Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6JB1

Structure of pancreatic ATP-sensitive potassium channel bound with repaglinide and ATPgammaS at 3.3A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001508	biological_process	action potential
A	0001666	biological_process	response to hypoxia
A	0001669	cellular_component	acrosomal vesicle
A	0002931	biological_process	response to ischemia
A	0003229	biological_process	ventricular cardiac muscle tissue development
A	0005242	molecular_function	inward rectifier potassium channel activity
A	0005249	molecular_function	voltage-gated potassium channel activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005635	cellular_component	nuclear envelope
A	0005737	cellular_component	cytoplasm
A	0005768	cellular_component	endosome
A	0005886	cellular_component	plasma membrane
A	0006006	biological_process	glucose metabolic process
A	0006813	biological_process	potassium ion transport
A	0006915	biological_process	apoptotic process
A	0006950	biological_process	response to stress
A	0008282	cellular_component	inward rectifying potassium channel
A	0008340	biological_process	determination of adult lifespan
A	0009410	biological_process	response to xenobiotic stimulus
A	0014704	cellular_component	intercalated disc
A	0015272	molecular_function	ATP-activated inward rectifier potassium channel activity
A	0016020	cellular_component	membrane
A	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
A	0030315	cellular_component	T-tubule
A	0030506	molecular_function	ankyrin binding
A	0030673	cellular_component	axolemma
A	0030955	molecular_function	potassium ion binding
A	0031072	molecular_function	heat shock protein binding
A	0031669	biological_process	cellular response to nutrient levels
A	0032355	biological_process	response to estradiol
A	0033198	biological_process	response to ATP
A	0033574	biological_process	response to testosterone
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034702	cellular_component	monoatomic ion channel complex
A	0034765	biological_process	regulation of monoatomic ion transmembrane transport
A	0042383	cellular_component	sarcolemma
A	0042391	biological_process	regulation of membrane potential
A	0042734	cellular_component	presynaptic membrane
A	0043025	cellular_component	neuronal cell body
A	0044325	molecular_function	transmembrane transporter binding
A	0046676	biological_process	negative regulation of insulin secretion
A	0050796	biological_process	regulation of insulin secretion
A	0050877	biological_process	nervous system process
A	0061762	biological_process	CAMKK-AMPK signaling cascade
A	0070852	cellular_component	cell body fiber
A	0071316	biological_process	cellular response to nicotine
A	0071333	biological_process	cellular response to glucose stimulus
A	0071356	biological_process	cellular response to tumor necrosis factor
A	0071805	biological_process	potassium ion transmembrane transport
A	0098662	biological_process	inorganic cation transmembrane transport
A	0098978	cellular_component	glutamatergic synapse
A	0099505	biological_process	regulation of presynaptic membrane potential
A	0099508	molecular_function	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
A	1903078	biological_process	positive regulation of protein localization to plasma membrane
A	1904638	biological_process	response to resveratrol
A	1990573	biological_process	potassium ion import across plasma membrane
B	0005267	molecular_function	potassium channel activity
B	0005524	molecular_function	ATP binding
B	0005886	cellular_component	plasma membrane
B	0006813	biological_process	potassium ion transport
B	0008281	molecular_function	sulfonylurea receptor activity
B	0008282	cellular_component	inward rectifying potassium channel
B	0016020	cellular_component	membrane
B	0016887	molecular_function	ATP hydrolysis activity
B	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
B	0032991	cellular_component	protein-containing complex
B	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
B	0042626	molecular_function	ATPase-coupled transmembrane transporter activity
B	0043531	molecular_function	ADP binding
B	0044325	molecular_function	transmembrane transporter binding
B	0046676	biological_process	negative regulation of insulin secretion
B	0050905	biological_process	neuromuscular process
B	0055085	biological_process	transmembrane transport
B	0061535	biological_process	glutamate secretion, neurotransmission
B	0071805	biological_process	potassium ion transmembrane transport
B	0098655	biological_process	monoatomic cation transmembrane transport
B	0098662	biological_process	inorganic cation transmembrane transport
B	0098793	cellular_component	presynapse
B	0140359	molecular_function	ABC-type transporter activity
C	0001508	biological_process	action potential
C	0001666	biological_process	response to hypoxia
C	0001669	cellular_component	acrosomal vesicle
C	0002931	biological_process	response to ischemia
C	0003229	biological_process	ventricular cardiac muscle tissue development
C	0005242	molecular_function	inward rectifier potassium channel activity
C	0005249	molecular_function	voltage-gated potassium channel activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005635	cellular_component	nuclear envelope
C	0005737	cellular_component	cytoplasm
C	0005768	cellular_component	endosome
C	0005886	cellular_component	plasma membrane
C	0006006	biological_process	glucose metabolic process
C	0006813	biological_process	potassium ion transport
C	0006915	biological_process	apoptotic process
C	0006950	biological_process	response to stress
C	0008282	cellular_component	inward rectifying potassium channel
C	0008340	biological_process	determination of adult lifespan
C	0009410	biological_process	response to xenobiotic stimulus
C	0014704	cellular_component	intercalated disc
C	0015272	molecular_function	ATP-activated inward rectifier potassium channel activity
C	0016020	cellular_component	membrane
C	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
C	0030315	cellular_component	T-tubule
C	0030506	molecular_function	ankyrin binding
C	0030673	cellular_component	axolemma
C	0030955	molecular_function	potassium ion binding
C	0031072	molecular_function	heat shock protein binding
C	0031669	biological_process	cellular response to nutrient levels
C	0032355	biological_process	response to estradiol
C	0033198	biological_process	response to ATP
C	0033574	biological_process	response to testosterone
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0034702	cellular_component	monoatomic ion channel complex
C	0034765	biological_process	regulation of monoatomic ion transmembrane transport
C	0042383	cellular_component	sarcolemma
C	0042391	biological_process	regulation of membrane potential
C	0042734	cellular_component	presynaptic membrane
C	0043025	cellular_component	neuronal cell body
C	0044325	molecular_function	transmembrane transporter binding
C	0046676	biological_process	negative regulation of insulin secretion
C	0050796	biological_process	regulation of insulin secretion
C	0050877	biological_process	nervous system process
C	0061762	biological_process	CAMKK-AMPK signaling cascade
C	0070852	cellular_component	cell body fiber
C	0071316	biological_process	cellular response to nicotine
C	0071333	biological_process	cellular response to glucose stimulus
C	0071356	biological_process	cellular response to tumor necrosis factor
C	0071805	biological_process	potassium ion transmembrane transport
C	0098662	biological_process	inorganic cation transmembrane transport
C	0098978	cellular_component	glutamatergic synapse
C	0099505	biological_process	regulation of presynaptic membrane potential
C	0099508	molecular_function	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
C	1903078	biological_process	positive regulation of protein localization to plasma membrane
C	1904638	biological_process	response to resveratrol
C	1990573	biological_process	potassium ion import across plasma membrane
D	0005267	molecular_function	potassium channel activity
D	0005524	molecular_function	ATP binding
D	0005886	cellular_component	plasma membrane
D	0006813	biological_process	potassium ion transport
D	0008281	molecular_function	sulfonylurea receptor activity
D	0008282	cellular_component	inward rectifying potassium channel
D	0016020	cellular_component	membrane
D	0016887	molecular_function	ATP hydrolysis activity
D	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
D	0032991	cellular_component	protein-containing complex
D	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
D	0042626	molecular_function	ATPase-coupled transmembrane transporter activity
D	0043531	molecular_function	ADP binding
D	0044325	molecular_function	transmembrane transporter binding
D	0046676	biological_process	negative regulation of insulin secretion
D	0050905	biological_process	neuromuscular process
D	0055085	biological_process	transmembrane transport
D	0061535	biological_process	glutamate secretion, neurotransmission
D	0071805	biological_process	potassium ion transmembrane transport
D	0098655	biological_process	monoatomic cation transmembrane transport
D	0098662	biological_process	inorganic cation transmembrane transport
D	0098793	cellular_component	presynapse
D	0140359	molecular_function	ABC-type transporter activity
E	0001508	biological_process	action potential
E	0001666	biological_process	response to hypoxia
E	0001669	cellular_component	acrosomal vesicle
E	0002931	biological_process	response to ischemia
E	0003229	biological_process	ventricular cardiac muscle tissue development
E	0005242	molecular_function	inward rectifier potassium channel activity
E	0005249	molecular_function	voltage-gated potassium channel activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005635	cellular_component	nuclear envelope
E	0005737	cellular_component	cytoplasm
E	0005768	cellular_component	endosome
E	0005886	cellular_component	plasma membrane
E	0006006	biological_process	glucose metabolic process
E	0006813	biological_process	potassium ion transport
E	0006915	biological_process	apoptotic process
E	0006950	biological_process	response to stress
E	0008282	cellular_component	inward rectifying potassium channel
E	0008340	biological_process	determination of adult lifespan
E	0009410	biological_process	response to xenobiotic stimulus
E	0014704	cellular_component	intercalated disc
E	0015272	molecular_function	ATP-activated inward rectifier potassium channel activity
E	0016020	cellular_component	membrane
E	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
E	0030315	cellular_component	T-tubule
E	0030506	molecular_function	ankyrin binding
E	0030673	cellular_component	axolemma
E	0030955	molecular_function	potassium ion binding
E	0031072	molecular_function	heat shock protein binding
E	0031669	biological_process	cellular response to nutrient levels
E	0032355	biological_process	response to estradiol
E	0033198	biological_process	response to ATP
E	0033574	biological_process	response to testosterone
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0034702	cellular_component	monoatomic ion channel complex
E	0034765	biological_process	regulation of monoatomic ion transmembrane transport
E	0042383	cellular_component	sarcolemma
E	0042391	biological_process	regulation of membrane potential
E	0042734	cellular_component	presynaptic membrane
E	0043025	cellular_component	neuronal cell body
E	0044325	molecular_function	transmembrane transporter binding
E	0046676	biological_process	negative regulation of insulin secretion
E	0050796	biological_process	regulation of insulin secretion
E	0050877	biological_process	nervous system process
E	0061762	biological_process	CAMKK-AMPK signaling cascade
E	0070852	cellular_component	cell body fiber
E	0071316	biological_process	cellular response to nicotine
E	0071333	biological_process	cellular response to glucose stimulus
E	0071356	biological_process	cellular response to tumor necrosis factor
E	0071805	biological_process	potassium ion transmembrane transport
E	0098662	biological_process	inorganic cation transmembrane transport
E	0098978	cellular_component	glutamatergic synapse
E	0099505	biological_process	regulation of presynaptic membrane potential
E	0099508	molecular_function	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
E	1903078	biological_process	positive regulation of protein localization to plasma membrane
E	1904638	biological_process	response to resveratrol
E	1990573	biological_process	potassium ion import across plasma membrane
F	0005267	molecular_function	potassium channel activity
F	0005524	molecular_function	ATP binding
F	0005886	cellular_component	plasma membrane
F	0006813	biological_process	potassium ion transport
F	0008281	molecular_function	sulfonylurea receptor activity
F	0008282	cellular_component	inward rectifying potassium channel
F	0016020	cellular_component	membrane
F	0016887	molecular_function	ATP hydrolysis activity
F	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
F	0032991	cellular_component	protein-containing complex
F	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
F	0042626	molecular_function	ATPase-coupled transmembrane transporter activity
F	0043531	molecular_function	ADP binding
F	0044325	molecular_function	transmembrane transporter binding
F	0046676	biological_process	negative regulation of insulin secretion
F	0050905	biological_process	neuromuscular process
F	0055085	biological_process	transmembrane transport
F	0061535	biological_process	glutamate secretion, neurotransmission
F	0071805	biological_process	potassium ion transmembrane transport
F	0098655	biological_process	monoatomic cation transmembrane transport
F	0098662	biological_process	inorganic cation transmembrane transport
F	0098793	cellular_component	presynapse
F	0140359	molecular_function	ABC-type transporter activity
G	0001508	biological_process	action potential
G	0001666	biological_process	response to hypoxia
G	0001669	cellular_component	acrosomal vesicle
G	0002931	biological_process	response to ischemia
G	0003229	biological_process	ventricular cardiac muscle tissue development
G	0005242	molecular_function	inward rectifier potassium channel activity
G	0005249	molecular_function	voltage-gated potassium channel activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005635	cellular_component	nuclear envelope
G	0005737	cellular_component	cytoplasm
G	0005768	cellular_component	endosome
G	0005886	cellular_component	plasma membrane
G	0006006	biological_process	glucose metabolic process
G	0006813	biological_process	potassium ion transport
G	0006915	biological_process	apoptotic process
G	0006950	biological_process	response to stress
G	0008282	cellular_component	inward rectifying potassium channel
G	0008340	biological_process	determination of adult lifespan
G	0009410	biological_process	response to xenobiotic stimulus
G	0014704	cellular_component	intercalated disc
G	0015272	molecular_function	ATP-activated inward rectifier potassium channel activity
G	0016020	cellular_component	membrane
G	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
G	0030315	cellular_component	T-tubule
G	0030506	molecular_function	ankyrin binding
G	0030673	cellular_component	axolemma
G	0030955	molecular_function	potassium ion binding
G	0031072	molecular_function	heat shock protein binding
G	0031669	biological_process	cellular response to nutrient levels
G	0032355	biological_process	response to estradiol
G	0033198	biological_process	response to ATP
G	0033574	biological_process	response to testosterone
G	0034220	biological_process	monoatomic ion transmembrane transport
G	0034702	cellular_component	monoatomic ion channel complex
G	0034765	biological_process	regulation of monoatomic ion transmembrane transport
G	0042383	cellular_component	sarcolemma
G	0042391	biological_process	regulation of membrane potential
G	0042734	cellular_component	presynaptic membrane
G	0043025	cellular_component	neuronal cell body
G	0044325	molecular_function	transmembrane transporter binding
G	0046676	biological_process	negative regulation of insulin secretion
G	0050796	biological_process	regulation of insulin secretion
G	0050877	biological_process	nervous system process
G	0061762	biological_process	CAMKK-AMPK signaling cascade
G	0070852	cellular_component	cell body fiber
G	0071316	biological_process	cellular response to nicotine
G	0071333	biological_process	cellular response to glucose stimulus
G	0071356	biological_process	cellular response to tumor necrosis factor
G	0071805	biological_process	potassium ion transmembrane transport
G	0098662	biological_process	inorganic cation transmembrane transport
G	0098978	cellular_component	glutamatergic synapse
G	0099505	biological_process	regulation of presynaptic membrane potential
G	0099508	molecular_function	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
G	1903078	biological_process	positive regulation of protein localization to plasma membrane
G	1904638	biological_process	response to resveratrol
G	1990573	biological_process	potassium ion import across plasma membrane
H	0005267	molecular_function	potassium channel activity
H	0005524	molecular_function	ATP binding
H	0005886	cellular_component	plasma membrane
H	0006813	biological_process	potassium ion transport
H	0008281	molecular_function	sulfonylurea receptor activity
H	0008282	cellular_component	inward rectifying potassium channel
H	0016020	cellular_component	membrane
H	0016887	molecular_function	ATP hydrolysis activity
H	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
H	0032991	cellular_component	protein-containing complex
H	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
H	0042626	molecular_function	ATPase-coupled transmembrane transporter activity
H	0043531	molecular_function	ADP binding
H	0044325	molecular_function	transmembrane transporter binding
H	0046676	biological_process	negative regulation of insulin secretion
H	0050905	biological_process	neuromuscular process
H	0055085	biological_process	transmembrane transport
H	0061535	biological_process	glutamate secretion, neurotransmission
H	0071805	biological_process	potassium ion transmembrane transport
H	0098655	biological_process	monoatomic cation transmembrane transport
H	0098662	biological_process	inorganic cation transmembrane transport
H	0098793	cellular_component	presynapse
H	0140359	molecular_function	ABC-type transporter activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue POV A 401

Chain	Residue
A	LEU85
A	LEU92
A	ILE93
A	ALA96
A	HIS97
A	ASN107
A	LEU144
A	ILE148
B	POV1609

site_id	AC2
Number of Residues	10
Details	binding site for residue AGS A 402

Chain	Residue
A	ASN48
A	ILE49
A	ARG50
A	ARG54
B	GLU203
G	LYS39
G	PHE183
G	LYS185
G	TYR330
G	GLY334

site_id	AC3
Number of Residues	11
Details	binding site for residue AJP B 1601

Chain	Residue
B	ASN426
B	TRP430
B	ASN547
B	VAL587
B	THR588
B	PHE591
B	LYS602
B	TYR1294
B	TRP1297
B	ASP1304
B	BJX1603

site_id	AC4
Number of Residues	11
Details	binding site for residue AGS B 1602

Chain	Residue
B	THR404
B	TRP688
B	GLN714
B	VAL715
B	GLY716
B	CYS717
B	GLY718
B	LYS719
B	SER720
B	SER721
B	GLN775

site_id	AC5
Number of Residues	12
Details	binding site for residue BJX B 1603

Chain	Residue
B	TYR377
B	ILE381
B	TRP430
B	LEU434
B	ASN437
B	LEU592
B	VAL596
B	ASN1245
B	ARG1246
B	GLU1249
B	ARG1300
B	AJP1601

site_id	AC6
Number of Residues	6
Details	binding site for residue POV B 1604

Chain	Residue
B	ILE93
B	GLY97
B	ARG102
B	TYR107
B	POV1605
B	POV1606

site_id	AC7
Number of Residues	4
Details	binding site for residue POV B 1605

Chain	Residue
B	ARG102
B	POV1604
B	POV1607
B	POV1608

site_id	AC8
Number of Residues	7
Details	binding site for residue POV B 1606

Chain	Residue
B	ILE89
B	ALA90
B	ILE93
B	GLY111
B	ASN354
B	POV1604
B	POV1611

site_id	AC9
Number of Residues	7
Details	binding site for residue POV B 1607

Chain	Residue
A	LEU80
A	SER118
B	PRO2
B	POV1605
B	POV1608
C	LEU147
C	ILE150

site_id	AD1
Number of Residues	15
Details	binding site for residue POV B 1608

Chain	Residue
A	LEU84
A	MET88
A	TRP91
A	HIS115
A	SER116
A	PHE117
B	LEU3
B	ALA4
B	PHE5
B	SER12
B	TYR15
B	PHE41
B	MET112
B	POV1605
B	POV1607

site_id	AD2
Number of Residues	4
Details	binding site for residue POV B 1609

Chain	Residue
A	POV401
B	GLY20
B	VAL21
B	LEU31

site_id	AD3
Number of Residues	2
Details	binding site for residue POV B 1610

Chain	Residue
B	ALA365
B	TYR454

site_id	AD4
Number of Residues	3
Details	binding site for residue POV B 1611

Chain	Residue
B	ALA1265
B	POV1606
B	TYR356

site_id	AD5
Number of Residues	5
Details	binding site for residue PTY B 1612

Chain	Residue
B	VAL121
B	VAL122
B	HIS125
B	LEU225
B	PTY1614

site_id	AD6
Number of Residues	6
Details	binding site for residue PTY B 1613

Chain	Residue
B	ILE76
B	ILE80
B	LEU224
B	PHE305
B	PHE372
B	PTY1615

site_id	AD7
Number of Residues	7
Details	binding site for residue PTY B 1614

Chain	Residue
B	TRP65
B	HIS125
B	VAL222
B	ASN223
B	LEU225
B	TRP231
B	PTY1612

site_id	AD8
Number of Residues	11
Details	binding site for residue PTY B 1615

Chain	Residue
B	PHE79
B	LEU224
B	LYS227
B	GLY228
B	LEU301
B	PHE305
B	LEU367
B	THR371
B	PHE372
B	ALA375
B	PTY1613

site_id	AD9
Number of Residues	10
Details	binding site for residue AGS C 401

Chain	Residue
A	LYS39
A	PHE183
A	LYS185
A	TYR330
A	GLY334
C	ASN48
C	ILE49
C	ARG50
C	ARG54
D	GLU203

site_id	AE1
Number of Residues	9
Details	binding site for residue POV C 402

Chain	Residue
C	LEU85
C	LEU92
C	ILE93
C	ALA96
C	HIS97
C	ASN107
C	LEU144
C	ILE148
D	POV1609

site_id	AE2
Number of Residues	11
Details	binding site for residue AJP D 1601

Chain	Residue
D	ASN426
D	TRP430
D	ASN547
D	VAL587
D	THR588
D	PHE591
D	LYS602
D	TYR1294
D	TRP1297
D	ASP1304
D	BJX1603

site_id	AE3
Number of Residues	11
Details	binding site for residue AGS D 1602

Chain	Residue
D	THR404
D	TRP688
D	GLN714
D	VAL715
D	GLY716
D	CYS717
D	GLY718
D	LYS719
D	SER720
D	SER721
D	GLN775

site_id	AE4
Number of Residues	12
Details	binding site for residue BJX D 1603

Chain	Residue
D	TYR377
D	ILE381
D	TRP430
D	LEU434
D	ASN437
D	LEU592
D	VAL596
D	ASN1245
D	ARG1246
D	GLU1249
D	ARG1300
D	AJP1601

site_id	AE5
Number of Residues	6
Details	binding site for residue POV D 1604

Chain	Residue
D	ILE93
D	GLY97
D	ARG102
D	TYR107
D	POV1605
D	POV1606

site_id	AE6
Number of Residues	4
Details	binding site for residue POV D 1605

Chain	Residue
D	ARG102
D	POV1604
D	POV1607
D	POV1608

site_id	AE7
Number of Residues	7
Details	binding site for residue POV D 1606

Chain	Residue
D	ILE89
D	ALA90
D	ILE93
D	GLY111
D	ASN354
D	POV1604
D	POV1611

site_id	AE8
Number of Residues	7
Details	binding site for residue POV D 1607

Chain	Residue
C	LEU80
C	SER118
D	PRO2
D	POV1605
D	POV1608
E	LEU147
E	ILE150

site_id	AE9
Number of Residues	15
Details	binding site for residue POV D 1608

Chain	Residue
C	LEU84
C	MET88
C	TRP91
C	HIS115
C	SER116
C	PHE117
D	LEU3
D	ALA4
D	PHE5
D	SER12
D	TYR15
D	PHE41
D	MET112
D	POV1605
D	POV1607

site_id	AF1
Number of Residues	4
Details	binding site for residue POV D 1609

Chain	Residue
C	POV402
D	GLY20
D	VAL21
D	LEU31

site_id	AF2
Number of Residues	2
Details	binding site for residue POV D 1610

Chain	Residue
D	ALA365
D	TYR454

site_id	AF3
Number of Residues	3
Details	binding site for residue POV D 1611

Chain	Residue
D	TYR356
D	ALA1265
D	POV1606

site_id	AF4
Number of Residues	5
Details	binding site for residue PTY D 1612

Chain	Residue
D	VAL121
D	VAL122
D	HIS125
D	LEU225
D	PTY1614

site_id	AF5
Number of Residues	6
Details	binding site for residue PTY D 1613

Chain	Residue
D	ILE76
D	ILE80
D	LEU224
D	PHE305
D	PHE372
D	PTY1615

site_id	AF6
Number of Residues	7
Details	binding site for residue PTY D 1614

Chain	Residue
D	TRP65
D	HIS125
D	VAL222
D	ASN223
D	LEU225
D	TRP231
D	PTY1612

site_id	AF7
Number of Residues	11
Details	binding site for residue PTY D 1615

Chain	Residue
D	PHE79
D	LEU224
D	LYS227
D	GLY228
D	LEU301
D	PHE305
D	LEU367
D	THR371
D	PHE372
D	ALA375
D	PTY1613

site_id	AF8
Number of Residues	10
Details	binding site for residue AGS E 401

Chain	Residue
C	LYS39
C	PHE183
C	LYS185
C	TYR330
C	GLY334
E	ASN48
E	ILE49
E	ARG50
E	ARG54
F	GLU203

site_id	AF9
Number of Residues	9
Details	binding site for residue POV E 402

Chain	Residue
E	LEU85
E	LEU92
E	ILE93
E	ALA96
E	HIS97
E	ASN107
E	LEU144
E	ILE148
F	POV1609

site_id	AG1
Number of Residues	11
Details	binding site for residue AJP F 1601

Chain	Residue
F	ASN426
F	TRP430
F	ASN547
F	VAL587
F	THR588
F	PHE591
F	LYS602
F	TYR1294
F	TRP1297
F	ASP1304
F	BJX1603

site_id	AG2
Number of Residues	11
Details	binding site for residue AGS F 1602

Chain	Residue
F	THR404
F	TRP688
F	GLN714
F	VAL715
F	GLY716
F	CYS717
F	GLY718
F	LYS719
F	SER720
F	SER721
F	GLN775

site_id	AG3
Number of Residues	12
Details	binding site for residue BJX F 1603

Chain	Residue
F	TYR377
F	ILE381
F	TRP430
F	LEU434
F	ASN437
F	LEU592
F	VAL596
F	ASN1245
F	ARG1246
F	GLU1249
F	ARG1300
F	AJP1601

site_id	AG4
Number of Residues	6
Details	binding site for residue POV F 1604

Chain	Residue
F	ILE93
F	GLY97
F	ARG102
F	TYR107
F	POV1605
F	POV1606

site_id	AG5
Number of Residues	4
Details	binding site for residue POV F 1605

Chain	Residue
F	ARG102
F	POV1604
F	POV1607
F	POV1608

site_id	AG6
Number of Residues	7
Details	binding site for residue POV F 1606

Chain	Residue
F	ILE89
F	ALA90
F	ILE93
F	GLY111
F	ASN354
F	POV1604
F	POV1611

site_id	AG7
Number of Residues	7
Details	binding site for residue POV F 1607

Chain	Residue
E	LEU80
E	SER118
F	PRO2
F	POV1605
F	POV1608
G	LEU147
G	ILE150

site_id	AG8
Number of Residues	15
Details	binding site for residue POV F 1608

Chain	Residue
E	LEU84
E	MET88
E	TRP91
E	HIS115
E	SER116
E	PHE117
F	LEU3
F	ALA4
F	PHE5
F	SER12
F	TYR15
F	PHE41
F	MET112
F	POV1605
F	POV1607

site_id	AG9
Number of Residues	4
Details	binding site for residue POV F 1609

Chain	Residue
E	POV402
F	GLY20
F	VAL21
F	LEU31

site_id	AH1
Number of Residues	2
Details	binding site for residue POV F 1610

Chain	Residue
F	ALA365
F	TYR454

site_id	AH2
Number of Residues	3
Details	binding site for residue POV F 1611

Chain	Residue
F	TYR356
F	ALA1265
F	POV1606

site_id	AH3
Number of Residues	5
Details	binding site for residue PTY F 1612

Chain	Residue
F	VAL121
F	VAL122
F	HIS125
F	LEU225
F	PTY1614

site_id	AH4
Number of Residues	6
Details	binding site for residue PTY F 1613

Chain	Residue
F	ILE76
F	ILE80
F	LEU224
F	PHE305
F	PHE372
F	PTY1615

site_id	AH5
Number of Residues	7
Details	binding site for residue PTY F 1614

Chain	Residue
F	TRP65
F	HIS125
F	VAL222
F	ASN223
F	LEU225
F	TRP231
F	PTY1612

site_id	AH6
Number of Residues	11
Details	binding site for residue PTY F 1615

Chain	Residue
F	PHE79
F	LEU224
F	LYS227
F	GLY228
F	LEU301
F	PHE305
F	LEU367
F	THR371
F	PHE372
F	ALA375
F	PTY1613

site_id	AH7
Number of Residues	10
Details	binding site for residue AGS G 401

Chain	Residue
E	LYS39
E	PHE183
E	LYS185
E	TYR330
E	GLY334
G	ASN48
G	ILE49
G	ARG50
G	ARG54
H	GLU203

site_id	AH8
Number of Residues	9
Details	binding site for residue POV G 402

Chain	Residue
G	LEU85
G	LEU92
G	ILE93
G	ALA96
G	HIS97
G	ASN107
G	LEU144
G	ILE148
H	POV1609

site_id	AH9
Number of Residues	11
Details	binding site for residue AJP H 1601

Chain	Residue
H	ASN426
H	TRP430
H	ASN547
H	VAL587
H	THR588
H	PHE591
H	LYS602
H	TYR1294
H	TRP1297
H	ASP1304
H	BJX1603

site_id	AI1
Number of Residues	11
Details	binding site for residue AGS H 1602

Chain	Residue
H	THR404
H	TRP688
H	GLN714
H	VAL715
H	GLY716
H	CYS717
H	GLY718
H	LYS719
H	SER720
H	SER721
H	GLN775

site_id	AI2
Number of Residues	12
Details	binding site for residue BJX H 1603

Chain	Residue
H	TYR377
H	ILE381
H	TRP430
H	LEU434
H	ASN437
H	LEU592
H	VAL596
H	ASN1245
H	ARG1246
H	GLU1249
H	ARG1300
H	AJP1601

site_id	AI3
Number of Residues	6
Details	binding site for residue POV H 1604

Chain	Residue
H	ILE93
H	GLY97
H	ARG102
H	TYR107
H	POV1605
H	POV1606

site_id	AI4
Number of Residues	4
Details	binding site for residue POV H 1605

Chain	Residue
H	ARG102
H	POV1604
H	POV1607
H	POV1608

site_id	AI5
Number of Residues	7
Details	binding site for residue POV H 1606

Chain	Residue
H	ILE89
H	ALA90
H	ILE93
H	GLY111
H	ASN354
H	POV1604
H	POV1611

site_id	AI6
Number of Residues	7
Details	binding site for residue POV H 1607

Chain	Residue
A	LEU147
A	ILE150
G	LEU80
G	SER118
H	PRO2
H	POV1605
H	POV1608

site_id	AI7
Number of Residues	15
Details	binding site for residue POV H 1608

Chain	Residue
G	LEU84
G	MET88
G	TRP91
G	HIS115
G	SER116
G	PHE117
H	LEU3
H	ALA4
H	PHE5
H	SER12
H	TYR15
H	PHE41
H	MET112
H	POV1605
H	POV1607

site_id	AI8
Number of Residues	4
Details	binding site for residue POV H 1609

Chain	Residue
G	POV402
H	GLY20
H	VAL21
H	LEU31

site_id	AI9
Number of Residues	2
Details	binding site for residue POV H 1610

Chain	Residue
H	ALA365
H	TYR454

site_id	AJ1
Number of Residues	3
Details	binding site for residue POV H 1611

Chain	Residue
H	TYR356
H	ALA1265
H	POV1606

site_id	AJ2
Number of Residues	5
Details	binding site for residue PTY H 1612

Chain	Residue
H	VAL121
H	VAL122
H	HIS125
H	LEU225
H	PTY1614

site_id	AJ3
Number of Residues	6
Details	binding site for residue PTY H 1613

Chain	Residue
H	ILE76
H	ILE80
H	LEU224
H	PHE305
H	PHE372
H	PTY1615

site_id	AJ4
Number of Residues	7
Details	binding site for residue PTY H 1614

Chain	Residue
H	TRP65
H	HIS125
H	VAL222
H	ASN223
H	LEU225
H	TRP231
H	PTY1612

site_id	AJ5
Number of Residues	11
Details	binding site for residue PTY H 1615

Chain	Residue
H	PHE79
H	LEU224
H	LYS227
H	GLY228
H	LEU301
H	PHE305
H	LEU367
H	THR371
H	PHE372
H	ALA375
H	PTY1613

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQRQRISVARAL

Chain	Residue	Details
B	LEU830-LEU844
B	PHE1482-PHE1496

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1160
Details	TOPO_DOM: Cytoplasmic => ECO:0000250

Chain	Residue	Details
A	MET1-TRP68
A	ILE167-SER390
C	MET1-TRP68
C	ILE167-SER390
E	MET1-TRP68
E	ILE167-SER390
G	MET1-TRP68
G	ILE167-SER390

site_id	SWS_FT_FI2
Number of Residues	96
Details	TRANSMEM: Helical; Name=M1 => ECO:0000250

Chain	Residue	Details
A	PRO69-ILE93
C	PRO69-ILE93
E	PRO69-ILE93
G	PRO69-ILE93

site_id	SWS_FT_FI3
Number of Residues	120
Details	TOPO_DOM: Extracellular => ECO:0000250

Chain	Residue	Details
A	ALA94-SER116
A	ARG136-LEU144
C	ALA94-SER116
C	ARG136-LEU144
E	ALA94-SER116
E	ARG136-LEU144
G	ALA94-SER116
G	ARG136-LEU144

site_id	SWS_FT_FI4
Number of Residues	44
Details	INTRAMEM: Helical; Pore-forming; Name=H5 => ECO:0000250

Chain	Residue	Details
A	PHE117-GLN128
C	PHE117-GLN128
E	PHE117-GLN128
G	PHE117-GLN128

site_id	SWS_FT_FI5
Number of Residues	24
Details	INTRAMEM: Pore-forming => ECO:0000250

Chain	Residue	Details
A	VAL129-GLY135
C	VAL129-GLY135
E	VAL129-GLY135
G	VAL129-GLY135

site_id	SWS_FT_FI6
Number of Residues	84
Details	TRANSMEM: Helical; Name=M2 => ECO:0000250

Chain	Residue	Details
A	ALA145-CYS166
C	ALA145-CYS166
E	ALA145-CYS166
G	ALA145-CYS166

site_id	SWS_FT_FI7
Number of Residues	4
Details	SITE: Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium => ECO:0000250

Chain	Residue	Details
A	ASN160
C	ASN160
E	ASN160
G	ASN160

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by MAPK1 => ECO:0000250\|UniProtKB:Q14654

Chain	Residue	Details
A	THR341
C	THR341
E	THR341
G	THR341

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Phosphoserine; by MAPK1 => ECO:0000250\|UniProtKB:Q14654

Chain	Residue	Details
A	SER385
C	SER385
E	SER385
G	SER385

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)