6J6T
Crystal Structure of HDA15 HD domain
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000118 | cellular_component | histone deacetylase complex |
| A | 0004407 | molecular_function | histone deacetylase activity |
| A | 0006325 | biological_process | chromatin organization |
| A | 0016575 | biological_process | histone deacetylation |
| B | 0000118 | cellular_component | histone deacetylase complex |
| B | 0004407 | molecular_function | histone deacetylase activity |
| B | 0006325 | biological_process | chromatin organization |
| B | 0016575 | biological_process | histone deacetylation |
| C | 0000118 | cellular_component | histone deacetylase complex |
| C | 0004407 | molecular_function | histone deacetylase activity |
| C | 0006325 | biological_process | chromatin organization |
| C | 0016575 | biological_process | histone deacetylation |
| D | 0000118 | cellular_component | histone deacetylase complex |
| D | 0004407 | molecular_function | histone deacetylase activity |
| D | 0006325 | biological_process | chromatin organization |
| D | 0016575 | biological_process | histone deacetylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue ZN A 601 |
| Chain | Residue |
| A | ASP313 |
| A | HIS315 |
| A | ASP404 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue K A 602 |
| Chain | Residue |
| A | ASP311 |
| A | ASP313 |
| A | HIS315 |
| A | SER334 |
| A | LEU335 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 603 |
| Chain | Residue |
| A | LYS205 |
| A | GLN206 |
| C | THR213 |
| C | SER214 |
| C | GLU215 |
| A | THR204 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 604 |
| Chain | Residue |
| A | THR213 |
| A | SER214 |
| A | GLU215 |
| A | HOH704 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue ZN B 601 |
| Chain | Residue |
| B | ASP313 |
| B | HIS315 |
| B | ASP404 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue K B 602 |
| Chain | Residue |
| B | ASP311 |
| B | ASP313 |
| B | HIS315 |
| B | SER334 |
| B | LEU335 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 603 |
| Chain | Residue |
| B | ASN327 |
| B | LYS328 |
| B | SER329 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 604 |
| Chain | Residue |
| B | ASN445 |
| B | ARG447 |
| D | SER148 |
| D | LYS265 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 B 605 |
| Chain | Residue |
| A | ARG157 |
| A | ARG243 |
| A | HOH770 |
| B | THR204 |
| B | LYS205 |
| B | ARG246 |
| B | HOH743 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue ZN C 601 |
| Chain | Residue |
| C | ASP313 |
| C | HIS315 |
| C | ASP404 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue K C 602 |
| Chain | Residue |
| C | ASP311 |
| C | ASP313 |
| C | HIS315 |
| C | SER334 |
| C | LEU335 |
| site_id | AD3 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 C 603 |
| Chain | Residue |
| C | ARG179 |
| C | HOH709 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue ZN D 601 |
| Chain | Residue |
| D | ASP313 |
| D | HIS315 |
| D | ASP404 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue K D 602 |
| Chain | Residue |
| D | ASP311 |
| D | ASP313 |
| D | HIS315 |
| D | SER334 |
| D | LEU335 |
| site_id | AD6 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 D 603 |
| Chain | Residue |
| D | ARG179 |
| D | HOH708 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 D 604 |
| Chain | Residue |
| D | THR204 |
| D | LYS205 |
| D | HOH759 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 939 |
| Details | Region: {"description":"Histone deacetylase"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"31061103","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"32878973","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J6T","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Site: {"description":"Polarizes the scissile carbonyl of the substrate","evidences":[{"source":"PubMed","id":"32878973","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J6T","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
