6J7F
Complex of GGTaseIII, farnesyl-Ykt6 (C-terminal methylated), and GGPP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008318 | molecular_function | protein prenyltransferase activity |
| A | 0018342 | biological_process | protein prenylation |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004659 | molecular_function | prenyltransferase activity |
| B | 0004661 | molecular_function | protein geranylgeranyltransferase activity |
| B | 0004663 | molecular_function | Rab geranylgeranyltransferase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0005968 | cellular_component | Rab-protein geranylgeranyltransferase complex |
| B | 0006888 | biological_process | endoplasmic reticulum to Golgi vesicle-mediated transport |
| B | 0007601 | biological_process | visual perception |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0008318 | molecular_function | protein prenyltransferase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0018344 | biological_process | protein geranylgeranylation |
| B | 0031267 | molecular_function | small GTPase binding |
| B | 0036211 | biological_process | protein modification process |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0000139 | cellular_component | Golgi membrane |
| C | 0005484 | molecular_function | SNAP receptor activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005768 | cellular_component | endosome |
| C | 0005783 | cellular_component | endoplasmic reticulum |
| C | 0005794 | cellular_component | Golgi apparatus |
| C | 0005829 | cellular_component | cytosol |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006888 | biological_process | endoplasmic reticulum to Golgi vesicle-mediated transport |
| C | 0006903 | biological_process | vesicle targeting |
| C | 0006904 | biological_process | vesicle docking involved in exocytosis |
| C | 0015031 | biological_process | protein transport |
| C | 0016020 | cellular_component | membrane |
| C | 0016192 | biological_process | vesicle-mediated transport |
| C | 0016740 | molecular_function | transferase activity |
| C | 0019706 | molecular_function | protein-cysteine S-palmitoyltransferase activity |
| C | 0030133 | cellular_component | transport vesicle |
| C | 0030659 | cellular_component | cytoplasmic vesicle membrane |
| C | 0031201 | cellular_component | SNARE complex |
| C | 0031410 | cellular_component | cytoplasmic vesicle |
| C | 0033116 | cellular_component | endoplasmic reticulum-Golgi intermediate compartment membrane |
| C | 0042147 | biological_process | retrograde transport, endosome to Golgi |
| C | 0043025 | cellular_component | neuronal cell body |
| C | 0045296 | molecular_function | cadherin binding |
| C | 0061025 | biological_process | membrane fusion |
| C | 0097440 | cellular_component | apical dendrite |
| C | 0097441 | cellular_component | basal dendrite |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue TLA B 401 |
| Chain | Residue |
| A | TYR42 |
| B | LYS250 |
| B | GLY253 |
| B | ARG254 |
| B | LEU255 |
| B | HIS256 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue FAR B 402 |
| Chain | Residue |
| B | TRP52 |
| B | PHE289 |
| C | CMT195 |
| B | TYR30 |
| B | GLY49 |
| B | ILE50 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue GER B 403 |
| Chain | Residue |
| B | GLN103 |
| B | GLY192 |
| B | GLN193 |
| B | TYR195 |
| B | CYS196 |
| B | TYR241 |
| B | TRP244 |
| C | CYS194 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue DPO B 404 |
| Chain | Residue |
| A | LYS135 |
| A | TYR191 |
| A | SER193 |
| B | HIS190 |
| B | ARG232 |
| B | LYS235 |
| B | TYR241 |
| C | CYS194 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"PFTA 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"PFTA 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"PFTA 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 41 |
| Details | Repeat: {"description":"PFTB 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 41 |
| Details | Repeat: {"description":"PFTB 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 41 |
| Details | Repeat: {"description":"PFTB 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 41 |
| Details | Repeat: {"description":"PFTB 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 41 |
| Details | Repeat: {"description":"PFTB 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"PFTB 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q08603","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 118 |
| Details | Domain: {"description":"Longin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00231","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"15479160","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
