Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6J5T

Reconstitution and structure of a plant NLR resistosome conferring immunity

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005886	cellular_component	plasma membrane
A	0006468	biological_process	protein phosphorylation
A	0006952	biological_process	defense response
A	0009507	cellular_component	chloroplast
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0030957	molecular_function	Tat protein binding
A	0106310	molecular_function	protein serine kinase activity
A	1900426	biological_process	positive regulation of defense response to bacterium
B	0000166	molecular_function	nucleotide binding
B	0004672	molecular_function	protein kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005886	cellular_component	plasma membrane
B	0006468	biological_process	protein phosphorylation
B	0006952	biological_process	defense response
B	0007166	biological_process	cell surface receptor signaling pathway
B	0009266	biological_process	response to temperature stimulus
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0042742	biological_process	defense response to bacterium
B	1900426	biological_process	positive regulation of defense response to bacterium
C	0000166	molecular_function	nucleotide binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005886	cellular_component	plasma membrane
C	0006952	biological_process	defense response
C	0042742	biological_process	defense response to bacterium
C	0043531	molecular_function	ADP binding
C	0050776	biological_process	regulation of immune response
C	0050829	biological_process	defense response to Gram-negative bacterium
C	0051707	biological_process	response to other organism
C	0098542	biological_process	defense response to other organism
D	0000166	molecular_function	nucleotide binding
D	0004672	molecular_function	protein kinase activity
D	0004674	molecular_function	protein serine/threonine kinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005886	cellular_component	plasma membrane
D	0006468	biological_process	protein phosphorylation
D	0006952	biological_process	defense response
D	0009507	cellular_component	chloroplast
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity
D	0030957	molecular_function	Tat protein binding
D	0106310	molecular_function	protein serine kinase activity
D	1900426	biological_process	positive regulation of defense response to bacterium
E	0000166	molecular_function	nucleotide binding
E	0004672	molecular_function	protein kinase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005886	cellular_component	plasma membrane
E	0006468	biological_process	protein phosphorylation
E	0006952	biological_process	defense response
E	0007166	biological_process	cell surface receptor signaling pathway
E	0009266	biological_process	response to temperature stimulus
E	0016301	molecular_function	kinase activity
E	0016740	molecular_function	transferase activity
E	0042742	biological_process	defense response to bacterium
E	1900426	biological_process	positive regulation of defense response to bacterium
F	0000166	molecular_function	nucleotide binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005886	cellular_component	plasma membrane
F	0006952	biological_process	defense response
F	0042742	biological_process	defense response to bacterium
F	0043531	molecular_function	ADP binding
F	0050776	biological_process	regulation of immune response
F	0050829	biological_process	defense response to Gram-negative bacterium
F	0051707	biological_process	response to other organism
F	0098542	biological_process	defense response to other organism
G	0000166	molecular_function	nucleotide binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005886	cellular_component	plasma membrane
G	0006952	biological_process	defense response
G	0042742	biological_process	defense response to bacterium
G	0043531	molecular_function	ADP binding
G	0050776	biological_process	regulation of immune response
G	0050829	biological_process	defense response to Gram-negative bacterium
G	0051707	biological_process	response to other organism
G	0098542	biological_process	defense response to other organism
H	0000166	molecular_function	nucleotide binding
H	0004672	molecular_function	protein kinase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005886	cellular_component	plasma membrane
H	0006468	biological_process	protein phosphorylation
H	0006952	biological_process	defense response
H	0007166	biological_process	cell surface receptor signaling pathway
H	0009266	biological_process	response to temperature stimulus
H	0016301	molecular_function	kinase activity
H	0016740	molecular_function	transferase activity
H	0042742	biological_process	defense response to bacterium
H	1900426	biological_process	positive regulation of defense response to bacterium
I	0000166	molecular_function	nucleotide binding
I	0004672	molecular_function	protein kinase activity
I	0004674	molecular_function	protein serine/threonine kinase activity
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005634	cellular_component	nucleus
I	0005886	cellular_component	plasma membrane
I	0006468	biological_process	protein phosphorylation
I	0006952	biological_process	defense response
I	0009507	cellular_component	chloroplast
I	0016301	molecular_function	kinase activity
I	0016740	molecular_function	transferase activity
I	0030957	molecular_function	Tat protein binding
I	0106310	molecular_function	protein serine kinase activity
I	1900426	biological_process	positive regulation of defense response to bacterium
J	0000166	molecular_function	nucleotide binding
J	0004672	molecular_function	protein kinase activity
J	0004674	molecular_function	protein serine/threonine kinase activity
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005634	cellular_component	nucleus
J	0005886	cellular_component	plasma membrane
J	0006468	biological_process	protein phosphorylation
J	0006952	biological_process	defense response
J	0009507	cellular_component	chloroplast
J	0016301	molecular_function	kinase activity
J	0016740	molecular_function	transferase activity
J	0030957	molecular_function	Tat protein binding
J	0106310	molecular_function	protein serine kinase activity
J	1900426	biological_process	positive regulation of defense response to bacterium
K	0000166	molecular_function	nucleotide binding
K	0004672	molecular_function	protein kinase activity
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005886	cellular_component	plasma membrane
K	0006468	biological_process	protein phosphorylation
K	0006952	biological_process	defense response
K	0007166	biological_process	cell surface receptor signaling pathway
K	0009266	biological_process	response to temperature stimulus
K	0016301	molecular_function	kinase activity
K	0016740	molecular_function	transferase activity
K	0042742	biological_process	defense response to bacterium
K	1900426	biological_process	positive regulation of defense response to bacterium
L	0000166	molecular_function	nucleotide binding
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005886	cellular_component	plasma membrane
L	0006952	biological_process	defense response
L	0042742	biological_process	defense response to bacterium
L	0043531	molecular_function	ADP binding
L	0050776	biological_process	regulation of immune response
L	0050829	biological_process	defense response to Gram-negative bacterium
L	0051707	biological_process	response to other organism
L	0098542	biological_process	defense response to other organism
M	0000166	molecular_function	nucleotide binding
M	0004672	molecular_function	protein kinase activity
M	0004674	molecular_function	protein serine/threonine kinase activity
M	0005515	molecular_function	protein binding
M	0005524	molecular_function	ATP binding
M	0005634	cellular_component	nucleus
M	0005886	cellular_component	plasma membrane
M	0006468	biological_process	protein phosphorylation
M	0006952	biological_process	defense response
M	0009507	cellular_component	chloroplast
M	0016301	molecular_function	kinase activity
M	0016740	molecular_function	transferase activity
M	0030957	molecular_function	Tat protein binding
M	0106310	molecular_function	protein serine kinase activity
M	1900426	biological_process	positive regulation of defense response to bacterium
N	0000166	molecular_function	nucleotide binding
N	0004672	molecular_function	protein kinase activity
N	0005515	molecular_function	protein binding
N	0005524	molecular_function	ATP binding
N	0005886	cellular_component	plasma membrane
N	0006468	biological_process	protein phosphorylation
N	0006952	biological_process	defense response
N	0007166	biological_process	cell surface receptor signaling pathway
N	0009266	biological_process	response to temperature stimulus
N	0016301	molecular_function	kinase activity
N	0016740	molecular_function	transferase activity
N	0042742	biological_process	defense response to bacterium
N	1900426	biological_process	positive regulation of defense response to bacterium
O	0000166	molecular_function	nucleotide binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005886	cellular_component	plasma membrane
O	0006952	biological_process	defense response
O	0042742	biological_process	defense response to bacterium
O	0043531	molecular_function	ADP binding
O	0050776	biological_process	regulation of immune response
O	0050829	biological_process	defense response to Gram-negative bacterium
O	0051707	biological_process	response to other organism
O	0098542	biological_process	defense response to other organism

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	33
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGGFGCVFkGwidqtsltasrpgsgiv.VAVK

Chain	Residue	Details
I	LEU92-LYS124

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ViYrDFKaaNILL

Chain	Residue	Details
I	VAL215-LEU227

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	10
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"O48814","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	5
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"O48814","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	10
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"O48814","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	45
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	1230
Details	Domain: {"description":"NB-ARC","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	115
Details	Repeat: {"description":"LRR 1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	120
Details	Repeat: {"description":"LRR 2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	120
Details	Repeat: {"description":"LRR 3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	115
Details	Repeat: {"description":"LRR 4","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	115
Details	Repeat: {"description":"LRR 5","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	130
Details	Repeat: {"description":"LRR 6","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	255
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30948527","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J6I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	40
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30948526","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30948527","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J5W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J6I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30948526","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J5W","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)