Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6JCV

Cryo-EM structure of Sulfolobus solfataricus ketol-acid reductoisomerase (Sso-KARI) with Mg2+ at pH7.5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004455	molecular_function	ketol-acid reductoisomerase activity
A	0008652	biological_process	amino acid biosynthetic process
A	0009082	biological_process	branched-chain amino acid biosynthetic process
A	0009097	biological_process	isoleucine biosynthetic process
A	0009099	biological_process	valine biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
B	0004455	molecular_function	ketol-acid reductoisomerase activity
B	0008652	biological_process	amino acid biosynthetic process
B	0009082	biological_process	branched-chain amino acid biosynthetic process
B	0009097	biological_process	isoleucine biosynthetic process
B	0009099	biological_process	valine biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
C	0004455	molecular_function	ketol-acid reductoisomerase activity
C	0008652	biological_process	amino acid biosynthetic process
C	0009082	biological_process	branched-chain amino acid biosynthetic process
C	0009097	biological_process	isoleucine biosynthetic process
C	0009099	biological_process	valine biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
D	0004455	molecular_function	ketol-acid reductoisomerase activity
D	0008652	biological_process	amino acid biosynthetic process
D	0009082	biological_process	branched-chain amino acid biosynthetic process
D	0009097	biological_process	isoleucine biosynthetic process
D	0009099	biological_process	valine biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
E	0004455	molecular_function	ketol-acid reductoisomerase activity
E	0008652	biological_process	amino acid biosynthetic process
E	0009082	biological_process	branched-chain amino acid biosynthetic process
E	0009097	biological_process	isoleucine biosynthetic process
E	0009099	biological_process	valine biosynthetic process
E	0016491	molecular_function	oxidoreductase activity
F	0004455	molecular_function	ketol-acid reductoisomerase activity
F	0008652	biological_process	amino acid biosynthetic process
F	0009082	biological_process	branched-chain amino acid biosynthetic process
F	0009097	biological_process	isoleucine biosynthetic process
F	0009099	biological_process	valine biosynthetic process
F	0016491	molecular_function	oxidoreductase activity
G	0004455	molecular_function	ketol-acid reductoisomerase activity
G	0008652	biological_process	amino acid biosynthetic process
G	0009082	biological_process	branched-chain amino acid biosynthetic process
G	0009097	biological_process	isoleucine biosynthetic process
G	0009099	biological_process	valine biosynthetic process
G	0016491	molecular_function	oxidoreductase activity
H	0004455	molecular_function	ketol-acid reductoisomerase activity
H	0008652	biological_process	amino acid biosynthetic process
H	0009082	biological_process	branched-chain amino acid biosynthetic process
H	0009097	biological_process	isoleucine biosynthetic process
H	0009099	biological_process	valine biosynthetic process
H	0016491	molecular_function	oxidoreductase activity
I	0004455	molecular_function	ketol-acid reductoisomerase activity
I	0008652	biological_process	amino acid biosynthetic process
I	0009082	biological_process	branched-chain amino acid biosynthetic process
I	0009097	biological_process	isoleucine biosynthetic process
I	0009099	biological_process	valine biosynthetic process
I	0016491	molecular_function	oxidoreductase activity
J	0004455	molecular_function	ketol-acid reductoisomerase activity
J	0008652	biological_process	amino acid biosynthetic process
J	0009082	biological_process	branched-chain amino acid biosynthetic process
J	0009097	biological_process	isoleucine biosynthetic process
J	0009099	biological_process	valine biosynthetic process
J	0016491	molecular_function	oxidoreductase activity
K	0004455	molecular_function	ketol-acid reductoisomerase activity
K	0008652	biological_process	amino acid biosynthetic process
K	0009082	biological_process	branched-chain amino acid biosynthetic process
K	0009097	biological_process	isoleucine biosynthetic process
K	0009099	biological_process	valine biosynthetic process
K	0016491	molecular_function	oxidoreductase activity
L	0004455	molecular_function	ketol-acid reductoisomerase activity
L	0008652	biological_process	amino acid biosynthetic process
L	0009082	biological_process	branched-chain amino acid biosynthetic process
L	0009097	biological_process	isoleucine biosynthetic process
L	0009099	biological_process	valine biosynthetic process
L	0016491	molecular_function	oxidoreductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue MG A 401

Chain	Residue
A	GLU195
B	SER257

site_id	AC2
Number of Residues	4
Details	binding site for residue MG A 402

Chain	Residue
A	ARG130
A	ASP191
B	GLU227
B	GLU233

site_id	AC3
Number of Residues	2
Details	binding site for residue MG A 403

Chain	Residue
A	SER257
B	GLU195

site_id	AC4
Number of Residues	4
Details	binding site for residue MG A 404

Chain	Residue
A	GLU233
B	ARG130
B	ASP191
A	GLU227

site_id	AC5
Number of Residues	2
Details	binding site for residue MG C 401

Chain	Residue
C	GLU195
D	SER257

site_id	AC6
Number of Residues	4
Details	binding site for residue MG C 402

Chain	Residue
C	ARG130
C	ASP191
D	GLU227
D	GLU233

site_id	AC7
Number of Residues	2
Details	binding site for residue MG C 403

Chain	Residue
C	SER257
D	GLU195

site_id	AC8
Number of Residues	4
Details	binding site for residue MG C 404

Chain	Residue
C	GLU227
C	GLU233
D	ARG130
D	ASP191

site_id	AC9
Number of Residues	2
Details	binding site for residue MG E 401

Chain	Residue
E	GLU195
F	SER257

site_id	AD1
Number of Residues	4
Details	binding site for residue MG E 402

Chain	Residue
E	ARG130
E	ASP191
F	GLU227
F	GLU233

site_id	AD2
Number of Residues	2
Details	binding site for residue MG E 403

Chain	Residue
E	SER257
F	GLU195

site_id	AD3
Number of Residues	4
Details	binding site for residue MG E 404

Chain	Residue
E	GLU227
E	GLU233
F	ARG130
F	ASP191

site_id	AD4
Number of Residues	2
Details	binding site for residue MG G 401

Chain	Residue
G	GLU195
H	SER257

site_id	AD5
Number of Residues	4
Details	binding site for residue MG G 402

Chain	Residue
G	ARG130
G	ASP191
H	GLU227
H	GLU233

site_id	AD6
Number of Residues	2
Details	binding site for residue MG G 403

Chain	Residue
G	SER257
H	GLU195

site_id	AD7
Number of Residues	4
Details	binding site for residue MG G 404

Chain	Residue
G	GLU227
G	GLU233
H	ARG130
H	ASP191

site_id	AD8
Number of Residues	2
Details	binding site for residue MG I 401

Chain	Residue
I	GLU195
J	SER257

site_id	AD9
Number of Residues	2
Details	binding site for residue MG I 402

Chain	Residue
I	SER257
J	GLU195

site_id	AE1
Number of Residues	4
Details	binding site for residue MG I 403

Chain	Residue
I	GLU227
I	GLU233
J	ARG130
J	ASP191

site_id	AE2
Number of Residues	4
Details	binding site for residue MG J 401

Chain	Residue
I	ARG130
I	ASP191
J	GLU227
J	GLU233

site_id	AE3
Number of Residues	2
Details	binding site for residue MG K 401

Chain	Residue
K	GLU195
L	SER257

site_id	AE4
Number of Residues	4
Details	binding site for residue MG K 402

Chain	Residue
K	ARG130
K	ASP191
L	GLU227
L	GLU233

site_id	AE5
Number of Residues	2
Details	binding site for residue MG K 403

Chain	Residue
K	SER257
L	GLU195

site_id	AE6
Number of Residues	4
Details	binding site for residue MG K 404

Chain	Residue
K	GLU227
K	GLU233
L	ARG130
L	ASP191

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)