6J4X

RNA polymerase II elongation complex bound with Elf1 and Spt4/5, stalled at SHL(-1) of the nucleosome (+1A)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000428	cellular_component	DNA-directed RNA polymerase complex
A	0001055	molecular_function	RNA polymerase II activity
A	0003677	molecular_function	DNA binding
A	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
A	0005634	cellular_component	nucleus
A	0005665	cellular_component	RNA polymerase II, core complex
A	0006351	biological_process	DNA-templated transcription
A	0006366	biological_process	transcription by RNA polymerase II
A	0016779	molecular_function	nucleotidyltransferase activity
A	0034062	molecular_function	5'-3' RNA polymerase activity
A	0046872	molecular_function	metal ion binding
B	0000428	cellular_component	DNA-directed RNA polymerase complex
B	0001055	molecular_function	RNA polymerase II activity
B	0003677	molecular_function	DNA binding
B	0003723	molecular_function	RNA binding
B	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
B	0005654	cellular_component	nucleoplasm
B	0005665	cellular_component	RNA polymerase II, core complex
B	0005721	cellular_component	pericentric heterochromatin
B	0006351	biological_process	DNA-templated transcription
B	0006366	biological_process	transcription by RNA polymerase II
B	0006367	biological_process	transcription initiation at RNA polymerase II promoter
B	0016779	molecular_function	nucleotidyltransferase activity
B	0032549	molecular_function	ribonucleoside binding
B	0034062	molecular_function	5'-3' RNA polymerase activity
B	0046872	molecular_function	metal ion binding
B	0140727	biological_process	siRNA-mediated pericentric heterochromatin formation
C	0000428	cellular_component	DNA-directed RNA polymerase complex
C	0001055	molecular_function	RNA polymerase II activity
C	0003677	molecular_function	DNA binding
C	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
C	0005665	cellular_component	RNA polymerase II, core complex
C	0006351	biological_process	DNA-templated transcription
C	0006366	biological_process	transcription by RNA polymerase II
C	0046872	molecular_function	metal ion binding
C	0046983	molecular_function	protein dimerization activity
C	0055029	cellular_component	nuclear DNA-directed RNA polymerase complex
D	0000166	molecular_function	nucleotide binding
D	0000288	biological_process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
D	0000932	cellular_component	P-body
D	0001172	biological_process	RNA-templated transcription
D	0003697	molecular_function	single-stranded DNA binding
D	0003727	molecular_function	single-stranded RNA binding
D	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
D	0003968	molecular_function	RNA-dependent RNA polymerase activity
D	0005634	cellular_component	nucleus
D	0005665	cellular_component	RNA polymerase II, core complex
D	0005737	cellular_component	cytoplasm
D	0006352	biological_process	DNA-templated transcription initiation
D	0006366	biological_process	transcription by RNA polymerase II
D	0006367	biological_process	transcription initiation at RNA polymerase II promoter
D	0006368	biological_process	transcription elongation by RNA polymerase II
D	0030880	cellular_component	RNA polymerase complex
D	0031369	molecular_function	translation initiation factor binding
D	0044237	biological_process	cellular metabolic process
D	0045948	biological_process	positive regulation of translational initiation
D	1990328	cellular_component	RPB4-RPB7 complex
E	0001054	molecular_function	RNA polymerase I activity
E	0001055	molecular_function	RNA polymerase II activity
E	0001056	molecular_function	RNA polymerase III activity
E	0001172	biological_process	RNA-templated transcription
E	0003677	molecular_function	DNA binding
E	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
E	0003968	molecular_function	RNA-dependent RNA polymerase activity
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005665	cellular_component	RNA polymerase II, core complex
E	0005666	cellular_component	RNA polymerase III complex
E	0005736	cellular_component	RNA polymerase I complex
E	0006351	biological_process	DNA-templated transcription
E	0006360	biological_process	transcription by RNA polymerase I
E	0006361	biological_process	transcription initiation at RNA polymerase I promoter
E	0006362	biological_process	transcription elongation by RNA polymerase I
E	0006363	biological_process	termination of RNA polymerase I transcription
E	0006366	biological_process	transcription by RNA polymerase II
E	0006367	biological_process	transcription initiation at RNA polymerase II promoter
E	0006368	biological_process	transcription elongation by RNA polymerase II
E	0006383	biological_process	transcription by RNA polymerase III
E	0006384	biological_process	transcription initiation at RNA polymerase III promoter
E	0006386	biological_process	termination of RNA polymerase III transcription
E	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
E	0042797	biological_process	tRNA transcription by RNA polymerase III
F	0000428	cellular_component	DNA-directed RNA polymerase complex
F	0001054	molecular_function	RNA polymerase I activity
F	0001055	molecular_function	RNA polymerase II activity
F	0001056	molecular_function	RNA polymerase III activity
F	0001172	biological_process	RNA-templated transcription
F	0003677	molecular_function	DNA binding
F	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
F	0003968	molecular_function	RNA-dependent RNA polymerase activity
F	0005634	cellular_component	nucleus
F	0005665	cellular_component	RNA polymerase II, core complex
F	0005666	cellular_component	RNA polymerase III complex
F	0005736	cellular_component	RNA polymerase I complex
F	0006351	biological_process	DNA-templated transcription
F	0006360	biological_process	transcription by RNA polymerase I
F	0006361	biological_process	transcription initiation at RNA polymerase I promoter
F	0006362	biological_process	transcription elongation by RNA polymerase I
F	0006363	biological_process	termination of RNA polymerase I transcription
F	0006366	biological_process	transcription by RNA polymerase II
F	0006367	biological_process	transcription initiation at RNA polymerase II promoter
F	0006368	biological_process	transcription elongation by RNA polymerase II
F	0006383	biological_process	transcription by RNA polymerase III
F	0006384	biological_process	transcription initiation at RNA polymerase III promoter
F	0006386	biological_process	termination of RNA polymerase III transcription
F	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
F	0042797	biological_process	tRNA transcription by RNA polymerase III
G	0000428	cellular_component	DNA-directed RNA polymerase complex
G	0000932	cellular_component	P-body
G	0003676	molecular_function	nucleic acid binding
G	0003697	molecular_function	single-stranded DNA binding
G	0003727	molecular_function	single-stranded RNA binding
G	0005634	cellular_component	nucleus
G	0005665	cellular_component	RNA polymerase II, core complex
G	0006351	biological_process	DNA-templated transcription
G	0006352	biological_process	DNA-templated transcription initiation
G	0006367	biological_process	transcription initiation at RNA polymerase II promoter
G	0010590	biological_process	regulation of septum digestion after cytokinesis
G	0031369	molecular_function	translation initiation factor binding
G	0045948	biological_process	positive regulation of translational initiation
G	0055029	cellular_component	nuclear DNA-directed RNA polymerase complex
G	0060213	biological_process	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
H	0001054	molecular_function	RNA polymerase I activity
H	0001055	molecular_function	RNA polymerase II activity
H	0001056	molecular_function	RNA polymerase III activity
H	0001172	biological_process	RNA-templated transcription
H	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
H	0003968	molecular_function	RNA-dependent RNA polymerase activity
H	0005634	cellular_component	nucleus
H	0005665	cellular_component	RNA polymerase II, core complex
H	0005666	cellular_component	RNA polymerase III complex
H	0005736	cellular_component	RNA polymerase I complex
H	0006351	biological_process	DNA-templated transcription
H	0006360	biological_process	transcription by RNA polymerase I
H	0006361	biological_process	transcription initiation at RNA polymerase I promoter
H	0006362	biological_process	transcription elongation by RNA polymerase I
H	0006363	biological_process	termination of RNA polymerase I transcription
H	0006366	biological_process	transcription by RNA polymerase II
H	0006367	biological_process	transcription initiation at RNA polymerase II promoter
H	0006368	biological_process	transcription elongation by RNA polymerase II
H	0006383	biological_process	transcription by RNA polymerase III
H	0006384	biological_process	transcription initiation at RNA polymerase III promoter
H	0006386	biological_process	termination of RNA polymerase III transcription
H	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
H	0042797	biological_process	tRNA transcription by RNA polymerase III
I	0000428	cellular_component	DNA-directed RNA polymerase complex
I	0001193	biological_process	maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II
I	0003676	molecular_function	nucleic acid binding
I	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005665	cellular_component	RNA polymerase II, core complex
I	0005730	cellular_component	nucleolus
I	0006283	biological_process	transcription-coupled nucleotide-excision repair
I	0006351	biological_process	DNA-templated transcription
I	0006367	biological_process	transcription initiation at RNA polymerase II promoter
I	0008270	molecular_function	zinc ion binding
I	0046872	molecular_function	metal ion binding
I	0055029	cellular_component	nuclear DNA-directed RNA polymerase complex
J	0000428	cellular_component	DNA-directed RNA polymerase complex
J	0001054	molecular_function	RNA polymerase I activity
J	0001055	molecular_function	RNA polymerase II activity
J	0001056	molecular_function	RNA polymerase III activity
J	0003677	molecular_function	DNA binding
J	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
J	0005665	cellular_component	RNA polymerase II, core complex
J	0005666	cellular_component	RNA polymerase III complex
J	0005736	cellular_component	RNA polymerase I complex
J	0006351	biological_process	DNA-templated transcription
J	0006360	biological_process	transcription by RNA polymerase I
J	0006366	biological_process	transcription by RNA polymerase II
J	0006367	biological_process	transcription initiation at RNA polymerase II promoter
J	0006383	biological_process	transcription by RNA polymerase III
J	0008270	molecular_function	zinc ion binding
J	0042797	biological_process	tRNA transcription by RNA polymerase III
J	0046872	molecular_function	metal ion binding
K	0000428	cellular_component	DNA-directed RNA polymerase complex
K	0001055	molecular_function	RNA polymerase II activity
K	0001172	biological_process	RNA-templated transcription
K	0003677	molecular_function	DNA binding
K	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
K	0003968	molecular_function	RNA-dependent RNA polymerase activity
K	0005634	cellular_component	nucleus
K	0005665	cellular_component	RNA polymerase II, core complex
K	0006351	biological_process	DNA-templated transcription
K	0006366	biological_process	transcription by RNA polymerase II
K	0006367	biological_process	transcription initiation at RNA polymerase II promoter
K	0006368	biological_process	transcription elongation by RNA polymerase II
K	0006369	biological_process	termination of RNA polymerase II transcription
K	0046983	molecular_function	protein dimerization activity
L	0001054	molecular_function	RNA polymerase I activity
L	0001055	molecular_function	RNA polymerase II activity
L	0001056	molecular_function	RNA polymerase III activity
L	0003677	molecular_function	DNA binding
L	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
L	0005665	cellular_component	RNA polymerase II, core complex
L	0005666	cellular_component	RNA polymerase III complex
L	0005736	cellular_component	RNA polymerase I complex
L	0006351	biological_process	DNA-templated transcription
L	0006360	biological_process	transcription by RNA polymerase I
L	0006366	biological_process	transcription by RNA polymerase II
L	0006383	biological_process	transcription by RNA polymerase III
L	0008270	molecular_function	zinc ion binding
L	0046872	molecular_function	metal ion binding
M	0000993	molecular_function	RNA polymerase II complex binding
M	0005634	cellular_component	nucleus
M	0006368	biological_process	transcription elongation by RNA polymerase II
M	0008023	cellular_component	transcription elongation factor complex
M	0046872	molecular_function	metal ion binding
V	0000775	cellular_component	chromosome, centromeric region
V	0000993	molecular_function	RNA polymerase II complex binding
V	0005634	cellular_component	nucleus
V	0005694	cellular_component	chromosome
V	0006325	biological_process	chromatin organization
V	0006355	biological_process	regulation of DNA-templated transcription
V	0006368	biological_process	transcription elongation by RNA polymerase II
V	0008270	molecular_function	zinc ion binding
V	0032044	cellular_component	DSIF complex
V	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
V	0140673	biological_process	transcription elongation-coupled chromatin remodeling
W	0003711	molecular_function	transcription elongation factor activity
W	0003729	molecular_function	mRNA binding
W	0005634	cellular_component	nucleus
W	0006325	biological_process	chromatin organization
W	0006354	biological_process	DNA-templated transcription elongation
W	0006357	biological_process	regulation of transcription by RNA polymerase II
W	0006368	biological_process	transcription elongation by RNA polymerase II
W	0032044	cellular_component	DSIF complex
W	0032784	biological_process	regulation of DNA-templated transcription elongation
W	0140463	molecular_function	chromatin-protein adaptor activity
a	0000775	cellular_component	chromosome, centromeric region
a	0000781	cellular_component	chromosome, telomeric region
a	0000785	cellular_component	chromatin
a	0000786	cellular_component	nucleosome
a	0000939	cellular_component	inner kinetochore
a	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
a	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
a	0001556	biological_process	oocyte maturation
a	0001649	biological_process	osteoblast differentiation
a	0001740	cellular_component	Barr body
a	0003677	molecular_function	DNA binding
a	0005515	molecular_function	protein binding
a	0005576	cellular_component	extracellular region
a	0005634	cellular_component	nucleus
a	0005654	cellular_component	nucleoplasm
a	0005694	cellular_component	chromosome
a	0006334	biological_process	nucleosome assembly
a	0006997	biological_process	nucleus organization
a	0007283	biological_process	spermatogenesis
a	0007286	biological_process	spermatid development
a	0007338	biological_process	single fertilization
a	0007566	biological_process	embryo implantation
a	0008283	biological_process	cell population proliferation
a	0008584	biological_process	male gonad development
a	0030307	biological_process	positive regulation of cell growth
a	0030527	molecular_function	structural constituent of chromatin
a	0031492	molecular_function	nucleosomal DNA binding
a	0031508	biological_process	pericentric heterochromatin formation
a	0031509	biological_process	subtelomeric heterochromatin formation
a	0032200	biological_process	telomere organization
a	0032991	cellular_component	protein-containing complex
a	0035264	biological_process	multicellular organism growth
a	0042692	biological_process	muscle cell differentiation
a	0046982	molecular_function	protein heterodimerization activity
a	0048477	biological_process	oogenesis
a	0070062	cellular_component	extracellular exosome
a	0090230	biological_process	regulation of centromere complex assembly
a	1902340	biological_process	negative regulation of chromosome condensation
b	0000781	cellular_component	chromosome, telomeric region
b	0000786	cellular_component	nucleosome
b	0003677	molecular_function	DNA binding
b	0003723	molecular_function	RNA binding
b	0005515	molecular_function	protein binding
b	0005576	cellular_component	extracellular region
b	0005634	cellular_component	nucleus
b	0005654	cellular_component	nucleoplasm
b	0005694	cellular_component	chromosome
b	0006325	biological_process	chromatin organization
b	0006334	biological_process	nucleosome assembly
b	0016020	cellular_component	membrane
b	0030527	molecular_function	structural constituent of chromatin
b	0032200	biological_process	telomere organization
b	0032991	cellular_component	protein-containing complex
b	0043505	cellular_component	CENP-A containing nucleosome
b	0045653	biological_process	negative regulation of megakaryocyte differentiation
b	0046982	molecular_function	protein heterodimerization activity
b	0061644	biological_process	protein localization to CENP-A containing chromatin
b	0070062	cellular_component	extracellular exosome
c	0000786	cellular_component	nucleosome
c	0003677	molecular_function	DNA binding
c	0005515	molecular_function	protein binding
c	0005634	cellular_component	nucleus
c	0005694	cellular_component	chromosome
c	0006325	biological_process	chromatin organization
c	0008285	biological_process	negative regulation of cell population proliferation
c	0030527	molecular_function	structural constituent of chromatin
c	0031492	molecular_function	nucleosomal DNA binding
c	0031507	biological_process	heterochromatin formation
c	0043505	cellular_component	CENP-A containing nucleosome
c	0046982	molecular_function	protein heterodimerization activity
c	0061644	biological_process	protein localization to CENP-A containing chromatin
c	0070062	cellular_component	extracellular exosome
d	0000786	cellular_component	nucleosome
d	0001530	molecular_function	lipopolysaccharide binding
d	0002227	biological_process	innate immune response in mucosa
d	0003677	molecular_function	DNA binding
d	0005515	molecular_function	protein binding
d	0005615	cellular_component	extracellular space
d	0005634	cellular_component	nucleus
d	0005654	cellular_component	nucleoplasm
d	0005694	cellular_component	chromosome
d	0005829	cellular_component	cytosol
d	0005886	cellular_component	plasma membrane
d	0006325	biological_process	chromatin organization
d	0006334	biological_process	nucleosome assembly
d	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
d	0019731	biological_process	antibacterial humoral response
d	0030527	molecular_function	structural constituent of chromatin
d	0031640	biological_process	killing of cells of another organism
d	0042742	biological_process	defense response to bacterium
d	0043505	cellular_component	CENP-A containing nucleosome
d	0046982	molecular_function	protein heterodimerization activity
d	0050829	biological_process	defense response to Gram-negative bacterium
d	0050830	biological_process	defense response to Gram-positive bacterium
d	0061644	biological_process	protein localization to CENP-A containing chromatin
d	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
e	0000775	cellular_component	chromosome, centromeric region
e	0000781	cellular_component	chromosome, telomeric region
e	0000785	cellular_component	chromatin
e	0000786	cellular_component	nucleosome
e	0000939	cellular_component	inner kinetochore
e	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
e	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
e	0001556	biological_process	oocyte maturation
e	0001649	biological_process	osteoblast differentiation
e	0001740	cellular_component	Barr body
e	0003677	molecular_function	DNA binding
e	0005515	molecular_function	protein binding
e	0005576	cellular_component	extracellular region
e	0005634	cellular_component	nucleus
e	0005654	cellular_component	nucleoplasm
e	0005694	cellular_component	chromosome
e	0006334	biological_process	nucleosome assembly
e	0006997	biological_process	nucleus organization
e	0007283	biological_process	spermatogenesis
e	0007286	biological_process	spermatid development
e	0007338	biological_process	single fertilization
e	0007566	biological_process	embryo implantation
e	0008283	biological_process	cell population proliferation
e	0008584	biological_process	male gonad development
e	0030307	biological_process	positive regulation of cell growth
e	0030527	molecular_function	structural constituent of chromatin
e	0031492	molecular_function	nucleosomal DNA binding
e	0031508	biological_process	pericentric heterochromatin formation
e	0031509	biological_process	subtelomeric heterochromatin formation
e	0032200	biological_process	telomere organization
e	0032991	cellular_component	protein-containing complex
e	0035264	biological_process	multicellular organism growth
e	0042692	biological_process	muscle cell differentiation
e	0046982	molecular_function	protein heterodimerization activity
e	0048477	biological_process	oogenesis
e	0070062	cellular_component	extracellular exosome
e	0090230	biological_process	regulation of centromere complex assembly
e	1902340	biological_process	negative regulation of chromosome condensation
f	0000781	cellular_component	chromosome, telomeric region
f	0000786	cellular_component	nucleosome
f	0003677	molecular_function	DNA binding
f	0003723	molecular_function	RNA binding
f	0005515	molecular_function	protein binding
f	0005576	cellular_component	extracellular region
f	0005634	cellular_component	nucleus
f	0005654	cellular_component	nucleoplasm
f	0005694	cellular_component	chromosome
f	0006325	biological_process	chromatin organization
f	0006334	biological_process	nucleosome assembly
f	0016020	cellular_component	membrane
f	0030527	molecular_function	structural constituent of chromatin
f	0032200	biological_process	telomere organization
f	0032991	cellular_component	protein-containing complex
f	0043505	cellular_component	CENP-A containing nucleosome
f	0045653	biological_process	negative regulation of megakaryocyte differentiation
f	0046982	molecular_function	protein heterodimerization activity
f	0061644	biological_process	protein localization to CENP-A containing chromatin
f	0070062	cellular_component	extracellular exosome
g	0000786	cellular_component	nucleosome
g	0003677	molecular_function	DNA binding
g	0005515	molecular_function	protein binding
g	0005634	cellular_component	nucleus
g	0005694	cellular_component	chromosome
g	0006325	biological_process	chromatin organization
g	0008285	biological_process	negative regulation of cell population proliferation
g	0030527	molecular_function	structural constituent of chromatin
g	0031492	molecular_function	nucleosomal DNA binding
g	0031507	biological_process	heterochromatin formation
g	0043505	cellular_component	CENP-A containing nucleosome
g	0046982	molecular_function	protein heterodimerization activity
g	0061644	biological_process	protein localization to CENP-A containing chromatin
g	0070062	cellular_component	extracellular exosome
h	0000786	cellular_component	nucleosome
h	0001530	molecular_function	lipopolysaccharide binding
h	0002227	biological_process	innate immune response in mucosa
h	0003677	molecular_function	DNA binding
h	0005515	molecular_function	protein binding
h	0005615	cellular_component	extracellular space
h	0005634	cellular_component	nucleus
h	0005654	cellular_component	nucleoplasm
h	0005694	cellular_component	chromosome
h	0005829	cellular_component	cytosol
h	0005886	cellular_component	plasma membrane
h	0006325	biological_process	chromatin organization
h	0006334	biological_process	nucleosome assembly
h	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
h	0019731	biological_process	antibacterial humoral response
h	0030527	molecular_function	structural constituent of chromatin
h	0031640	biological_process	killing of cells of another organism
h	0042742	biological_process	defense response to bacterium
h	0043505	cellular_component	CENP-A containing nucleosome
h	0046982	molecular_function	protein heterodimerization activity
h	0050829	biological_process	defense response to Gram-negative bacterium
h	0050830	biological_process	defense response to Gram-positive bacterium
h	0061644	biological_process	protein localization to CENP-A containing chromatin
h	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 1801

Chain	Residue
A	CYS67
A	CYS70
A	CYS77
A	HIS80

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 1802

Chain	Residue
A	CYS107
A	ASN109
A	CYS110
A	CYS168

---

site_id	AC3
Number of Residues	4
Details	binding site for residue MG A 1803

Chain	Residue
A	ASP484
A	ASP486
P	G10
A	ASP482

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN B 1301

Chain	Residue
B	CYS1163
B	CYS1166
B	CYS1182
B	CYS1185

---

site_id	AC5
Number of Residues	5
Details	binding site for residue ZN C 401

Chain	Residue
C	CYS85
C	CYS87
C	CYS91
C	GLU93
C	CYS94

---

site_id	AC6
Number of Residues	5
Details	binding site for residue ZN I 201

Chain	Residue
I	CYS75
I	CYS78
I	CYS103
I	ASN105
I	CYS106

---

site_id	AC7
Number of Residues	3
Details	binding site for residue ZN I 202

Chain	Residue
I	CYS10
I	CYS29
I	CYS32

---

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN J 101

Chain	Residue
J	CYS7
J	CYS10
J	CYS44
J	CYS45

---

site_id	AC9
Number of Residues	5
Details	binding site for residue ZN L 101

Chain	Residue
L	CYS33
L	CYS36
L	CYS50
L	GLU52
L	CYS53

---

site_id	AD1
Number of Residues	5
Details	binding site for residue ZN M 201

Chain	Residue
M	CYS25
M	CYS28
M	CYS49
M	CYS52
M	LEU54

---

site_id	AD2
Number of Residues	4
Details	binding site for residue ZN V 300

Chain	Residue
V	CYS12
V	CYS15
V	CYS29
V	CYS32

---

Functional Information from PROSITE/UniProt

site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLqFPV

Chain	Residue	Details
c	ALA21-VAL27

---

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
b	GLY14-HIS18

---

site_id	PS00115
Number of Residues	7
Details	RNA_POL_II_REPEAT Eukaryotic RNA polymerase II heptapeptide repeat. YSPTSPS

Chain	Residue	Details
A	TYR1560-SER1566
A	TYR1567-SER1573
A	TYR1574-SER1580
A	TYR1581-SER1587
A	TYR1588-SER1594
A	TYR1595-SER1601
A	TYR1602-SER1608
A	TYR1609-SER1615
A	TYR1616-SER1622

---

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
a	LYS14-LEU20

---

site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG

Chain	Residue	Details
d	ARG89-GLY111

---

site_id	PS00446
Number of Residues	41
Details	RNA_POL_D_30KD RNA polymerases D / 30 to 40 Kd subunits signature. NSLRRtmlaevptlAidlVeikmNtSvlaDEfIShRLGLIP

Chain	Residue	Details
C	ASN30-PRO70

---

site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
a	PRO66-ILE74

---

site_id	PS01030
Number of Residues	27
Details	RNA_POL_M_15KD RNA polymerases M / 15 Kd subunits signature. FCLECNNMLypkedkenqrllysCrnC

Chain	Residue	Details
I	PHE6-CYS32

---

site_id	PS01110
Number of Residues	14
Details	RNA_POL_H_23KD RNA polymerases H / 23 Kd subunits signature. HELVPKHirLsdGE

Chain	Residue	Details
E	HIS146-GLU159

---

site_id	PS01111
Number of Residues	15
Details	RNA_POL_K_14KD RNA polymerases K / 14 to 18 Kd subunits signature. TkYErARiLGtRAlQ

Chain	Residue	Details
F	THR86-GLN100

---

site_id	PS01112
Number of Residues	10
Details	RNA_POL_N_8KD RNA polymerases N / 8 Kd subunits signature. IIPVrCFSCG

Chain	Residue	Details
J	ILE2-GLY11

---

site_id	PS01154
Number of Residues	32
Details	RNA_POL_L_13KD RNA polymerases L / 13 to 16 Kd subunits signature. FerEdHTLaNlLreeLalypdVtfvaYkveHP

Chain	Residue	Details
K	PHE35-PRO66

---

site_id	PS01166
Number of Residues	13
Details	RNA_POL_BETA RNA polymerases beta chain signature. GdKFASrHGQKGT

Chain	Residue	Details
B	GLY977-THR989

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: N-acetylproline => ECO:0000250|UniProtKB:P23527

Chain	Residue	Details
d	PRO-2
h	PRO-2

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: ADP-ribosyl glutamic acid => ECO:0000269|PubMed:27530147

Chain	Residue	Details
d	GLU-1
h	GLU-1

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	MOD_RES: N6-lactoyllysine; alternate => ECO:0000269|PubMed:31645732

Chain	Residue	Details
d	LYS2
h	LYS8
h	LYS12
h	LYS13
h	LYS17
h	LYS20
h	LYS40
h	LYS82
d	LYS8
d	LYS12
d	LYS13
d	LYS17
d	LYS20
d	LYS40
d	LYS82
h	LYS2

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: ADP-ribosylserine => ECO:0000269|PubMed:34874266

Chain	Residue	Details
d	SER3
h	SER3
g	LYS9
g	LYS95

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: N6-crotonyllysine; alternate => ECO:0000269|PubMed:21925322

Chain	Residue	Details
d	LYS9
h	LYS9
b	LYS44
f	LYS8
f	LYS16
f	LYS44

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphoserine; by STK4/MST1 => ECO:0000269|PubMed:12757711

Chain	Residue	Details
d	SER11
h	SER11
b	LYS77
b	LYS91
f	LYS12
f	LYS31
f	LYS77
f	LYS91

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: N6-(2-hydroxyisobutyryl)lysine => ECO:0000269|PubMed:24681537

Chain	Residue	Details
d	LYS21
h	LYS21
g	LYS74
g	LYS75

---

site_id	SWS_FT_FI8
Number of Residues	6
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435

Chain	Residue	Details
d	LYS31
d	LYS113
d	LYS117
h	LYS31
h	LYS113
h	LYS117

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: PolyADP-ribosyl glutamic acid => ECO:0000250|UniProtKB:Q64475

Chain	Residue	Details
d	GLU32
h	GLU32
c	LYS125
g	LYS118
g	LYS119
g	LYS125

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: Phosphoserine; by AMPK => ECO:0000250|UniProtKB:Q64475

Chain	Residue	Details
d	SER33
h	SER33

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16627869

Chain	Residue	Details
d	LYS43
d	LYS105
h	LYS43
h	LYS105

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	MOD_RES: N6-(2-hydroxyisobutyryl)lysine; alternate => ECO:0000269|PubMed:24681537

Chain	Residue	Details
d	LYS54
h	LYS54
g	LYS119

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	MOD_RES: Dimethylated arginine => ECO:0000250|UniProtKB:Q96A08

Chain	Residue	Details
d	ARG76
h	ARG76
e	LYS18
e	LYS64

---

site_id	SWS_FT_FI14
Number of Residues	4
Details	MOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:Q96A08

Chain	Residue	Details
d	ARG83
d	ARG89
h	ARG83
h	ARG89

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q00729

Chain	Residue	Details
d	THR112
h	THR112
f	LYS91

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	CARBOHYD: O-linked (GlcNAc) serine => ECO:0000250|UniProtKB:P62807

Chain	Residue	Details
d	SER109
h	SER109
b	LYS79
f	LYS20
f	LYS59
f	LYS79

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0000250|UniProtKB:P58876

Chain	Residue	Details
d	LYS2
h	LYS2

---

site_id	SWS_FT_FI18
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:16627869, ECO:0000269|PubMed:16713563

Chain	Residue	Details
a	SER31
d	LYS117
h	LYS117

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0000250|UniProtKB:Q5QNW6

Chain	Residue	Details
d	LYS17
h	LYS17

---

site_id	SWS_FT_FI20
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:21726816

Chain	Residue	Details
d	LYS31
h	LYS31

---

site_id	SWS_FT_FI21
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:20850016

Chain	Residue	Details
a	SER57
e	SER57

---

site_id	SWS_FT_FI22
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435, ECO:0000269|PubMed:29211711

Chain	Residue	Details
a	LYS79
e	LYS79

---

site_id	SWS_FT_FI23
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:20850016

Chain	Residue	Details
a	THR80
e	THR80

---

site_id	SWS_FT_FI24
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
a	SER86
e	SER86

---

site_id	SWS_FT_FI25
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
a	THR107
e	THR107

---

site_id	SWS_FT_FI26
Number of Residues	2
Details	MOD_RES: N6-glutaryllysine; alternate => ECO:0000269|PubMed:31542297

Chain	Residue	Details
a	LYS115
e	LYS115

---

site_id	SWS_FT_FI27
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435, ECO:0000269|PubMed:27436229

Chain	Residue	Details
a	LYS122
e	LYS122

---

site_id	SWS_FT_FI28
Number of Residues	2
Details	LIPID: N6-decanoyllysine => ECO:0000269|PubMed:35939806

Chain	Residue	Details
a	LYS18
e	LYS18

---