6J1N
Anisodus acutangulus type III polyketide sythase AaPKS2 in complex with 4-carboxy-3-oxobutanoyl-CoA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0009710 | biological_process | tropane alkaloid biosynthetic process |
| A | 0009813 | biological_process | flavonoid biosynthetic process |
| A | 0016625 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0030639 | biological_process | polyketide biosynthetic process |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0009710 | biological_process | tropane alkaloid biosynthetic process |
| B | 0009813 | biological_process | flavonoid biosynthetic process |
| B | 0016625 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0030639 | biological_process | polyketide biosynthetic process |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | binding site for residue B7X A 401 |
| Chain | Residue |
| A | LYS57 |
| A | PHE217 |
| A | CYS269 |
| A | HIS305 |
| A | GLY307 |
| A | ALA310 |
| A | ILE311 |
| A | ASN338 |
| A | SER340 |
| A | GLY376 |
| A | PRO377 |
| A | ARG60 |
| B | MET139 |
| A | ILE61 |
| A | ARG64 |
| A | ARG134 |
| A | GLY165 |
| A | CYS166 |
| A | ASP209 |
| A | LEU216 |
| site_id | AC2 |
| Number of Residues | 24 |
| Details | binding site for Di-peptide B7X B 401 and CYS B 166 |
| Chain | Residue |
| A | MET139 |
| B | LYS57 |
| B | ARG60 |
| B | ARG64 |
| B | ARG134 |
| B | GLY165 |
| B | PHE167 |
| B | ALA168 |
| B | ASP209 |
| B | LEU216 |
| B | PHE217 |
| B | CYS269 |
| B | LYS271 |
| B | PRO274 |
| B | HIS305 |
| B | GLY307 |
| B | ALA310 |
| B | ASN338 |
| B | SER340 |
| B | PHE375 |
| B | GLY376 |
| B | PRO377 |
| B | HOH519 |
| B | HOH533 |
Functional Information from PROSITE/UniProt
| site_id | PS00441 |
| Number of Residues | 17 |
| Details | CHALCONE_SYNTH Chalcone and stilbene synthases active site. RLmMyQqGCFAGGTmLR |
| Chain | Residue | Details |
| A | ARG158-ARG174 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile; acyl-thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU10023","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"31492848","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J1M","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"31492848","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31492848","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J1N","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
