process	isoleucine biosynthetic process
G	0009099	biological_process	L-valine biosynthetic process
G	0016491	molecular_function	oxidoreductase activity
H	0004455	molecular_function	ketol-acid reductoisomerase activity
H	0008652	biological_process	amino acid biosynthetic process
H	0009082	biological_process	branched-chain amino acid biosynthetic process
H	0009097	biological_process	isoleucine biosynthetic process
H	0009099	biological_process	L-valine biosynthetic process
H	0016491	molecular_function	oxidoreductase activity
I	0004455	molecular_function	ketol-acid reductoisomerase activity
I	0008652	biological_process	amino acid biosynthetic process
I	0009082	biological_process	branched-chain amino acid biosynthetic process
I	0009097	biological_process	isoleucine biosynthetic process
I	0009099	biological_process	L-valine biosynthetic process
I	0016491	molecular_function	oxidoreductase activity
J	0004455	molecular_function	ketol-acid reductoisomerase activity
J	0008652	biological_process	amino acid biosynthetic process
J	0009082	biological_process	branched-chain amino acid biosynthetic process
J	0009097	biological_process	isoleucine biosynthetic process
J	0009099	biological_process	L-valine biosynthetic process
J	0016491	molecular_function	oxidoreductase activity
K	0004455	molecular_function	ketol-acid reductoisomerase activity
K	0008652	biological_process	amino acid biosynthetic process
K	0009082	biological_process	branched-chain amino acid biosynthetic process
K	0009097	biological_process	isoleucine biosynthetic process
K	0009099	biological_process	L-valine biosynthetic process
K	0016491	molecular_function	oxidoreductase activity
L	0004455	molecular_function	ketol-acid reductoisomerase activity
L	0008652	biological_process	amino acid biosynthetic process
L	0009082	biological_process	branched-chain amino acid biosynthetic process
L	0009097	biological_process	isoleucine biosynthetic process
L	0009099	biological_process	L-valine biosynthetic process
L	0016491	molecular_function	oxidoreductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	binding site for residue MG A 401

Chain	Residue
A	ASP191

site_id	AC2
Number of Residues	3
Details	binding site for residue MG A 402

Chain	Residue
A	GLU227
A	GLU233
B	SER194

site_id	AC3
Number of Residues	3
Details	binding site for residue MG B 401

Chain	Residue
A	SER194
B	GLU227
B	GLU233

site_id	AC4
Number of Residues	1
Details	binding site for residue MG B 402

Chain	Residue
B	ASP191

site_id	AC5
Number of Residues	1
Details	binding site for residue MG C 401

Chain	Residue
C	ASP191

site_id	AC6
Number of Residues	3
Details	binding site for residue MG C 402

Chain	Residue
C	GLU227
C	GLU233
D	SER194

site_id	AC7
Number of Residues	3
Details	binding site for residue MG D 401

Chain	Residue
C	SER194
D	GLU227
D	GLU233

site_id	AC8
Number of Residues	1
Details	binding site for residue MG D 402

Chain	Residue
D	ASP191

site_id	AC9
Number of Residues	1
Details	binding site for residue MG E 401

Chain	Residue
E	ASP191

site_id	AD1
Number of Residues	3
Details	binding site for residue MG E 402

Chain	Residue
E	GLU227
E	GLU233
F	SER194

site_id	AD2
Number of Residues	3
Details	binding site for residue MG F 401

Chain	Residue
E	SER194
F	GLU227
F	GLU233

site_id	AD3
Number of Residues	1
Details	binding site for residue MG F 402

Chain	Residue
F	ASP191

site_id	AD4
Number of Residues	1
Details	binding site for residue MG G 401

Chain	Residue
G	ASP191

site_id	AD5
Number of Residues	3
Details	binding site for residue MG G 402

Chain	Residue
G	GLU227
G	GLU233
H	SER194

site_id	AD6
Number of Residues	3
Details	binding site for residue MG H 401

Chain	Residue
G	SER194
H	GLU227
H	GLU233

site_id	AD7
Number of Residues	1
Details	binding site for residue MG H 402

Chain	Residue
H	ASP191

site_id	AD8
Number of Residues	1
Details	binding site for residue MG I 401

Chain	Residue
I	ASP191

site_id	AD9
Number of Residues	3
Details	binding site for residue MG I 402

Chain	Residue
I	GLU227
I	GLU233
J	SER194

site_id	AE1
Number of Residues	3
Details	binding site for residue MG J 401

Chain	Residue
I	SER194
J	GLU227
J	GLU233

site_id	AE2
Number of Residues	1
Details	binding site for residue MG J 402

Chain	Residue
J	ASP191

site_id	AE3
Number of Residues	1
Details	binding site for residue MG K 401

Chain	Residue
K	ASP191

site_id	AE4
Number of Residues	3
Details	binding site for residue MG K 402

Chain	Residue
K	GLU227
K	GLU233
L	SER194

site_id	AE5
Number of Residues	3
Details	binding site for residue MG L 401

Chain	Residue
K	SER194
L	GLU227
L	GLU233

site_id	AE6
Number of Residues	1
Details	binding site for residue MG L 402

Chain	Residue
L	ASP191

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)